摘要
<正>The emerging role of gut microbiota as a key player in the development of neurodegenerative disorders:Mammals have evolved togetherwithcommensalmicrobiotatoestablishasymbioticrelationship in which they regulate reciprocally by synthesizing and responding to several common chemical substances. In this regard, gut microbiota
引文
Arpaia N,Campbell C,Fan X,Dikiy S,van der Veeken J,deRoos P,Liu H,Cross JR,Pfeffer K,Coffer PJ,Rudensky AY(2013)Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.Nature504:451-455.
Berer K,Gerdes LA,Cekanaviciute E,Jia X,Xiao L,Xia Z,Liu C,Klotz L,Stauffer U,Baranzini SE,Kumpfel T,Hohlfeld R,Krishnamoorthy G,Wekerle H(2017)Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice.Proc Natl Acad Sci U S A 114:10719-10724.
Campos-Acuna J,Elgueta D,Pacheco R(2019)T-cell-driven inflammation as a mediator of the gut-brain axis involved in Parkinson’s disease.Front Immunol10:239.
Choi JG,Kim N,Ju IG,Eo H,Lim SM,Jang SE,Kim DH,Oh MS(2018)Oral administration of Proteus mirabilis damages dopaminergic neurons and motor functions in mice.Sci Rep 8:1275.
Gonzalez H,Contreras F,Pacheco R(2015)Regulation of the neurodegenerative process associated to Parkinson’s disease by CD4+T-cells.J Neuroimmune Pharmacol 10:561-575.
Horai R,Zarate-Blades CR,Dillenburg-Pilla P,Chen J,Kielczewski JL,Silver PB,Jittayasothorn Y,Chan CC,Yamane H,Honda K,Caspi RR(2015)Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site.Immunity 43:343-353.
Lodygin D,Hermann M,Schweingruber N,Flugel-Koch C,Watanabe T,Schlosser C,Merlini A,Korner H,Chang HF,Fischer HJ,Reichardt HM,Zagrebelsky M,Mollenhauer B,Kugler S,Fitzner D,Frahm J,Stadelmann C,Haberl M,Odoardi F,Flugel A(2019)β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.Nature 566:503-508.
Lyte M(2013)Microbial endocrinology in the microbiome-gut-brain axis:how bacterial production and utilization of neurochemicals influence behavior.PLoS Pathog 9:e1003726.
Sampson TR,Debelius JW,Thron T,Janssen S,Shastri GG,Ilhan ZE,Challis C,Schretter CE,Rocha S,Gradinaru V,Chesselet MF,Keshavarzian A,Shannon KM,Krajmalnik-Brown R,Wittung-Stafshede P,Knight R,Mazmanian SK(2016)Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease.Cell 167:1469-1480.e1412.
Sulzer D,Alcalay RN,Garretti F,Cote L,Kanter E,Agin-Liebes J,Liong C,McMurtrey C,Hildebrand WH,Mao X,Dawson VL,Dawson TM,Oseroff C,Pham J,Sidney J,Dillon MB,Carpenter C,Weiskopf D,Phillips E,Mallal S,et al.(2017)T cells from patients with Parkinson’s disease recognize alpha-synuclein peptides.Nature 546:656-661.
Zhang YG,Wu S,Yi J,Xia Y,Jin D,Zhou J,Sun J(2017)Target intestinal microbiota to alleviate disease progression in amyotrophic lateral sclerosis.Clin Ther 39:322-336.
Zhuang ZQ,Shen LL,Li WW,Fu X,Zeng F,Gui L,Lu Y,Cai M,Zhu C,Tan YL,Zheng P,Li HY,Zhu J,Zhou HD,Bu XL,Wang YJ(2018)Gut microbiota is altered in patients with Alzheimer’s disease.J Alzheimers Dis 63:1337-1346.