妊娠合并抗凝血酶Ⅲ缺乏症合并胎盘早剥1例报道及文献分析
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摘要
<正>抗凝血酶(Antithrombin,AT) Ⅲ缺乏为临床罕见病,白种人AT缺乏症存在的比例为1/500～1/5 000,我国人群遗传性AT缺乏资料尚不完善[1]。 1965年瑞典医师Egeberg[2]首先报道了遗传性AT缺乏症,它属于常染色体显性遗传疾病,AT Ⅲ缺乏的患者由于AT Ⅲ缺乏,导致抗凝血障碍,容易发生血栓,主要是静脉血栓栓塞(venous thromboembolism,VTE),极少发生动脉血栓。本研究报道1例妊
引文
[1] 程志鹏,唐亮,陆铉,等.遗传性抗凝血酶及遗传性蛋白C联合缺乏症家系研究 [J].临床血液学杂志,2014,27(5):375-378.
[2] Egeberg O.Inherited antithrombin deficiency causing thrombophilia[J].Thromb Diath Haemorrh,1965,13(2):516-530.
[3] Bock SC,Wion KL,Vehar GA,et al.Cloning and expression of the cDNA for human antithrombin III [J].Nucleic Acids Res,1982(10):8113-8125.
[4] 胡豫.中国人群静脉血栓形成的分子遗传学研究(二)[J].临床血液学杂志,2014,27(7):543-546.
[5] Erkens PM,Prins MH.Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism [J].Cochrane Database Syst Rev,2010,(9):CD001100.
[6] Bramham K,Retter A,Robinson SE,et al.How I treat heterozygous hereditary antithrombin deficiency in pregnancy [J].Thromb Haemost,2013,110(3):550-559.
[7] Bates SM,Greer IA,Middeldorp S,et al.VTE,thrombophilia,antithrombotic therapy,and pregnancy antithrombotic therapy and prevention of thrombosis,9th ed:American college of chest physicians Evidence-Based clinical practice guidelines[J].Chest,2012,141(2,S):E 691S-E 736S.
[8] Horlocker TT,Wedel DJ,Benzon H,et al.Regional anesthesia in the anticoagulated patient:defining the risks (the second ASRA Consensus Conference on Neuraxial Anesthesia and Anticoagulation)[J].Reg Anesth Pain Med,2003,28(3):172-197.
[9] Dulitzki M,Pauzner R,Langevitz P,et al.Low-molecular-weight heparin during pregnancy and delivery:Preliminary experience with 41 pregnancies[J].Obstet Gynecol,1996,87(3):380-383.
[10] Bates SM,Ginsberg JS.How we manage venous thromboembolism during pregnancy [J].Blood,2002,100(10):3470.
[11] Kamel H,Navi BB,Sriram N,et al.Risk of a thrombotic event after the 6-week postpartum period [J].N Engl J Med,2014,370(14):1307-1315.
[12] Mantha S,Karp R,Raghavan V,et al.Assessing the risk of venous thromboembolic events in women taking progestin-only contraception:a meta-analysis[J].BMJ,2012,345(aug07 2):e 4944.
[2] Egeberg O.Inherited antithrombin deficiency causing thrombophilia[J].Thromb Diath Haemorrh,1965,13(2):516-530.
[3] Bock SC,Wion KL,Vehar GA,et al.Cloning and expression of the cDNA for human antithrombin III [J].Nucleic Acids Res,1982(10):8113-8125.
[4] 胡豫.中国人群静脉血栓形成的分子遗传学研究(二)[J].临床血液学杂志,2014,27(7):543-546.
[5] Erkens PM,Prins MH.Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism [J].Cochrane Database Syst Rev,2010,(9):CD001100.
[6] Bramham K,Retter A,Robinson SE,et al.How I treat heterozygous hereditary antithrombin deficiency in pregnancy [J].Thromb Haemost,2013,110(3):550-559.
[7] Bates SM,Greer IA,Middeldorp S,et al.VTE,thrombophilia,antithrombotic therapy,and pregnancy antithrombotic therapy and prevention of thrombosis,9th ed:American college of chest physicians Evidence-Based clinical practice guidelines[J].Chest,2012,141(2,S):E 691S-E 736S.
[8] Horlocker TT,Wedel DJ,Benzon H,et al.Regional anesthesia in the anticoagulated patient:defining the risks (the second ASRA Consensus Conference on Neuraxial Anesthesia and Anticoagulation)[J].Reg Anesth Pain Med,2003,28(3):172-197.
[9] Dulitzki M,Pauzner R,Langevitz P,et al.Low-molecular-weight heparin during pregnancy and delivery:Preliminary experience with 41 pregnancies[J].Obstet Gynecol,1996,87(3):380-383.
[10] Bates SM,Ginsberg JS.How we manage venous thromboembolism during pregnancy [J].Blood,2002,100(10):3470.
[11] Kamel H,Navi BB,Sriram N,et al.Risk of a thrombotic event after the 6-week postpartum period [J].N Engl J Med,2014,370(14):1307-1315.
[12] Mantha S,Karp R,Raghavan V,et al.Assessing the risk of venous thromboembolic events in women taking progestin-only contraception:a meta-analysis[J].BMJ,2012,345(aug07 2):e 4944.