钠尿肽的中枢调控功能研究进展
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摘要
目的:作为存在于机体的一类重要肽类激素,钠尿肽家族成员主要包括心房钠尿肽(atrial natriuretic peptide,肽(dendroaspis natriuretic peptide, DNP)、心室钠尿肽(ventricle natriuretic peptide, Ve NP)和血管钠肽(vasonatrinoeptide,Va NP)等。此外,因与经典的钠尿肽成员结构相似,骨织素(osteocrin,OSTN)也被认为是钠尿肽家族的一员。钠尿肽家族成员结构相对保守,功能多样,除发挥利尿、利钠、扩张血管、降低血压等功能外,还与焦虑、抑郁、学习记忆等中枢神经行为调控密切相关。本文就钠尿肽家族成员结构特征、中枢调控功能及其机制研究进展作一综述。
Natriuretic peptide( NP),one kind of important hormone existing in human tissues,mainly includes atrial natriuretic peptide( ANP),brain natriuretic peptide( BNP),C-type natriuretic peptide( CNP),Dendroaspis natriuretic peptide( DNP),ventricle natriuretic peptide( VeNP) and vasonatrinoeptide( Va NP). Most recently,considering its higher similarities of structure to that of classic NPs,osteocrin was reported to be the 7 th member of NPs. All NPs are highly conservative in molecular structure and functions. In addition to their physiological roles in diuresis,natriuresis,vasolilatation,decopression,the regulatory effects of NPs on neuronal behaviors,such as anxiety,depression,learning and memory have been reported. The present review aims to summarize the structural characters,the regulatory functions on neural behaviors and the underlying mechanism of NPs,and tries to provide a reference for further study of their neuromodulatory functions.
Natriuretic peptide( NP),one kind of important hormone existing in human tissues,mainly includes atrial natriuretic peptide( ANP),brain natriuretic peptide( BNP),C-type natriuretic peptide( CNP),Dendroaspis natriuretic peptide( DNP),ventricle natriuretic peptide( VeNP) and vasonatrinoeptide( Va NP). Most recently,considering its higher similarities of structure to that of classic NPs,osteocrin was reported to be the 7 th member of NPs. All NPs are highly conservative in molecular structure and functions. In addition to their physiological roles in diuresis,natriuresis,vasolilatation,decopression,the regulatory effects of NPs on neuronal behaviors,such as anxiety,depression,learning and memory have been reported. The present review aims to summarize the structural characters,the regulatory functions on neural behaviors and the underlying mechanism of NPs,and tries to provide a reference for further study of their neuromodulatory functions.
引文
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[2]Riederer P,Korczyn A D,Ali S S,et al. The diabetic brain and cognition[J]. J Neural Transm(Vienna),2017,124(11):1431-1454.
[3]Miyazaki T,Otani K,Chiba A,et al. A new secretory peptide of natriuretic peptide family,osteocrin,suppresses the progression of congestive heart failure after myocardial infarction[J]. Circ Res,2018,122(5):742-751.
[4]Zhang D,Wang X,Wang B,et al. Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors[J]. Mol Psychiatry,2017,22(7):1044-1055.
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[7]Bie P. Natriuretic peptides and normal body fluid regulation[J]. Compr Physiol,2018,8(3):1211-1249.
[8] Miyazaki T,Otani K,Chiba A,et al. A new secretory peptide of natriuretic peptide family,osteocrin,suppresses the progression of congestive heart failure after myocardial infarction[J]. Circ Res,2018,122(5):742-751.
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[10]Chiba A,Watanabe-Takano H,Terai K,et al. Osteocrin,a peptide secreted from the heart and other tissues,contributes to cranial osteogenesis and chondrogenesis in zebrafish[J]. Development,2017,144(2):334-344.
[11]Jiang Y S,Lei J Y,Chen Y,et al. Vasonatrin peptide stimulates both of the natriuretic peptide receptors,NPRA and NPRB[J]. Biochem Biophys Res Commun,2014,446(4):1276-1280.
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[15]Biro E,Toth G,Telegdy G. Effect of receptor blockers on brain natriuretic peptide and C-type natriuretic peptide caused anxiolytic state in rats[J]. Neuropeptides,1996,30(1):59-65.
[16]Montkowski A,Jahn H,Strohle A,et al. C-type natriuretic peptide exerts effects opposing those of atrial natriuretic peptide on anxiety-related behaviour in rats[J]. Brain Res,1998,792(2):358-360.
[17]Bidzseranova A,Gueron J,Balaspiri L,et al. Intracerebroventricularly administered atrial natriuretric peptide(ANP)antiserum attenuates fear-motivated learning behavior in rats[J]. Peptides,1992,13(5):957-960.
[18]Telegdy G,Adamik A,Glover V. The action of isatin(2,3-dioxoindole)an endogenous indole on brain natriuretic and Ctype natriuretic peptide-induced facilitation of memory consolidation in passive-avoidance learning in rats[J]. Brain Res Bull,2000,53(3):367-370.
[19]Telegdy G,Kokavszky K,Nyerges A. Action of C-type natriuretic peptide(CNP)on passive avoidance learning in rats:involvement of transmitters[J]. Eur J Neurosci,1999,11(9):3302-3306.
[20] Barmashenko G,Buttgereit J,Herring N,et al. Regulation of hippocampal synaptic plasticity thresholds and changes in exploratory and learning behavior in dominant negative NPR-B mutant rats[J]. Front Mol Neurosci,2014,7:95.
[21]von der Goltz C,Jahn H,Mutschler J,et al. Intraperitoneal atrial natriuretic peptide attenuates anxiety-related behaviour during alcohol withdrawal in mice[J]. Pharmacopsychiatry,2014,47(3):97-100.
[22]Kiefer F,Andersohn F,Jahn H,et al. Involvement of plasma atrial natriuretic peptide in protracted alcohol withdrawal[J].Acta Psychiatr Scand,2002,105(1):65-70.
[23]Mutschler J,Bilbao A,von der Goltz C,et al. Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors[J]. Alcohol Alcohol,2010,45(1):13-16.
[24]Glahn A,Riera K R,Rhein M,et al. Alcohol-induced changes in methylation status of individual Cp G sites,and serum levels of vasopressin and atrial natriuretic peptide in alcohol-dependent patients during detoxification treatment[J]. Eur Addict Res,2014,20(3):143-150.
[25]Karpyak V M,Winham S J,Biernacka J M,et al. Association of GATA4 sequence variation with alcohol dependence[J].Addict Biol,2014,19(2):312-315.
[26] Kostev K,Teichgraber F,Konrad M,et al. Association between chronic somatic conditions and depression in children and adolescents:A retrospective study of 13,326 patients[J]. J Affect Disord,2018,245:697-701.
[27]Wang L,Zhang D,Tian X,et al.[Effects of electroacupuncture on synaptic plasticity in hippocampal CA3 area of rats with chronic stress depression][J]. Zhongguo Zhen Jiu,2017,37(2):162-168.
[28]Fangauf S V,Herbeck B B,Meyer T,et al. Associations of NT-pro BNP and parameters of mental health in depressed coronary artery disease patients[J]. Psychoneuroendocrinology,2018,96:188-194.
[29]Menard C,Pfau M L,Hodes G E,et al. Social stress induces neurovascular pathology promoting depression[J]. Nat Neurosci,2017,20(12):1752-1760.
[30]Wann B P,Audet M C,Gibb J,et al. Anhedonia and altered cardiac atrial natriuretic peptide following chronic stressor and endotoxin treatment in mice[J]. Psychoneuroendocrinology,2010,35(2):233-240.
[31]Krogh J,Strohle A,Westrin A,et al. N-terminal pro-atrial natriuretic peptide response to acute exercise in depressed patients and healthy controls[J]. Psychoneuroendocrinology,2011,36(5):656-663.
[32]Wiggins A K,Shen P J,Gundlach A L. Atrial natriuretic peptide expression is increased in rat cerebral cortex following spreading depression:possible contribution to sd-induced neuroprotection[J]. Neuroscience,2003,118(3):715-726.
[33]Kaczmarczyk M,Otte C,Wiedemann K,et al. Major depression and atrial natriuretic peptide:The role of adverse childhood experiences[J]. Psychoneuroendocrinology,2018,101:7-11.
[34]Fangauf S V,Herbeck B B,Meyer T,et al. Associations of NT-pro BNP and parameters of mental health in depressed coronary artery disease patients[J]. Psychoneuroendocrinology,2018,96:188-194.
[35]Li P,Tang X D,Cai Z X,et al. CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan[J]. World J Gastroenterol,2015,21(5):1518-1530.
[36]Rapley S A,Prickett T,Dalrymple-Alford J C,et al. Environmental Enrichment Elicits a Transient Rise of Bioactive C-Type Natriuretic Peptide in Young but Not Aged Rats[J]. Front Behav Neurosci,2018,12:142.
[37] Esmaili Z,Heydari A. Effect of acute caffeine administration on PTZ-induced seizure threshold in mice:Involvement of adenosine receptors and NO-c GMP signaling pathway[J]. Epilepsy Res,2018,149:1-8.
[38]Ostadhadi S,Shakiba S,Norouzi-Javidan A,et al. The role of nitric oxide-c GMP pathway in selegiline antidepressant-like effect in the mice forced swim test[J]. Pharmacol Rep,2018,70(5):1015-1022.
[39]De Jonge H R,Tilly B C,Hogema B M,et al. c GMP inhibition of type 3 phosphodiesterase is the major mechanism by which C-type natriuretic peptide activates CFTR in the shark rectal gland[J]. Am J Physiol Cell Physiol,2014,306(4):C343-C353.
[40]Strohle A,Feller C,Strasburger C J,et al. Anxiety modulation by the heart? Aerobic exercise and atrial natriuretic peptide[J].Psychoneuroendocrinology,2006,31(9):1127-1130.
[41]Ufnal M,Skrzypecki J. Blood borne hormones in a cross-talk between peripheral and brain mechanisms regulating blood pressure,the role of circumventricular organs[J]. Neuropeptides,2014,48(2):65-73.
[2]Riederer P,Korczyn A D,Ali S S,et al. The diabetic brain and cognition[J]. J Neural Transm(Vienna),2017,124(11):1431-1454.
[3]Miyazaki T,Otani K,Chiba A,et al. A new secretory peptide of natriuretic peptide family,osteocrin,suppresses the progression of congestive heart failure after myocardial infarction[J]. Circ Res,2018,122(5):742-751.
[4]Zhang D,Wang X,Wang B,et al. Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors[J]. Mol Psychiatry,2017,22(7):1044-1055.
[5]Ogawa T,de Bold A J. The heart as an endocrine organ[J]. Endocr Connect,2014,3(2):R31-R44.
[6]Takefuji M,Murohara T. Corticotropin-releasing hormone family and their receptors in the cardiovascular system[J]. Circ J,2019,83(2):261-266.
[7]Bie P. Natriuretic peptides and normal body fluid regulation[J]. Compr Physiol,2018,8(3):1211-1249.
[8] Miyazaki T,Otani K,Chiba A,et al. A new secretory peptide of natriuretic peptide family,osteocrin,suppresses the progression of congestive heart failure after myocardial infarction[J]. Circ Res,2018,122(5):742-751.
[9]Potter L R. Guanylyl cyclase structure,function and regulation[J]. Cellular Signalling,2011,23(12):1921-1926.
[10]Chiba A,Watanabe-Takano H,Terai K,et al. Osteocrin,a peptide secreted from the heart and other tissues,contributes to cranial osteogenesis and chondrogenesis in zebrafish[J]. Development,2017,144(2):334-344.
[11]Jiang Y S,Lei J Y,Chen Y,et al. Vasonatrin peptide stimulates both of the natriuretic peptide receptors,NPRA and NPRB[J]. Biochem Biophys Res Commun,2014,446(4):1276-1280.
[12]Nishikimi T,Kuwahara K,Nakao K. Current biochemistry,molecular biology,and clinical relevance of natriuretic peptides[J]. J Cardiol,2011,57(2):131-140.
[13]Kellner M,Wiedemann K,Holsboer F. Atrial natriuretic factor inhibits the CRH-stimulated secretion of ACTH and cortisol in man.[J]. Life Sciences,1992,50(24):1835-1842.
[14]Wiedemann K,Jahn H,Yassouridis A,et al. Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptideinduced panic attacks:preliminary findings[J]. Arch Gen Psychiatry,2001,58(4):371-377.
[15]Biro E,Toth G,Telegdy G. Effect of receptor blockers on brain natriuretic peptide and C-type natriuretic peptide caused anxiolytic state in rats[J]. Neuropeptides,1996,30(1):59-65.
[16]Montkowski A,Jahn H,Strohle A,et al. C-type natriuretic peptide exerts effects opposing those of atrial natriuretic peptide on anxiety-related behaviour in rats[J]. Brain Res,1998,792(2):358-360.
[17]Bidzseranova A,Gueron J,Balaspiri L,et al. Intracerebroventricularly administered atrial natriuretric peptide(ANP)antiserum attenuates fear-motivated learning behavior in rats[J]. Peptides,1992,13(5):957-960.
[18]Telegdy G,Adamik A,Glover V. The action of isatin(2,3-dioxoindole)an endogenous indole on brain natriuretic and Ctype natriuretic peptide-induced facilitation of memory consolidation in passive-avoidance learning in rats[J]. Brain Res Bull,2000,53(3):367-370.
[19]Telegdy G,Kokavszky K,Nyerges A. Action of C-type natriuretic peptide(CNP)on passive avoidance learning in rats:involvement of transmitters[J]. Eur J Neurosci,1999,11(9):3302-3306.
[20] Barmashenko G,Buttgereit J,Herring N,et al. Regulation of hippocampal synaptic plasticity thresholds and changes in exploratory and learning behavior in dominant negative NPR-B mutant rats[J]. Front Mol Neurosci,2014,7:95.
[21]von der Goltz C,Jahn H,Mutschler J,et al. Intraperitoneal atrial natriuretic peptide attenuates anxiety-related behaviour during alcohol withdrawal in mice[J]. Pharmacopsychiatry,2014,47(3):97-100.
[22]Kiefer F,Andersohn F,Jahn H,et al. Involvement of plasma atrial natriuretic peptide in protracted alcohol withdrawal[J].Acta Psychiatr Scand,2002,105(1):65-70.
[23]Mutschler J,Bilbao A,von der Goltz C,et al. Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors[J]. Alcohol Alcohol,2010,45(1):13-16.
[24]Glahn A,Riera K R,Rhein M,et al. Alcohol-induced changes in methylation status of individual Cp G sites,and serum levels of vasopressin and atrial natriuretic peptide in alcohol-dependent patients during detoxification treatment[J]. Eur Addict Res,2014,20(3):143-150.
[25]Karpyak V M,Winham S J,Biernacka J M,et al. Association of GATA4 sequence variation with alcohol dependence[J].Addict Biol,2014,19(2):312-315.
[26] Kostev K,Teichgraber F,Konrad M,et al. Association between chronic somatic conditions and depression in children and adolescents:A retrospective study of 13,326 patients[J]. J Affect Disord,2018,245:697-701.
[27]Wang L,Zhang D,Tian X,et al.[Effects of electroacupuncture on synaptic plasticity in hippocampal CA3 area of rats with chronic stress depression][J]. Zhongguo Zhen Jiu,2017,37(2):162-168.
[28]Fangauf S V,Herbeck B B,Meyer T,et al. Associations of NT-pro BNP and parameters of mental health in depressed coronary artery disease patients[J]. Psychoneuroendocrinology,2018,96:188-194.
[29]Menard C,Pfau M L,Hodes G E,et al. Social stress induces neurovascular pathology promoting depression[J]. Nat Neurosci,2017,20(12):1752-1760.
[30]Wann B P,Audet M C,Gibb J,et al. Anhedonia and altered cardiac atrial natriuretic peptide following chronic stressor and endotoxin treatment in mice[J]. Psychoneuroendocrinology,2010,35(2):233-240.
[31]Krogh J,Strohle A,Westrin A,et al. N-terminal pro-atrial natriuretic peptide response to acute exercise in depressed patients and healthy controls[J]. Psychoneuroendocrinology,2011,36(5):656-663.
[32]Wiggins A K,Shen P J,Gundlach A L. Atrial natriuretic peptide expression is increased in rat cerebral cortex following spreading depression:possible contribution to sd-induced neuroprotection[J]. Neuroscience,2003,118(3):715-726.
[33]Kaczmarczyk M,Otte C,Wiedemann K,et al. Major depression and atrial natriuretic peptide:The role of adverse childhood experiences[J]. Psychoneuroendocrinology,2018,101:7-11.
[34]Fangauf S V,Herbeck B B,Meyer T,et al. Associations of NT-pro BNP and parameters of mental health in depressed coronary artery disease patients[J]. Psychoneuroendocrinology,2018,96:188-194.
[35]Li P,Tang X D,Cai Z X,et al. CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan[J]. World J Gastroenterol,2015,21(5):1518-1530.
[36]Rapley S A,Prickett T,Dalrymple-Alford J C,et al. Environmental Enrichment Elicits a Transient Rise of Bioactive C-Type Natriuretic Peptide in Young but Not Aged Rats[J]. Front Behav Neurosci,2018,12:142.
[37] Esmaili Z,Heydari A. Effect of acute caffeine administration on PTZ-induced seizure threshold in mice:Involvement of adenosine receptors and NO-c GMP signaling pathway[J]. Epilepsy Res,2018,149:1-8.
[38]Ostadhadi S,Shakiba S,Norouzi-Javidan A,et al. The role of nitric oxide-c GMP pathway in selegiline antidepressant-like effect in the mice forced swim test[J]. Pharmacol Rep,2018,70(5):1015-1022.
[39]De Jonge H R,Tilly B C,Hogema B M,et al. c GMP inhibition of type 3 phosphodiesterase is the major mechanism by which C-type natriuretic peptide activates CFTR in the shark rectal gland[J]. Am J Physiol Cell Physiol,2014,306(4):C343-C353.
[40]Strohle A,Feller C,Strasburger C J,et al. Anxiety modulation by the heart? Aerobic exercise and atrial natriuretic peptide[J].Psychoneuroendocrinology,2006,31(9):1127-1130.
[41]Ufnal M,Skrzypecki J. Blood borne hormones in a cross-talk between peripheral and brain mechanisms regulating blood pressure,the role of circumventricular organs[J]. Neuropeptides,2014,48(2):65-73.