中西医结合治疗睑板腺功能障碍患者白内障术后干眼症的效果及对泪膜稳定性的影响
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摘要
目的探讨中西医结合治疗睑板腺功能障碍患者白内障术后干眼症的效果及对泪膜稳定性的影响。方法 130例睑板腺功能障碍白内障术后干眼症患者,根据治疗方法不同分为对照组(70例)和观察组(60例)。对照组患者采用常规西药治疗,观察组患者采用中西医结合治疗。比较两组患者临床疗效及治疗前后泪膜稳定性、中医症候积分。结果观察组患者总有效率为91.67%,显著高于对照组的78.57%,差异具有统计学意义(P<0.05)。治疗前,两组患者平均泪膜破裂时间(ATBUT)、首次泪膜破裂时间(BUT)、非侵入式泪河高度(NITMH)比较差异无统计学意义(P>0.05);治疗6个月后,两组患者ATBUT、BUT、NITMH较本组治疗前及治疗1 d、3个月后增加,差异具有统计学意义(P<0.05);治疗1 d、3个月、6个月后,观察组患者ATBUT、BUT、NITMH均优于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者目干涩不爽、灼热感、羞明惧光、赤丝盘虬、视物不清积分比较差异无统计学意义(P>0.05);治疗6个月后,两组患者目干涩不爽、灼热感、羞明惧光、赤丝盘虬、视物不清积分较本组治疗前下降,且观察组显著低于对照组,差异具有统计学意义(P<0.05)。结论中西医结合治疗睑板腺功能障碍患者白内障术后干眼症能显著提高临床疗效,改善临床症状、恢复泪膜稳定性,值得推荐使用。
Objective To discuss the effect of integrated traditional Chinese and Western medicine on dry eye after cataract surgery in patients with tarsal gland dysfunction and its influence on tear film stability. Methods A total of 130 dry eye patients with tarsal gland dysfunction after cataract surgery were divided by different treatment methods into control group(70 cases) and observation group(60 cases). The control group was treated with conventional Western medicine, and the observation group was treated with integrated traditional Chinese and Western medicine. Comparison were made on clinical efficacy, tear film stability and traditional Chinese medicine integral before and after treatment in two groups. Results The observation group had significantly higher total effective rate as 91.67% than 78.57% in the control group, and the difference was statistically significant(P<0.05). Before treatment, both groups had no statistically significant difference in average tear break-up time(ATBUT), first break-up time(BUT) and non-invasive tear meniscus height(NITMH)(P>0.05). After 6 months of treatment, both groups had increased ATBUT, BUT and NITMH than those before treatment and after 1 d and 3 months of treatment. Their difference was statistically significant(P<0.05). After 1 d, 3 months and 6 months of treatment, the observation group had better ATBUT, BUT and NITMH than the control group, and the difference was statistically significant(P<0.05). Before treatment, both groups had no statistically significant difference in dry eyes, burning sensation, shyness and fear of light, red silk coiling, blurred vision integral(P>0.05). After 6 months of treatment, both groups had decreased dry eyes, burning sensation, shyness and fear of light, red silk coiling, blurred vision integral than those before treatment, and the observation group was significantly lower than the control group. Their difference was statistically significant(P<0.05). Conclusion Integrated traditional Chinese and Western medicine can significantly improve clinical efficacy of dry eye in patients with tarsal gland dysfunction after cataract surgery, improve their clinical symptoms and restore tear film stability. It is worthy of promotion and application.
Objective To discuss the effect of integrated traditional Chinese and Western medicine on dry eye after cataract surgery in patients with tarsal gland dysfunction and its influence on tear film stability. Methods A total of 130 dry eye patients with tarsal gland dysfunction after cataract surgery were divided by different treatment methods into control group(70 cases) and observation group(60 cases). The control group was treated with conventional Western medicine, and the observation group was treated with integrated traditional Chinese and Western medicine. Comparison were made on clinical efficacy, tear film stability and traditional Chinese medicine integral before and after treatment in two groups. Results The observation group had significantly higher total effective rate as 91.67% than 78.57% in the control group, and the difference was statistically significant(P<0.05). Before treatment, both groups had no statistically significant difference in average tear break-up time(ATBUT), first break-up time(BUT) and non-invasive tear meniscus height(NITMH)(P>0.05). After 6 months of treatment, both groups had increased ATBUT, BUT and NITMH than those before treatment and after 1 d and 3 months of treatment. Their difference was statistically significant(P<0.05). After 1 d, 3 months and 6 months of treatment, the observation group had better ATBUT, BUT and NITMH than the control group, and the difference was statistically significant(P<0.05). Before treatment, both groups had no statistically significant difference in dry eyes, burning sensation, shyness and fear of light, red silk coiling, blurred vision integral(P>0.05). After 6 months of treatment, both groups had decreased dry eyes, burning sensation, shyness and fear of light, red silk coiling, blurred vision integral than those before treatment, and the observation group was significantly lower than the control group. Their difference was statistically significant(P<0.05). Conclusion Integrated traditional Chinese and Western medicine can significantly improve clinical efficacy of dry eye in patients with tarsal gland dysfunction after cataract surgery, improve their clinical symptoms and restore tear film stability. It is worthy of promotion and application.
引文
[1]陈志丽,王红霞.玻璃酸钠联合rhEGF滴眼液治疗白内障术后干眼症泪膜的疗效分析.重庆医学, 2016, 45(6):123-126.
[2]肖国武.睑板腺功能障碍的中医辨证论治//世界中医药学会联合会眼科专业委员会国际眼科学术研讨会, 2014:135.
[3]任敏子.中西医结合治疗中老年睑板腺功能障碍导致的干眼症的疗效评价.广西医科大学学报, 2016, 33(3):463-466.
[4]杜坤悦之.补肾明目汤联合水蒸气加热仪及眼睑按摩治疗睑板腺功能障碍伴干眼疗效及其对泪液中IL-1Ra、fractalkine/CX3CL1水平的影响.陕西中医, 2017, 38(12):1747-1749.
[5]陈中锋.睑板腺功能障碍导致干眼症的原因及治疗方法研究.吉林医学, 2013, 34(33):7005.
[6]李琼,高启孝.睑板腺功能障碍性干眼症临床治疗.养生保健指南(医药研究), 2015(8):35.
[7]李占峰.改良睑板腺按摩联合热敷及药物治疗睑板腺功能障碍性干眼症患者的疗效.医疗装备, 2018, 31(16):21-22.
[8]侯定善.睑板腺功能障碍性干眼症中西医多元化治疗临床观察.社区医学杂志, 2018, 16(17):44-48.
[9]杨欣娟,陈亚江,王丽,等.睑板腺挤压术联合药物综合治疗睑板腺功能障碍性干眼症的临床应用.健康之路, 2016(5):19.
[10]何清,马喜桃.中药熏洗联合玻璃酸钠对睑板腺功能障碍性干眼症的影响.中国临床医生杂志, 2018, 46(11):123-125.
[11]于莉,黎明,周晓萍,等.睑板腺功能障碍性干眼症临床治疗探讨.中国实用眼科杂志, 2014, 32(1):1398.
[12]利焕廉,周金文,左炜.玻璃酸钠滴眼液对白内障术后干眼症患者泪膜结构及稳定性的影响.泰山医学院学报, 2017,38(4):420-421.
[13]常晓雪,相义会,郭秀华,等.妥布霉素地塞米松眼膏联合玻璃酸钠治疗睑板腺功能障碍性干眼症的临床效果观察.中国医刊, 2018(7):770-773.
[2]肖国武.睑板腺功能障碍的中医辨证论治//世界中医药学会联合会眼科专业委员会国际眼科学术研讨会, 2014:135.
[3]任敏子.中西医结合治疗中老年睑板腺功能障碍导致的干眼症的疗效评价.广西医科大学学报, 2016, 33(3):463-466.
[4]杜坤悦之.补肾明目汤联合水蒸气加热仪及眼睑按摩治疗睑板腺功能障碍伴干眼疗效及其对泪液中IL-1Ra、fractalkine/CX3CL1水平的影响.陕西中医, 2017, 38(12):1747-1749.
[5]陈中锋.睑板腺功能障碍导致干眼症的原因及治疗方法研究.吉林医学, 2013, 34(33):7005.
[6]李琼,高启孝.睑板腺功能障碍性干眼症临床治疗.养生保健指南(医药研究), 2015(8):35.
[7]李占峰.改良睑板腺按摩联合热敷及药物治疗睑板腺功能障碍性干眼症患者的疗效.医疗装备, 2018, 31(16):21-22.
[8]侯定善.睑板腺功能障碍性干眼症中西医多元化治疗临床观察.社区医学杂志, 2018, 16(17):44-48.
[9]杨欣娟,陈亚江,王丽,等.睑板腺挤压术联合药物综合治疗睑板腺功能障碍性干眼症的临床应用.健康之路, 2016(5):19.
[10]何清,马喜桃.中药熏洗联合玻璃酸钠对睑板腺功能障碍性干眼症的影响.中国临床医生杂志, 2018, 46(11):123-125.
[11]于莉,黎明,周晓萍,等.睑板腺功能障碍性干眼症临床治疗探讨.中国实用眼科杂志, 2014, 32(1):1398.
[12]利焕廉,周金文,左炜.玻璃酸钠滴眼液对白内障术后干眼症患者泪膜结构及稳定性的影响.泰山医学院学报, 2017,38(4):420-421.
[13]常晓雪,相义会,郭秀华,等.妥布霉素地塞米松眼膏联合玻璃酸钠治疗睑板腺功能障碍性干眼症的临床效果观察.中国医刊, 2018(7):770-773.
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