摘要
通过将介孔生物玻璃(MBG)和四氧化三铁(Fe_3O_4)纳米颗粒复合制备出Fe_3O_4/MBG复合骨水泥,并详细研究了Fe_3O_4纳米颗粒的添加对骨水泥凝结时间、抗压强度、生物活性、降解性能以及磁热性能的影响。研究结果表明,Fe_3O_4/MBG骨水泥具有较好的抗压强度,随着Fe_3O_4纳米颗粒量的增加,Fe_3O_4/MBG骨水泥的凝结时间延长、磁热性能提高,但几乎没有对骨水泥的生物活性和降解性能产生影响。
Magnetite/mesoporous bioglass( Fe_3O_4/MBG) composite cements were successfully prepared by the addition of Fe_3O_4 nanoparticles into MBG cements. The effects of the Fe_3O_4 nanoparticles addition on the setting time,compressive strength,bioactivity,biodegradability and magnetic heating ability were investigated. The results showed that the Fe_3O_4/MBG cements had good compressive strength,and exhibited the prolonged setting time and enhanced magnetic heating ability with increasing Fe_3O_4 nanoparticles content. However,the Fe_3O_4 addition had little effect on the bioactivity and biodegradability.
引文
[1]Shi Q H,Wang J F,Zhang J P,et al.Rapid-setting,mesoporous,bioactive glass cements that induce accelerated in vitro apatite formation[J].Advanced Materials,2006,18(8):1038-1042.
[2]Kawashita M,Kawamura K,Li Z.PMMA-based bone cements containing magnetite particles for the hyperthermia of cancer[J].Acta Biomaterialia,2010,6(8):3187-3192.
[3]Matsumine A,Kusuzaki K,Matsubara T,et al.Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field[J].Clinical&Experimental Metastasis,2007,24(3):191-200.
[4]Perez R A,Patel K D,Kim H W.Novel magnetic nanocomposite injectables:Calcium phosphate cements impregnated with ultrafine magnetic nanoparticles for bone regeneration[J].Royal Society of Chemistry Advances,2015,5(18):13411-13419.
[5]Yan X,Yu C,Zhou X,et al.Highly ordered mesoporous bioactive glasses with superior in vitro bone-forming bioactivities[J].Angewandte Chemie International Edition,2004,43(44):5980-5984.
[6]Lohe M R,Gedrich K,Freudenberg T,et al.Heating and separation using nanomagnet-functionalized metal-organic frameworks[J].Chemical Communications,2011,47(11):3075-3077.
[7]El-Fiqi A,Kim J H,Perez R A,et al.Novel bioactive nanocomposite cement formulations with potential properties:incorporation of the nanoparticle form of mesoporous bioactive glass into calcium phosphate cements[J].Journal of Materials Chemistry B,2015,3(7):1321-1334.
[8]Vlad M D,del Valle L J,BarracóM,et al.Iron oxide nanoparticles significantly enhances the injectability of apatitic bone cement for vertebroplasty[J].Spine,2008,33(21):2290-2298.
[9]Hesaraki S,Alizadeh M,Borhan S,et al.Polymerizable nanoparticulate silica-reinforced calcium phosphate bone cement[J].Journal of Biomedical Materials Research Part B(Applied Biomaterials),2012,100(6):1627-1635.
[10]Zhou H,Luchini T J F,Agarwal A K,et al.Development of monetitenanosilica bone cement:A preliminary study[J].Journal of Biomedical Materials Research Part B(Applied Biomaterials),2014,102(8):1620-1626.