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蛋白质组学及蛋白质翻译后修饰在畜牧领域中的应用研究进展
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  • 英文篇名:Research Progress on Application of Proteomics and Post-translational Modification of Proteins in Animal Husbandry
  • 作者:王欣悦 ; 张莉
  • 英文作者:WANG Xinyue;ZHANG Li;Institute of Animal Sciences,Chinese Academy of Agricultural Sciences;
  • 关键词:蛋白质组学 ; 畜牧 ; 蛋白质翻译后修饰(PTMs)
  • 英文关键词:proteomics;;animal husbandry;;protein post-translation modification(PTMs)
  • 中文刊名:GWXK
  • 英文刊名:China Animal Husbandry & Veterinary Medicine
  • 机构:中国农业科学院北京畜牧兽医研究所;
  • 出版日期:2019-04-20
  • 出版单位:中国畜牧兽医
  • 年:2019
  • 期:v.46
  • 基金:国家自然基金联合基金重点支持项目“绵羊骨骼肌纤维形成的生物学特征与分子机制研究”(U1503285);; 中国农业科学院基本科研业务费重大项目储备计划“肉用绵羊基因组学育种技术优化与应用”(Y2017XM02)
  • 语种:中文;
  • 页:GWXK201904014
  • 页数:11
  • CN:04
  • ISSN:11-4843/S
  • 分类号:115-125
摘要
蛋白质组学是一门全方位研究生命结构功能、生理功能及生命活动规律的新兴学科,已成为后基因组时代研究的重要内容,在很多领域得到广泛关注,同时为畜牧科学的发展与创新提供了全新的研究思路和技术手段。目前,蛋白质组学在畜禽生长发育、繁殖、营养、疾病、肉质等方面均有涉及,并通过各种研究手段发掘出一批与畜禽重要经济性状相关的蛋白质,对生产有重要的理论指导意义。蛋白质翻译后修饰(post-translation modifications,PTMs)作为蛋白质组学研究的一个重要分支,在增加蛋白质多样性和进行复杂生理学调控过程中发挥着重要的作用,能更好地揭示生命现象的本质与规律。作者对蛋白质组学及PTMs在畜牧领域中的应用研究进展进行了综述。
        Proteomics is a new subject that studies the function of life structure,physiology and life activities rule comprehensively,it has become an important part of post-genomics research,which has been extensively concerned in many fields,it also provides brand new research ideas and technical means for the development and innovation of animal science.At present,proteomics is involved in animal growth,reproduction,nutrition,disease and meat quality in livestock and poultry,and a batch of proteins related to the important economic traits have been mined through various methods,which contributes important theoretical reference for production.Post-translation modifications(PTMs) is an important branch of proteomics research,which plays an important role in increasing protein diversity and studying complex physiological regulatory process.The author reviews the advances and applications of proteomics and PTMs in animal husbandry.
引文
[1] SWINBANKS D.Government backs proteome proposal[J].Nature,1995,378(6558):653.
    [2] WILKINS M R,SANCHEZ J C,GOOLEY A A,et al.Progress with proteome projects:Why all proteins expressed by a genome should be identified and how to do it[J].Biotechnology and Genetic Engineering Reviews,1996,13(1):19-50.
    [3] SIMPSON R J,DOROW D S.Cancer proteomics:From signaling networks to tumor markers[J].Trends in Biotechnology,2001,19(10):S40-S48.
    [4] WANG E T,SANDBERG R,LUO S,et al.Alternative isoform regulation in human tissue transcrip-tomes[J].Nature,2008,456(7221):470-476.
    [5] KESKIN O,TUNCBAG N,GURSOY A.Predicting protein-protein interactions from the molecular to the proteome level[J].Chemical Reviews,2016,116(8):4884.
    [6] 宋春侠,孙珍,秦洪强,等.修饰蛋白质组学分离鉴定新技术新方法[J].科学通报,2013,58(30):3007-3016. SONG C X,SUN Z,QIN H Q,et al.The new method and technology for the characterization and identification of post-translational modifications of proteins[J].Chinese Science Bulletin,2013,58(30):3007-3016.(in Chinese)
    [7] 何大澄,肖雪媛.差异蛋白质组学及其应用[J].北京师范大学学报(自然科学版),2002,38(4):558-562. HE D C,XIAO X Y.Differential proteomics and its applications[J].Journal of Beijing Normal University,2002,38(4):558-562.(in Chinese)
    [8] 王欣,唐婕.动物科学中的蛋白质组学技术应用[J].畜牧与饲料科学,2017,38(11):43-47. WANG X,TANG J.Application of proteomics technology in animal science researches[J].Animal Husbandry and Feed Science,2017,38(11):43-47.(in Chinese)
    [9] 米思远,徐忠金,师科荣.蛋白质组学及其在家畜研究中的应用[J].畜牧与兽医,2016,48(10):119-124. MI S Y,XU Z J,SHI K R. Proteomics and its application in the livestock researches[J].Animal Husbandry & Veterinary Medicine,2016,48(10):119-124.(in Chinese)
    [10] O’FARRELL P H.High resolution two-dimensional electrophoresis of proteins[J].Journal of Biological Chemistry,1975,250(10):4007.
    [11] 胡莉萍,沈岩.双向凝胶电泳技术、蛋白质组学与基础和临床医学[J].医学分子生物学杂志,2001,23(2):118-121. HU L P,SHEN Y.Two-dimensional electrophoresis technique,proteomics and clinical medicine[J].Journal of Medical Molecular Biology,2001,23(2):118-121.(in Chinese)
    [12] GYGI S P,CORTHALS G L,ZHANG Y,et al.Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(17):9390-9395.
    [13] UNLü M,MORGAN M E,MINDEN J S.Difference gel electrophoresis:A single gel method for detecting changes in protein extracts[J].Electrophoresis,1997,18(11):2071-2077.
    [14] YAMASHITA M,FENN J B.Electrospray ion source.Another variation on the free-jet theme[J].Journal of Physical Chemistry,1984,88(20):4451-4459.
    [15] BEAVIS R C,CHAIT B T.Matrix-assisted laser-desorption mass spectrometry using 355 nm radiation[J].Rapid Communications in Mass Spectrometry,1989,3(12):436.
    [16] 盛龙生,苏焕华,郭丹滨.色谱质谱联用技术[M].北京:化学工业出版社,2006. SHENG L S,SU H H,GUO D B.Chromatography-mass Spectrometry Technology[M].Beijing:Chemical Industry Press,2006.(in Chinese)
    [17] WEI W.Progress in fourier transform ion cyclotron resonance mass spectroscopy[J].Progress in Chemistry,2005,17(2):336-342.
    [18] ENS W,STANDING K G.Hybrid quadrupole/time-of-flight mass spectrometers for analysis of biomolecules[J].Methods Enzymol,2005,402:49-78.
    [19] 杨倩,王丹,常丽丽,等.生物质谱技术研究进展及其在蛋白质组学中的应用[J].中国农学通报,2015,31(1):239-246. YANG Q,WANG D,CHANG L L,et al.Progress in mass spectrometry and its application in proteomics[J].Chinese Agricultural Science Bulletin,2015,31(1):239-246.(in Chinese)
    [20] RD Y J,SPEICHER S,GRIFFIN P R,et al.Peptide mass maps:A highly informative approach to protein identification[J].Analytical Biochemistry,1993,214(2):397-408.
    [21] 王希,朱友林.现代质谱技术在蛋白质组学中的应用及其最新进展[J].生物技术通讯,2006,17(3):465-467. WANG X,ZHU Y L.Modern mass spectrometry’s application and advances in proteomics[J].Letters in Biotechnology,2006,17(3):465-467.(in Chinese)
    [22] 柳展基,杨小红,毕玉平.蛋白质组学在农业中的应用[J].分子植物育种,2006,4(z1):106-110. LIU Z J,YANG X H,BI Y P.Proteomics and its application in the agriculture[J].Molecular Plant Breeding,2006,4(z1):106-110.(in Chinese)
    [23] ZHANG W Z,KRUTCHINSKY A N,CHAIT B T.“De Novo” peptide sequeneing by MALDI-quadrupole-ion trap mass speetrometry:A preliminary study[J].Journal of the American Society for Mass Spectrometry,2003,14(9):1012-1021.
    [24] RD Y J.Mass spectral analysis in proteomics[J].Annual Review of Biophysics and Biomolecular Structure,2004,33(1):297.
    [25] HUANG H,LIN S,GARCIA B A,et al.Quantitative proteomic analysis of histone modifications[J].Chemical Reviews,2015,115(6):2376-2418.
    [26] BLACKSTOCK W P,WEIR M P.Proteomics:Quantitative and physical mapping of cellular proteins[J].Trends in Biotechnology,1999,17(3):121-127.
    [27] HOEDT E,ZHANG G,NEUBERT T A.Stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomics[J].Advances in Experimental Medicine & Biology,2014,806:93.
    [28] TEMME N M,STRIKWERDA J.Tandem mass tags:A novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS[J].Analytical Chemistry,2003,75(8):1895-1904.
    [29] WIESE S,REIDEGELD K A,MEYER H E,et al.Protein labeling by iTRAQ:A new tool for quantitative mass spectrometry in proteome research[J].Proteomics,2007,7(6):340-350.
    [30] FU C,HU J,LIU T,et al.Quantitative analysis of redox-sensitive proteome with DIGE and ICAT[J].Journal of Proteome Research,2008,7(9):3789-3802.
    [31] OLD W M,MEYER-ARENDT K,AVELINE-WOLF L,et al.Comparison of label-free methods for quantifying human proteins by shotgun proteomics[J].Molecular & Cellular Proteomics,2005,4(10):1487-1502.
    [32] HUNG C W,THOLEY A.Tandem mass tag protein labeling for top-down identification and quantification[J].Analytical Chemistry,2012,84(1):161-170.
    [33] ONG S E,BLAGOEV B,KRATCHMAROVA I,et al.Stable isotope labeling by amino acids in cell culture,SILAC,as a simple and accurate approach to expression proteomics[J].Molecular & Cellular Proteomics,2002,1(5):376-386.
    [34] WU W W,WANG G,BAEK S J,et al.Comparative study of three proteomic quantitative methods,DIGE,cICAT,and iTRAQ,using 2D gel- or LC-MALDI TOF/TOF[J].Journal of Proteome Research,2006,5(3):651-658.
    [35] 黄啸.生物信息学在蛋白质组学上的应用[J].安徽农业科学,2006,34(23):6142-6144. HUANG X.Application of bio-informatics in proteomics[J].Journal of Anhui Agricultural Sciences,2006,34(23):6142-6144.(in Chinese)
    [36] HAN J Z,WANG Y B.Proteomics:Present and future in food science and technology[J].Trends in Food Science & Technology,2008,19(1):26-30.
    [37] PICARD B,LEFAUCHEUR L,BERRI C,et al.Muscle fibre ontogenesis in farm animal species[J].Reproduction Nutrition Development,2002,42(5):415-431.
    [38] BENDIXEN E.The use of proteomics in meat science[J].Meat Science,2005,71(1):138-149.
    [39] DOHERTY M K,MCLEAN L,HAYTER J R,et al.The proteome of chicken skeletal muscle:Changes in soluble protein expression during growth in a layer strain[J].Proteomics,2004,4(7):2082-2093.
    [40] WANG Z,PENG S,LI Q,et al.iTRAQ-based proteomic analysis reveals key proteins affecting muscle growth and lipid deposition in pigs[J].Scientific Reports,2017,7:46717.
    [41] BOULEY J,MEUNIER B,CHAMBON C,et al.Proteomic analysis of bovine skeletal muscle hypertrophy[J].Proteomics,2010,5(2):490-500.
    [42] FERREIRA A M,GROSSMANN J,FORTES C,et al.The sheep (Ovis aries) muscle proteome:Decoding the mechanisms of tolerance to seasonal weight loss using label-free proteomics[J].Journal of Proteomics,2017,161:57-67.
    [43] MONIN G,LAMBOOY E,KLONT R.Influence of temperature variation on the metabolism of pig muscle in situ and after excision[J].Meat Science,1995,40(2):149-158.
    [44] 贾建磊,张勤文,张红见,等.青藏高原有机牦牛背最长肌肌肉的差异蛋白质组学[J].肉类研究,2016,30(6):15-18. JIA J L,ZHANG Q W,ZHANG H J,et al.Differential proteomics analysis of fresh and refrigerated longissimus dorsi muscles of organically raised yaks from the Qinghai-Tibetan plateau[J].Meat Research,2016,30(6):15-18.
    [45] PARK B Y,KIM N K,LEE C S,et al.Effect of fiber type on postmortem proteolysis in longissimus muscle of Landrace and Korean native Black pigs[J].Meat Science,2007,77(4):482-491.
    [46] MOLETTE C,REMIGNON H,BABILE R.Modification of glycolyzing enzymes lowers meat quality of turkey[J].Poultry Science,2005,84(1):119-127.
    [47] LAMETSCH R,KARLSSON A,ROSENVOLD K,et al.Postmortem proteome changes of porcine muscle related to tenderness[J].Journal of Agricultural & Food Chemistry,2003,51(24):6992-6997.
    [48] TAYLOR R G,GEESINK G H,THOMPSON V F,et al.Is Z-disk degradation responsible for postmortem tenderization?[J].Journal of Animal Science,1995,73(5):1351.
    [49] LI H,LINKE W A,OBERHAUSER A F,et al.Reverse engineering of the giant muscle protein titin[J].Nature,2002,418(6901):998-1002.
    [50] HOROWITS R,KEMPNER E S,BISHER M E,et al.A physiological role for titin and nebulin in skeletal muscle[J].Nature,1986,323(6084):160-164.
    [51] KOOHMARAIE M,SHACKELFORD S D,WHEELER T L,et al.A muscle hypertrophy condition in lamb (callipyge):Characterization of effects on muscle growth and meat quality traits[J].Journal of Animal Science,1995,73(12):3596-3607.
    [52] VAN LAACK R J M.The Role of Proteins in Water-holding Capacity of Meat[M].America:Quality Attributes of Muscle Foods,1999.
    [53] PENNY I F.Protein denaturation and water-holding capacity in pork muscle[J].International Journal of Food Science & Technology,1969,4(3):269-273.
    [54] LIN J,WU Y,HAN B,et al.iTRAQ-based proteomic profiling of granulosa cells from lamb and ewe after superstimulation[J].Theriogenology,2017,101:99-108.
    [55] MIAO X,LUO Q,ZHAO H,et al.Ovarian proteomic study reveals the possible molecular mechanism for hyperprolificacy of Small Tail Han sheep[J].Scientific Reports,2016,6:27606.
    [56] SUN L,MIPAM T D,ZHAO F,et al.Comparative testis proteome of cattleyak from different developmental stages[J].Animal,2016,11(1):101-111.
    [57] 薛夫光.利用iTRAQ蛋白质组学技术筛选与种公鸡繁殖力相关的候选蛋白[D].北京:中国农业科学院,2015. XUE F G.iTRAQ-based proteomic analyses for identification of candidate proteins underlying the fecundity of breeder cocks[D].Beijing:Chinese Academy of Agricultural Sciences,2015.(in Chinese)
    [58] 杨梅,徐鑫,张居明,等.蛋白质组学在人乳及牛乳蛋白研究中的应用现状[J].食品与发酵工业,2014,40(11):182-187. YANG M,XU X,ZHANG J M,et al.The advance of proteomics research applications in human milk and bovine milk[J].Food and Fermentation Industries,2014,40(11):182-187.(in Chinese)
    [59] MADAAN V.Review:Applications of mass spectrometry techniques in the investigation of milk proteome[J].European Journal of Mass Spectrometry,2011,17(4):305-320.
    [60] YANG Y,BU D,ZHAO X,et al.Proteomic analysis of cow,yak,buffalo,goat and camel milk whey proteins:Quantitative differential expression patterns[J].Journal of Proteome Research,2013,12(4):1660-1667.
    [61] YANG Y,NAN Z,ZHAO X,et al.Proteomic characterization and comparison of mammalian milk fat globule proteomes by iTRAQ analysis[J].Journal of Proteomics,2015,116:34-43.
    [62] 杨永新,王加启,卜登攀,等.不同体细胞数牛乳中乳蛋白的比较蛋白质组学研究[J].中国农业科学,2011,44(12):2545-2552. YANG Y X,WANG J Q,BU D P,et al.Comparative proteomic analysis of the changes of milk protein associated with somatic cell counts[J].Scientia Agricultura Sinica,2011,44(12):2545-2552.(in Chinese)
    [63] 邱宁,马美湖.鸡蛋蛋白质组学研究现状与展望[J].中国家禽,2011,33(2):4-10. QIU N,MA M H.Current status and prospects of egg proteomics research[J].China Poultry,2011,33(2):4-10.(in Chinese)
    [64] WANG J,WU J.Proteomic analysis of fertilized egg white during early incubation[J].Eupa Open Proteomics,2014,2:38-59.
    [65] QIU N,MA M,CAI Z,et al.Proteomic analysis of egg white proteins during the early phase of embryonic development[J].Journal of Proteomics,2012,75(6):1895-1905.
    [66] ALMEIDA A M,PLOWMAN J E,HARLAND D P,et al.Influence of feed restriction on the wool proteome:A combined iTRAQ and fiber structural study[J].Journal of Proteomics,2014,103(3):170-177.
    [67] 高丽霞,张燕军,张文广,等.内蒙古白绒山羊毛囊发育周期蛋白质表达谱分析[J].农业生物技术学报,2014,22(6):727-735. GAO L X,ZHANG Y J,ZHANG W G,et al.Analysis of protein expression profile of hair follicle cycle of Inner Mongolia cashmere goat(Capra cashmere)[J].Journal of Agricultural Biotechnology,2014,22(6):727-735.(in Chinese)
    [68] HUANG J,LUO G,ZHANG Z,et al.iTRAQ-proteomics and bioinformatics analyses of mammary tissue from cows with clinical mastitis due to natural infection with Staphylococci aureus[J].BMC Genomics,2014,15(1):839.
    [69] HOGARTH C J,FITZPATRICK J L,NOLAN A M,et al.Differential protein composition of bovine whey:A comparison of whey from healthy animals and from those with clinical mastitis[J].Proteomics,2004,4(7):2094-2100.
    [70] 谢宇舟,密克,李军,等.猪源大肠杆菌O157∶H7与O157的差异蛋白质组学分析[J].基因组学与应用生物学,2012,31(6):531-537. XIE Y Z,MI K,LI J,et al.Differential proteomic analysis between Escherichia coli isolates O157∶H7 and O157 from swine[J].Genomics and Applied Biology,2012,31(6):531-537.(in Chinese)
    [71] NAGARAJ S H,HARSHA H C,REVERTER A,et al.Proteomic analysis of the abomasal mucosal response following infection by the nematode,Haemonchus contortus,in genetically resistant and susceptible sheep[J].Journal of Proteomics,2012,75(7):2141-2152.
    [72] EDVARDSSON U,ALEXANDERSSON M,NYSTR?M A,et al.A proteome analysis of livers from obese (ob/ob) mice treated with the peroxisome proliferator WY14,643[J].Electrophoresis,1999,20(4-5):935-942.
    [73] DANIEL H.Genomics and proteomics:Importance for the future of nutrition research[J].British Journal of Nutrition,2002,87(S2):S305-S311.
    [74] 刘红南,李垚,张丽欣,等.蛋白质组学在动物营养中的应用[J].中国饲料,2009,8:29-30. LIU H N,LI Y,ZHANG L X,et al.Application of proteomics technology in animal nutrition[J].China Feed,2009,8:29-30.(in Chinese)
    [75] 孟庆石.利用蛋白质组和磷酸化组学技术研究肉鸡热应激调控机制[D].北京:中国农业科学院,2016. MENG Q S.The study of broilers regulation mechanism under heat stress using proteomics and phosphoproteomics[D].Beijing:Chinese Academy of Agricultural Sciences,2016.(in Chinese)
    [76] 辛向博.Myostatin基因对骨骼肌代谢机制影响的定量蛋白组学与磷酸化蛋白组学研究[D].天津:天津农学院,2018. XIN X B.Quantitative proteomics and phosphoproteomics study on the effect of myostatin gene on skeletal muscle metabolism[D].Tianjin:Tianjin Agricultural College,2018.(in Chinese)
    [77] 王思丹,李春保,温思颖,等.禁食处理和宰后时间对鸡肉蛋白磷酸化水平的影响[J].食品科学,2013,34(19):270-274. WANG S D,LI C B,WEN S Y,et al.Effect of fasting and postmortem time on protein phosphorylation of chicken muscle[J].Food Science,2013,34(19):270-274.(in Chinese)
    [78] 张爽,张楠,朱良齐,等.宰后早期猪肉、牛肉和鸡肉中能量代谢及蛋白质磷酸化[J].食品科学,2017,38(9):72-78. ZHANG S,ZHANG N,ZHU L Q,et al.Energy metabolism and protein phosphorylation of pork,beef and chicken during the early postmortem period[J].Food Science,2017,38(9):72-78.(in Chinese)
    [79] 李蒙.蛋白质磷酸化调控肉色稳定性的作用机制[D].北京:中国农业科学院,2017. LI M.Mechanism of meat color stability regulated by protein phosphorylation[D].Beijing:Chinese Academy of Agricultural Sciences,2017.(in Chinese)
    [80] 付杰丽,李玉华,甄林青,等.杜洛克猪精子体外4 ℃保存过程中活力参数及蛋白修饰变化[J].上海交通大学学报(农业科学版),2016,34(5):27-34. FU J L,LI Y H,ZHEN L Q,et al.Research on motility and protein modifications of Duroc sperm preserved at 4 ℃ in vitro[J].Journal of Shanghai Jiaotong University,2016,34(5):27-34 (in Chinese)
    [81] 胡启蒙.梅山猪和杜洛克猪精子活力和蛋白磷酸化比较研究[D].上海:上海交通大学,2014. HU Q M.The differences in sperm motility and protein phosphorylation between Meishan boar and Duroc boar[D].Shanghai:Shanghai Jiaotong University,2014.(in Chinese)
    [82] LUO J,MITRA A,TIAN F,et al.Histone methylation analysis and pathway predictions in chickens after MDV infection[J].PLoS One,2012,7(7):e41849.
    [83] 李珊珊,王加启,魏宏阳,等.乳蛋白磷酸化分析方法研究进展[J].东北农业大学学报,2010,41(1):149-152. LI S S,WANG J Q,WEI H Y,et al.Advances in research method of protein phosphorylation in milk[J].Journal of Northeast Agricultural University,2010,41(1):149-152.(in Chinese)
    [84] LIANG L,WANG H,SHI H,et al.A designed peptide targets two types of modifications of p53 with anti-cancer activity[J].Cell Chemical Biology,2018,25(6):761-774.
    [85] ZHAO C,WANG P,SI T,et al.MAP kinase cascades regulate the cold response by modulating ICE1 protein stability[J].Developmental Cell,2017,43(5):618-629.
    [86] KWON O K,KIM S J,LEE Y,et al.Global analysis of phosphoproteome dynamics in embryonic development of zebrafish (Danio rerio)[J].Proteomics,2016,16(1):136-149.
    [87] CARRICO C,MEYER J G,HE W,et al.The mitochondrial acylome emerges:Proteomics,regulation by sirtuins,and metabolic and disease implications[J].Cell Metabolism,2018,27(3):497-512.

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