丹皮酚衍生物及其药理活性研究进展
|
摘要
丹皮酚具有广泛的药理活性,主要具有保护心脑血管系统、促进微循环、抗菌、抗炎、抗肿瘤、抗氧化、抗变态反应、增强免疫力以及治疗糖尿病、骨质疏松症等作用。近年来,为了提高丹皮酚生物利用度,不仅改进其人工合成的方法,还对丹皮酚进行了大量的结构修饰及改造,包括羰基、酚羟基、羰基α-氢、甲氧基以及苯环,生成了羧酸酯类、磺酸酯类、磷酸酯类、醚类、NO供体类、糖苷化类、丹皮酚钠盐、Schiff碱类、噻唑类、肟类、羟烷基化类、α,β-不饱和酮类、胺甲基化类、α-氢卤代类、去甲基化类、苯环卤代类16种丹皮酚衍生物。结合国内外有关丹皮酚衍生物的文献,对丹皮酚衍生物及其药理活性方面进行综述,为此类化合物的进一步研究提供参考。
Paeonol has a wide range of pharmacological activities. It is mainly used to protect cardiovascular and cerebrovascular system, promote microcirculation, antibacterial and anti-inflammatory, antitumor, anti-oxidation, anti-allergic reaction, enhance immunity, and treat diabetic osteoporosis, etc. In recent years, it not only improves the method of artificially synthesizing paeonol, but also carries out a large number of structural modification and transformation of paeonol. Five major parts, carbonyl, phenolic hydroxyl,carbonyl α-H, methoxy, and benzene rings, have been mainly modified. About 16 kinds of paeonol derivatives were produced including carboxylic acid esters, sulfonates esters, phosphates esters, ethers, NO donors, glycosidation, paeonol sodium, Schiff bases,thiazoles, oximes, hydroxyalkylation, α,β-unsaturated ketones, aminomethylation, α-H halogenation, demethylation, and benzene ring halogenation. In this paper, the derivatives of paeonol and their pharmacological activities were reviewed in combination with the literatures on paeonol derivatives at home and abroad. This article may provide basis for further study of this type of compound.
Paeonol has a wide range of pharmacological activities. It is mainly used to protect cardiovascular and cerebrovascular system, promote microcirculation, antibacterial and anti-inflammatory, antitumor, anti-oxidation, anti-allergic reaction, enhance immunity, and treat diabetic osteoporosis, etc. In recent years, it not only improves the method of artificially synthesizing paeonol, but also carries out a large number of structural modification and transformation of paeonol. Five major parts, carbonyl, phenolic hydroxyl,carbonyl α-H, methoxy, and benzene rings, have been mainly modified. About 16 kinds of paeonol derivatives were produced including carboxylic acid esters, sulfonates esters, phosphates esters, ethers, NO donors, glycosidation, paeonol sodium, Schiff bases,thiazoles, oximes, hydroxyalkylation, α,β-unsaturated ketones, aminomethylation, α-H halogenation, demethylation, and benzene ring halogenation. In this paper, the derivatives of paeonol and their pharmacological activities were reviewed in combination with the literatures on paeonol derivatives at home and abroad. This article may provide basis for further study of this type of compound.
引文
[1]中国药典[S].一部.2010.
[2]高立民,满其倩.丹皮酚抗肿瘤作用及作用机制研究进展[J].药物评价研究,2016,39(2):296-299.
[3]张燕丽,孟凡佳,付起凤,等.牡丹皮中有效成分丹皮酚的抗癌作用研究进展[J].中医药信息,2016,33(1):117-119.
[4]Liao W Y,Tsai T H,Ho T Y,et al.Neuroprotective effect of paeonol mediates anti-inflammation via suppressing Toll-like receptor 2 and Toll-like receptor 4 signaling pathways in cerebral ischemia-reperfusion injured rats[J].Evidence-Based Compl Altern Med,2016,2016,doi:10.1155/2016/3704647.
[5]蒋丽丽,张彦龙,王春杰,等.牡丹皮中有效成分丹皮酚的药理活性研究进展[J].现代诊断与治疗,2016,27(22):4223-4224.
[6]张金艳,赵乐,李贻奎,等.丹皮酚心血管活性的研究进展[J].中药新药与临床药理,2016,27(1):148-150.
[7]李前宽.丹皮酚对动脉粥样硬化炎性损伤的保护作用[D].承德:承德医学院,2017.
[8]Zhu X L,Chen J J,Han F,et al.Novel antidepressant effects of paeonol alleviate neuronal injury with concomitant alterations in BDNF,Rac1 and RhoA levels in chronic unpredictable mild stress rats[J].Psychopharmacology,2018,235(2):1-15.
[9]Kim S H,Kim S A,Park M K,et al.Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha[J].Int Immunopharmacol,2004,4(2):279-287.
[10]Liu J,Feng L,Ma D,et al.Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat[J].JEthnopharmacol,2013,150(1):371-381.
[11]袁金伟,屈凌波,白云亮,等.丹皮酚结构改造研究进展[J].河南工业大学学报:自然科学版,2011,32(3):88-94.
[12]明东升,漆小梅,谢茵,等.提高丹皮酚提取液中丹皮酚含量的方法研究[J].山西医科大学学报,1994(3):291-293.
[13]林英光,姚煜东.牡丹皮超临界萃取及其萃取物的应用研究[J].日用化学工业,2002,4(5):33-36.
[14]杨海丽,曲德利,王建华.徐长卿化学成份的提取分离与含量测定[J].黑龙江医学,1996,9(3):139-140.
[15]汪显阳,朱贞石,胡瑞芳.正交设计法优选丹皮酚的合成工艺[J].中国药物化学杂志,1993,3(3):187-190.
[16]王学军,刘建利,王江凯.丹皮酚衍生物的合成及其抗肿瘤细胞增殖研究[J].药学学报,2012,47(1):72-76.
[17]陈广萍,曾凡菊.丹皮酚及其衍生物的研究概述[J].科技展望,2017,27(10):79-80.
[18]程杰,方志杰,姜宇华,等.丹皮酚的新法制备及其糖苷化衍生物的合成[J].化学研究与应用,2009,21(10):1469-1472.
[19]徐鸣夏,陈芬儿.新乙酰水杨酸酯衍生物:中国,CN1106790 A[P].1995-08-16.
[20]潘显道,费勤志,朱承根,等.5个丹皮酚酯的合成和体外抗肿瘤活性研究[J].安徽医药,2004,8(1):16-18.
[21]崔京浩,敖桂珍.一种新型非甾体抗炎药制备方法及其抗炎镇痛作用:中国,CN102079703A[P].2011-06-01.
[22]彭永练,胡丁旺,姜玉才,等.酯类双缩合化合物的合成及抗炎活性研究[J].中国医院药学杂志,2016,36(8):625-629.
[23]Sheng Z,Ge S,Xu X,et al.Correction:Design,synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors[J].Med Chem Commun,2018,9(5):853-861.
[24]Huang T J,Chuang H,Liang Y C,et al.Design,synthesis,and bioevaluation of paeonol derivatives as potential anti-HBV agents[J].Eur J Med Chem,2015,90(90C):428-435.
[25]Pao K C,Zhao J F,Lee T S,et al.Low-dose paeonol derivatives alleviate lipid accumulation[J].RSC Adv,2014,5(8):5652-5656.
[26]Ju Z,Li G,Wang J,et al.Highly regioselective synthesis of novel 4-O-phosphorylated paeonol analogs[J].Phosphorus Sulfur Silicon Related Elements,2012,187(7):859-863.
[27]Li X,Chen X,Yuan J,et al.Synthesis and characterization of phosphoramide piperazine analogs of paeonol[J].Phosphorus Sulfur Silicon Related Elements,2015,190(4):404-410.
[28]楚小晶,朱莹莹,敖桂珍.新型丹皮酚衍生物的合成[J].合成化学,2013,21(5):554-557.
[29]李如法,温旭辉,窦后松.以丹皮酚为母体合成的丙醇胺类醚化合物及其衍生物:中国,CN1513832A[P].2004-07-21.
[30]吴丽君,刘存芳.丹皮酚衍生物的合成及其生物活性研究进展[J].江苏调味副食品,2017,2(2):10-11.
[31]李芳耀,杨新平,林家逊.丹皮酚衍生物的合成及其生物活性研究[J].时珍国医国药,2012,23(3):641-642.
[32]Li W,Koike K,Asada Y,et al.Biotransformation of paeonol by Panax ginseng,root and cell cultures[J].JMol Catal B Enzym,2005,35(4):117-121.
[33]Han F,Zhuang T T,Chen J J,et al.Novel derivative of paeonol,paeononlsilatie sodium,alleviates behavioral damage and hippocampal dendritic injury in Alzheimer’s disease concurrent with cofilin1/phosphorylated-cofilin1and RAC1/CDC42 alterations in rats[J].PLo S One,2017,12(9):e0185102.
[34]高健,相海鹰,许同桃,等.丹皮酚及其席夫碱衍生物的抑菌性研究[J].化学试剂,2007,29(1):59-60.
[35]解方元,马勇,丁二雄,等.丹皮酚Schiff碱的合成及结构表征[J].渭南师范学院学报,2013,28(2):143-144.
[36]康建军,陈丽敏,林友文.丹皮酚双席夫碱的合成及其抗氧化活性研究[J].福建医科大学学报,2011,45(1):26-28.
[37]许同桃.丹皮酚衍生物抗氧化活性研究[J].天津化工,2012,26(4):20-22.
[38]吝敏,刘晓丹,操照伟.丹皮酚缩乙醇胺及其镍(II)配合物的合成与抑菌性研究[J].广东化工,2013,40(244):24-26.
[39]Tsai C H,Hsu M H,Huang P H,et al.A paeonol derivative,YPH-PA3 promotes the differentiation of monocyte/macrophage lineage precursor cells into osteoblasts and enhances their autophagy[J].Eur JPharmacol,2018,832(91):104-113.
[40]Tsai C Y,Kapoor M,Huang Y P,et al.Synthesis and evaluation of aminothiazole-paeonol derivatives as potential anticancer agents[J].Molecules,2016,21(2):145.
[41]Fu P K,Yang C Y,Huang S C,et al.Evaluation of LPS-induced acute lung injury attenuation in rats by aminothiazole-paeonol derivatives[J].Molecules,2017,doi:10.3390/molecules22101605.
[42]Lee H J,Kim S A,Lee H J,et al.Paeonol oxime inhibits bFGF-induced angiogenesis and reduces VEGF levels in fibrosarcoma cells[J].PLoS One,2010,5(8):e12358.
[43]刘存芳,王俊宏,邵先钊,等.碱催化Aldol缩合反应制备丹皮酚衍生物及其晶体结构[J].科学技术与工程,2017,17(30):155-160.
[44]刘存芳.丹皮酚衍生物-3-羟基-1-(2-羟基-4-甲氧基苯)-3-(2′-溴苯)-1-丙酮的合成及其抗菌活性[J].农药学学报,2016,18(1):119-123.
[45]赖普辉,田光辉,赵桦.一种丹皮酚衍生物的合成及其抗菌活性[J].武汉大学学报:理学版,2010,56(5):523-526.
[46]袁明,许勤龙,李家明,等.丹皮酚衍生物的研究进展[J].亚太传统医药,2012,8(9):194-199.
[47]Kaneko S,Cooper C B,Nishioka N,et al.Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei[J].Tetrahedron,2011,67(29):5346-5359.
[48]Juvale K,Pape V F,Wiese M.Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein[J].Bioorg Med Chem,2012,20(1):346-355.
[49]Kachadourian R,Day B J,Pugazhenti S,et al.A synthetic chalcone as a potent inducer of glutathione biosynthesis[J].J Med Chem,2012,55(3):1382-1388.
[50]袁金伟,屈凌波,白云亮,等.丹皮酚结构改造研究进展[J].河南工业大学学报:自然科学版,2011,32(3):88-94.
[51]王俊宏,刘存芳,邵先钊,等.碱催化合成4-甲基-2′-羟基-4′-甲氧基查尔酮及其晶体结构[J].天然产物研究与开发,2017,29(9):1573-1579.
[52]於秀芝,徐秀娟.2-羧基苯基烷基酮与芳香胺的Mannich反应[J].北京师范大学学报:自然科学版,1992,(2):211-214.
[53]Reddy M V,Su C R,Chiou W F,et al.Design,synthesis,and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents[J].Bioorg Med Chem,2008,16(15):7358-7370.
[54]Doifode K B,Marathey M G.Reactions of cupric bromide in dioxane.Formation ofι-bromo-O-hydroxyacetophenone[J].J Org Chem,2002,29(7):2025-2026.
[55]祁俊生,付川,王远亮.芍药酮的溴化反应[J].化学研究与应用,2003,15(4):577-578.
[56]董环文,李科,郑灿辉,等.3-胺基取代苯并吡喃酮类化合物的设计合成及抗肿瘤活性[J].化学学报,2009,67(8):819-824.
[57]Anh H T,Cuc N T,Tai B H,et al.Synthesis of chromonylthiazolidines and their cytotoxicity to human cancer cell lines[J].Molecules,2015,20(1):1151-60.
[58]Huang Y P,Shih H P,Liang Y C,et al.Advanced generation of paeonol-phenylsufonyl derivatives as potential anti-HBV agents[J].RSC Adv,2016,6(49):43556-43562.
[59]Zhang L,Qu L,Zhang B,et al.A convenient method for the synthesis of cyclophosphamide analogues[J].Phosphorus Sulfur Silicon Related Elements,2008,183(2/3):799-803.
[60]候丙波,郑丽玲,绪广林,等.去甲丹皮酚衍生物的合成及其抗炎活性[J].合成化学,2011,19(1):28-31.
[61]楚小晶,刘金宜,绪广林,等.酮洛芬衍生物的合成及其抗炎活性[J].抗感染药学,2013,10(2):95-97.
[62]许同桃,高健,许兴友,等.丹皮酚及其衍生物的研究进展[J].中国药业,2008,17(3):3-5.
[63]刘本臣.丹皮酚的研究进展[J].中草药,2007,38(11):附4-附6.
[2]高立民,满其倩.丹皮酚抗肿瘤作用及作用机制研究进展[J].药物评价研究,2016,39(2):296-299.
[3]张燕丽,孟凡佳,付起凤,等.牡丹皮中有效成分丹皮酚的抗癌作用研究进展[J].中医药信息,2016,33(1):117-119.
[4]Liao W Y,Tsai T H,Ho T Y,et al.Neuroprotective effect of paeonol mediates anti-inflammation via suppressing Toll-like receptor 2 and Toll-like receptor 4 signaling pathways in cerebral ischemia-reperfusion injured rats[J].Evidence-Based Compl Altern Med,2016,2016,doi:10.1155/2016/3704647.
[5]蒋丽丽,张彦龙,王春杰,等.牡丹皮中有效成分丹皮酚的药理活性研究进展[J].现代诊断与治疗,2016,27(22):4223-4224.
[6]张金艳,赵乐,李贻奎,等.丹皮酚心血管活性的研究进展[J].中药新药与临床药理,2016,27(1):148-150.
[7]李前宽.丹皮酚对动脉粥样硬化炎性损伤的保护作用[D].承德:承德医学院,2017.
[8]Zhu X L,Chen J J,Han F,et al.Novel antidepressant effects of paeonol alleviate neuronal injury with concomitant alterations in BDNF,Rac1 and RhoA levels in chronic unpredictable mild stress rats[J].Psychopharmacology,2018,235(2):1-15.
[9]Kim S H,Kim S A,Park M K,et al.Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha[J].Int Immunopharmacol,2004,4(2):279-287.
[10]Liu J,Feng L,Ma D,et al.Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat[J].JEthnopharmacol,2013,150(1):371-381.
[11]袁金伟,屈凌波,白云亮,等.丹皮酚结构改造研究进展[J].河南工业大学学报:自然科学版,2011,32(3):88-94.
[12]明东升,漆小梅,谢茵,等.提高丹皮酚提取液中丹皮酚含量的方法研究[J].山西医科大学学报,1994(3):291-293.
[13]林英光,姚煜东.牡丹皮超临界萃取及其萃取物的应用研究[J].日用化学工业,2002,4(5):33-36.
[14]杨海丽,曲德利,王建华.徐长卿化学成份的提取分离与含量测定[J].黑龙江医学,1996,9(3):139-140.
[15]汪显阳,朱贞石,胡瑞芳.正交设计法优选丹皮酚的合成工艺[J].中国药物化学杂志,1993,3(3):187-190.
[16]王学军,刘建利,王江凯.丹皮酚衍生物的合成及其抗肿瘤细胞增殖研究[J].药学学报,2012,47(1):72-76.
[17]陈广萍,曾凡菊.丹皮酚及其衍生物的研究概述[J].科技展望,2017,27(10):79-80.
[18]程杰,方志杰,姜宇华,等.丹皮酚的新法制备及其糖苷化衍生物的合成[J].化学研究与应用,2009,21(10):1469-1472.
[19]徐鸣夏,陈芬儿.新乙酰水杨酸酯衍生物:中国,CN1106790 A[P].1995-08-16.
[20]潘显道,费勤志,朱承根,等.5个丹皮酚酯的合成和体外抗肿瘤活性研究[J].安徽医药,2004,8(1):16-18.
[21]崔京浩,敖桂珍.一种新型非甾体抗炎药制备方法及其抗炎镇痛作用:中国,CN102079703A[P].2011-06-01.
[22]彭永练,胡丁旺,姜玉才,等.酯类双缩合化合物的合成及抗炎活性研究[J].中国医院药学杂志,2016,36(8):625-629.
[23]Sheng Z,Ge S,Xu X,et al.Correction:Design,synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors[J].Med Chem Commun,2018,9(5):853-861.
[24]Huang T J,Chuang H,Liang Y C,et al.Design,synthesis,and bioevaluation of paeonol derivatives as potential anti-HBV agents[J].Eur J Med Chem,2015,90(90C):428-435.
[25]Pao K C,Zhao J F,Lee T S,et al.Low-dose paeonol derivatives alleviate lipid accumulation[J].RSC Adv,2014,5(8):5652-5656.
[26]Ju Z,Li G,Wang J,et al.Highly regioselective synthesis of novel 4-O-phosphorylated paeonol analogs[J].Phosphorus Sulfur Silicon Related Elements,2012,187(7):859-863.
[27]Li X,Chen X,Yuan J,et al.Synthesis and characterization of phosphoramide piperazine analogs of paeonol[J].Phosphorus Sulfur Silicon Related Elements,2015,190(4):404-410.
[28]楚小晶,朱莹莹,敖桂珍.新型丹皮酚衍生物的合成[J].合成化学,2013,21(5):554-557.
[29]李如法,温旭辉,窦后松.以丹皮酚为母体合成的丙醇胺类醚化合物及其衍生物:中国,CN1513832A[P].2004-07-21.
[30]吴丽君,刘存芳.丹皮酚衍生物的合成及其生物活性研究进展[J].江苏调味副食品,2017,2(2):10-11.
[31]李芳耀,杨新平,林家逊.丹皮酚衍生物的合成及其生物活性研究[J].时珍国医国药,2012,23(3):641-642.
[32]Li W,Koike K,Asada Y,et al.Biotransformation of paeonol by Panax ginseng,root and cell cultures[J].JMol Catal B Enzym,2005,35(4):117-121.
[33]Han F,Zhuang T T,Chen J J,et al.Novel derivative of paeonol,paeononlsilatie sodium,alleviates behavioral damage and hippocampal dendritic injury in Alzheimer’s disease concurrent with cofilin1/phosphorylated-cofilin1and RAC1/CDC42 alterations in rats[J].PLo S One,2017,12(9):e0185102.
[34]高健,相海鹰,许同桃,等.丹皮酚及其席夫碱衍生物的抑菌性研究[J].化学试剂,2007,29(1):59-60.
[35]解方元,马勇,丁二雄,等.丹皮酚Schiff碱的合成及结构表征[J].渭南师范学院学报,2013,28(2):143-144.
[36]康建军,陈丽敏,林友文.丹皮酚双席夫碱的合成及其抗氧化活性研究[J].福建医科大学学报,2011,45(1):26-28.
[37]许同桃.丹皮酚衍生物抗氧化活性研究[J].天津化工,2012,26(4):20-22.
[38]吝敏,刘晓丹,操照伟.丹皮酚缩乙醇胺及其镍(II)配合物的合成与抑菌性研究[J].广东化工,2013,40(244):24-26.
[39]Tsai C H,Hsu M H,Huang P H,et al.A paeonol derivative,YPH-PA3 promotes the differentiation of monocyte/macrophage lineage precursor cells into osteoblasts and enhances their autophagy[J].Eur JPharmacol,2018,832(91):104-113.
[40]Tsai C Y,Kapoor M,Huang Y P,et al.Synthesis and evaluation of aminothiazole-paeonol derivatives as potential anticancer agents[J].Molecules,2016,21(2):145.
[41]Fu P K,Yang C Y,Huang S C,et al.Evaluation of LPS-induced acute lung injury attenuation in rats by aminothiazole-paeonol derivatives[J].Molecules,2017,doi:10.3390/molecules22101605.
[42]Lee H J,Kim S A,Lee H J,et al.Paeonol oxime inhibits bFGF-induced angiogenesis and reduces VEGF levels in fibrosarcoma cells[J].PLoS One,2010,5(8):e12358.
[43]刘存芳,王俊宏,邵先钊,等.碱催化Aldol缩合反应制备丹皮酚衍生物及其晶体结构[J].科学技术与工程,2017,17(30):155-160.
[44]刘存芳.丹皮酚衍生物-3-羟基-1-(2-羟基-4-甲氧基苯)-3-(2′-溴苯)-1-丙酮的合成及其抗菌活性[J].农药学学报,2016,18(1):119-123.
[45]赖普辉,田光辉,赵桦.一种丹皮酚衍生物的合成及其抗菌活性[J].武汉大学学报:理学版,2010,56(5):523-526.
[46]袁明,许勤龙,李家明,等.丹皮酚衍生物的研究进展[J].亚太传统医药,2012,8(9):194-199.
[47]Kaneko S,Cooper C B,Nishioka N,et al.Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei[J].Tetrahedron,2011,67(29):5346-5359.
[48]Juvale K,Pape V F,Wiese M.Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein[J].Bioorg Med Chem,2012,20(1):346-355.
[49]Kachadourian R,Day B J,Pugazhenti S,et al.A synthetic chalcone as a potent inducer of glutathione biosynthesis[J].J Med Chem,2012,55(3):1382-1388.
[50]袁金伟,屈凌波,白云亮,等.丹皮酚结构改造研究进展[J].河南工业大学学报:自然科学版,2011,32(3):88-94.
[51]王俊宏,刘存芳,邵先钊,等.碱催化合成4-甲基-2′-羟基-4′-甲氧基查尔酮及其晶体结构[J].天然产物研究与开发,2017,29(9):1573-1579.
[52]於秀芝,徐秀娟.2-羧基苯基烷基酮与芳香胺的Mannich反应[J].北京师范大学学报:自然科学版,1992,(2):211-214.
[53]Reddy M V,Su C R,Chiou W F,et al.Design,synthesis,and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents[J].Bioorg Med Chem,2008,16(15):7358-7370.
[54]Doifode K B,Marathey M G.Reactions of cupric bromide in dioxane.Formation ofι-bromo-O-hydroxyacetophenone[J].J Org Chem,2002,29(7):2025-2026.
[55]祁俊生,付川,王远亮.芍药酮的溴化反应[J].化学研究与应用,2003,15(4):577-578.
[56]董环文,李科,郑灿辉,等.3-胺基取代苯并吡喃酮类化合物的设计合成及抗肿瘤活性[J].化学学报,2009,67(8):819-824.
[57]Anh H T,Cuc N T,Tai B H,et al.Synthesis of chromonylthiazolidines and their cytotoxicity to human cancer cell lines[J].Molecules,2015,20(1):1151-60.
[58]Huang Y P,Shih H P,Liang Y C,et al.Advanced generation of paeonol-phenylsufonyl derivatives as potential anti-HBV agents[J].RSC Adv,2016,6(49):43556-43562.
[59]Zhang L,Qu L,Zhang B,et al.A convenient method for the synthesis of cyclophosphamide analogues[J].Phosphorus Sulfur Silicon Related Elements,2008,183(2/3):799-803.
[60]候丙波,郑丽玲,绪广林,等.去甲丹皮酚衍生物的合成及其抗炎活性[J].合成化学,2011,19(1):28-31.
[61]楚小晶,刘金宜,绪广林,等.酮洛芬衍生物的合成及其抗炎活性[J].抗感染药学,2013,10(2):95-97.
[62]许同桃,高健,许兴友,等.丹皮酚及其衍生物的研究进展[J].中国药业,2008,17(3):3-5.
[63]刘本臣.丹皮酚的研究进展[J].中草药,2007,38(11):附4-附6.