动物肝脏移植模型的应用研究进展
摘要
肝脏移植作为目前治疗终末期肝病最有效的方法,一直面临着供体短缺、术后并发症较多和生存率较低等方面的问题,这也导致相关人体研究受到诸多限制。动物肝脏移植模型在肝脏移植研究的发展过程中发挥了关键作用。大型实验动物如猪、犬、猴等在肝脏大体解剖上与人体类似,便于进行手术方法和移植物保存方面的研究并易于应用到临床;而小型实验动物如大鼠、小鼠等因其在移植技术和基因敲除方面的优越性,而更适于开展大规模的肝脏移植术后缺血再灌注损伤和移植物状态监测等方面的基础机制研究。
引文
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[19]Chen ZH,Wang C,Wei FX,et al. Adenovirus-mediated OX40Ig gene transfer induces long-term survival of orthotopic liver allograft in rats[J]. Transpl Immunol,2018,48:32-38.
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[24]Nakamura K,Kageyama S,Yue S,et al. Heme oxygenase-1 regulates sirtuin-1-autophagy pathway in liver transplantation:From mouse to human[J]. Am J Transplant,2018,18(5):1110-1121.
[25]Cheng Q,He SQ,Gao D,et al. Early application of auxiliary partial orthotopic liver transplantation in murine model of wilson disease[J]. Transplantation,2015,99(11):2317-2324.
[26]Kao TL,Chen YL,Kuan YP,et al. Estrogen-estrogen receptor alpha signaling facilitates bilirubin metabolism in regenerating liver through regulating cytochrome P450 2A6 expression[J]. Cell Transplant,2017,26(11):1822-1829.
[27]Al-Saeedi M,Steinebrunner N,Kudsi H,et al. Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure[J]. Cell Death Dis,2018,9(2):132.
[28]Lu D,Wang W,Liu J,et al. Peroxiredoxins in inflammatory liver diseases and ischemic/reperfusion injury in liver transplantation[J]. Food Chem Toxicol,2018,113:83-89.
[2]Ekser B,Markmann JF,Tector AJ. Current status of pig liver xenotransplantation[J]. Int J Surg,2015,23:240-246.
[3]Vogel T,Brockman JG,Pigott D,et al. Successful transplantation of porcine liver grafts following 48-hour normothermic preservation[J]. PLo S One,2017,12(11):e0188494.
[4]Zhang ZB,Gao W,Liu L,et al. Normothermic machine perfusion protects against liver ischemia-reperfusion injury during reducedsize liver transplantation in pigs[J]. Ann Transplant,2019,24:9-17.
[5]Echeverri J,Goldaracena N,Kaths JM,et al. Comparison of BQ123,epoprostenol,and verapamil as vasodilators during normothermic ex vivo liver machine perfusion[J]. Transplantation,2018,102(4):601-608.
[6]Maione F,Gilbo N,Lazzaro S,et al. Porcine isolated liver perfusion for the study of ischemia reperfusion injury:a systematic review[J]. Transplantation,2018,102(7):1039-1049.
[7]Kebschull L,Theilmann LFC,Mohr A,et al. EPOR2/betacR2-independendent effects of low-dose epoetin-alpha in porcine liver transplantation[J]. Biosci Rep,2017,37(6):1007.
[8]Zhou W,Lin L,Cheng Y,et al. Ursolic acid improves liver transplantation and inhibits apoptosis in miniature pigs using donation after cardiac death[J]. Cell Physiol Biochem,2017,43(1):331-338.
[9]Hessheimer AJ,Vendrell M,Munoz J,et al. Heparin but not tissue plasminogen activator improves outcomes in donation after circulatory death liver transplantation in a porcine model[J]. Liver Transpl,2018,24(5):665-676.
[10]Selten JW,Verhoeven CJ,Heedfeld V,et al. The release of microRNA-122 during liver preservation is associated with early allograft dysfunction and graft survival after transplantation[J]. Liver Transpl,2017,23(7):946-956.
[11]Li C,Zhao Q,Zhang W,et al. MicroRNA-146b-5p identified in porcine liver donation model is associated with early allograft dysfunction in human liver transplantation[J]. Med Sci Monit,2017,23:5876-5884.
[12]Zhao DF,Dong Q,Zhang T. Effects of static cold storage and hypothermic machine perfusion on oxidative stress factors,adhesion molecules,and zinc finger transcription factor proteins before and after liver transplantation[J]. Ann Transplant,2017,22:96-100.
[13]Ashour MT,Elsebae M,Ezzat H,et al. Partial portal vein arterialization maintains regeneration after critical major hepatectomy:experimental study[J]. J Egypt Soc Parasitol,2015,45(1):167-175.
[14]Kim H,Kim H,Lee SK,et al. Memory T cells are significantly increased in rejected liver allografts of rhesus monkeys[J]. Liver Transpl,2018,24(2):256-268.
[15]Kim H,Kim H,Lee JI,et al. Surgical techniques of allogeneic liver transplantation in a nonhuman primate model[J]. Transplant Proc,2017,49(5):1150-1152.
[16]Lee S,Charters AC,Chandler JG,et al. A technique for orthotopic liver transplantation in the rat[J]. Transplantation,1973,16(6):664-669.
[17]Rigo F,De Stefano N,Navarro-Tableros V,et al. Extracellular vesicles from human liver stem cells reduce injury in an ex vivo normothermic hypoxic rat liver perfusion model[J]. Transplantation,2018,102(5):e205-e210.
[18]Zeng C,Hu X,Wang Y,et al. A novel hypothermic machine perfusion system using a Life Port Kidney Transporter for the preservation of rat liver[J]. Exp Ther Med,2018,15(2):1410-1416.
[19]Chen ZH,Wang C,Wei FX,et al. Adenovirus-mediated OX40Ig gene transfer induces long-term survival of orthotopic liver allograft in rats[J]. Transpl Immunol,2018,48:32-38.
[20]Van Erp AC,Rebolledo RA. Organ-specific responses during brain death:increased aerobic metabolism in the liver and anaerobic metabolism with decreased perfusion in the kidneys[J]. Sci Rep,2018,8(1):4405.
[21]Liu Z,Zhang X,Xiao Q,et al. Pretreatment donors after circulatory death with simvastatin alleviates liver ischemia reperfusion injury through a KLF2-dependent mechanism in rat[J]. Oxid Med Cell Longev,2017,2017:3861914.
[22]Tang Y,Chu H,Cao G,et al. S-Adenosylmethionine attenuates bile duct early warm ischemia reperfusion injury after rat liver transplantation[J]. Mol Immunol,2018,95:83-90.
[23]Cheng MX,Huang P,He Q,et al. Liver x receptors activation attenuates ischemia reperfusion injury of liver graft in rats[J]. J Invest Surg,2017,29:1-6.
[24]Nakamura K,Kageyama S,Yue S,et al. Heme oxygenase-1 regulates sirtuin-1-autophagy pathway in liver transplantation:From mouse to human[J]. Am J Transplant,2018,18(5):1110-1121.
[25]Cheng Q,He SQ,Gao D,et al. Early application of auxiliary partial orthotopic liver transplantation in murine model of wilson disease[J]. Transplantation,2015,99(11):2317-2324.
[26]Kao TL,Chen YL,Kuan YP,et al. Estrogen-estrogen receptor alpha signaling facilitates bilirubin metabolism in regenerating liver through regulating cytochrome P450 2A6 expression[J]. Cell Transplant,2017,26(11):1822-1829.
[27]Al-Saeedi M,Steinebrunner N,Kudsi H,et al. Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure[J]. Cell Death Dis,2018,9(2):132.
[28]Lu D,Wang W,Liu J,et al. Peroxiredoxins in inflammatory liver diseases and ischemic/reperfusion injury in liver transplantation[J]. Food Chem Toxicol,2018,113:83-89.