骨桥蛋白与草酸钙结石形成的关系研究进展
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摘要
<正>泌尿系结石发病率在人群中居高不下,欧美地区调查研究显示, 5%～10%的人一生中至少发生1次泌尿系结石[1]。我国泌尿系结石平均发病率达到6.5%,南方地区更高,达到11.6%[2]。近年来,国内泌尿系结石的发病率呈上升趋势,并且经治疗后5年内复发率在50.0%以上[3]。尿路结石以草酸钙结石及其混合成分为主要类型。骨桥蛋白(Osteopontin,OPN)在体外能抑制草酸钙晶体的成核、生长和聚集,但在体内能促进草酸钙结石形成。现从OP
引文
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[7] Clemente N,Raineri D,Cappellano G,et al.Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases[J].J Immunol Res,2016,2016:7675437.
[8] Sivakumar S,Niranjali Devaraj S.Tertiary structure prediction and identification of druggable pocket in the cancer biomarker-Osteopontin-c[J].J Diabetes Metab Disord,2014,13(1):13.
[9] 常连胜.骨桥蛋白与肾结石[J].国外医学.泌尿系统分册,2002,22(3):192-194.
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[11] Bouleftour W,Bouet G,Granito RN,et al.Blocking the expression of both bone sialoprotein (BSP) and osteopontin (OPN) impairs the anabolic action of PTH in mouse calvaria bone[J].J Cell Physiol,2015,230(3):568-577.
[12] 彭秀梅.孕酮和雌二醇对牦牛输卵管糖蛋白及骨桥蛋白表达的影响[D].兰州:甘肃农业大学,2017.
[13] 鞠华龙,蔡岫颖.生长激素对大鼠正畸牙齿移动过程中骨桥蛋白表达的影响[J].中南大学学报(医学版),2017,42(9):1037-1041.
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[20] 关晓峰,邓耀良,孙丙华,等.高草酸尿症大鼠肾骨桥蛋白的表达与尿液草酸排泄的关系[J].中华实验外科杂志,2009,26(6):807.
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[23] Chien YC,Mansouri A,Jiang W,et al.Modulation of calcium oxalate dihydrate growth by phosphorylated osteopontin peptides[J].J Struct Biol,2018,204(2):131-144.
[24] Langdon A,Grohe B.The osteopontin-controlled switching of calcium oxalate monohydrate morphologies in artificial urine provides insights into the formation of papillary kidney stones[J].Colloids Surf B Biointerfaces,2016,146:296-306.
[25] Mo L,Liaw L,Evan AP,et al.Renal calcinosis and stone formation in mice lacking osteopontin,Tamm-Horsfall protein,or both[J].Am J Physiol Renal Physiol,2007,293(6):F1935-1943.
[26] 欧善际.草酸钙晶体对大鼠肾小管上皮细胞骨桥蛋白表达的影响[D].长春:吉林大学,2011.
[27] Hirose M,Tozawa K,Okada A,et al.Role of osteopontin in early phase of renal crystal formation:immunohistochemical and microstructural comparisons with osteopontin knock-out mice[J].Urol Res,2012,40(2):121-129.
[28] 吴敬彰,赵津津,张占五,等.TRPV5和OPN在泌尿系结石患者肾组织中的表达及意义[J].广东医学,2016,37(20):3101-3104.
[29] 赵明,易虎.骨桥蛋白对大鼠发生草酸钙肾脏结石的影响[J].中国老年学杂志,2018,38(4):926-927.
[30] 邓茂放,陈彤,王会镇,等.乌梅提取物对肾结石模型大鼠肾功能的保护作用及机制研究[J].中国临床药理学杂志,2018,34(15):1872-1874,1885.
[31] 闫晓煜,黄志红,肖创清.泌尿系统结石相关标志物的研究进展[J].国际检验医学杂志,2018,39(7):871-873,896.
[32] Min W,Shiraga H,Chalko C,et al.Quantitative studies of human urinary excretion of uropontin[J].Kidney Int.1998,53(1):189-193.
[33] Asplin JR,Arsenault D,Parks JH,et al.Contribution of human uropontin to inhibition of calcium oxalate crystallization[J].Kidney Int,1998,53(1):194-199.
[34] Yasui T,Fujita K,Hayashi Y,et al.Quantification of osteopontin in the urine of healthy and stone-forming men[J].Urol Res,1999,27(4):225-230.
[35] Thurgood LA,S?rensen ES,Ryall RL.The effect of intracrystalline and surface-bound osteopontin on the attachment of calcium oxalate dihydrate crystals to Madin-Darby canine kidney (MDCK) cells in ultrafiltered human urine[J].BJU Int,2012,109(7):1100-1109.
[36] 王炎,林峰,翁雪云,等.加味健脾益肾方对草酸钙肾结石患者术后尿骨桥蛋白的影响[J].中国中医药信息杂志,2015,27(7):36-39.
[37] Konya E,Umekawa T,Iguchi M,et al.The role of osteopontin on calcium oxalate crystal formation[J].Eur Urol,2003,43(5):564-571.
[2] Yang Y,Deng Y,Wang Y.Major geogenic factors controlling geographical clustering of urolithiasis in China[J].Sci Total Environ,2016,571:1164-1171.
[3] Zeng G,Mai Z,Xia S,et al.Prevalence of kidney stones in China:an ultrasonography based cross-sectional study[J].BJU Int,2017,120(1):109-116.
[4] Chen Q,Shou P,Zhang L,et al.An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells[J].Stem Cells,2014,32(2):327-337.
[5] 吴寒,李镇利,邢昊,等.骨桥蛋白在肝细胞癌诊治中的作用[J].临床肝胆病杂志,2018,34(9):1999-2003.
[6] Caballero D,Li Y,Ponsetto J,et al.Impaired urinary osteopontin excretion in Npt2a-/- mice[J].Am J Physiol Renal Physiol,2017,312(1):F77-F83.
[7] Clemente N,Raineri D,Cappellano G,et al.Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases[J].J Immunol Res,2016,2016:7675437.
[8] Sivakumar S,Niranjali Devaraj S.Tertiary structure prediction and identification of druggable pocket in the cancer biomarker-Osteopontin-c[J].J Diabetes Metab Disord,2014,13(1):13.
[9] 常连胜.骨桥蛋白与肾结石[J].国外医学.泌尿系统分册,2002,22(3):192-194.
[10] Yan Y,Jiang F,Lai Y,et al.Effect of Thyrotropin on Osteopontin,Integrin αvβ3,and VCAM-1 in the Endothelium via Activation of Akt[J].Int J Mol Sci,2016,17(9):1484.
[11] Bouleftour W,Bouet G,Granito RN,et al.Blocking the expression of both bone sialoprotein (BSP) and osteopontin (OPN) impairs the anabolic action of PTH in mouse calvaria bone[J].J Cell Physiol,2015,230(3):568-577.
[12] 彭秀梅.孕酮和雌二醇对牦牛输卵管糖蛋白及骨桥蛋白表达的影响[D].兰州:甘肃农业大学,2017.
[13] 鞠华龙,蔡岫颖.生长激素对大鼠正畸牙齿移动过程中骨桥蛋白表达的影响[J].中南大学学报(医学版),2017,42(9):1037-1041.
[14] Ashkar S,Weber GF,Panoutsakopoulou V,et al.Eta-1 (osteopontin):an early component of type-1 (cell-mediated) immunity,Science[J].2000,287(5454):860-864.
[15] Zhao H,Chen Q,Alam A,et al.The role of osteopontin in the progression of solid organ tumour[J].Cell Death Dis,2018,9(3):356.
[16] Foster BL,Ao M2,Salmon CR,et al.Osteopontin regulates dentin and alveolar bone development and mineralization[J].Bone,2018,107:196-207.
[17] Higashi A,Dohi Y,Uraoka N,et al.The Potential Role of Inflammation Associated with Interaction between Osteopontin and CD44 in a Case of Pulmonary Tumor Thrombotic Microangiopathy Caused by Breast Cancer[J].Intern Med,2015,54(22):2877-2880.
[18] Jonassen JA,Kohjlmoto Y,Scheid C,et al.Oxalate toxicity in renal cells[J].Urol Res,2005,33(5):329-339.
[19] Khan SR,Johnson JM,Peck AB,et al.Expression of osteopontin in rat kidneys:induction during ethylene glycol induced calcium oxalate nephrolithiasis[J].J Urol,2002,168(3):1173-1181.
[20] 关晓峰,邓耀良,孙丙华,等.高草酸尿症大鼠肾骨桥蛋白的表达与尿液草酸排泄的关系[J].中华实验外科杂志,2009,26(6):807.
[21] Lieske JC,Leonard R,Toback FG.Adhesion of calcium oxalate monohydrate crystals to renal epithelial cells is inhibited by specific anions[J].Am J Physiol,1995,268(4Pt2):F604-F612.
[22] Wesson JA,Johnson RJ,Mazzali M,et al.Osteopontin is a critical inhibitor of calcium oxalate crystal formation and retention in renal tubules[J].J Am Soc Nephrol,2003,14(1):139-147.
[23] Chien YC,Mansouri A,Jiang W,et al.Modulation of calcium oxalate dihydrate growth by phosphorylated osteopontin peptides[J].J Struct Biol,2018,204(2):131-144.
[24] Langdon A,Grohe B.The osteopontin-controlled switching of calcium oxalate monohydrate morphologies in artificial urine provides insights into the formation of papillary kidney stones[J].Colloids Surf B Biointerfaces,2016,146:296-306.
[25] Mo L,Liaw L,Evan AP,et al.Renal calcinosis and stone formation in mice lacking osteopontin,Tamm-Horsfall protein,or both[J].Am J Physiol Renal Physiol,2007,293(6):F1935-1943.
[26] 欧善际.草酸钙晶体对大鼠肾小管上皮细胞骨桥蛋白表达的影响[D].长春:吉林大学,2011.
[27] Hirose M,Tozawa K,Okada A,et al.Role of osteopontin in early phase of renal crystal formation:immunohistochemical and microstructural comparisons with osteopontin knock-out mice[J].Urol Res,2012,40(2):121-129.
[28] 吴敬彰,赵津津,张占五,等.TRPV5和OPN在泌尿系结石患者肾组织中的表达及意义[J].广东医学,2016,37(20):3101-3104.
[29] 赵明,易虎.骨桥蛋白对大鼠发生草酸钙肾脏结石的影响[J].中国老年学杂志,2018,38(4):926-927.
[30] 邓茂放,陈彤,王会镇,等.乌梅提取物对肾结石模型大鼠肾功能的保护作用及机制研究[J].中国临床药理学杂志,2018,34(15):1872-1874,1885.
[31] 闫晓煜,黄志红,肖创清.泌尿系统结石相关标志物的研究进展[J].国际检验医学杂志,2018,39(7):871-873,896.
[32] Min W,Shiraga H,Chalko C,et al.Quantitative studies of human urinary excretion of uropontin[J].Kidney Int.1998,53(1):189-193.
[33] Asplin JR,Arsenault D,Parks JH,et al.Contribution of human uropontin to inhibition of calcium oxalate crystallization[J].Kidney Int,1998,53(1):194-199.
[34] Yasui T,Fujita K,Hayashi Y,et al.Quantification of osteopontin in the urine of healthy and stone-forming men[J].Urol Res,1999,27(4):225-230.
[35] Thurgood LA,S?rensen ES,Ryall RL.The effect of intracrystalline and surface-bound osteopontin on the attachment of calcium oxalate dihydrate crystals to Madin-Darby canine kidney (MDCK) cells in ultrafiltered human urine[J].BJU Int,2012,109(7):1100-1109.
[36] 王炎,林峰,翁雪云,等.加味健脾益肾方对草酸钙肾结石患者术后尿骨桥蛋白的影响[J].中国中医药信息杂志,2015,27(7):36-39.
[37] Konya E,Umekawa T,Iguchi M,et al.The role of osteopontin on calcium oxalate crystal formation[J].Eur Urol,2003,43(5):564-571.