Ⅰ型磷脂酰肌醇4-磷酸5-激酶在神经发育性疾病中的作用及其机制研究
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摘要
<正>Ⅰ型磷脂酰肌醇4-磷酸5-激酶(typeⅠphosphatidylinositol 4-phosphate 5-kinase,PIP5KIs)是体内合成4,5-二磷酸磷脂酰肌醇[phosphatidylinositol4,5-bisphosphate,PI(4,5)P2]的关键酶,PIP5KIs催化磷酸化4-磷酸磷脂酰肌醇(PI4P)肌醇环上第
引文
[1]Porciello N,Kunkl M,Viola A,et al.Phosphatidylinositol4-phosphate 5-kinases in the regulation of T cell activation[J].Front Immunol,2016,7:186.
[2]Dyson JM,Conduit SE,Feeney SJ,et al.INPP5E regulates phosphoinositide-dependent cilia transition zone function[J].J Cell Biol,2016,216(1):247-263.
[3]Saarikangas J,Kourdougli N,Senju Y,et al.MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation[J].Dev Cell,2015,33(6):644-659.
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[6]Nakamura Y,Fukami K.Regulation and physiological functions of mammalian phospholipase C[J].J Biochem,2017,161(4):315-321.
[7]De Craene JO,Bertazzi DL,B?r S,et al.Phosphoinositides,major actors in membrane trafficking and lipid signaling pathways[J].Int J Mol Sci,2017,18(3):634-654.
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[10]Van den Bout I,Divecha N.PIP5K-driven Ptd Ins(4,5)P2synthesis:regulation and cellular functions[J].J Cell Sci,2009,122(21):3837-3850.
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[16]Liu T,Lee SY.Phosphatidylinositol 4-phosphate 5-kinase a negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells[J].Exp Mol Med,2013,45:16.
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[19]Hernández-Deviez DJ,Roth MG,Casanova JE,et al.ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate5-kinase[J].Mol Biol Cell,2003,15(1):111-120.
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[21]Yu LY,Chou RH,Chen LT,et al.EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1Cdependent calcium signaling[J].J Biol Chem,2011,286(11):9657-9667.
[22]Yamazaki M,Yamauchi Y,Goshima Y,et al.Phosphatidylinositol 4-phosphate 5-kinase regulates growth cone morphology and Semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons[J].Neurosci Lett,2013,547:59-64.
[23]Chao WT,Daquinag AC,Ashcroft F,et al.Type I PIPKαregulates directed cell migration by modulating Rac1 plasma membrane targeting and activation[J].J Cell Biol,2010,190(2):247-262.
[24]Chao WT,Ashcroft F,Daquinag AC,et al.Type I phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting 1 integrin endocytosis[J].Mol Cell Biol,2010,30(18):4463-4479.
[25]Wang Y,Lian L,Golden JA,et al.PIP5KI is required for cardiovascular and neuronal development[J].PNAS,2007,104(28):11748-11753.
[26]Li X,Zhou Q,Sunkara M,et al.Ubiquitylation of phosphatidylinositol 4-phosphate5-kinase type I c by HECTD1 regulates focal adhesion dynamics and cell migration[J].J Cell Sci,2013,126:2617-2628.
[27]刘梅.PIP5KI家族在自噬中的功能研究[D].北京:清华大学生命科学学院,2013:4-15.
[28]Narkis G,Ofir R,Landau D,et al.Lethal contractural syndrome type3(LCCS3)is caused by amutation in PIP5K1C,which encodes PIPKI gamma of the phophatidylinsitol pathway[J].Am J Hum Genet,2007,81:530-539.
[29]Fancy SP,Harrington EP,Yuen TJ,et al.Axin2 as regulatory and therapeutic target in newborn brain injuryand remyelination[J].Nat Neurosci,2011,14:1009-1016.
[30]郑臻,母得志.骨髓间充质干细胞治疗缺氧缺血性脑损伤的研究现状[J].中华妇幼临床医学杂志(电子版),2017,13(4):373-377.
[31]张平,肖淑珠,徐淑婷.胎儿宫内缺血缺氧心电图表现的新认知[J].中国产前诊断杂志(电子版),2017,9(4):18-20.
[32]Lee HK,Chaboub LS,Zhu W,et al.Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS[J].Neuron,2015,85(6):1227-1243.
[33]Lee HK,Deneen B.Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord[J].Dev Cell,2012,22(1):183-196.
[34]Broggini T,Schnell L,Ghoochani A,et al.Plasticity Related Gene 3(PRG3)overcomes myelin‐associated growth inhibition and promotes functional recovery after spinal cord injury[J].AGING(Albany NY),2016,8(10):2463-2438.
[35]成胜权.出生缺陷及常见出生缺陷早期诊断和干预[J].发育医学电子杂志,2015,3(1):1-7.
[36]Campion A,Lee C,Bao N,et al.A parental perspective concerning barriers to care for neural tube defects in China[J].Surg Neurol Int,2017,8:195.
[37]Ramya S,Shyamasundar S,Bay BH,et al.Maternal diabetes alters expression of micro RNAs that regulate genes critical for neural tube development[J].Front Mol Neurosci,2017,10:237.
[38]Di Paolo G,Moskowitz HS,Gipson K,et al.Impaired Ptd Ins(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking[J].Nature,2004,431(7007):415-422.
[39]Liu A,Sui D,Wu D,et al.The activation loop of PIP5K functions as a membrane sensor essential for lipid substrate processing[J].Sci Adv,2016,2(11):e1600925.
[40]Jafari N,Zheng Q,Li L,et al.p70S6K1(S6K1)-mediated phosphorylation regulates phosphatidylinositol 4-phosphate5-kinase type I degradation and cell invasion[J].J Biol Chem,2016,291(49):25729-25741.
[2]Dyson JM,Conduit SE,Feeney SJ,et al.INPP5E regulates phosphoinositide-dependent cilia transition zone function[J].J Cell Biol,2016,216(1):247-263.
[3]Saarikangas J,Kourdougli N,Senju Y,et al.MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation[J].Dev Cell,2015,33(6):644-659.
[4]Khelashvili G,Weinstein H.Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops[J].Biochim Biophys Acta,2015,1848(9):1765-1774.
[5]Kolay S,Basu U,Raghu P.Control of diverse subcellular processes by a single multi-functional lipid phosphatidylinositol 4,5-bisphosphate[PI(4,5)P2][J].Biochem J,2016,473(12):1681-1692.
[6]Nakamura Y,Fukami K.Regulation and physiological functions of mammalian phospholipase C[J].J Biochem,2017,161(4):315-321.
[7]De Craene JO,Bertazzi DL,B?r S,et al.Phosphoinositides,major actors in membrane trafficking and lipid signaling pathways[J].Int J Mol Sci,2017,18(3):634-654.
[8]Monteiro ME,Sarmento MJ,Fernandes F.Role of calcium in membrane interactions by PI(4,5)P2-binding proteins[J].Biochem Soc Trans,2014,42(5):1441-1446.
[9]Sakagami H,Katsumata O,Hara Y,et al.Preferential localization of type I phosphatidylinositol 4-phosphate5-kinaseγat the periactive zone of mouse photoreceptor ribbon synapses[J].Brain Res,2014,8:51.
[10]Van den Bout I,Divecha N.PIP5K-driven Ptd Ins(4,5)P2synthesis:regulation and cellular functions[J].J Cell Sci,2009,122(21):3837-3850.
[11]Liu A,Sui D,Wu D,et al.The activation loop of PIP5K functions as a membrane sensor essential for lipid substrate processing[J].Sci Adv,2016,2(11):e1600925.
[12]Xia Y,Irvine RF,Giudici ML.Phosphatidylinositol4-phosphate 5-kinase Ic_v6,a new splice variant found in rodents and humans[J].Biochem Biophys Res Commun,2011,411:416-420.
[13]Funakoshi Y,Hasegawa H,Kanaho Y.Regulation of PIP5K activity by arf6 and its physiological significance[J].J Cell Physiol,2011,226:888-895.
[14]Volpicelli-Daley LA,Lucast L,Gong LW,et al.Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain[J].J Biol Chem,2010,285:28708-28714.
[15]Lacalle RA,de Karam JC,Martínez-Mu?oz L,et al.Type I phosphatidylinositol 4-phosphate 5-kinase homoand heterodimerization determines its membrane localization and activity[J].FASEB J,2015,29(6):2371-2385.
[16]Liu T,Lee SY.Phosphatidylinositol 4-phosphate 5-kinase a negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells[J].Exp Mol Med,2013,45:16.
[17]Li XT,Liang Z,Wang TT,et al.Brain-derived neurotrophic factor promotes growth of neurons and neural stem cells possibly by triggering the phosphoinositide 3-Kinase/AKT/glycogen synthase kinase-3β/β-catenin pathway[J].CNS Neurol Disord Drug Targets,2017,16(7):828-836.
[18]Oswald MCW,Garnham N,Sweeney ST,et al.Regulation of neuronal development and function by ROS[J].FEBS Lett,2018,592(5):679-691.
[19]Hernández-Deviez DJ,Roth MG,Casanova JE,et al.ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate5-kinase[J].Mol Biol Cell,2003,15(1):111-120.
[20]Noda Y,Niwa S,Homma,et al.Phosphatidylinositol4-phosphate 5-kinase alpha(PIPKα)regulates neuronal microtubule depolymerase kinesin,KIF2A and suppresses elongation of axon branches[J].Proc Natl Acad Sci,2012,109(5):1725-1730.
[21]Yu LY,Chou RH,Chen LT,et al.EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1Cdependent calcium signaling[J].J Biol Chem,2011,286(11):9657-9667.
[22]Yamazaki M,Yamauchi Y,Goshima Y,et al.Phosphatidylinositol 4-phosphate 5-kinase regulates growth cone morphology and Semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons[J].Neurosci Lett,2013,547:59-64.
[23]Chao WT,Daquinag AC,Ashcroft F,et al.Type I PIPKαregulates directed cell migration by modulating Rac1 plasma membrane targeting and activation[J].J Cell Biol,2010,190(2):247-262.
[24]Chao WT,Ashcroft F,Daquinag AC,et al.Type I phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting 1 integrin endocytosis[J].Mol Cell Biol,2010,30(18):4463-4479.
[25]Wang Y,Lian L,Golden JA,et al.PIP5KI is required for cardiovascular and neuronal development[J].PNAS,2007,104(28):11748-11753.
[26]Li X,Zhou Q,Sunkara M,et al.Ubiquitylation of phosphatidylinositol 4-phosphate5-kinase type I c by HECTD1 regulates focal adhesion dynamics and cell migration[J].J Cell Sci,2013,126:2617-2628.
[27]刘梅.PIP5KI家族在自噬中的功能研究[D].北京:清华大学生命科学学院,2013:4-15.
[28]Narkis G,Ofir R,Landau D,et al.Lethal contractural syndrome type3(LCCS3)is caused by amutation in PIP5K1C,which encodes PIPKI gamma of the phophatidylinsitol pathway[J].Am J Hum Genet,2007,81:530-539.
[29]Fancy SP,Harrington EP,Yuen TJ,et al.Axin2 as regulatory and therapeutic target in newborn brain injuryand remyelination[J].Nat Neurosci,2011,14:1009-1016.
[30]郑臻,母得志.骨髓间充质干细胞治疗缺氧缺血性脑损伤的研究现状[J].中华妇幼临床医学杂志(电子版),2017,13(4):373-377.
[31]张平,肖淑珠,徐淑婷.胎儿宫内缺血缺氧心电图表现的新认知[J].中国产前诊断杂志(电子版),2017,9(4):18-20.
[32]Lee HK,Chaboub LS,Zhu W,et al.Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS[J].Neuron,2015,85(6):1227-1243.
[33]Lee HK,Deneen B.Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord[J].Dev Cell,2012,22(1):183-196.
[34]Broggini T,Schnell L,Ghoochani A,et al.Plasticity Related Gene 3(PRG3)overcomes myelin‐associated growth inhibition and promotes functional recovery after spinal cord injury[J].AGING(Albany NY),2016,8(10):2463-2438.
[35]成胜权.出生缺陷及常见出生缺陷早期诊断和干预[J].发育医学电子杂志,2015,3(1):1-7.
[36]Campion A,Lee C,Bao N,et al.A parental perspective concerning barriers to care for neural tube defects in China[J].Surg Neurol Int,2017,8:195.
[37]Ramya S,Shyamasundar S,Bay BH,et al.Maternal diabetes alters expression of micro RNAs that regulate genes critical for neural tube development[J].Front Mol Neurosci,2017,10:237.
[38]Di Paolo G,Moskowitz HS,Gipson K,et al.Impaired Ptd Ins(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking[J].Nature,2004,431(7007):415-422.
[39]Liu A,Sui D,Wu D,et al.The activation loop of PIP5K functions as a membrane sensor essential for lipid substrate processing[J].Sci Adv,2016,2(11):e1600925.
[40]Jafari N,Zheng Q,Li L,et al.p70S6K1(S6K1)-mediated phosphorylation regulates phosphatidylinositol 4-phosphate5-kinase type I degradation and cell invasion[J].J Biol Chem,2016,291(49):25729-25741.