严格饮食干预疗法对过敏性紫癜疗效分析
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摘要
目的探讨严格饮食干预治疗后能否降低过敏性紫癜各种合并症如紫癜肾炎、胰腺炎、消化道大量出血等的发生率。方法选择2010年1月—2014年12月5年间确诊为过敏性紫癜的患儿,进行随机分组治疗,并跟踪随访,记录其病情变化及转归情况,采用X2检验进行统计学分析。结果经过统计分析发现,严格饮食干预治疗后,消化道出血、大面积皮下出血斑点片、胰腺炎、紫癜性肾炎发生率明显降低,差异具有统计学意义(P <0. 05)。脑炎发生率差异无统计学意义(P> 0. 05)。结论对于过敏性紫癜,严格饮食干预治疗几乎无任何明显不良反应、且操作简单,可以作为一种积极的治疗过敏性紫癜的方法。
Objective The main purpose of this study was to evaluate a treatment method of the strict diet in children with Henoch-Schonlein purpura. Methods Totally 127 cases who was admitted in hospital was divided into two groups randomly. The method of strict diet treatment was given to the one of the two groups. Results The morbidity of the Henoeh-Sehonlein purpura nephritis,pancreatitis and massive hemorrhage of gastrointestinal tract in the group with strict diet treatment is lower than the other group obviously. Conclusion Foods are a common reason that cause Henoch-Schonlein purpura,so the strict diet treatment can reduce the mobidity of the Henoch-Schonlein purpura nephritis,pancreatitis and massive hemorrhage of gastrointestinal tract.
Objective The main purpose of this study was to evaluate a treatment method of the strict diet in children with Henoch-Schonlein purpura. Methods Totally 127 cases who was admitted in hospital was divided into two groups randomly. The method of strict diet treatment was given to the one of the two groups. Results The morbidity of the Henoeh-Sehonlein purpura nephritis,pancreatitis and massive hemorrhage of gastrointestinal tract in the group with strict diet treatment is lower than the other group obviously. Conclusion Foods are a common reason that cause Henoch-Schonlein purpura,so the strict diet treatment can reduce the mobidity of the Henoch-Schonlein purpura nephritis,pancreatitis and massive hemorrhage of gastrointestinal tract.
引文
[1]中华医学会儿科学分会肾脏病学组.儿童常见肾脏疾病诊治循证指南(二):紫癜性肾炎的诊治循证指南(试行)[J].中华儿科杂志,2009,47(12):911-913.
[2] Stewart M,Savage JM,Bell B,et al. Long-term renal prognosis of Henoch-Schonle in purpura in an unselected childhood population[J]. Eur J Pediatr,1988,147(2):113-115.
[3]吴玉斌.过敏性紫癜肾炎的治疗进展[J].中国实用儿科杂志,2006,21(6):411-413.
[4] Chang WL,Yang YH,Wang LC,et al. Renal manifestations in Henoch-Schonlein purpura:a 10-year clinical study[J]. Pediatr Nephrol,2005,20(9):1269-1272.
[5]刘静,陆彪.过敏性紫癜临床特征及肾脏损害危险因素Logistic回归分析[J].宁夏医科大学学报. 2011,33(6):528-531.
[6]廖若水.过敏性紫癜患儿肾脏损害的危险因素分析[J].临床研究,2012,10(31)246-248.
[7] FT Saulsbury. Clinical update Henoeh-Schonle in purpura[J].Lancet,2007,369(9566):976-978.
[8]高吉照,焦玉清,卢思广.儿童过敏性紫癜肾脏损害的临床相关因素分析[J].南京医科大学学报·自然科学版. 2007,27(4):312-316.
[9]邸翠兰,马宏.儿童过敏性紫癜肾脏损害相关因素的临床分析[J].中国药物与临床. 2012,12(7):951-953.
[10]吴春蕾,樊忠民,夏正坤,等.血管紧张素原基因多态性与儿童过敏性紫癜及紫癜性肾炎的关系[J].临床儿科杂志,2009,27(4):314-316.
[11]夏殉,鹿玲.过敏性紫瘫患儿肾脏损害的危险因素分析[J].实用儿科临床杂志. 2010. 25(9):654-655.
[12]杨谨.过敏性紫瘫患儿血浆中血栓调节蛋白含量与蛋白C活性的测定及意义[J].实用医学杂志,2007,23(12):1938.
[13] Yang YH,Chuang YH,Wang LC,et al. The immunobiology of Henoch-Schonlein purpura[J]. Autoimmun Rev. 2008,7(3):179-184.
[14]朱聪智,谭继英.不同年龄段儿童过敏性紫癜过敏原检测与分析[J].中国临床研究,2011,24(2):124-125.
[2] Stewart M,Savage JM,Bell B,et al. Long-term renal prognosis of Henoch-Schonle in purpura in an unselected childhood population[J]. Eur J Pediatr,1988,147(2):113-115.
[3]吴玉斌.过敏性紫癜肾炎的治疗进展[J].中国实用儿科杂志,2006,21(6):411-413.
[4] Chang WL,Yang YH,Wang LC,et al. Renal manifestations in Henoch-Schonlein purpura:a 10-year clinical study[J]. Pediatr Nephrol,2005,20(9):1269-1272.
[5]刘静,陆彪.过敏性紫癜临床特征及肾脏损害危险因素Logistic回归分析[J].宁夏医科大学学报. 2011,33(6):528-531.
[6]廖若水.过敏性紫癜患儿肾脏损害的危险因素分析[J].临床研究,2012,10(31)246-248.
[7] FT Saulsbury. Clinical update Henoeh-Schonle in purpura[J].Lancet,2007,369(9566):976-978.
[8]高吉照,焦玉清,卢思广.儿童过敏性紫癜肾脏损害的临床相关因素分析[J].南京医科大学学报·自然科学版. 2007,27(4):312-316.
[9]邸翠兰,马宏.儿童过敏性紫癜肾脏损害相关因素的临床分析[J].中国药物与临床. 2012,12(7):951-953.
[10]吴春蕾,樊忠民,夏正坤,等.血管紧张素原基因多态性与儿童过敏性紫癜及紫癜性肾炎的关系[J].临床儿科杂志,2009,27(4):314-316.
[11]夏殉,鹿玲.过敏性紫瘫患儿肾脏损害的危险因素分析[J].实用儿科临床杂志. 2010. 25(9):654-655.
[12]杨谨.过敏性紫瘫患儿血浆中血栓调节蛋白含量与蛋白C活性的测定及意义[J].实用医学杂志,2007,23(12):1938.
[13] Yang YH,Chuang YH,Wang LC,et al. The immunobiology of Henoch-Schonlein purpura[J]. Autoimmun Rev. 2008,7(3):179-184.
[14]朱聪智,谭继英.不同年龄段儿童过敏性紫癜过敏原检测与分析[J].中国临床研究,2011,24(2):124-125.