益气消瘤方干预食管癌患者化疗中免疫功能的临床观察
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摘要
目的:观察益气消瘤方对食管癌患者化疗中免疫功能的影响。方法:将符合标准的72例食管癌患者随机分为对照组和治疗组,每组各36例,对照组给予常规化疗方案,观察组在化疗基础上口服益气消瘤方,观察2组治疗前后免疫功能指标变化情况。结果:治疗后观察组CD4~+、CD4~+/CD8~+均明显升高(P<0.05),CD8~+明显降低(P<0.05),且明显优于对照组(P均<0.05)。观察组不良反应发生率明显低于对照组(P<0.05)。结论:益气消瘤方配合化疗治疗食管癌,可明显提高临床治疗有效率,改善患者的免疫功能,提高患者生存质量。
Objective: To observe the effect of Yiqi Xiaoliu decoction on immune function of chemotherapy in patients with esophageal cancer; Methods: 72 cases of esophageal cancer patients were randomly divided into control group and treatment group with 36 cases in each group,the control group was given conventional chemotherapy,the observation group received chemotherapy oral Yiqi Xiaoliu decoction,observe the changes of immune function indexes of the 2 groups before and after results after treatment treatment; Result the observation group CD4+,CD4+/CD8+ were significantly increased(P<0.05),CD8+ decreased significantly(P<0.05),and significantly better than the cotrol group(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclusion: Yiqi Xiaoma recipe combined with chemotherapy in the treatment of esophageal cancer can obviously improve the efficiency of clinical treatment,improve the immune function of the patients and improve the quality of life of the patients.
Objective: To observe the effect of Yiqi Xiaoliu decoction on immune function of chemotherapy in patients with esophageal cancer; Methods: 72 cases of esophageal cancer patients were randomly divided into control group and treatment group with 36 cases in each group,the control group was given conventional chemotherapy,the observation group received chemotherapy oral Yiqi Xiaoliu decoction,observe the changes of immune function indexes of the 2 groups before and after results after treatment treatment; Result the observation group CD4+,CD4+/CD8+ were significantly increased(P<0.05),CD8+ decreased significantly(P<0.05),and significantly better than the cotrol group(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclusion: Yiqi Xiaoma recipe combined with chemotherapy in the treatment of esophageal cancer can obviously improve the efficiency of clinical treatment,improve the immune function of the patients and improve the quality of life of the patients.
引文
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[7]王延春.扶正平消汤联合化疗对恶性肿瘤病人免疫功能影响的研究[D].济南:山东中医药大学,2002.
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[10]侯天将,尚静,由凤鸣,等.化疗所致骨髓抑制的中医病机要素及临床治疗分析[J].云南中医中药杂志,2016,37(9):31-33.
[2]中国抗癌协会食管癌专业委员会.食管癌规范化诊疗指南[S].北京:中国协和医科大学出版社,2011:8-30.
[3]郑筱英.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:13-15.
[4]赵翌,刘基巍,WangXS,等.肿瘤常见症状及中医症状调查表的设计[J].中华肿瘤防治杂志,2008,15(11):861
[5]裘法祖,武忠弼,吴在德,等.肿瘤免疫学[M].湖北:湖北科学技术出版社,1998:32-36.
[6]王书奎,周振英,吴晓柳,等.恶性肿瘤转移与患者免疫活性细胞水平的相关性研究[J].中国免疫学杂志,2003,19(1l):786-788.
[7]王延春.扶正平消汤联合化疗对恶性肿瘤病人免疫功能影响的研究[D].济南:山东中医药大学,2002.
[8]柳长华.巢元方·诸病源候论(宋刻本)[M].北京:北京科学技术出版社,2016:261.
[9]殷东风.药汤剂对恶性肿瘤患者细胞免疫功能的影响[J].实用内科杂志,2011,25(8):25-27.
[10]侯天将,尚静,由凤鸣,等.化疗所致骨髓抑制的中医病机要素及临床治疗分析[J].云南中医中药杂志,2016,37(9):31-33.