养血柔肝法与补肾活血法治疗早期膝骨关节炎疗效对比分析
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摘要
目的:观察养血柔肝法治疗早期膝骨关节炎的疗效,探讨早期膝骨关节炎的主要病机。方法:将78例早期膝骨关节炎患者随机分为2组,治疗组采用养血柔肝法治疗,对照组采用补肾法治疗,观察两组治疗前后的WOMAC评分。结果:治疗后两组VAS疼痛评分和WOMAC评分均降低,且治疗组降低程度大于对照组。结论:在膝骨关节炎早期,痿症是其主要病机所在,从肝论治为有效的治疗方法。
Objective: To observe the curative effect of Yangxue Rougan method and Bushen Huoxue method on early knee osteoarthritis and to explore the main pathogenesis of early knee osteoarthritis. Methods: 78 patients with early knee osteoarthritis were randomly divided into 2 groups. The treatment group was treated with nourishing blood and softening the liver. The control group was treated with tonifying kidney. The WOMAC scores before and after treatment were observed in both groups. Results: After treatment, the VAS pain score and WOMAC score were lower in both groups, and the treatment group was lower than the control group. Conclusion: In the early stage of knee osteoarthritis,snoring is the main pathogenesis, and treatment from the liver is an effective treatment.
Objective: To observe the curative effect of Yangxue Rougan method and Bushen Huoxue method on early knee osteoarthritis and to explore the main pathogenesis of early knee osteoarthritis. Methods: 78 patients with early knee osteoarthritis were randomly divided into 2 groups. The treatment group was treated with nourishing blood and softening the liver. The control group was treated with tonifying kidney. The WOMAC scores before and after treatment were observed in both groups. Results: After treatment, the VAS pain score and WOMAC score were lower in both groups, and the treatment group was lower than the control group. Conclusion: In the early stage of knee osteoarthritis,snoring is the main pathogenesis, and treatment from the liver is an effective treatment.
引文
[1]石印玉,徐荣善,陈友红.养血软坚方治疗膝骨关节炎的临床报告[J].中国中医骨伤科,1994,2(4):33-36.
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[3]KellgrenJH,LawrenceJS.Radiologicalassessmentofosteoarthrosis[J].AnnRheumDis,1957,16(4):494-502.
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[5]陈蔚,郭燕梅,李晓英,等.西安大略和麦克马斯特大学骨关节炎指数的重测信度[J].中国康复理论与实践,2010(1):23-24.
[6]孙志涛,牛维.古人治疗“骨痹”用药规律研究[J].中华中医药杂志,2016(11):4779-4782.
[7]郝胜坤,纪斌,石继祥,等.补肾活血中药治疗膝骨关节炎的作用机制[J].中医正骨,2017(4):31-33.
[8]李念虎,夏雷,乙胜,等.补肾活血方对骨关节炎模型大鼠关节滑液IL-1β及关节软骨DDR2水平的影响[J].中国中医骨伤科杂志,2013(8):1-4.
[9]韦尼,薛智丰,陈自佳,等.补肾通络颗粒对膝骨关节炎大鼠血清细胞因子及关节软骨含水率的影响[J].风湿病与关节炎,2015(10):5-9.
[10]吕广武,黄月芳,王伟东,等.补肾袪瘀经验方对膝骨性关节炎大鼠模型的影响[J].浙江中医杂志,2016(6):420-421.
[11]梁杰,柳维林,韩平,等.补肾壮筋汤对兔膝骨关节炎软骨形态学和骨架蛋白ROCK、Cofilin、Phospho-Cofilin、LIMK1和Phospho-LIMK1的影响[J].中华中医药杂志,2015(10):3732-3735.
[12]吴刚,童培建.补肾活血汤含药血清干预体外培养大鼠骨髓间充质干细胞成软骨分化及补肾活血汤联合骨髓间充质干细胞治疗大鼠膝骨关节炎的实验研究[J].中医正骨,2018(1):6-11.
[13]李佳,朱爱松,谢晚晴,等.关于补肾中药防治骨关节炎分子机制的体外实验研究[J].中国骨质疏松杂志,2016(7):877-882.
[14]张冲,赵伟,赵建,等.中药补肾固筋方治疗膝骨关节炎的临床观察[J].中国骨质疏松杂志,2013(5):514-518.
[15]姚东文,王清玉,石树培,等.补肾活血汤对膝骨关节炎及关节液细胞因子影响的研究[J].中医药通报,2014(2):49-52.
[16]潘建科,洪坤豪,刘军,等.补肾活血中药治疗膝骨关节炎有效性和安全性的系统评价[J].中华中医药杂志,2016(12):5248-5256.
[17]李西海,陈后煌,叶蕻芝,等.补肾柔肝法治疗骨关节炎筋骨失养的作用探讨[J].风湿病与关节炎,2016(6):40-42.
[18]曹月龙,庞坚,詹红生,等.肌肉因素与骨关节炎的临床研究现状[J].中国骨伤,2008(6):476-479.
[19]SerraoPR,VasilceacFA,Gramani-Say,etal.Menwithearlydegreesofkneeosteoarthritispresentfunctionalandmorphologicalimpairmentsofthequadricepsfemorismuscle[J].AmJPhysMedRehabil,2015,94(1):70-81.
[20]都亚楠,鞠宝兆.筋痹与《黄帝内经》[J].实用中医内科杂志,2012(10):24-25.
[2]邱贵兴.骨关节炎诊治指南(2007年版)[J].中华关节外科杂志(电子版),2007,1(4):281-285.
[3]KellgrenJH,LawrenceJS.Radiologicalassessmentofosteoarthrosis[J].AnnRheumDis,1957,16(4):494-502.
[4]GobbiA,LadD,PetreraM,et.al.SymptomaticEarlyOsteoarthritisoftheKneeTreatedWithPulsedElectromagneticFields:Two-YearFollow-up[J].Cartilage,2014,5(2):78-85.
[5]陈蔚,郭燕梅,李晓英,等.西安大略和麦克马斯特大学骨关节炎指数的重测信度[J].中国康复理论与实践,2010(1):23-24.
[6]孙志涛,牛维.古人治疗“骨痹”用药规律研究[J].中华中医药杂志,2016(11):4779-4782.
[7]郝胜坤,纪斌,石继祥,等.补肾活血中药治疗膝骨关节炎的作用机制[J].中医正骨,2017(4):31-33.
[8]李念虎,夏雷,乙胜,等.补肾活血方对骨关节炎模型大鼠关节滑液IL-1β及关节软骨DDR2水平的影响[J].中国中医骨伤科杂志,2013(8):1-4.
[9]韦尼,薛智丰,陈自佳,等.补肾通络颗粒对膝骨关节炎大鼠血清细胞因子及关节软骨含水率的影响[J].风湿病与关节炎,2015(10):5-9.
[10]吕广武,黄月芳,王伟东,等.补肾袪瘀经验方对膝骨性关节炎大鼠模型的影响[J].浙江中医杂志,2016(6):420-421.
[11]梁杰,柳维林,韩平,等.补肾壮筋汤对兔膝骨关节炎软骨形态学和骨架蛋白ROCK、Cofilin、Phospho-Cofilin、LIMK1和Phospho-LIMK1的影响[J].中华中医药杂志,2015(10):3732-3735.
[12]吴刚,童培建.补肾活血汤含药血清干预体外培养大鼠骨髓间充质干细胞成软骨分化及补肾活血汤联合骨髓间充质干细胞治疗大鼠膝骨关节炎的实验研究[J].中医正骨,2018(1):6-11.
[13]李佳,朱爱松,谢晚晴,等.关于补肾中药防治骨关节炎分子机制的体外实验研究[J].中国骨质疏松杂志,2016(7):877-882.
[14]张冲,赵伟,赵建,等.中药补肾固筋方治疗膝骨关节炎的临床观察[J].中国骨质疏松杂志,2013(5):514-518.
[15]姚东文,王清玉,石树培,等.补肾活血汤对膝骨关节炎及关节液细胞因子影响的研究[J].中医药通报,2014(2):49-52.
[16]潘建科,洪坤豪,刘军,等.补肾活血中药治疗膝骨关节炎有效性和安全性的系统评价[J].中华中医药杂志,2016(12):5248-5256.
[17]李西海,陈后煌,叶蕻芝,等.补肾柔肝法治疗骨关节炎筋骨失养的作用探讨[J].风湿病与关节炎,2016(6):40-42.
[18]曹月龙,庞坚,詹红生,等.肌肉因素与骨关节炎的临床研究现状[J].中国骨伤,2008(6):476-479.
[19]SerraoPR,VasilceacFA,Gramani-Say,etal.Menwithearlydegreesofkneeosteoarthritispresentfunctionalandmorphologicalimpairmentsofthequadricepsfemorismuscle[J].AmJPhysMedRehabil,2015,94(1):70-81.
[20]都亚楠,鞠宝兆.筋痹与《黄帝内经》[J].实用中医内科杂志,2012(10):24-25.
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