父系肥胖对子代影响及其机制
摘要
高脂饮食对健康的影响可以在DNA序列不发生改变的情况下,通过精子细胞传递给后代。因此父系肥胖不仅影响自身健康,也可通过精子的表观遗传调控作用对子代造成影响。本文就国内外父系肥胖对子代影响及其表观遗传机制的研究现况作一简要综述,为预防疾病的发生发展以及遗传学发病机制提供理论依据。
引文
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[2] 马玉周,张家棋.父母亲肥胖对子代影响的现状[J].公共卫生与预防医学,2015,26(3):70-72.
[3] MCPHERSON N O,BELL V G,ZANDER-FOX D L,et al.When two obese parents are worse than one! Impacts on emberyo and fetal development[J].Am J Physiol Endocrinol Metab,2015,309(6):E568.
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[5] BINDER N K,HANNAN N J,GARDNER D K.Paternal diet-induced obesity retards early mouse embryo development,mitochondrial activity and pregnancy health[J].Plos One,2012,7(12):e52304.
[6] MITCHELL M,BAKOS H W,LANE M.Paternal diet-induced obesity impairs embryo development and implantation in the mouse[J].Fertil Steril,2011,95(4):1349.
[7] MCPHERSON N O,FULLSTON T,AITKEN R J,et al.Paternal obesity,interventions,and mechanistic pathways to impaired health in offspring[J].Ann Nutr Metab,2014,64(34):231.
[8] NG S F,LIN R C,LAYBUTT D R,et al.Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring[J].Nature,2010,467(7318):963-966.
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[10] LECOMTE V,MALONEY C A,WANG K,et al.Male offspring from obese fathers develop growth defects associated with perturbation of the lipid metabolism[J].Obes Res Clin Pract,2014,8:57.
[11] MASUYAMA H,MITSUI T,EGUCHI T,et al.The effects of paternal high-fat diet exposure on offspring metabolism with epigenetic changes in the mouse adiponectin and leptin gene promoters[J].Am J Physiol Endocrinol Metab,2016,311(1):E236.
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[14] 张洁,李慧阁,傅力,等.高脂饮食干预父代C57BL/6d鼠对子代肝脏脂肪沉积的影响[J].中华肝脏病杂志,2017,25(2):139-144.
[15] TERASHIMA M,BARBOUR S,REN J,et al.Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression[J].Epigenetics,2015,10(9):861-871.
[16] FULLSTON T,PALMER N O,OWENS J A,et al.Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice[J].Human Reprod,2012,27(5):1391-1400.
[17] FULLSTON T,MCPHERSON N O,OWENS J A,et al.Paternal obesity induces metabolic and sperm disturbances in male offspring that are exacerbated by their exposure to an “obesogenic” diet[J].Physiol Rep,2015,3(3):12336.
[18] MCPHERSON N O,FULLSTON T,BAKOS H W,et al.Obese father’s metabolic state,adiposity,and reproductive capacity indicate son’s reproductive health[J].Fertil Steril,2014,101(3):865-873.
[19] MORAEUS L,LISSNER L,YNGVE A,et al.Multi-level influences on childhood obesity in Sweden:societal factors,parental determinants and child’s lifestyle[J].Int J Obes,2012,36(7):969.
[20] DANIELZIK S,LANGN?SE K,MAST M,et al.Impact of parental BMI on the manifestation of overweight 5-7 year old children[J].Eur J Nutr,2002,41(3):132-138.
[21] BURKE V,BEILIN L J,DUNBAR D.Family lifestyle and parental body mass index as predictors of body mass index in Australian children:a longitudinal study[J].Int J Obes Relat Metab Disord,2001,25(2):147-157.
[22] 于洋,李辉,夏秀兰,等.父母肥胖对儿童期肥胖的影响[J].中国公共卫生,2002,18(12):1463-1464.
[23] 李晓卉,郭红侠,黄艳丽,等.父母超重肥胖对儿童青少年超重肥胖的影响[J].中国学校卫生,2016,37(2):239-242.
[24] 柳纪红.父母BMI对儿童青少年超重肥胖的影响[D].沈阳:中国医科大学,2012.
[25] MCCARTHY K,YE Y L,YUAN S,et al.Parental weight status and offspring cardiovascular disease risks:a cross-sectional study of Chinese children[J].Prev Chronic Dis,2015,12(1):E01.
[26] VIK K L,ROMUNDSTAD P,CARSLAKE D,et al.Comparison of father-offspring and mother- offspring associations of cardiovascular risk factors:family linkage within the population-based HUNT Study,Norway[J].Int J Epidemiol,2014,43(3):760-771.
[27] LABAYEN I,RUIZ J R,ORTEGA F B,et al.Intergenerational cardiovascular disease risk factors involve both maternal and paternal BMI[J].Diabetes Care,2010,33(4):894-900.
[28] FULLSTON T,OHLSSON TEAGUE E M,PALMER N O,et al.Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content[J].FASEB J,2013,27(10):4226-4243.
[29] WANG Y,LIU H,SUN Z.Lamarck rises from his grave:parental environment-induced epigenetic inheritance in model organisms and humans[J].Biol RevCamb Philos Soc,2017,92(4):2084-2111.
[30] QIAN M X,PANG Y,LIU C H,et al.Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis[J].Cell,2013,153(5):1012-1024.
[31] PORTELA A,ESTELLER M.Epigenetic modifications and human disease[J].Nat Biotechnol,2010,28:1057-1068.
[32] BINDER N K,BEARD S A,KAITU'U-LINO T J,et al.Paternal obesity in a rodent model affects placental gene expression ina sex-specific manner[J].Reproduction,2015,149:435-444.
[33] WU S C,ZHANG Y.Active DNA demethylation:Many roads lead to rome[J].Nat Rev Mol Cell Biol,2010,11:607-620.
[34] HAMMOUD S S,NIX D A,ZHANG H,et al.Distinctive chromatin in human sperm packages genes for embryo development[J].Nature,2009,460:473-478.
[35] RAAD G,HAZZOURI M,BOTTINI S,et al.Paternal obesity:how bad is it for sperm quality and progeny health[J].Basic Clin Androl,2017,27(1):20.
[36] CARRELL D T,HAMMOUD S S.The human sperm epigenome and its potential role in embryonic development[J].Mol Hum Reprod,2010,16:37-47.
[37] SONG N,LIU J,AN S,et al.Immunohistochemical analysis of histone H3 modifications in germ cells during mouse spermatogenesis[J].Acta Histochem Et Cytochem,2011,44(4):183.
[38] PENG L,SETO E.Deacetylation of nonhistone proteins by HDACs and the implications in cancer[J].Handb Exp Pharmacol,2011,206:39.
[39] 曹忠红.精子tsRNAs在父源获得性性状跨代遗传中的作用研究[D].北京:中国科学院大学,2016.
[40] SATO A,OTSU E,SUZUKI R,et al.DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm[J].Fertil Steril,2009,17(12):1582-1591.
[41] SOUBRY A,GUO L,HUANG Z,et al.Obesity-related DNA methylation at imprinted genes in human sperm:results from the TIEGER study[J].Clin Epigen,2016,8(1):51.
[42] SOUBRY A,MURPHY S K,WANG F,et al.Newborns of obese parents have altered DNA methylation patterns at imprinted genes[J].Int J Obes,2015,39:650-657.
[43] DHAR S,THOTA A.Insights into role of bromodomain,testis-specific(Brdt)in acetylated histone H4-dependent chromatin remodeling in mammalian spermiogenesis[J].J Biol Chem,2012,287(9):6387-6405.
[2] 马玉周,张家棋.父母亲肥胖对子代影响的现状[J].公共卫生与预防医学,2015,26(3):70-72.
[3] MCPHERSON N O,BELL V G,ZANDER-FOX D L,et al.When two obese parents are worse than one! Impacts on emberyo and fetal development[J].Am J Physiol Endocrinol Metab,2015,309(6):E568.
[4] BINDER N K,MITCHELL M,GARDNER D K.Parental diet-induced obesity leads to retarded early mouse embryo development and altered carbohydrate utilisation by the blastocyst [J].Reprod Fertil Dev,2012,24(6):804-812.
[5] BINDER N K,HANNAN N J,GARDNER D K.Paternal diet-induced obesity retards early mouse embryo development,mitochondrial activity and pregnancy health[J].Plos One,2012,7(12):e52304.
[6] MITCHELL M,BAKOS H W,LANE M.Paternal diet-induced obesity impairs embryo development and implantation in the mouse[J].Fertil Steril,2011,95(4):1349.
[7] MCPHERSON N O,FULLSTON T,AITKEN R J,et al.Paternal obesity,interventions,and mechanistic pathways to impaired health in offspring[J].Ann Nutr Metab,2014,64(34):231.
[8] NG S F,LIN R C,LAYBUTT D R,et al.Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring[J].Nature,2010,467(7318):963-966.
[9] ORNELLAS F,BRINGHENTI I,MATTOS BANF,et al.Father’s obesity programs the adipose tissue in the offspring via the local renin-angiotensin system and MAPKs pathways,especially in adult male mice[J].Eur J Nutr,2017(5):1-12.
[10] LECOMTE V,MALONEY C A,WANG K,et al.Male offspring from obese fathers develop growth defects associated with perturbation of the lipid metabolism[J].Obes Res Clin Pract,2014,8:57.
[11] MASUYAMA H,MITSUI T,EGUCHI T,et al.The effects of paternal high-fat diet exposure on offspring metabolism with epigenetic changes in the mouse adiponectin and leptin gene promoters[J].Am J Physiol Endocrinol Metab,2016,311(1):E236.
[12] PARK J H,YOO Y,CHO M,et al.Diet-induced obesity leads to metabolic dysregulation in offspring via endoplasmic reticulum stress in a sex-specific manner[J].Int J Obes,2018,42(2):244-251.
[13] CHOWDHURY S S,VIRGINIE L,ERLICH J H,et al.Paternal high fat diet in rats leads to renal accumulation of lipid and tubular changes in adult offspring[J].Nutrients,2016,8(9):E521.
[14] 张洁,李慧阁,傅力,等.高脂饮食干预父代C57BL/6d鼠对子代肝脏脂肪沉积的影响[J].中华肝脏病杂志,2017,25(2):139-144.
[15] TERASHIMA M,BARBOUR S,REN J,et al.Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression[J].Epigenetics,2015,10(9):861-871.
[16] FULLSTON T,PALMER N O,OWENS J A,et al.Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice[J].Human Reprod,2012,27(5):1391-1400.
[17] FULLSTON T,MCPHERSON N O,OWENS J A,et al.Paternal obesity induces metabolic and sperm disturbances in male offspring that are exacerbated by their exposure to an “obesogenic” diet[J].Physiol Rep,2015,3(3):12336.
[18] MCPHERSON N O,FULLSTON T,BAKOS H W,et al.Obese father’s metabolic state,adiposity,and reproductive capacity indicate son’s reproductive health[J].Fertil Steril,2014,101(3):865-873.
[19] MORAEUS L,LISSNER L,YNGVE A,et al.Multi-level influences on childhood obesity in Sweden:societal factors,parental determinants and child’s lifestyle[J].Int J Obes,2012,36(7):969.
[20] DANIELZIK S,LANGN?SE K,MAST M,et al.Impact of parental BMI on the manifestation of overweight 5-7 year old children[J].Eur J Nutr,2002,41(3):132-138.
[21] BURKE V,BEILIN L J,DUNBAR D.Family lifestyle and parental body mass index as predictors of body mass index in Australian children:a longitudinal study[J].Int J Obes Relat Metab Disord,2001,25(2):147-157.
[22] 于洋,李辉,夏秀兰,等.父母肥胖对儿童期肥胖的影响[J].中国公共卫生,2002,18(12):1463-1464.
[23] 李晓卉,郭红侠,黄艳丽,等.父母超重肥胖对儿童青少年超重肥胖的影响[J].中国学校卫生,2016,37(2):239-242.
[24] 柳纪红.父母BMI对儿童青少年超重肥胖的影响[D].沈阳:中国医科大学,2012.
[25] MCCARTHY K,YE Y L,YUAN S,et al.Parental weight status and offspring cardiovascular disease risks:a cross-sectional study of Chinese children[J].Prev Chronic Dis,2015,12(1):E01.
[26] VIK K L,ROMUNDSTAD P,CARSLAKE D,et al.Comparison of father-offspring and mother- offspring associations of cardiovascular risk factors:family linkage within the population-based HUNT Study,Norway[J].Int J Epidemiol,2014,43(3):760-771.
[27] LABAYEN I,RUIZ J R,ORTEGA F B,et al.Intergenerational cardiovascular disease risk factors involve both maternal and paternal BMI[J].Diabetes Care,2010,33(4):894-900.
[28] FULLSTON T,OHLSSON TEAGUE E M,PALMER N O,et al.Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content[J].FASEB J,2013,27(10):4226-4243.
[29] WANG Y,LIU H,SUN Z.Lamarck rises from his grave:parental environment-induced epigenetic inheritance in model organisms and humans[J].Biol RevCamb Philos Soc,2017,92(4):2084-2111.
[30] QIAN M X,PANG Y,LIU C H,et al.Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis[J].Cell,2013,153(5):1012-1024.
[31] PORTELA A,ESTELLER M.Epigenetic modifications and human disease[J].Nat Biotechnol,2010,28:1057-1068.
[32] BINDER N K,BEARD S A,KAITU'U-LINO T J,et al.Paternal obesity in a rodent model affects placental gene expression ina sex-specific manner[J].Reproduction,2015,149:435-444.
[33] WU S C,ZHANG Y.Active DNA demethylation:Many roads lead to rome[J].Nat Rev Mol Cell Biol,2010,11:607-620.
[34] HAMMOUD S S,NIX D A,ZHANG H,et al.Distinctive chromatin in human sperm packages genes for embryo development[J].Nature,2009,460:473-478.
[35] RAAD G,HAZZOURI M,BOTTINI S,et al.Paternal obesity:how bad is it for sperm quality and progeny health[J].Basic Clin Androl,2017,27(1):20.
[36] CARRELL D T,HAMMOUD S S.The human sperm epigenome and its potential role in embryonic development[J].Mol Hum Reprod,2010,16:37-47.
[37] SONG N,LIU J,AN S,et al.Immunohistochemical analysis of histone H3 modifications in germ cells during mouse spermatogenesis[J].Acta Histochem Et Cytochem,2011,44(4):183.
[38] PENG L,SETO E.Deacetylation of nonhistone proteins by HDACs and the implications in cancer[J].Handb Exp Pharmacol,2011,206:39.
[39] 曹忠红.精子tsRNAs在父源获得性性状跨代遗传中的作用研究[D].北京:中国科学院大学,2016.
[40] SATO A,OTSU E,SUZUKI R,et al.DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm[J].Fertil Steril,2009,17(12):1582-1591.
[41] SOUBRY A,GUO L,HUANG Z,et al.Obesity-related DNA methylation at imprinted genes in human sperm:results from the TIEGER study[J].Clin Epigen,2016,8(1):51.
[42] SOUBRY A,MURPHY S K,WANG F,et al.Newborns of obese parents have altered DNA methylation patterns at imprinted genes[J].Int J Obes,2015,39:650-657.
[43] DHAR S,THOTA A.Insights into role of bromodomain,testis-specific(Brdt)in acetylated histone H4-dependent chromatin remodeling in mammalian spermiogenesis[J].J Biol Chem,2012,287(9):6387-6405.