艾灸对良性前列腺增生患者性激素及前列腺特异性抗原的影响
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摘要
目的:通过研究艾灸对良性前列腺增生患者体内性激素和前列腺特异性抗原(prostate specific antigen,PSA)的影响,探讨艾灸治疗前列腺炎的相关机制。方法:采用艾条温和灸治疗良性前列腺增生患者25例,比较观察患者治疗前后的前列腺症状评分(IPSS)及生活质量指数评分(QOL),并采用化学发光法检测患者治疗前后体内睾酮、雌二醇、PSA表达水平。结果:艾灸治疗后患者临床症状明显减轻,生活质量明显提高,IPSS及QOL评分与治疗前比较,差异有统计学意义(P<0.01),且治疗后患者体内睾酮、雌二醇、睾酮/雌二醇明显升高(P<0.01或P<0.05),PSA含量明显降低(P<0.01)。结论:艾灸可以明显减轻良性前列腺增生患者的临床症状,提高其生活质量,其机制可能是通过提高睾酮、雌二醇及睾酮水平,同时降低其PSA水平。
Objective: To observe the effect of moxibustion on sex hormones and prostate specific antigen(PSA) in patients with benign prostatic hyperplasia, and to explore the mechanism of moxibustion in the treatment of prostatitis. Methods: Twenty-five patients with benign prostatic hyperplasia were treated with moxa stick moxibustion. The prostate symptom score(IPSS) and quality of life index score(QOL) were compared before and after treatment. The expression levels of testosterone, estradiol and PSA were detected by chemiluminescence method before and after treatment. Results: After moxibustion treatment, the clinical symptoms and quality of life of patients were significantly alleviated, and the scores of IPSS and QOL were significantly higher than those before treatment(P<0.01). After moxibustion treatment, testosterone, estradiol and testosterone/estradiol in patients were significantly increased(P<0.01 or P<0.05), and the content of PSA was significantly decreased(P<0.01).Conclusion: Moxibustion therapy can significantly alleviate the clinical symptoms of benign prostatic hyperplasia patients and improve their quality of life. Its mechanism may be through improving the levels of testosterone,estradiol and testosterone, and at the same time reducing the level of PSA.
Objective: To observe the effect of moxibustion on sex hormones and prostate specific antigen(PSA) in patients with benign prostatic hyperplasia, and to explore the mechanism of moxibustion in the treatment of prostatitis. Methods: Twenty-five patients with benign prostatic hyperplasia were treated with moxa stick moxibustion. The prostate symptom score(IPSS) and quality of life index score(QOL) were compared before and after treatment. The expression levels of testosterone, estradiol and PSA were detected by chemiluminescence method before and after treatment. Results: After moxibustion treatment, the clinical symptoms and quality of life of patients were significantly alleviated, and the scores of IPSS and QOL were significantly higher than those before treatment(P<0.01). After moxibustion treatment, testosterone, estradiol and testosterone/estradiol in patients were significantly increased(P<0.01 or P<0.05), and the content of PSA was significantly decreased(P<0.01).Conclusion: Moxibustion therapy can significantly alleviate the clinical symptoms of benign prostatic hyperplasia patients and improve their quality of life. Its mechanism may be through improving the levels of testosterone,estradiol and testosterone, and at the same time reducing the level of PSA.
引文
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[11]段晓慧,潘晓明,肖永新,等.老年前列腺增生症血清性相关激素(FSH、LH、E2、T、PRL、P、T/E2)变化观察[J].中国性科学,2009,17(1):10-13.
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[14]孟元,丁留成,卫中庆.前列腺增生伴组织学炎症与前列腺特异性抗原异常升高研究进展[J].医学研究生学报,2013,26(2):214-218.
[15]刘贺亮,邵国兴,王中琨.年龄、前列腺体积对前列腺增生PSA的影响[J].现代泌尿外科杂志,1996,1(1):24-25.
[16]刘智勇.血清PSA及其相关形式与前列腺疾病关系的研究[D].上海:第二军医大学,2006.
[2]郝琳.我国人口老龄化问题研究及对策[D].曲阜:曲阜师范大学,2014.
[3]杨士杰.白藜芦醇减轻大鼠代谢综合征诱导前列腺增生机制的研究[D].石家庄:河北医科大学,2015.
[4]郑秋平.抗凋亡蛋白Bcl-XL的表达在前列腺增生衰老逃逸机制中的作用探讨[D].广州:南方医科大学,2014.
[5]段建敏,秦大山,陈一戎,等.前列腺增生患者血清铜、锌、镉、镍测定[J].兰州医学院学报,1997,23(4):35-36.
[6]陈友强,唐立明.天癸灸抗衰老作用的临床观察[J].实用老年医学,1994,8(3):115-117.
[7]姜小英.艾灸足三里、关元穴对血液流变性的影响[J].四川中医,2001,19(3):75.
[8]邓倩萍,姜小英.艾灸对老年心脑血管患者血液流变学的影响[J].针灸临床杂志,2005,21(4):43-44.
[9]韩冰,郑继成,杨文增.良性前列腺增生患者的血液流变学观察[J].临床泌尿外科杂志,1993,8(2):104-105.
[10]姜磊.针刺配合艾灸治疗良性前列腺增生症(肾虚血瘀型)的临床观察[D].哈尔滨:黑龙江中医药大学,2015.
[11]段晓慧,潘晓明,肖永新,等.老年前列腺增生症血清性相关激素(FSH、LH、E2、T、PRL、P、T/E2)变化观察[J].中国性科学,2009,17(1):10-13.
[12]颜纯海,单玉喜,李玲玲.前列腺增生症中雌、孕激素受体检测[J].中华内分泌代谢杂志,1995,11(4):225-227,252.
[13]张鸿毅,保庭毅.环境内分泌干扰物的拟激素作用对前列腺增生影响的研究现状[J].西南国防医药,2012,22(1):102-105.
[14]孟元,丁留成,卫中庆.前列腺增生伴组织学炎症与前列腺特异性抗原异常升高研究进展[J].医学研究生学报,2013,26(2):214-218.
[15]刘贺亮,邵国兴,王中琨.年龄、前列腺体积对前列腺增生PSA的影响[J].现代泌尿外科杂志,1996,1(1):24-25.
[16]刘智勇.血清PSA及其相关形式与前列腺疾病关系的研究[D].上海:第二军医大学,2006.