口腔癌患者口腔组织中P16、Ki-67、CyclinD1的表达及其临床意义

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英文篇名：Expressions of P16,ki-67 and CyclinD1 in oral tissue of patients with oral cancer and their clinical significance 作者：刘族志 ; 王秋玲 ; 赵永兴 英文作者：LIU Zuzhi;WANG Qiuling;ZHAO Yongxing;Department of Stomatology,Danzhou People's Hospital;Medical Center of Stomatology,Haikou Hospital Affilliated to Xiangya Medical College,Central South University; 关键词：口腔癌 ; P16 ; Ki-67 ; CyclinD1 英文关键词：oral cancer;;P16;;Ki-67;;CyclinD1 中文刊名：TDYX 英文刊名：Modern Medical Journal 机构：儋州市人民医院口腔科;中南大学湘雅医学院附属海口医院口腔医学中心; 出版日期：2019-01-25 出版单位：现代医学 年：2019 期：v.47;No.307 基金：国家级自然科学基金资助项目(260166) 语种：中文; 页：TDYX201901001 页数：4 CN：01 ISSN：32-1659/R 分类号：7-10

摘要

目的:研究口腔癌组织中P16、Ki-67、CyclinD1的表达及其临床意义。方法:收集确诊为口腔癌患者的口腔活检组织标本35例(观察组)及同期正常口腔黏膜组织标本35例(对照组),采用免疫组织化学法检测两组组织切片中P16、Ki-67、CyclinD1表达率,分析P16阳性表达与患者生存时间的关系。结果:观察组P16阳性率(71. 43%)显著低于对照组(82. 86%),Ki-67阳性率(82. 86%)、CyclinD1阳性率(40. 00%)均明显高于对照组(分别为14. 29%和5. 71%),差异均有统计学意义(P <0. 05)。P16阳性患者3年生存率明显低于P16阴性患者,差异有统计学意义(P <0. 05)。结论:P16、Ki-67及CyclinD1的表达情况与口腔癌发展密切相关,三者的检测对口腔癌的早期诊断及预后判断具有参考价值。
        Objective: To study the expression and their clinical significance of P16,Ki-67 and CyclinD1 in oral cancer tissues. Methods: Thirty-five biopsy tissue samples diagnosed as oral cancer were collected( observation group),35 normal oral mucosa tissue samples were selected at the same time( control group),and the expressions of P16,ki-67 and CyclinD1 in tissue sections of the two groups were detected by immunohistochemistry. Positive expression rates of P16,ki-67,CyclinD1 and relationship between expression of P16 and patient survival rate were observed in the two groups. Results: The positive rate of P16 in the observation group( 71. 43%) was significantly lower than that in the control group( 82. 86%),and the positive rates of ki-67 and CyclinD1 in the observation group were 82. 86% and 40. 00%,reapectively,both were significantly higher than those of the control group,with statistically significant differences( P < 0. 05). After 3 years,the survival rate of the patients with P16 positive was less than the patients with P16 negative,and the difference was significant( P < 0. 05). Conclusions: P16 is low expression in oral cancer,and its expression is closely related to the development of oral cancer. Ki-67 and CyclinD1 are all highly expressed,and their expressions can provide a reference value for the early diagnosis and prognosis judgment of oral cancer.

引文

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