保胎灵辅助治疗改善肾虚证先兆流产疗效观察及对血清TNF-α、PIBF水平的影响
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摘要
目的:探讨保胎灵辅助治疗肾虚证先兆流产的临床疗效及对肿瘤坏死因子-α(TNF-α)、孕激素诱导阻滞因子(PIBF)水平的影响。方法:将先兆流产患者68例随机分为对照组34例和治疗组34例;对照组给予地屈孕酮片治疗,治疗组在对照组的基础上口服保胎灵片;2组疗程均为2周,观察比较2组血止和腰酸、腹痛缓解时间、妊娠结局及临床疗效,并检测2组患者血清TNF-α、PIBF水平。结果:临床疗效总有效率治疗组为94.12%,对照组为73.53%,2组比较,差异有统计学意义(P<0.05)。正常妊娠率治疗组为91.18%,对照组为67.65%,2组比较,差异有统计学意义(P <0.05)。治疗后,治疗组患者血止和腰酸、腹痛缓解时间均明显短于对照组(P <0.05)。治疗后,2组血清TNF-α水平较治疗前降低(P <0.05),PIBF水平明较治疗前升高(P <0.05);且治疗组上述两项指标改善较对照组更显著(P <0.05)。结论:在地屈孕酮片治疗的基础上,保胎灵辅助治疗肾虚证先兆流产能提高临床疗效及正常妊娠率,迅速改善患者临床症状,其机制可能与调节体内TNF-α、PIBF水平有关。
Objective: To explore the clinical effect of Baotailing in adjuvant treatment of threatened abortion with kidney deficiency syndrome and its effect on the levels of serum tumor necrosis factor-α(TNF-α) and progesterone-induced blocking factor(PIBF). Methods:Divided 68 cases of patients with threatened abortion into the control group and the treatment group randomly,34 cases in each group. The control group received dydrogesterone tablets, while the treatment group additionally received the oral administration of Baotailing tablets. The treatment for both groups lasted for two weeks. Observed and compared the time of hemostasis and relief in waist soreness and abdominal pain,pregnancy outcome and clinical effect in both groups,and detected the levels of serum TNF-α and PIBF of patients in both groups. Results:The total effective rate was 94.12% in the treatment group and 73.53% in the control group,difference being significant(P < 0.05). The rate of normal pregnancy was 91.18% in the treatment group and 67.65% in the control group, difference being significant(P < 0.05). After treatment, the time of hemostasis and relief in waist soreness and abdominal pain in the treatment group was significantly shorter than that in the control group respectively(P < 0.05). After treatment,the level of serum TNF-α in both groups was lower than that before treatment(P < 0.05),and the level of PIBF was higher than that before treatment(P < 0.05);the two indexes above in the treatment group were improved more significantly than those in the control group(P <0.05). Conclusion: Based on dydrogesterone tablets, Baotailing in adjuvant treatment of threatened abortion with kidney deficiency syndrome can promote the clinical effect and the rate of normal pregnancy and quickly improve the clinical symptoms of patients. Its functional mechanism may be related to adjusting the levels of serum TNF-α and PIBF.
Objective: To explore the clinical effect of Baotailing in adjuvant treatment of threatened abortion with kidney deficiency syndrome and its effect on the levels of serum tumor necrosis factor-α(TNF-α) and progesterone-induced blocking factor(PIBF). Methods:Divided 68 cases of patients with threatened abortion into the control group and the treatment group randomly,34 cases in each group. The control group received dydrogesterone tablets, while the treatment group additionally received the oral administration of Baotailing tablets. The treatment for both groups lasted for two weeks. Observed and compared the time of hemostasis and relief in waist soreness and abdominal pain,pregnancy outcome and clinical effect in both groups,and detected the levels of serum TNF-α and PIBF of patients in both groups. Results:The total effective rate was 94.12% in the treatment group and 73.53% in the control group,difference being significant(P < 0.05). The rate of normal pregnancy was 91.18% in the treatment group and 67.65% in the control group, difference being significant(P < 0.05). After treatment, the time of hemostasis and relief in waist soreness and abdominal pain in the treatment group was significantly shorter than that in the control group respectively(P < 0.05). After treatment,the level of serum TNF-α in both groups was lower than that before treatment(P < 0.05),and the level of PIBF was higher than that before treatment(P < 0.05);the two indexes above in the treatment group were improved more significantly than those in the control group(P <0.05). Conclusion: Based on dydrogesterone tablets, Baotailing in adjuvant treatment of threatened abortion with kidney deficiency syndrome can promote the clinical effect and the rate of normal pregnancy and quickly improve the clinical symptoms of patients. Its functional mechanism may be related to adjusting the levels of serum TNF-α and PIBF.
引文
[1]蔡志善,黄河.低剂量黄体酮注射液联合保胎无忧胶囊治疗先兆流产的疗效分析[J].中国药房,2017,28(6):759-761.
[2]徐淑敏,刘宏奇.刘宏奇教授治疗先兆流产的经验[J].浙江中医药大学学报,2016,40(12):939-941.
[3]萧梓楷,易佰蓉,罗梦妮.保胎灵胶囊治疗先兆流产的临床疗效与安全性分析[J].现代诊断与治疗,2017,28(4):612-614.
[4]乐杰.妇产科学[M].7版.北京:人民卫生出版社,2008:83.
[5]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:253-258.
[6]毛燕舞,徐素君,徐晓敏,等.中药内服外敷对肾虚型早期先兆流产患者性激素水平及短期妊娠预后的影响[J].上海中医药杂志,2018,52(3):58-61.
[7]邓玉娥,杜小利.圣世散对先兆流产模型小鼠血清TNF-α及IL-10的影响[J].广东医学,2017,38(22):3410-3412.
[8]朱静,张芸,李小燕,等.寿胎丸加味联合黄体酮对早期先兆流产患者血清TNF-α与IL-10的影响[J].云南中医中药杂志,2016,37(11):46-47.
[9]吴昕,李艳青,胡俊攀.孕宝煎剂对先兆流产患者孕激素诱导阻滞因子及内分泌因子影响的临床研究[J].中华中医药杂志,2017,32(12):5678-5681.
[10]杨小芳,彭君醒,叶国娟.孕激素对先兆流产患者血清PIBF水平变化及妊娠结局的影响[J].中国妇幼保健,2016,31(9):1920-1922.
[2]徐淑敏,刘宏奇.刘宏奇教授治疗先兆流产的经验[J].浙江中医药大学学报,2016,40(12):939-941.
[3]萧梓楷,易佰蓉,罗梦妮.保胎灵胶囊治疗先兆流产的临床疗效与安全性分析[J].现代诊断与治疗,2017,28(4):612-614.
[4]乐杰.妇产科学[M].7版.北京:人民卫生出版社,2008:83.
[5]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:253-258.
[6]毛燕舞,徐素君,徐晓敏,等.中药内服外敷对肾虚型早期先兆流产患者性激素水平及短期妊娠预后的影响[J].上海中医药杂志,2018,52(3):58-61.
[7]邓玉娥,杜小利.圣世散对先兆流产模型小鼠血清TNF-α及IL-10的影响[J].广东医学,2017,38(22):3410-3412.
[8]朱静,张芸,李小燕,等.寿胎丸加味联合黄体酮对早期先兆流产患者血清TNF-α与IL-10的影响[J].云南中医中药杂志,2016,37(11):46-47.
[9]吴昕,李艳青,胡俊攀.孕宝煎剂对先兆流产患者孕激素诱导阻滞因子及内分泌因子影响的临床研究[J].中华中医药杂志,2017,32(12):5678-5681.
[10]杨小芳,彭君醒,叶国娟.孕激素对先兆流产患者血清PIBF水平变化及妊娠结局的影响[J].中国妇幼保健,2016,31(9):1920-1922.