基于药效物质基础的熟地黄质-效评价研究进展
|
摘要
通过综述熟地黄的化学成分、活性成分药理作用、炮制研究,阐释熟地黄的药效物质基础,从整体的角度探究不同炮制程度熟地黄的全面质-效评价,以期揭示熟地黄炮制的科学内涵,为熟地黄的质-效评价和炮制终点的确定提供新的思路。
The chemical constituents, pharmacological action of active components, and processing of Rehmanniae Radix Praeparata were reviewed in this study to explain its pharmacodynamic material basis and explore the quality and efficacy evaluation of Rehmanniae Radix Praeparata with different processing degrees from the view of the whole. This paper is expected to reveal the scientific connotation of processing, providing new research ideas for the quality and efficacy evaluation and the determination of the possessing end-point of Rehmanniae Radix Praeparata.
The chemical constituents, pharmacological action of active components, and processing of Rehmanniae Radix Praeparata were reviewed in this study to explain its pharmacodynamic material basis and explore the quality and efficacy evaluation of Rehmanniae Radix Praeparata with different processing degrees from the view of the whole. This paper is expected to reveal the scientific connotation of processing, providing new research ideas for the quality and efficacy evaluation and the determination of the possessing end-point of Rehmanniae Radix Praeparata.
引文
[1]中国药典[S].一部.2015.
[2]刘彦飞.地黄活性物质与功能研究[D].北京:北京协和医学院,2013.
[3]江云,张超.熟地黄炮制工艺及质量标准的探讨[J].中药与临床,2017,8(6):21-25.
[4]张丽萍,李军,张振凌,等.熟地黄炮制方法的历史沿革[J].河南中医学院学报,2005,20(2):69-71.
[5]孟祥龙,马俊楠,张朔生,等.熟地黄炮制(九蒸九晒)过程中药效化学成分量变化及炮制辅料对其影响研究[J].中草药,2016,47(5):752-759.
[6]周丽,徐金娣,毛茜,等.地黄加工炮制研究新进展及展望[J].中药材,2016,39(5):1184-1190.
[7]Zhou L,Xu J D,Zhou S S,et al.Chemomics-based marker compounds mining and mimetic processing for exploring chemical mechanisms in traditional processing of herbal medicines,a continuous study on Rehmanniae Radix[J].J Chromatogr A,2017,1530(2):232-240.
[8]李行诺,周盂宇,沈培强,等.生地黄化学成分研究[J].中国中药杂志,2011,36(22):3125-3129.
[9]刘彦飞,梁东,罗桓,等.地黄的化学成分研究[J].中草药,2014,45(1):16-22.
[10]Feng W,Lv Y,Zheng K,et al.A new megastigmane from fresh roots of Rehmannia glutinosa[J].Acta Pharm Sin B,2013,3(5):333-336.
[11]付国辉,杜鑫.地黄化学成分及药理作用研究进展[J].中国医药科学,2015,5(15):39-41.
[12]杨雨.地黄炮制品成分分析的研究进展[J].药物分析杂志,2010,30(7):1332-1335.
[13]Zhou L,Xu J D,Zhou S S,et al.Integrating targeted glycomics and untargeted metabolomics to investigate the processing chemistry of herbal medicines,a case study on Rehmanniae Radix[J].J Chromatogr A,2016,1472(2):74-87.
[14]钟伯雄,张婉,刘伟志,等.炮制对生药化学成分的影响研究概述[J].时珍国医国药,2011,22(11):2763-2764.
[15]张寒,张婷盼,张彦,等.不同炮制方法对杜仲中重金属含量及其赋存形态的影响[J].国际药学研究杂志,2017,44(5):437-441.
[16]拜玲,钟进芳,吴晓云,等.生地熟地中矿物元素的测定与分析[J].广东微量元素科学,2009,16(10):50-55.
[17]徐旭耀,唐纯良,潘荣楷,等.火焰原子吸收法测定中草药生地黄熟地黄中的钙镁铁钾[J].微量元素与健康研究,2007,24(6):19-21.
[18]王军,于震,李更生,等.地黄苷A对“阴虚”及免疫功能低下小鼠的药理作用[J].中国药学杂志,2002,37(1):22-24.
[19]于震,王军,李更生,等.地黄甙D滋阴补血和降血糖作用的实验研究[J].辽宁中医杂志,2001,28(4):240-242.
[20]Cai Q,Ma T,Tian Y,et al.Catalpol inhibits ischemia-induced premyelinating oligodendrocyte damage through regulation of intercellular calcium homeostasis via Na+/Ca2+exchanger 3[J].Int J Mol Sci,2018,19(7):1925-1943.
[21]Xu D,Wang L,Jiang Z,et al.A new hypoglycemic mechanism of catalpol revealed by enhancing MyoD/MyoG-mediated myogenesis[J].Life Sci,2018,209(18):313-323.
[22]刘培建,苗明三,高渐联.熟地黄多糖对气血双虚小鼠全血细胞及血清粒-巨噬细胞集落刺激因子水平的影响[J].中国组织工程研究与临床康复,2008,12(38):7543-7546.
[23]黄霞,庆慧,王惠森,等.熟地水煎剂及其提取物对小鼠外周血象影响的比较研究[J].中成药,2002,24(2):35-37.
[24]武卫红.地黄寡糖的制备工艺及其药理活性研究[D].济南:山东大学,2006.
[25]段素芳.水苏糖的功能及应用[J].饮料工业,2016,19(5):74-78.
[26]Liang Q D,Gao Y,Tan H L,et al.Effects of four Si-Wu-Tang’s constituents and their combination on irradiated mice[J].Biol Pharm Bull,2006,29(7):1378-1382.
[27]Xu G G,Pagare P P,Ghatge M S,et al.Design,synthesis,and biological evaluation of ester and ether derivatives of antisickling agent 5-HMF for the treatment of sickle cell disease[J].Mol Pharm,2017,14(10):3499-3511.
[28]Lin A S,Qian K,Usami Y,et al.5-Hydroxymethyl-2-furfural,a clinical trials agent for sickle cell anemia,and its mono/di-glucosides from classically processed steamed Rehmanniae Radix[J].J Nat Med,2008,62(2):164-167.
[29]于震,王军,李更生,等.地黄苷A对环磷酰胺致小鼠白细胞减少症的影响[J].中草药,2001,32(11):45-47.
[30]管斯琪,陈培丰,祝雨田,等.熟地黄多糖对阿霉素致小鼠骨髓抑制及免疫功能损伤的影响[J].浙江中医药大学学报,2014,38(3):312-315.
[31]Alizadeh M,Khodaei H,Mesgari Abbasi M,et al.Assessing the effect of 5-hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin[J].J Sci Food Agric,2017,97(12):3979-3984.
[32]Han Y,Jung H W,Lee J Y,et al.2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatory responses in lipopolysaccharide-stimulated RAW264.7 macrophages[J].J Med Food,2012,15(6):505-510.
[33]Liu C,Chen K,Lu Y,et al.Catalpol provides a protective effect on fibrillary Aβ1-42-induced barrier disruption in an in vitro model of the blood-brain barrier[J].Phytother Res,2018,32(6):1047-1055.
[34]梁建庆,何建成.复方地黄颗粒和毛蕊花糖苷治疗帕金森病模型大鼠的作用靶标研究[J].解放军医学杂志,2018,43(8):641-646.
[35]Geng X,Tian X,Tu P,et al.Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson’s disease[J].Eur J Pharmacol,2007,564(1/3):66-74.
[36]高莉,彭晓明,霍仕霞,等.毛蕊花糖苷改善D-半乳糖致亚急性衰老小鼠脑损伤的作用[J].中草药,2014,45(1):81-85.
[37]崔豪,冯静,崔瑛,等.熟地黄及其多糖中枢抑制作用研究[J].河南中医学院学报,2006,21(6):18-19.
[38]张丽娜,金国琴.熟地有效成分甘露三糖对高浓度皮质酮损伤的海马神经细胞SGK/BDNF/GCR表达的影响[J].中药药理与临床,2011,27(5):16-20.
[39]Lee Y,Gao Q,Kim E,et al.Pretreatment with5-hydroxymethyl-2-furaldehyde blocks scopolamineinduced learning deficit in contextual and spatial memory in male mice[J].Pharmacol Biochem Behavior,2015,134(7):57-64.
[40]张丽娜,张天良,金国琴,等.5-羟甲基糠醛对皮质酮损伤型海马神经元P-synapsin I蛋白表达的影响[J].中国老年学杂志,2015,35(9):2305-2307.
[41]Jiang P,Xiang L,Chen Z,et al.Catalpol alleviates renal damage by improving lipid metabolism in diabetic db/db mice[J].Am J Translat Resh,2018,10(6):1750-1761.
[42]Zhang H,Jia R,Wang F,et al.Catalpol protects mice against lipopolysaccharide/D-galactosamine-induced acute liver injury through inhibiting inflammatory and oxidative response[J].Oncotarget,2017,9(3):3887-3894.
[43]郑帅,杨敏.毛蕊花糖苷治疗糖尿病肾病的研究进展[J].医学综述,2018,24(16):3232-3236.
[44]Jiang Z Q,Ma Y X,Li M H,et al.5-Hydroxymethylfurfural protects against ERstress-induced apoptosis in GalN/TNF-α-injured L02hepatocytes through regulating the PERK-eIF2αsignaling pathway[J].Chin J Nat Med,2015,13(12):896-905.
[45]Li W,Qu X N,Han Y,et al.Ameliorative effects of5-hydroxymethyl-2-furfural(5-HMF)from Schisandra chinensis on alcoholic liver oxidative injury in mice[J].Int J Mol Sci,2015,16(2):2446-2457.
[46]Wang Z H,Hu Z S.Catalpol inhibits migration and induces apoptosis in gastric cancer cells and in athymic nude mice[J].Biomed Pharmacother,2018,103(7):1708-1719.
[47]王园,刘珂,邱邴勋,等.梓醇调控自噬和凋亡促进H2O2诱导的PC12细胞存活[J].西南大学学报:自然科学版,2018,40(2):27-34.
[48]邓锦芳,熊英,王淳,等.毛蕊花糖苷对顺铂诱导小鼠卵巢损害的保护作用[J].解剖科学进展,2017,23(3):257-261.
[49]梁颖,李冀,郭盛磊,等.熟地黄多糖对荷瘤小鼠肿瘤组织Cyt-C及Caspase-3基因表达的影响[J].中医药信息,2017,34(3):24-27.
[50]刘晓梅,彭芝榕,倪学勤,等.低聚果糖、乳酸杆菌对便秘模型大鼠的通便功能影响[J].食品科学,2013,34(11):296-299.
[51]赵玲.5-羟甲基糠醛抗氧化活性及其抑制肿瘤细胞增殖的作用机制[D].广州:华南理工大学,2014.
[52]Zhao L,Chen J,Su J,et al.In vitro antioxidant and antiproliferative activities of 5-hydroxymethylfurfural[J].J Agric Food Chem,2013,61(44):10604-10611.
[53]Zhang J H,Di Y,Wu L Y,et al.5-HMF prevents against oxidative injury via APE/Ref-1[J].Free Rad Res,2015,49(1):86-94.
[54]Tan X L,Zhang Y H,Cai J P,et al.5-(Hydroxymethyl)-2-furaldehyde inhibits adipogenic and enhances osteogenic differentiation of rat bone mesenchymal stem cells[J].Nat Prod Commun,2014,9(4):529-532.
[55]高耀,高丽,高晓霞,等.基于网络药理学的逍遥散抗抑郁活性成分作用靶点研究[J].药学学报,2015,50(12):1589-1595.
[56]樊克锋,赵建平,汤法银,等.FTIR对酒炖熟地黄炮制终点的量化分析[J].中国兽药杂志,2017,51(9):49-55.
[57]张静,马瑛.多指标综合平衡法-正交试验优化九蒸九晒地黄炮制工艺[J].中国药房,2016,27(7):962-965.
[58]钟恋,汪云伟,杨诗龙,等.地黄酒炖过程化学成分及“味”的关系[J].中成药,2015,37(5):1041-1044.
[59]钟恋.基于“性状”和化学成分的清蒸九制地黄过程研究[D].成都:成都中医药大学,2015.
[60]Liu Z R,Lou Z Y,Ding X,et al.Global characterization of neutral saccharides in crude and processed Radix Rehmanniae by hydrophilic interaction liquid chromatography tandem electrospray ionization time-of-flight mass spectrometry[J].Food Chem,2013,141(3):2833-2840.
[61]Chang W T,Thissen U,Ehlert K A,et al.Effects of growth conditions and processing on Rehmannia glutinosa using fingerprint strategy[J].Planta Med,2006,72(5):458-467.
[62]Chang W T,Choi Y H,van der Heijden R,et al.Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa roots[J].Chem Pharm Bull,2011,59(5):546-552.
[63]吴昱铮,王广基,郝海平.中药代谢组学研究进展[J].中国药科大学学报,2014,45(2):129-135.
[64]周丽.基于整体观的地黄“九蒸九制”质/效评价研究[D].南京:南京中医药大学,2017.
[65]冯永辉.浅谈熟地黄常见药对的配伍应用[J].陕西中医,2011,32(8):1064-1065.
[66]赵晓喆,赵思俊,田俊生,等.基于药效作用的龟龄集物质基础研究进展[J].中草药,2017,48(7):1424-1431.
[2]刘彦飞.地黄活性物质与功能研究[D].北京:北京协和医学院,2013.
[3]江云,张超.熟地黄炮制工艺及质量标准的探讨[J].中药与临床,2017,8(6):21-25.
[4]张丽萍,李军,张振凌,等.熟地黄炮制方法的历史沿革[J].河南中医学院学报,2005,20(2):69-71.
[5]孟祥龙,马俊楠,张朔生,等.熟地黄炮制(九蒸九晒)过程中药效化学成分量变化及炮制辅料对其影响研究[J].中草药,2016,47(5):752-759.
[6]周丽,徐金娣,毛茜,等.地黄加工炮制研究新进展及展望[J].中药材,2016,39(5):1184-1190.
[7]Zhou L,Xu J D,Zhou S S,et al.Chemomics-based marker compounds mining and mimetic processing for exploring chemical mechanisms in traditional processing of herbal medicines,a continuous study on Rehmanniae Radix[J].J Chromatogr A,2017,1530(2):232-240.
[8]李行诺,周盂宇,沈培强,等.生地黄化学成分研究[J].中国中药杂志,2011,36(22):3125-3129.
[9]刘彦飞,梁东,罗桓,等.地黄的化学成分研究[J].中草药,2014,45(1):16-22.
[10]Feng W,Lv Y,Zheng K,et al.A new megastigmane from fresh roots of Rehmannia glutinosa[J].Acta Pharm Sin B,2013,3(5):333-336.
[11]付国辉,杜鑫.地黄化学成分及药理作用研究进展[J].中国医药科学,2015,5(15):39-41.
[12]杨雨.地黄炮制品成分分析的研究进展[J].药物分析杂志,2010,30(7):1332-1335.
[13]Zhou L,Xu J D,Zhou S S,et al.Integrating targeted glycomics and untargeted metabolomics to investigate the processing chemistry of herbal medicines,a case study on Rehmanniae Radix[J].J Chromatogr A,2016,1472(2):74-87.
[14]钟伯雄,张婉,刘伟志,等.炮制对生药化学成分的影响研究概述[J].时珍国医国药,2011,22(11):2763-2764.
[15]张寒,张婷盼,张彦,等.不同炮制方法对杜仲中重金属含量及其赋存形态的影响[J].国际药学研究杂志,2017,44(5):437-441.
[16]拜玲,钟进芳,吴晓云,等.生地熟地中矿物元素的测定与分析[J].广东微量元素科学,2009,16(10):50-55.
[17]徐旭耀,唐纯良,潘荣楷,等.火焰原子吸收法测定中草药生地黄熟地黄中的钙镁铁钾[J].微量元素与健康研究,2007,24(6):19-21.
[18]王军,于震,李更生,等.地黄苷A对“阴虚”及免疫功能低下小鼠的药理作用[J].中国药学杂志,2002,37(1):22-24.
[19]于震,王军,李更生,等.地黄甙D滋阴补血和降血糖作用的实验研究[J].辽宁中医杂志,2001,28(4):240-242.
[20]Cai Q,Ma T,Tian Y,et al.Catalpol inhibits ischemia-induced premyelinating oligodendrocyte damage through regulation of intercellular calcium homeostasis via Na+/Ca2+exchanger 3[J].Int J Mol Sci,2018,19(7):1925-1943.
[21]Xu D,Wang L,Jiang Z,et al.A new hypoglycemic mechanism of catalpol revealed by enhancing MyoD/MyoG-mediated myogenesis[J].Life Sci,2018,209(18):313-323.
[22]刘培建,苗明三,高渐联.熟地黄多糖对气血双虚小鼠全血细胞及血清粒-巨噬细胞集落刺激因子水平的影响[J].中国组织工程研究与临床康复,2008,12(38):7543-7546.
[23]黄霞,庆慧,王惠森,等.熟地水煎剂及其提取物对小鼠外周血象影响的比较研究[J].中成药,2002,24(2):35-37.
[24]武卫红.地黄寡糖的制备工艺及其药理活性研究[D].济南:山东大学,2006.
[25]段素芳.水苏糖的功能及应用[J].饮料工业,2016,19(5):74-78.
[26]Liang Q D,Gao Y,Tan H L,et al.Effects of four Si-Wu-Tang’s constituents and their combination on irradiated mice[J].Biol Pharm Bull,2006,29(7):1378-1382.
[27]Xu G G,Pagare P P,Ghatge M S,et al.Design,synthesis,and biological evaluation of ester and ether derivatives of antisickling agent 5-HMF for the treatment of sickle cell disease[J].Mol Pharm,2017,14(10):3499-3511.
[28]Lin A S,Qian K,Usami Y,et al.5-Hydroxymethyl-2-furfural,a clinical trials agent for sickle cell anemia,and its mono/di-glucosides from classically processed steamed Rehmanniae Radix[J].J Nat Med,2008,62(2):164-167.
[29]于震,王军,李更生,等.地黄苷A对环磷酰胺致小鼠白细胞减少症的影响[J].中草药,2001,32(11):45-47.
[30]管斯琪,陈培丰,祝雨田,等.熟地黄多糖对阿霉素致小鼠骨髓抑制及免疫功能损伤的影响[J].浙江中医药大学学报,2014,38(3):312-315.
[31]Alizadeh M,Khodaei H,Mesgari Abbasi M,et al.Assessing the effect of 5-hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin[J].J Sci Food Agric,2017,97(12):3979-3984.
[32]Han Y,Jung H W,Lee J Y,et al.2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatory responses in lipopolysaccharide-stimulated RAW264.7 macrophages[J].J Med Food,2012,15(6):505-510.
[33]Liu C,Chen K,Lu Y,et al.Catalpol provides a protective effect on fibrillary Aβ1-42-induced barrier disruption in an in vitro model of the blood-brain barrier[J].Phytother Res,2018,32(6):1047-1055.
[34]梁建庆,何建成.复方地黄颗粒和毛蕊花糖苷治疗帕金森病模型大鼠的作用靶标研究[J].解放军医学杂志,2018,43(8):641-646.
[35]Geng X,Tian X,Tu P,et al.Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson’s disease[J].Eur J Pharmacol,2007,564(1/3):66-74.
[36]高莉,彭晓明,霍仕霞,等.毛蕊花糖苷改善D-半乳糖致亚急性衰老小鼠脑损伤的作用[J].中草药,2014,45(1):81-85.
[37]崔豪,冯静,崔瑛,等.熟地黄及其多糖中枢抑制作用研究[J].河南中医学院学报,2006,21(6):18-19.
[38]张丽娜,金国琴.熟地有效成分甘露三糖对高浓度皮质酮损伤的海马神经细胞SGK/BDNF/GCR表达的影响[J].中药药理与临床,2011,27(5):16-20.
[39]Lee Y,Gao Q,Kim E,et al.Pretreatment with5-hydroxymethyl-2-furaldehyde blocks scopolamineinduced learning deficit in contextual and spatial memory in male mice[J].Pharmacol Biochem Behavior,2015,134(7):57-64.
[40]张丽娜,张天良,金国琴,等.5-羟甲基糠醛对皮质酮损伤型海马神经元P-synapsin I蛋白表达的影响[J].中国老年学杂志,2015,35(9):2305-2307.
[41]Jiang P,Xiang L,Chen Z,et al.Catalpol alleviates renal damage by improving lipid metabolism in diabetic db/db mice[J].Am J Translat Resh,2018,10(6):1750-1761.
[42]Zhang H,Jia R,Wang F,et al.Catalpol protects mice against lipopolysaccharide/D-galactosamine-induced acute liver injury through inhibiting inflammatory and oxidative response[J].Oncotarget,2017,9(3):3887-3894.
[43]郑帅,杨敏.毛蕊花糖苷治疗糖尿病肾病的研究进展[J].医学综述,2018,24(16):3232-3236.
[44]Jiang Z Q,Ma Y X,Li M H,et al.5-Hydroxymethylfurfural protects against ERstress-induced apoptosis in GalN/TNF-α-injured L02hepatocytes through regulating the PERK-eIF2αsignaling pathway[J].Chin J Nat Med,2015,13(12):896-905.
[45]Li W,Qu X N,Han Y,et al.Ameliorative effects of5-hydroxymethyl-2-furfural(5-HMF)from Schisandra chinensis on alcoholic liver oxidative injury in mice[J].Int J Mol Sci,2015,16(2):2446-2457.
[46]Wang Z H,Hu Z S.Catalpol inhibits migration and induces apoptosis in gastric cancer cells and in athymic nude mice[J].Biomed Pharmacother,2018,103(7):1708-1719.
[47]王园,刘珂,邱邴勋,等.梓醇调控自噬和凋亡促进H2O2诱导的PC12细胞存活[J].西南大学学报:自然科学版,2018,40(2):27-34.
[48]邓锦芳,熊英,王淳,等.毛蕊花糖苷对顺铂诱导小鼠卵巢损害的保护作用[J].解剖科学进展,2017,23(3):257-261.
[49]梁颖,李冀,郭盛磊,等.熟地黄多糖对荷瘤小鼠肿瘤组织Cyt-C及Caspase-3基因表达的影响[J].中医药信息,2017,34(3):24-27.
[50]刘晓梅,彭芝榕,倪学勤,等.低聚果糖、乳酸杆菌对便秘模型大鼠的通便功能影响[J].食品科学,2013,34(11):296-299.
[51]赵玲.5-羟甲基糠醛抗氧化活性及其抑制肿瘤细胞增殖的作用机制[D].广州:华南理工大学,2014.
[52]Zhao L,Chen J,Su J,et al.In vitro antioxidant and antiproliferative activities of 5-hydroxymethylfurfural[J].J Agric Food Chem,2013,61(44):10604-10611.
[53]Zhang J H,Di Y,Wu L Y,et al.5-HMF prevents against oxidative injury via APE/Ref-1[J].Free Rad Res,2015,49(1):86-94.
[54]Tan X L,Zhang Y H,Cai J P,et al.5-(Hydroxymethyl)-2-furaldehyde inhibits adipogenic and enhances osteogenic differentiation of rat bone mesenchymal stem cells[J].Nat Prod Commun,2014,9(4):529-532.
[55]高耀,高丽,高晓霞,等.基于网络药理学的逍遥散抗抑郁活性成分作用靶点研究[J].药学学报,2015,50(12):1589-1595.
[56]樊克锋,赵建平,汤法银,等.FTIR对酒炖熟地黄炮制终点的量化分析[J].中国兽药杂志,2017,51(9):49-55.
[57]张静,马瑛.多指标综合平衡法-正交试验优化九蒸九晒地黄炮制工艺[J].中国药房,2016,27(7):962-965.
[58]钟恋,汪云伟,杨诗龙,等.地黄酒炖过程化学成分及“味”的关系[J].中成药,2015,37(5):1041-1044.
[59]钟恋.基于“性状”和化学成分的清蒸九制地黄过程研究[D].成都:成都中医药大学,2015.
[60]Liu Z R,Lou Z Y,Ding X,et al.Global characterization of neutral saccharides in crude and processed Radix Rehmanniae by hydrophilic interaction liquid chromatography tandem electrospray ionization time-of-flight mass spectrometry[J].Food Chem,2013,141(3):2833-2840.
[61]Chang W T,Thissen U,Ehlert K A,et al.Effects of growth conditions and processing on Rehmannia glutinosa using fingerprint strategy[J].Planta Med,2006,72(5):458-467.
[62]Chang W T,Choi Y H,van der Heijden R,et al.Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa roots[J].Chem Pharm Bull,2011,59(5):546-552.
[63]吴昱铮,王广基,郝海平.中药代谢组学研究进展[J].中国药科大学学报,2014,45(2):129-135.
[64]周丽.基于整体观的地黄“九蒸九制”质/效评价研究[D].南京:南京中医药大学,2017.
[65]冯永辉.浅谈熟地黄常见药对的配伍应用[J].陕西中医,2011,32(8):1064-1065.
[66]赵晓喆,赵思俊,田俊生,等.基于药效作用的龟龄集物质基础研究进展[J].中草药,2017,48(7):1424-1431.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |