糖尿病肾病患者1,25-二羟基维生素D3与骨钙素水平变化及其相关性分析
摘要
<正>糖尿病肾病(DN)是糖尿病(DM)慢性并发症之一,也是引起终末期肾病(ESRD)的主要原因~([1])。既往研究表明,糖尿病病程、脂代谢紊乱、氧化应激、糖基化终末产物、血管内皮功能紊乱等均可影响微血管并发症的发生发展。近年来的研究显示,维生素D、骨钙素可能参与其发生发展过程。本研究分析不同时期糖尿病肾病患者1,25-二羟基维生素D3及骨钙素水平变化及其相关性,探讨1,25-二羟基维生素D3及骨钙素在糖尿病肾病发生发展中的作用。1资料与方法1.1临床资料:收集2017年1月至11月在祁县人民医院收治的2型糖尿病患者120例作为研究对象,男性67例,女性
引文
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[9] Xu L,Zhang P,Guan H,et al. Vitamin D and its receptor regulatelipopoly-saccharide-induced transforming growth factor-beta,angiotensinogen expressionand podocytes apoptosis through the nuclear factor-kappaB pathway[J]. J Diabetes Investigation,2016,7(5):680-688.
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[11] Wang YB,He DW,Ni CP,et al. Vitamin D induces autophagy ofpancreaticβ-cells and enhances insulin secretion[J]. Mol MedRep,2016,14(3):2644-2650.
[12] Gulseth HL,Wium C,Angel K,et al. Effects of vitamin D supplementation on insulin sensitivity and insulin secretion in subjectswith type 2 diabetes and vitamin D deficiency:a randomized controlled trial[J]. Diabetes Care,2017,40(7):872-878.
[2] Mizokami A,Kawakubo-Yasukochi T,Hirata M. Osteocalcin and its endocrine functions[J]. Biochemical Pharmacology,2017,132:1-8.
[3] Al-Daghri NM,Al-Attas OS,Alkharfy KM,et al. Association of VDR-gene variants with factors related to the metabolic syndrome, type 2diabetes and vitaminD difeciency[J]. Gene,2014,542:129-133.
[4] Vrieling A,Seibold P,Johnson TS,et al. Circulating 25-hydroxyvitamin D and postmenopausal breast cancer survival:Influence of tmor characteristics and lifestyle factors?[J]. Int J Cancer,2014,134:2972-2983.
[5] Prietl B,Treiber G,Mader JK,et al. High-dose cholecalciferolsupplementation significantly in creases peripheral CD4(+)Tregsin heslthy adults without negatively affecting the frequency of other immune cells[J]. EurJ Nutr,2014,53:751-759.
[6] Oshiro Y,Tanaka H,Kawasaki F,et al. Partial remission by cyclosporine monotherapy in a patient with membranous nephropathy superimposed diabetic nephropathy[J]. CEN Case Rep,2016,5(2):219-222.
[7] Blumenthal SS. Evolution of treatment for diabetic nephropathy:historical progression from RAAS inhibition and onward[J].Postgrad Med,2011,123(6):166-179.
[8] Deng X,Cheng J,Shen M. Vitamin D improves diabetic nephropathy in rats by inhibiting renin and relieving oxidative stress[J]. J Endocrinological Investigation,2016,39(6):657-658.
[9] Xu L,Zhang P,Guan H,et al. Vitamin D and its receptor regulatelipopoly-saccharide-induced transforming growth factor-beta,angiotensinogen expressionand podocytes apoptosis through the nuclear factor-kappaB pathway[J]. J Diabetes Investigation,2016,7(5):680-688.
[10] Seyyed A,Bootorabi M,Ayremlou P,et al. The effect of vitaminD supplementation on insulin resistance,visceral fat and adiponectin in vitamin D deficient women with polycystic ovary syndrome:arandomized placebo-controlled trial[J]. Gynecol Endocrinol,2018,34(6):489-494.
[11] Wang YB,He DW,Ni CP,et al. Vitamin D induces autophagy ofpancreaticβ-cells and enhances insulin secretion[J]. Mol MedRep,2016,14(3):2644-2650.
[12] Gulseth HL,Wium C,Angel K,et al. Effects of vitamin D supplementation on insulin sensitivity and insulin secretion in subjectswith type 2 diabetes and vitamin D deficiency:a randomized controlled trial[J]. Diabetes Care,2017,40(7):872-878.