轻度轮状病毒肠炎伴良性惊厥患儿血清维生素D、钙、磷、甲状旁腺激素水平分析
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摘要
目的 检测轻度轮状病毒肠炎伴良性惊厥患儿血清25-(OH)D、钙(Ca)、磷(P)、甲状旁腺激素(PTH)水平,为临床补充维生素D提供参考。方法 选取2015-2018年每年10月-次年3月在江门市中心医院就诊的6月～2岁轻度轮状病毒肠炎伴良性惊厥患儿58例为病例组,同期该年龄段健康儿童62例为对照组,检测血清25-(OH)D、Ca、P、PTH水平及大便轮状病毒。结果 1)所有纳入对象中,多数血清25-(OH)D浓度处于不足或缺乏状态,极少数充足。2)病例组血清Ca、25-(OH)D浓度均低于对照组,差异有统计学意义(P<0.05);两组血清P及PTH浓度比较差异无统计学意义(P>0.05)。3)病例组和对照组血清25-(OH)D浓度和PTH浓度均呈负相关(r=-0.324、-0.264,P<0.05)。结论 江门市儿童血清25-(OH)D水平普遍不足或缺乏,儿童血钙、25-(OH)D含量低可能是轮状病毒肠炎伴惊厥发作的潜在危险因素。
Objective To detect serum levels of 25-(OH)D,calcium(Ca),phosphorus(P) and parathyroid hormone(PTH) in children with mild rotavirus enteritis and benign convulsions,in order to provide reference for clinical vitamin D supplementation. Methods A total of 58 cases of children aged 6 months to 2 years,who were with mild rotavirus enteritis and benign convulsions in Jiangmen Central Hospital from October to March in the following year from 2015 to 2018,were selected into case group.And 62 healthy children at the same time were selected as control group.Serum 25-(OH) D,calcium,phosphorus,PTH level and fecal rotavirus were tested in the two groups. Results 1)In all subjects,most serum 25-(OH)D concentrations were insufficient or deficient,only few were sufficient.2) Serum calcium and 25-(OH)D concentration in case group was significantly lower than those in control group(P<0.05),while the differences on serum P and PTH concentrations between the two groups were not significant(P>0.05).3) Serum 25-(OH)D concentration was negatively correlated with PTH concentration in case group and control group(r=-0.324,-0.264,P<0.05). Conclusion The serum level of 25-(OH) D in children in Jiangmen city is generally insufficient or deficient.And the low levels of serum Ca and 25-(OH)D may be the potentially risk factors for mild rotavirus enteritis and benign convulsions.The level of serum 25-(OH)D in the case group was lower than that in the control group.
Objective To detect serum levels of 25-(OH)D,calcium(Ca),phosphorus(P) and parathyroid hormone(PTH) in children with mild rotavirus enteritis and benign convulsions,in order to provide reference for clinical vitamin D supplementation. Methods A total of 58 cases of children aged 6 months to 2 years,who were with mild rotavirus enteritis and benign convulsions in Jiangmen Central Hospital from October to March in the following year from 2015 to 2018,were selected into case group.And 62 healthy children at the same time were selected as control group.Serum 25-(OH) D,calcium,phosphorus,PTH level and fecal rotavirus were tested in the two groups. Results 1)In all subjects,most serum 25-(OH)D concentrations were insufficient or deficient,only few were sufficient.2) Serum calcium and 25-(OH)D concentration in case group was significantly lower than those in control group(P<0.05),while the differences on serum P and PTH concentrations between the two groups were not significant(P>0.05).3) Serum 25-(OH)D concentration was negatively correlated with PTH concentration in case group and control group(r=-0.324,-0.264,P<0.05). Conclusion The serum level of 25-(OH) D in children in Jiangmen city is generally insufficient or deficient.And the low levels of serum Ca and 25-(OH)D may be the potentially risk factors for mild rotavirus enteritis and benign convulsions.The level of serum 25-(OH)D in the case group was lower than that in the control group.
引文
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[13] Pekkinen M,Saarnio E,Viljakainen HT,et al.Vitamin D binding protein genotype Is associated with serum 25-hydroxy vitamin D and PTH concentrations,as well as bone health in children and adolescents in Finland[J].PLoS One,2014,9(1):e87292.
[14] Houghton LA,Szymlek-Gay EA,GrayAR,et al.Predictors of vitamin D status and its association with parathyroid hormone in young New Zealand children[J].Am J Clin Nutr,2010,92(1):69-76.
[2] Kang B,Kwon YS.Benign convulsion with mild astroenteritis[J].Korean J Pediatr,2014.57(7):304-309.
[3] Holick MF.Vitamin D deficiency[J].N Engl J Med,2007,357(3):266-281.
[4] Fuleihan G,Bouillon R,Clarke B,et al.Serum 25-hydroxyvitamin D levels:variability,knowledgegaps,and the concept of a desirable range[J].Bone Miner Res,2015,30(7):1119-1133.
[5] Bucak IH,Qzturk AB,Alims H,et al.Is there a relationship between low vitamin D and rotaviral diarrhea?[J].Pediatr Int,2016,58(4):270-273.
[6] 中华医学会儿科学分会儿童保健学组,《中华儿科杂志》编辑委员会.儿童微量营养素缺乏防治建议[J].中华儿科杂志,2010,48(7):502-509.
[7] 符传博,丹利,唐家翔,等.1960-2013年华南地区霾污染大的时空变化及其与关键气候因子的关系[J].中国环境科学,2016,35(5):1313-1322.
[8] Carole BA,Raphael EC,Christine BF,et al.Sunlight and vitamin D:necessary for public health[J].J Am Coll Nutr,2015,34(4):359-365.
[9] 秦振英,梁冠禹,胡幼芳,等.儿童户外活动及体质指数与VitD营养状况的关系研究[J].中国儿童保健杂志,2017,25(4):334-337.
[10] Yeom JS,Kim YS,Park JS,et al.Role of Ca2+ homeostasis disruption in rotavirus-associated seizures[J].Child Neuro,2014;29(3):331-335.
[11] Tsiaras WG,Weinstock MA.Factors influencing vitamin D status[J].Acta Derm Venereol,2011,91(2):115-124.
[12] Haddow JE,Neveux LM,Palomaki GE,et al.The relationship between PTH and 25-hydroxy vitamin D early inpregnancy[J].Clin Endocrinol,2011,75(3):309-314.
[13] Pekkinen M,Saarnio E,Viljakainen HT,et al.Vitamin D binding protein genotype Is associated with serum 25-hydroxy vitamin D and PTH concentrations,as well as bone health in children and adolescents in Finland[J].PLoS One,2014,9(1):e87292.
[14] Houghton LA,Szymlek-Gay EA,GrayAR,et al.Predictors of vitamin D status and its association with parathyroid hormone in young New Zealand children[J].Am J Clin Nutr,2010,92(1):69-76.