Stereotactic body radiation therapy in patients with hepatocellular carcinoma: A mini-review
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摘要
Stereotactic body radiation therapy(SBRT) is an emerging treatment for hepatocellular carcinoma. This technique results in excellent local control rates with favorable toxicity profile despite being predominantly used in heavily pretreated patients or those unsuitable for other local therapies. SBRT may be used as a sole treatment or in combination with other local therapies as well as a bridging strategy for patient awaiting liver transplants. This brief review describes current practice of SBRT with respect to radiation technique, patient selection and treatment concepts. It summarizes available evidence from retroand prospective studies evaluating SBRT alone, SBRT in combination with other treatments and SBRT compared to other local treatment approaches.
Stereotactic body radiation therapy(SBRT) is an emerging treatment for hepatocellular carcinoma. This technique results in excellent local control rates with favorable toxicity profile despite being predominantly used in heavily pretreated patients or those unsuitable for other local therapies. SBRT may be used as a sole treatment or in combination with other local therapies as well as a bridging strategy for patient awaiting liver transplants. This brief review describes current practice of SBRT with respect to radiation technique, patient selection and treatment concepts. It summarizes available evidence from retroand prospective studies evaluating SBRT alone, SBRT in combination with other treatments and SBRT compared to other local treatment approaches.
Stereotactic body radiation therapy(SBRT) is an emerging treatment for hepatocellular carcinoma. This technique results in excellent local control rates with favorable toxicity profile despite being predominantly used in heavily pretreated patients or those unsuitable for other local therapies. SBRT may be used as a sole treatment or in combination with other local therapies as well as a bridging strategy for patient awaiting liver transplants. This brief review describes current practice of SBRT with respect to radiation technique, patient selection and treatment concepts. It summarizes available evidence from retroand prospective studies evaluating SBRT alone, SBRT in combination with other treatments and SBRT compared to other local treatment approaches.
引文
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4 Murray LJ,Dawson LA.Advances in Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma.Semin Radiat Oncol 2017;27:247-255[PMID:[[28577832 DOI:10.1016/j.semradonc.2017.02.002]
5 NCCN.Clinical Practice Guidelines in Oncology-Hepatobiliary Cancers.2018.Available from:https://www.nccn.org/patients/guidelines/hepatobiliary/
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12 Bhattacharya IS,Hoskin PJ.Stereotactic body radiotherapy for spinal and bone metastases.Clin Oncol(RColl Radiol)2015;27:298-306[PMID:[[25687175 DOI:10.1016/j.clon.2015.01.030]
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16 Bibault JE,Dewas S,Vautravers-Dewas C,Hollebecque A,Jarraya H,Lacornerie T,Lartigau E,Mirabel X.Stereotactic body radiation therapy for hepatocellular carcinoma:prognostic factors of local control,overall survival,and toxicity.PLoS One 2013;8:e77472[PMID:[[24147002 DOI:10.1371/journal.pone.0077472]
17 Huertas A,Baumann AS,Saunier-Kubs F,Salleron J,Oldrini G,Croisé-Laurent V,Barraud H,Ayav A,Bronowicki JP,Peiffert D.Stereotactic body radiation therapy as an ablative treatment for inoperable hepatocellular carcinoma.Radiother Oncol 2015;115:211-216[PMID:[[26028227 DOI:10.1016/j.radonc.2015.04.006]
18 Wunderink W,Méndez Romero A,Seppenwoolde Y,de Boer H,Levendag P,Heijmen B.Potentials and limitations of guiding liver stereotactic body radiation therapy set-up on liver-implanted fiducial markers.Int J Radiat Oncol Biol Phys 2010;77:1573-1583[PMID:[[20399034 DOI:10.1016/j.ijrobp.2009.10.040]
19 Wahl DR,Stenmark MH,Tao Y,Pollom EL,Caoili EM,Lawrence TS,Schipper MJ,Feng M.Outcomes After Stereotactic Body Radiotherapy or Radiofrequency Ablation for Hepatocellular Carcinoma.J Clin Oncol 2016;34:452-459[PMID:[[26628466 DOI:10.1200/JCO.2015.61.4925]
20 Sapir E,Tao Y,Schipper MJ,Bazzi L,Novelli PM,Devlin P,Owen D,Cuneo KC,Lawrence TS,Parikh ND,Feng M.Stereotactic Body Radiation Therapy as an Alternative to Transarterial Chemoembolization for Hepatocellular Carcinoma.Int J Radiat Oncol Biol Phys 2018;100:122-130[PMID:[[29066120 DOI:10.1016/j.ijrobp.2017.09.001]
21 Mohamed M,Katz AW,Tejani MA,Sharma AK,Kashyap R,Noel MS,Qiu H,Hezel AF,Ramaraju GA,Dokus MK,Orloff MS.Comparison of outcomes between SBRT,yttrium-90 radioembolization,transarterial chemoembolization,and radiofrequency ablation as bridge to transplant for hepatocellular carcinoma.Adv Radiat Oncol 2015;1:35-42[PMID:[[28799575 DOI:10.1016/j.adro.2015.12.003]
22 Herfarth KK,Hof H,Bahner ML,Lohr F,H?ss A,van Kaick G,Wannenmacher M,Debus J.Assessment of focal liver reaction by multiphasic CT after stereotactic single-dose radiotherapy of liver tumors.Int JRadiat Oncol Biol Phys 2003;57:444-451[PMID:[[12957256 DOI:10.1016/S0360-3016(03)00586-8]
23 Mendiratta-Lala M,Gu E,Owen D,Cuneo KC,Bazzi L,Lawrence TS,Hussain HK,Davenport MS.Imaging Findings Within the First 12 Months of Hepatocellular Carcinoma Treated With Stereotactic Body Radiation Therapy.Int J Radiat Oncol Biol Phys 2018;102:1063-1069[PMID:[[29029891 DOI:10.1016/j.ijrobp.2017.08.022]
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2 Delis SG,Dervenis C.Selection criteria for liver resection in patients with hepatocellular carcinoma and chronic liver disease.World J Gastroenterol 2008;14:3452-3460[PMID:[[18567070 DOI:10.3748/wjg.14.3452]
3 Gerum S,Heinz C,Belka C,Walter F,Paprottka P,De Toni EN,Roeder F.Stereotactic body radiation therapy(SBRT)in patients with hepatocellular carcinoma and oligometastatic liver disease.Radiat Oncol2018;13:100[PMID:[[29843752 DOI:10.1186/s13014-018-1048-4]
4 Murray LJ,Dawson LA.Advances in Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma.Semin Radiat Oncol 2017;27:247-255[PMID:[[28577832 DOI:10.1016/j.semradonc.2017.02.002]
5 NCCN.Clinical Practice Guidelines in Oncology-Hepatobiliary Cancers.2018.Available from:https://www.nccn.org/patients/guidelines/hepatobiliary/
6 Kalogeridi MA,Zygogianni A,Kyrgias G,Kouvaris J,Chatziioannou S,Kelekis N,Kouloulias V.Role of radiotherapy in the management of hepatocellular carcinoma:A systematic review.World J Hepatol2015;7:101-112[PMID:[[25625001 DOI:10.4254/wjh.v7.i1.101]
7 Waller LP,Deshpande V,Pyrsopoulos N.Hepatocellular carcinoma:A comprehensive review.World JHepatol 2015;7:2648-2663[PMID:[[26609342 DOI:10.4254/wjh.v7.i26.2648]
8 Guckenberger M,Andratschke N,Alheit H,Holy R,Moustakis C,Nestle U,Sauer O;Deutschen Gesellschaft für Radioonkologie(DEGRO).Definition of stereotactic body radiotherapy:principles and practice for the treatment of stage I non-small cell lung cancer.Strahlenther Onkol 2014;190:26-33[PMID:[[24052011 DOI:10.1007/s00066-013-0450-y]
9 Kocher M,Wittig A,Piroth MD,Treuer H,Seegenschmiedt H,Ruge M,Grosu AL,Guckenberger M.Stereotactic radiosurgery for treatment of brain metastases.A report of the DEGRO Working Group on Stereotactic Radiotherapy.Strahlenther Onkol 2014;190:521-532[PMID:[[24715242 DOI:10.1007/s00066-014-0648-7]
10 Tanadini-Lang S,Rieber J,Filippi AR,Fode MM,Streblow J,Adebahr S,Andratschke N,Blanck O,Boda-Heggemann J,Duma M,Eble MJ,Ernst I,Flentje M,Gerum S,Hass P,Henkenberens C,Hildebrandt G,Imhoff D,Kahl H,Klass ND,Krempien R,Lohaus F,Petersen C,Schrade E,Wendt TG,Wittig A,H?yer M,Ricardi U,Sterzing F,Guckenberger M.Nomogram based overall survival prediction in stereotactic body radiotherapy for oligo-metastatic lung disease.Radiother Oncol 2017;123:182-188[PMID:[[28169042 DOI:10.1016/j.radonc.2017.01.003]
11 Jereczek-Fossa BA,Ronchi S,Orecchia R.Is Stereotactic Body Radiotherapy(SBRT)in lymph node oligometastatic patients feasible and effective?Rep Pract Oncol Radiother 2015;20:472-483[PMID:[[26696788 DOI:10.1016/j.rpor.2014.10.004]
12 Bhattacharya IS,Hoskin PJ.Stereotactic body radiotherapy for spinal and bone metastases.Clin Oncol(RColl Radiol)2015;27:298-306[PMID:[[25687175 DOI:10.1016/j.clon.2015.01.030]
13 Zeng ZC,Seong J,Yoon SM,Cheng JC,Lam KO,Lee AS,Law A,Zhang JY,Hu Y.Consensus on Stereotactic Body Radiation Therapy for Small-Sized Hepatocellular Carcinoma at the 7th Asia-Pacific Primary Liver Cancer Expert Meeting.Liver Cancer 2017;6:264-274[PMID:[[29234630 DOI:10.1159/000475768]
14 Lasley FD,Mannina EM,Johnson CS,Perkins SM,Althouse S,Maluccio M,Kwo P,Cárdenes H.Treatment variables related to liver toxicity in patients with hepatocellular carcinoma,Child-Pugh class Aand B enrolled in a phase 1-2 trial of stereotactic body radiation therapy.Pract Radiat Oncol 2015;5:e443-e449[PMID:[[25899219 DOI:10.1016/j.prro.2015.02.007]
15 Yoon SM,Lim YS,Park MJ,Kim SY,Cho B,Shim JH,Kim KM,Lee HC,Chung YH,Lee YS,Lee SG,Lee YS,Park JH,Kim JH.Stereotactic body radiation therapy as an alternative treatment for small hepatocellular carcinoma.PLoS One 2013;8:e79854[PMID:[[24255719 DOI:10.1371/journal.pone.0079854]
16 Bibault JE,Dewas S,Vautravers-Dewas C,Hollebecque A,Jarraya H,Lacornerie T,Lartigau E,Mirabel X.Stereotactic body radiation therapy for hepatocellular carcinoma:prognostic factors of local control,overall survival,and toxicity.PLoS One 2013;8:e77472[PMID:[[24147002 DOI:10.1371/journal.pone.0077472]
17 Huertas A,Baumann AS,Saunier-Kubs F,Salleron J,Oldrini G,Croisé-Laurent V,Barraud H,Ayav A,Bronowicki JP,Peiffert D.Stereotactic body radiation therapy as an ablative treatment for inoperable hepatocellular carcinoma.Radiother Oncol 2015;115:211-216[PMID:[[26028227 DOI:10.1016/j.radonc.2015.04.006]
18 Wunderink W,Méndez Romero A,Seppenwoolde Y,de Boer H,Levendag P,Heijmen B.Potentials and limitations of guiding liver stereotactic body radiation therapy set-up on liver-implanted fiducial markers.Int J Radiat Oncol Biol Phys 2010;77:1573-1583[PMID:[[20399034 DOI:10.1016/j.ijrobp.2009.10.040]
19 Wahl DR,Stenmark MH,Tao Y,Pollom EL,Caoili EM,Lawrence TS,Schipper MJ,Feng M.Outcomes After Stereotactic Body Radiotherapy or Radiofrequency Ablation for Hepatocellular Carcinoma.J Clin Oncol 2016;34:452-459[PMID:[[26628466 DOI:10.1200/JCO.2015.61.4925]
20 Sapir E,Tao Y,Schipper MJ,Bazzi L,Novelli PM,Devlin P,Owen D,Cuneo KC,Lawrence TS,Parikh ND,Feng M.Stereotactic Body Radiation Therapy as an Alternative to Transarterial Chemoembolization for Hepatocellular Carcinoma.Int J Radiat Oncol Biol Phys 2018;100:122-130[PMID:[[29066120 DOI:10.1016/j.ijrobp.2017.09.001]
21 Mohamed M,Katz AW,Tejani MA,Sharma AK,Kashyap R,Noel MS,Qiu H,Hezel AF,Ramaraju GA,Dokus MK,Orloff MS.Comparison of outcomes between SBRT,yttrium-90 radioembolization,transarterial chemoembolization,and radiofrequency ablation as bridge to transplant for hepatocellular carcinoma.Adv Radiat Oncol 2015;1:35-42[PMID:[[28799575 DOI:10.1016/j.adro.2015.12.003]
22 Herfarth KK,Hof H,Bahner ML,Lohr F,H?ss A,van Kaick G,Wannenmacher M,Debus J.Assessment of focal liver reaction by multiphasic CT after stereotactic single-dose radiotherapy of liver tumors.Int JRadiat Oncol Biol Phys 2003;57:444-451[PMID:[[12957256 DOI:10.1016/S0360-3016(03)00586-8]
23 Mendiratta-Lala M,Gu E,Owen D,Cuneo KC,Bazzi L,Lawrence TS,Hussain HK,Davenport MS.Imaging Findings Within the First 12 Months of Hepatocellular Carcinoma Treated With Stereotactic Body Radiation Therapy.Int J Radiat Oncol Biol Phys 2018;102:1063-1069[PMID:[[29029891 DOI:10.1016/j.ijrobp.2017.08.022]
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