可见光催化C(sp~3)-C(sp~3)键的构筑
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摘要
本文对近年来可见光催化构筑C(sp~3)-C(sp~3)键的国内外最新研究成果进行概述,着重阐述了各类催化的催化体系、反应机理及在合成生物活性分子或药物分子方面的应用。在可见光催化的反应体系中引入过渡金属或手性催化剂,构建新颖的协同催化体系,可以实现在温和的条件下对C—C键构筑的精确控制,对于手性药物的设计、开发具有重要的意义。最后,对未来可见光催化构筑C—C键的发展进行展望。
We summarize the latest results of C(sp~3)-C(sp~3) coupling by visible-light photoredox catalysis in recent years and focus on the catalytic systems, reaction mechanisms and practical applications in synthesizing bioactivity molecules or drug molecules. Indeed, introducing transition metals or chiral catalysts in the visible light-catalyzed reaction system and the constructing of a novel synergistic catalysis system can make the precise formation of the C(sp~3)-C(sp~3) bond under mild conditions become a reality, which will have important implications for the design and development of chiral drugs. Finally, the future development of visible-light photoredox catalysis is prospected.
We summarize the latest results of C(sp~3)-C(sp~3) coupling by visible-light photoredox catalysis in recent years and focus on the catalytic systems, reaction mechanisms and practical applications in synthesizing bioactivity molecules or drug molecules. Indeed, introducing transition metals or chiral catalysts in the visible light-catalyzed reaction system and the constructing of a novel synergistic catalysis system can make the precise formation of the C(sp~3)-C(sp~3) bond under mild conditions become a reality, which will have important implications for the design and development of chiral drugs. Finally, the future development of visible-light photoredox catalysis is prospected.
引文
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[2] Romero N A, Nicewicz D A. Chem. Rev., 2016, 116: 10075.
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