厄贝沙坦联合美托洛尔对急诊重症心力衰竭患者左心射血分数、B型脑钠肽、心功能分级的影响
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摘要
目的探究厄贝沙坦联合美托洛尔对急诊重症心力衰竭患者左心射血分数、B型脑钠肽、心功能分级的影响。方法选取2015年12月~2016年12月本院急诊科收治的70例重症心力衰竭患者作为观察对象,采用数字分组法将选取的患者分为观察组和对照组,每组35例。观察组患者采用厄贝沙坦联合美托洛尔治疗,对照组患者采用常规疗法。分别观察两种治疗方法下患者的左心射血分数、B型脑钠肽、心功能分级的差异。结果治疗前,两组患者的左心射血分数、B型脑钠肽、心功能分级比较差异无统计学意义;治疗后,两组患者的病情均得到改善,但观察组患者的回复情况更佳,观察组患者的左心射血分数、B型脑钠肽、心功能分级显著优于对照组,二者之间各项指标比较差异具有统计学意义(P<0.05)。同时,观察组出现头晕、头痛等不良反应的患者有3例,占8.6%,对照组出现头晕、头痛等不良反应的患者有11例,占31.4%,两组间的不良反应发生率进行比较得出的差异具有统计学意义(c2=5.7143,P<0.05)。结论厄贝沙坦联合美托洛尔对急诊重症心力衰竭患者治疗的效果较好,有效改善了患者的左心射血分数、B型脑钠肽、心功能分级,并且患者出现不良反应的情况也较少,治疗的安全性和可行性也较高,值得在临床进行推广。
Objective To explore the urban bei sha Tanzania joint metoprolol for emergency and severe cases of left heart ejection fraction in patients with heart failure, b-type brain natriuretic peptide, the effect of cardiac function classification. Methods 70 patients with severe heart failure in the emergency department were in from December 2015 to December 2016 in our hospital as research object,.Adopting digital grouping will select patients were divided into observation and control group, 35 patients in each group. The observation group was treated with irbesartan combined with metoprolol and the control group was treated with conventional therapy. Under two treatment methods were observed in patients with left heart ejection fraction, b-type brain natriuretic peptide, the differences between the cardiac function classification. Results Before treatment, two groups of patients with left heart ejection fraction, b-type brain natriuretic peptide and heart function classification has no obvious difference, after treatment, the condition of two groups of patients were improved, but the observation group of patients with better reply situation, in patients with left heart ejection fraction, b-type brain natriuretic peptide and heart function classification is significantly better than that of control group, each index to compare the results between statistically significant(P < 0.05). At the same time, in the observation group of patients with dizziness, headaches and other adverse reactions in 3 cases, accounted for 8.6%, the control group, the adverse reactions such as dizziness, headache in 11 patients(31.4%), compared the incidence of adverse reactions between the two groups were significant difference of(c2=5.7143,P< 0.05). Conclusion Irbesartan joint metoprolol for emergency patients with severe heart failure treatment effect is good, effectively improve the patient's left heart ejection fraction, b-type brain natriuretic peptide and grade of cardiac function, and adverse reactions of patients is less, the safety and feasibility of treatment also is higher, is worth popularization in clinical.
Objective To explore the urban bei sha Tanzania joint metoprolol for emergency and severe cases of left heart ejection fraction in patients with heart failure, b-type brain natriuretic peptide, the effect of cardiac function classification. Methods 70 patients with severe heart failure in the emergency department were in from December 2015 to December 2016 in our hospital as research object,.Adopting digital grouping will select patients were divided into observation and control group, 35 patients in each group. The observation group was treated with irbesartan combined with metoprolol and the control group was treated with conventional therapy. Under two treatment methods were observed in patients with left heart ejection fraction, b-type brain natriuretic peptide, the differences between the cardiac function classification. Results Before treatment, two groups of patients with left heart ejection fraction, b-type brain natriuretic peptide and heart function classification has no obvious difference, after treatment, the condition of two groups of patients were improved, but the observation group of patients with better reply situation, in patients with left heart ejection fraction, b-type brain natriuretic peptide and heart function classification is significantly better than that of control group, each index to compare the results between statistically significant(P < 0.05). At the same time, in the observation group of patients with dizziness, headaches and other adverse reactions in 3 cases, accounted for 8.6%, the control group, the adverse reactions such as dizziness, headache in 11 patients(31.4%), compared the incidence of adverse reactions between the two groups were significant difference of(c2=5.7143,P< 0.05). Conclusion Irbesartan joint metoprolol for emergency patients with severe heart failure treatment effect is good, effectively improve the patient's left heart ejection fraction, b-type brain natriuretic peptide and grade of cardiac function, and adverse reactions of patients is less, the safety and feasibility of treatment also is higher, is worth popularization in clinical.
引文
[1]童成刚,刘贇,许慧娟,等.美托洛尔联合复方氢氯噻嗪治疗老年重症心力衰竭临床疗效及血流动力学的改善作用[J].医学综述,2016,22(10):2054-2057.
[2]侯健民,黄国孟.美托洛尔及厄贝沙坦氢氯噻嗪在老年重症心力衰竭急诊内科治疗中的应用[J].吉林医学,2012,33(27):5874-5875.
[3]Aissaoui N,Morshuis M,Paluszkiewicz L,et al.Comparison of biventricular and left ventricular assist devices for the management of severe right ventricular dysfunction in patients with end-stage heart failure[J].Asaio Journal,2014,60(4):400-406.
[4]Li X,Zhang XF,Wang TZ,et al.Regulation by bisoprolol for cardiac micro RNA expression in a rat volume-overload heart failure model[J].Journal of nanoscience and nanotechnology,2013,13(8):5267-5275.
[5]Cao WW,Chen JW,Chen YF,et al.Advanced glycation end products promote heart failure through inducing the immune maturation of dendritic cells[J].Applied biochemistry and biotechnology,Part A.enzyme engineering and biotechnology,2014,172(8):4062-4077.
[6]Yu SN,Lee MY.Bispectral analysis and genetic algorithm for congestive heart failure recognition based on heart rate variability[J].Computers in Biology and Medicine,2012,42(8):816-825.
[7]Yu SN,Lee MY.Conditional mutual information-based feature selection for congestive heart failure recognition using heart rate variability[J].Computer Methods&Programs in Biomedicine,2012,108(1):299-309.
[8]Sherwood LC,Sobieski MA,Koenig SC,et al.Benefits of aggressive medical management in a bovine model of chronic ischemic heart failure[J].Asaio journal,2013,59(3):221-229.
[2]侯健民,黄国孟.美托洛尔及厄贝沙坦氢氯噻嗪在老年重症心力衰竭急诊内科治疗中的应用[J].吉林医学,2012,33(27):5874-5875.
[3]Aissaoui N,Morshuis M,Paluszkiewicz L,et al.Comparison of biventricular and left ventricular assist devices for the management of severe right ventricular dysfunction in patients with end-stage heart failure[J].Asaio Journal,2014,60(4):400-406.
[4]Li X,Zhang XF,Wang TZ,et al.Regulation by bisoprolol for cardiac micro RNA expression in a rat volume-overload heart failure model[J].Journal of nanoscience and nanotechnology,2013,13(8):5267-5275.
[5]Cao WW,Chen JW,Chen YF,et al.Advanced glycation end products promote heart failure through inducing the immune maturation of dendritic cells[J].Applied biochemistry and biotechnology,Part A.enzyme engineering and biotechnology,2014,172(8):4062-4077.
[6]Yu SN,Lee MY.Bispectral analysis and genetic algorithm for congestive heart failure recognition based on heart rate variability[J].Computers in Biology and Medicine,2012,42(8):816-825.
[7]Yu SN,Lee MY.Conditional mutual information-based feature selection for congestive heart failure recognition using heart rate variability[J].Computer Methods&Programs in Biomedicine,2012,108(1):299-309.
[8]Sherwood LC,Sobieski MA,Koenig SC,et al.Benefits of aggressive medical management in a bovine model of chronic ischemic heart failure[J].Asaio journal,2013,59(3):221-229.