昼夜节律钟基因及TTFL模型的发现历程
|
摘要
生物昼夜节律钟基因的发现开创了生物钟研究的新时代。通过对果蝇昼夜节律钟分子机制的研究首次提出了TTFL模型,并在此基础上,通过对其他模式生物尤其是小鼠的研究使该模型得到进一步的发展和完善,对模式生物表型和生理学方面的研究及对模式生物基因克隆的研究,不仅揭示出生物钟演化的过程,而且也展示了科学家对之认识深化的历程。
引文
[1] Lisa Wulund, Akhilesh B Reddy. A brief history of circadian time:The emergence of redox oscillations as a novel component of biological rhythms.Perspectives in Science,2015,6(8):27.
[2]房继明.生物节律和生物钟.生物学通报,1993,28(7):4.
[3] AndréKlarsfeld, Jean-Christophe Leloup, Francois Rouyer.Circadian rhythms of locomotor activity in Drosophila. Behavioural Processes, 2003, 64(2):161.
[4]郑向平,张亚平,朱定良,等.生物钟基因period的分子机制.动物学研究,1998,19(6):473.
[5]张珞颖,叶晓雪.果蝇昼夜节律的调控机制.生命科学,2015,27(11):1346.
[6] Liu X, Zwiebel L J, Hinton D, et al. The period gene encodes a predominantly nuclear protein in adult Drosophila. J Neurosci, 1992,12(7):2735.
[7]李经才,于多,王芳,等.生物钟基因研究新进展.遗传,2004,26(1):89.
[8]周先举,袁春燕,杨旭科,等.果蝇昼夜节律的分子机制研究进展.生物化学与生物物理进展,2005,32(1):3.
[9] Allada R, White N E, So W V, et al. A mutant Drosophila homolog of mammalian clock disrupts circadian rhythms and transcription of period and timeless. Cell, 1993(5):791.
[10]王晓明,陈薇,李燕,等.隐花色素蛋白光依赖磁感应机制研究进展.生物技术,2014,24(3):95.
[11] Shawn A Cyran, Anna M Buchsbaum, Karen L Reddy. vrille,Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell,2003,112(2):329.
[12] Steven A Brown,Elzbieta Kowalska,Robert Dallmann.(Re)inventing the circadian feedback loop. Developmental Cell,2012,22(3):477.
[13] Vitaterna Martha Hotz, Takahashi Joseph S, Turek Fred W.Overview of circadian rhythms. Sourcealcohol Research&Health, 2001,25(2):85.
[14] Andrew S I Loudon, Andrei G Semikhodskii, Susan K Crosthwaite. A brief history of circadian time. Trends in Genetics,2000,16(11):477.
[15] Masao Doi, Jun Hirayama, Paolo Sassone-Corsi. Circadian regulator clock is a histone acetyltransferase. Cell, 2006,125(5):497.
[16]王悟苏,褚瑰燕,杨公社.Sirt1与生物钟的相互调控.中国生物化学与分子生物学通报,2015,31(7):674.
[2]房继明.生物节律和生物钟.生物学通报,1993,28(7):4.
[3] AndréKlarsfeld, Jean-Christophe Leloup, Francois Rouyer.Circadian rhythms of locomotor activity in Drosophila. Behavioural Processes, 2003, 64(2):161.
[4]郑向平,张亚平,朱定良,等.生物钟基因period的分子机制.动物学研究,1998,19(6):473.
[5]张珞颖,叶晓雪.果蝇昼夜节律的调控机制.生命科学,2015,27(11):1346.
[6] Liu X, Zwiebel L J, Hinton D, et al. The period gene encodes a predominantly nuclear protein in adult Drosophila. J Neurosci, 1992,12(7):2735.
[7]李经才,于多,王芳,等.生物钟基因研究新进展.遗传,2004,26(1):89.
[8]周先举,袁春燕,杨旭科,等.果蝇昼夜节律的分子机制研究进展.生物化学与生物物理进展,2005,32(1):3.
[9] Allada R, White N E, So W V, et al. A mutant Drosophila homolog of mammalian clock disrupts circadian rhythms and transcription of period and timeless. Cell, 1993(5):791.
[10]王晓明,陈薇,李燕,等.隐花色素蛋白光依赖磁感应机制研究进展.生物技术,2014,24(3):95.
[11] Shawn A Cyran, Anna M Buchsbaum, Karen L Reddy. vrille,Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell,2003,112(2):329.
[12] Steven A Brown,Elzbieta Kowalska,Robert Dallmann.(Re)inventing the circadian feedback loop. Developmental Cell,2012,22(3):477.
[13] Vitaterna Martha Hotz, Takahashi Joseph S, Turek Fred W.Overview of circadian rhythms. Sourcealcohol Research&Health, 2001,25(2):85.
[14] Andrew S I Loudon, Andrei G Semikhodskii, Susan K Crosthwaite. A brief history of circadian time. Trends in Genetics,2000,16(11):477.
[15] Masao Doi, Jun Hirayama, Paolo Sassone-Corsi. Circadian regulator clock is a histone acetyltransferase. Cell, 2006,125(5):497.
[16]王悟苏,褚瑰燕,杨公社.Sirt1与生物钟的相互调控.中国生物化学与分子生物学通报,2015,31(7):674.