聚氨酯/檀香精油微胶囊的形态调控与缓释效果优化
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摘要
以磷酸三钙(TCP)为分散剂,甲苯-2,4-二异氰酸酯(TDI)和聚乙二醇(PEG)为油相和水相反应单体,通过基于高速剪切分散的界面聚合制备包裹檀香精油在聚氨酯壁材内的微米级微胶囊。发现通过调节分散剂TCP质量分数、悬浮化剪切强度、芯材/壁材比等因素,可制得拥有不同粒径和囊壁厚度的精油微胶囊。对不同粒径和囊壁厚度的精油微胶囊进行热重分析,缓释速率测试结果显示,当微胶囊粒径为30μm、壁厚适中时,胶囊的缓释效果最佳。
By using tricalcium phosphate( TCP) as the dispersant,toluene-2,4-diisocyanate( TDI) and polyethylene glycol( PEG) as oil phase monomer and aqueous phase monomer respectively,micron-level microcapsules containing sandalwood oil in the polyurethane wall were prepared by interfacial polymerization based on high-speed shearing dispersion. Microcapsules with different diameter and wall thickness can by adjusting mass fraction of TCP,and suspending shear strength and the wall material / core ratio. Thermogravimetric analysis was conducted for microcapsules with different diameter and wall thickness. Slow release rate test result shows when the particle size is30μm and wall thickness is moderate,the slow-release effect of microcapsules is optimal.
By using tricalcium phosphate( TCP) as the dispersant,toluene-2,4-diisocyanate( TDI) and polyethylene glycol( PEG) as oil phase monomer and aqueous phase monomer respectively,micron-level microcapsules containing sandalwood oil in the polyurethane wall were prepared by interfacial polymerization based on high-speed shearing dispersion. Microcapsules with different diameter and wall thickness can by adjusting mass fraction of TCP,and suspending shear strength and the wall material / core ratio. Thermogravimetric analysis was conducted for microcapsules with different diameter and wall thickness. Slow release rate test result shows when the particle size is30μm and wall thickness is moderate,the slow-release effect of microcapsules is optimal.
引文
[1]WORWOOD V A.The fragrant mind:aromatherapy for personality,mind,mood and emotion[M].Novato:New World Library,2012:8-13.
[2]于丹凤,裴广玲.橄榄油微胶囊整理棉织物的性能[J].纺织学报,2012,33(10):98-102.YU Danfeng,PEI Guangling.Properties of cotton fabrics finished by olive oil microcapsules[J].Journal of Textile Research,2012,33(10):98-102.
[3]ROSENBAUER E M,LANDFESTER K,MUSYANOVYCH A.Surface-active monomer as a stabilizer for polyurea nanocapsules synthesized via interfacial polyadditionin inverse miniemulsion[J].Langmuir,2009,25(20):12084-12091.
[4]KEEN P H R,SLATER N K H,ROUTH A F.Encapsulation of amylase in colloidosomes[J].Langmuir,2014,30(8):1939-1948.
[5]ELZOGHBY A O,SAMY W M,ELGINDY N A.Albuminbased nanoparticles as potential controlled release drug delivery systems[J].Journal of Controlled Release,2012,157(2):168-182.
[6]BOUCHEMAL K,BRIANCON S,PERRIER E,et al.Synthesis and characterization of polyurethane and poly(ether-urethane)nanocapsules using a new technique of interfacial polycondensation combined to spontaneous emulsification[J].International Journal of Pharmaceutics,2004,269(1):89-100.
[7]SUBASINGHE U,GAMAGE M,HETTIARACHCHI D S.Essential oil content and composition of Indian sandalwood in Sri Lanka[J].Journal of Forestry Research,2013,24(1):127-130.
[8]REIS C P,NEUFELD R J,RIBEIRO A J,et al.Methods for preparation of drug-loaded polymeric nanoparticles[J].Nanomedicine:Nanotechnology,Biology and Medicine,2006,2(1):8-21.
[9]徐畅,陈智杰,金黔宏,等.界面聚合法制备聚氨酯/檀香精油微胶囊[J].丝绸,2013,50(11):6-10.XU Chang,CHEN Zhijie,JIN Qianhong,et al.Preparation of polyurethane/sandalwood microcapsules by interfacial polymerization[J].Journal of Silk,2013,50(11):6-10.
[10]戚栋明,陈智杰,赵晓丽.微悬浮法制备有机颜料微胶囊中的粒径调控[J].化工学报,2013,64(3):1118-1123.QI Dongming,CHEN Zhijie,ZHAO Xiaoli.Particle sizecontrol of organic pigmentmicrocapsules prepared via micro-suspension polymerization[J],Journal of Chemical Industry and Engineering(China),2013,64(3):1118-1123.
[11]VIVALDO-LIMA E,Wood P E,HAMIELEC A E,et al.An updated review on suspension polymerization[J].Industrial&Engineering Chemistry Research,1997,36(4):939-965.
[12]JAIN A,THAKUR D,GHOSHAL G,et al.Microencapsulation by complex coacervation using whey protein isolates and gum acacia:an approach to preserve the functionality and controlled release ofβ-carotene[J].Food and Bioprocess Technology,2015,8(8):1635-1644.
[13]ZHAO C Y,ZHANG G H.Review on microencapsulated phase change materials(MEPCMs):fabrication,characterization and applications[J].Renewable and Sustainable Energy Reviews,2011,15(8):3813-3832.
[14]陈岩,封萍.香精微胶囊的质量评价指标[J].上海应用技术学院学报:自然科学版,2012,12(1):18-21.CHEN Yan,FENG Ping.Evaluation indicators of fragrance microencapsules[J].Journal of Shanghai Institute of Technology:Natural Science,2012,12(1):18-21.
[2]于丹凤,裴广玲.橄榄油微胶囊整理棉织物的性能[J].纺织学报,2012,33(10):98-102.YU Danfeng,PEI Guangling.Properties of cotton fabrics finished by olive oil microcapsules[J].Journal of Textile Research,2012,33(10):98-102.
[3]ROSENBAUER E M,LANDFESTER K,MUSYANOVYCH A.Surface-active monomer as a stabilizer for polyurea nanocapsules synthesized via interfacial polyadditionin inverse miniemulsion[J].Langmuir,2009,25(20):12084-12091.
[4]KEEN P H R,SLATER N K H,ROUTH A F.Encapsulation of amylase in colloidosomes[J].Langmuir,2014,30(8):1939-1948.
[5]ELZOGHBY A O,SAMY W M,ELGINDY N A.Albuminbased nanoparticles as potential controlled release drug delivery systems[J].Journal of Controlled Release,2012,157(2):168-182.
[6]BOUCHEMAL K,BRIANCON S,PERRIER E,et al.Synthesis and characterization of polyurethane and poly(ether-urethane)nanocapsules using a new technique of interfacial polycondensation combined to spontaneous emulsification[J].International Journal of Pharmaceutics,2004,269(1):89-100.
[7]SUBASINGHE U,GAMAGE M,HETTIARACHCHI D S.Essential oil content and composition of Indian sandalwood in Sri Lanka[J].Journal of Forestry Research,2013,24(1):127-130.
[8]REIS C P,NEUFELD R J,RIBEIRO A J,et al.Methods for preparation of drug-loaded polymeric nanoparticles[J].Nanomedicine:Nanotechnology,Biology and Medicine,2006,2(1):8-21.
[9]徐畅,陈智杰,金黔宏,等.界面聚合法制备聚氨酯/檀香精油微胶囊[J].丝绸,2013,50(11):6-10.XU Chang,CHEN Zhijie,JIN Qianhong,et al.Preparation of polyurethane/sandalwood microcapsules by interfacial polymerization[J].Journal of Silk,2013,50(11):6-10.
[10]戚栋明,陈智杰,赵晓丽.微悬浮法制备有机颜料微胶囊中的粒径调控[J].化工学报,2013,64(3):1118-1123.QI Dongming,CHEN Zhijie,ZHAO Xiaoli.Particle sizecontrol of organic pigmentmicrocapsules prepared via micro-suspension polymerization[J],Journal of Chemical Industry and Engineering(China),2013,64(3):1118-1123.
[11]VIVALDO-LIMA E,Wood P E,HAMIELEC A E,et al.An updated review on suspension polymerization[J].Industrial&Engineering Chemistry Research,1997,36(4):939-965.
[12]JAIN A,THAKUR D,GHOSHAL G,et al.Microencapsulation by complex coacervation using whey protein isolates and gum acacia:an approach to preserve the functionality and controlled release ofβ-carotene[J].Food and Bioprocess Technology,2015,8(8):1635-1644.
[13]ZHAO C Y,ZHANG G H.Review on microencapsulated phase change materials(MEPCMs):fabrication,characterization and applications[J].Renewable and Sustainable Energy Reviews,2011,15(8):3813-3832.
[14]陈岩,封萍.香精微胶囊的质量评价指标[J].上海应用技术学院学报:自然科学版,2012,12(1):18-21.CHEN Yan,FENG Ping.Evaluation indicators of fragrance microencapsules[J].Journal of Shanghai Institute of Technology:Natural Science,2012,12(1):18-21.