鱼藤酮致帕金森病动物模型研究进展
摘要
帕金森病(Parkinson’s disease,PD)是一种常见的中枢神经系统退行性疾病,以黑质多巴胺能神经元退行性变性死亡和残存的神经元内形成Lewy小体为主要病理特征。这种疾病的发病机制尚未完全清楚,流行病学调查发现接触杀虫剂的人有多发帕金森病迹象,现已公认鱼藤酮作为一种杀虫剂可用来制作帕金森病模型。本文就鱼藤酮损伤的帕金森病动物模型研究进展进行综述,为进一步探讨帕金森病发病机制提供参考。
引文
[1] Le?o AHFF,Sarmento-Silva AJ,Santos JR,et al.Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson’s Disease:New Perspectives to a Long-Standing Model[J].Brain Pathology,2015,25(4):377-390.
[2] Cheng F,Vivacqua G,Yu S.The role of alpha-synuclein in neurotransmission and synaptic plasticity[J].Journal of Chemical Neuroanatomy,2011,42(4):242-248.
[3] Xiong N,Long X,Xiong J,et al.Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson’s disease models[J].Critical Reviews in Toxicology, 2012, 42(7):613-632.
[4] Johnson ME,Bobrovskaya L.An update on the rotenone models of Parkinson’s disease: Their ability to reproduce the features of clinical disease and model gene-environment interactions[J].Neurotoxicology, 2015, 46:101-116.
[5] Maniyath SP,Solaiappan N,Rathinasamy M. Neurobehavioural Changes in a Hemiparkinsonian Rat Model Induced by Rotenone[J].Journal of Clinical & Diagnostic Research Jcdr,2017,11(3):AF01- AF05.
[6] Subaraja M,Vanisree AJ.Rotenone causing dysfunctional mitochondria and lysosomes in cerebral ganglions of Lumbricus terrestris degenerate giant fibers and neuromuscular junctions[J].Chemosphere, 2016, 152:468-480.
[7] Xue X,Bian JS.Chapter Ten-Neuroprotective Effects of Hydrogen Sulfide in Parkinson’s Disease Animal Models:Methods and Protocols[J].Methods in Enzymology,2015,554:169-186.
[8] Wang SJ,Wang Q,Ma J,et al.Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson’s disease model rats[J].Neural regeneration research,2018,13(1):112-118.
[9] Zhang ZN,Zhang JS,Xiang J,et al.Subcutaneous rotenone rat model of Parkinson’s disease:Dose exploration study[J].Brain Research,2017,1655:104-113.
[10] Yuan J,Ren J,Wang Y,et al.Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson’s Disease[J].Plos One,2016,11(9):e0162696.
[11] El-Horany HE,El-Latif RNA,Elbatsh MM,et al.Ameliorative Effect of Quercetin on Neurochemical and Behavioral Deficits in Rotenone Rat Model of Parkinson’s Disease: Modulating Autophagy (Quercetin on Experimental Parkinson’s Disease)[J].Journal of Biochemical & Molecular Toxicology,2016,30(7):360-369.
[12] Alam M,Mayerhofer A,Schmidt WJ.The neurobehavioral changes induced by bilateral rotenone lesion in medial forebrain bundle of rats are reversed by L-DOPA.[J].Behavioural Brain Research,2004,151(1-2):117-124.
[13] Alam M,Schmidt WJ.Mitochondrial complex I inhibition depletes plasma testosterone in the rotenone model of Parkinson’s disease[J].Physiology & Behavior,2004,83(3):395-400.
[14] Drolet RE,Cannon JR,Montero L,et al.Chronic rotenone exposure reproduces Parkinson’s disease gastrointestinal neuropathology[J].Neurobiology of Disease,2009,36(1):96.
[15] Inden M,Kitamura Y,Abe M,et al.Parkinsonian rotenone mouse model:reevaluation of long-term administration of rotenone in C57BL/6 mice[J].Biological & Pharmaceutical Bulletin,2011,34(1):92-96.
[16] Carriere CH,Kang NH,Niles LP.Chronic low-dose melatonin treatment maintains nigrostriatal integrity in an intrastriatal rotenone model of Parkinson’s disease[J].Brain Research,2015,1633(4):115-125.
[17] 万叶,郭春燕,李永民,等.鱼藤酮诱导帕金森病模型的制备方法及其机制研究进展[J].中国药理学与毒理学杂志,2017,8(31):840-848.
[18] Sasajima H,Miyazono S,Noguchi T.Intranasal Administration of Rotenone to Mice Induces Dopaminergic Neurite Degeneration of Dopaminergic Neurons in the Substantia Nigra[J].Biological & pharmaceutical bulletin,2017,40(1):108-112.
[19] Rojo AI,Cavada C,de Sagarra MR,et al.Chronic inhalation of rotenone or paraquat does not induce Parkinson’s disease symptoms in mice or rats[J].Experimental Neurology,2007,208(1):120-126.
[20] Rui DSP,Aguiar AS,Matheus FC,et al.Intranasal Administration of Neurotoxicants in Animals:Support for the Olfactory Vector Hypothesis of Parkinson’s Disease[J].Neurotoxicity Research,2012,21(1):90-116.
[2] Cheng F,Vivacqua G,Yu S.The role of alpha-synuclein in neurotransmission and synaptic plasticity[J].Journal of Chemical Neuroanatomy,2011,42(4):242-248.
[3] Xiong N,Long X,Xiong J,et al.Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson’s disease models[J].Critical Reviews in Toxicology, 2012, 42(7):613-632.
[4] Johnson ME,Bobrovskaya L.An update on the rotenone models of Parkinson’s disease: Their ability to reproduce the features of clinical disease and model gene-environment interactions[J].Neurotoxicology, 2015, 46:101-116.
[5] Maniyath SP,Solaiappan N,Rathinasamy M. Neurobehavioural Changes in a Hemiparkinsonian Rat Model Induced by Rotenone[J].Journal of Clinical & Diagnostic Research Jcdr,2017,11(3):AF01- AF05.
[6] Subaraja M,Vanisree AJ.Rotenone causing dysfunctional mitochondria and lysosomes in cerebral ganglions of Lumbricus terrestris degenerate giant fibers and neuromuscular junctions[J].Chemosphere, 2016, 152:468-480.
[7] Xue X,Bian JS.Chapter Ten-Neuroprotective Effects of Hydrogen Sulfide in Parkinson’s Disease Animal Models:Methods and Protocols[J].Methods in Enzymology,2015,554:169-186.
[8] Wang SJ,Wang Q,Ma J,et al.Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson’s disease model rats[J].Neural regeneration research,2018,13(1):112-118.
[9] Zhang ZN,Zhang JS,Xiang J,et al.Subcutaneous rotenone rat model of Parkinson’s disease:Dose exploration study[J].Brain Research,2017,1655:104-113.
[10] Yuan J,Ren J,Wang Y,et al.Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson’s Disease[J].Plos One,2016,11(9):e0162696.
[11] El-Horany HE,El-Latif RNA,Elbatsh MM,et al.Ameliorative Effect of Quercetin on Neurochemical and Behavioral Deficits in Rotenone Rat Model of Parkinson’s Disease: Modulating Autophagy (Quercetin on Experimental Parkinson’s Disease)[J].Journal of Biochemical & Molecular Toxicology,2016,30(7):360-369.
[12] Alam M,Mayerhofer A,Schmidt WJ.The neurobehavioral changes induced by bilateral rotenone lesion in medial forebrain bundle of rats are reversed by L-DOPA.[J].Behavioural Brain Research,2004,151(1-2):117-124.
[13] Alam M,Schmidt WJ.Mitochondrial complex I inhibition depletes plasma testosterone in the rotenone model of Parkinson’s disease[J].Physiology & Behavior,2004,83(3):395-400.
[14] Drolet RE,Cannon JR,Montero L,et al.Chronic rotenone exposure reproduces Parkinson’s disease gastrointestinal neuropathology[J].Neurobiology of Disease,2009,36(1):96.
[15] Inden M,Kitamura Y,Abe M,et al.Parkinsonian rotenone mouse model:reevaluation of long-term administration of rotenone in C57BL/6 mice[J].Biological & Pharmaceutical Bulletin,2011,34(1):92-96.
[16] Carriere CH,Kang NH,Niles LP.Chronic low-dose melatonin treatment maintains nigrostriatal integrity in an intrastriatal rotenone model of Parkinson’s disease[J].Brain Research,2015,1633(4):115-125.
[17] 万叶,郭春燕,李永民,等.鱼藤酮诱导帕金森病模型的制备方法及其机制研究进展[J].中国药理学与毒理学杂志,2017,8(31):840-848.
[18] Sasajima H,Miyazono S,Noguchi T.Intranasal Administration of Rotenone to Mice Induces Dopaminergic Neurite Degeneration of Dopaminergic Neurons in the Substantia Nigra[J].Biological & pharmaceutical bulletin,2017,40(1):108-112.
[19] Rojo AI,Cavada C,de Sagarra MR,et al.Chronic inhalation of rotenone or paraquat does not induce Parkinson’s disease symptoms in mice or rats[J].Experimental Neurology,2007,208(1):120-126.
[20] Rui DSP,Aguiar AS,Matheus FC,et al.Intranasal Administration of Neurotoxicants in Animals:Support for the Olfactory Vector Hypothesis of Parkinson’s Disease[J].Neurotoxicity Research,2012,21(1):90-116.