多指标综合评分法优选芩黄凝胶剂提取工艺
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摘要
目的优选芩黄凝胶剂的提取工艺。方法以黄芩苷、芦荟大黄素、大黄酸、大黄素、大黄酚、大黄素甲醚的转移率为评价指标,采用L9(34)正交法优选芩黄凝胶剂的水提取与醇提取工艺。结果最佳水提取工艺为加6倍量水,浸泡0.5 h,回流提取2次,每次提取1.5 h;最佳醇提取工艺为加8倍量40%乙醇,回流提取3次,每次提取1.0 h。结论采用多指标综合评分法优选的芩黄凝胶剂提取工艺合理、可行。
OBJECTIVE To optimize the extraction technology of Qinhuang gel. METHODS With the transferring rate of baicalin, aloe emodin, rhein, emodin, chrysophanol, physcion as index, orthogonal design L9(34) was carried out for the optimum extraction technology of Qinhuang gel by water and ethanol. RESULTS The optimum extraction technology by water were as follows: 6-fold water, soaking 0.5 h, reflux extracting 2 times and 1.5 h each time; the optimum extraction technology by ethanol were as follows: 8-fold 40% ethanol, reflux extracting 3 times and 1.0 h each time. CONCLUSION The extraction technology of Qinhuang gel optimized by multicreteria comprehensive assessment is reasonable and practical.
OBJECTIVE To optimize the extraction technology of Qinhuang gel. METHODS With the transferring rate of baicalin, aloe emodin, rhein, emodin, chrysophanol, physcion as index, orthogonal design L9(34) was carried out for the optimum extraction technology of Qinhuang gel by water and ethanol. RESULTS The optimum extraction technology by water were as follows: 6-fold water, soaking 0.5 h, reflux extracting 2 times and 1.5 h each time; the optimum extraction technology by ethanol were as follows: 8-fold 40% ethanol, reflux extracting 3 times and 1.0 h each time. CONCLUSION The extraction technology of Qinhuang gel optimized by multicreteria comprehensive assessment is reasonable and practical.
引文
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