自拟通窍止咳汤治疗儿童上气道咳嗽综合征临床疗效评价
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摘要
目的:探讨自拟通窍止咳汤治疗儿童上气道咳嗽综合征(UACS)的临床疗效。方法:选取2017年1月—2018年6月在我院儿科门诊就诊的UACS患儿106例,随机分组,采取自拟通窍止咳汤治疗的53例患儿纳入治疗组,采取传统西医治疗方式的53例患儿纳入对照组,治疗持续7 d,观察两组患者在治疗前后临床咳嗽症状量化评分变化、咳嗽症状主观评估及两组UACS患儿临床综合疗效。结果:UACS患儿治疗后其咳嗽症状积分发生显著变化,同时治疗组患者治疗后咳嗽症状积分明显低于对照组(P<0.05);治疗组进行相应治疗后UACS患儿的咳嗽VAS评分较对照组显著低(P<0.05);治疗组治疗后达到临床控制的UACS患儿例数较对照组显著多,且疗效总有效率明显较对照组患者高(P<0.05)。结论:自拟通窍止咳汤治疗儿童UACS疗效确切,未出现明显不良反应,具有临床推广意义。
Objective:To investigate the clinical curative effect of self-made Tongqiao Zhike Decoction in the treatment of upper airway cough syndrome(UACS)in children. Methods:A total of 106 children with UACS who were admitted to the pediatric outpatient department of the hospital from January 2017 to June2018 were randomly divided into the treatment group(53 patients treated with self-made Tongqiao Zhike Decoction)and the control group(53 children treated with traditional Western medicine). Both groups were treated for 7 days. The changes in scores of clinical cough symptoms and subjective evaluation of cough symptoms before and after treatment,and the clinical curative effect in both groups were observed. Results:There were obvious changes in scores of cough symptoms after treatment,and the scores of the treatment group were significantly lower than those of the control group(P<0.05). The cough VAS score of the treatment group was significantly lower than that of the control group after treatment(P<0.05). The number of children with clinical control in the treatment group after treatment was significantly larger than that in the control group,and the total effective rate was significantly higher than that in the control group(P<0.05).Conclusion:Self-made Tongqiao Zhike Decoction is effective in the treatment of UACS in children,without obvious adverse reactions.
Objective:To investigate the clinical curative effect of self-made Tongqiao Zhike Decoction in the treatment of upper airway cough syndrome(UACS)in children. Methods:A total of 106 children with UACS who were admitted to the pediatric outpatient department of the hospital from January 2017 to June2018 were randomly divided into the treatment group(53 patients treated with self-made Tongqiao Zhike Decoction)and the control group(53 children treated with traditional Western medicine). Both groups were treated for 7 days. The changes in scores of clinical cough symptoms and subjective evaluation of cough symptoms before and after treatment,and the clinical curative effect in both groups were observed. Results:There were obvious changes in scores of cough symptoms after treatment,and the scores of the treatment group were significantly lower than those of the control group(P<0.05). The cough VAS score of the treatment group was significantly lower than that of the control group after treatment(P<0.05). The number of children with clinical control in the treatment group after treatment was significantly larger than that in the control group,and the total effective rate was significantly higher than that in the control group(P<0.05).Conclusion:Self-made Tongqiao Zhike Decoction is effective in the treatment of UACS in children,without obvious adverse reactions.
引文
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[15]孙娜,白晓红,刘芳.桑皮止咳方治疗小儿上气道咳嗽综合征的临床研究[J].中华中医药学刊,2016,34(4):885-887.
[16]刘淑芸,钟红卫,郑印淋,等.小柴胡汤加减治疗上气道咳嗽综合征的临床疗效研究[J].中国全科医学,2016,19(1):432-434.
[2]焦路燕,曹玲.儿童上气道咳嗽综合征[J].中国实用儿科杂志,2016,31(3):179-182.
[3]李斌恺,赖克方,LIBin-kai,等.慢性咳嗽的流行病学[J].中华结核和呼吸杂志,2010,33(1):62-66.
[4]刘殿玉,王秀坤.中西药结合治疗儿童上气道咳嗽综合征临床疗效分析[J].辽宁中医药大学学报,2012,14(11):195-196.
[5]翟莺莺.儿童上气道咳嗽综合征60例诊治分析[J].临床肺科杂志,2013,18(7):1221-1222.
[6]史锁芳.上气道咳嗽综合征中医证治探讨[J].南京中医药大学学报,2009,25(3):164-166.
[7]王烝,白晓红,刘芳.桑皮止咳方联合孟鲁司特治疗小儿咳嗽变异性哮喘临床研究[J].中华中医药学刊,2015,33(3):697-699.
[8]中华医学会儿科学分会呼吸学组.儿童慢性咳嗽诊断与治疗指南(试行)[J].中华儿科杂志,2008,46(2):104-107.
[9]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.
[10]中华医学会呼吸病学分会哮喘学组.咳嗽的诊断与治疗指南(2009版)[J].中华结核和呼吸杂志,2009,19(6):453-456.
[11]马迪将,诸琦,杨金维,等.鼻喷激素联合鼻腔冲洗对儿童上气道咳嗽综合征的疗效观察[J].中国全科医学,2014,17(2):217-219.
[12]陈雪梅,王儒平.浅析《内经》“五脏六腑皆令人咳,非独肺也”[J].时珍国医国药,2007,18(12):2964-2964.
[13]尹发明,刘立安.依据《素问·咳论》浅谈脏腑咳嗽[J].江苏中医药,2014,46(7):3-4.
[14]苏克雷,张业清.经方治疗慢性咳嗽的思路与方法[J].中国中药杂志,2018,43(12):2435-2441.
[15]孙娜,白晓红,刘芳.桑皮止咳方治疗小儿上气道咳嗽综合征的临床研究[J].中华中医药学刊,2016,34(4):885-887.
[16]刘淑芸,钟红卫,郑印淋,等.小柴胡汤加减治疗上气道咳嗽综合征的临床疗效研究[J].中国全科医学,2016,19(1):432-434.