配偶间HIV传播及影响因素研究进展
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摘要
经性传播已成为我国艾滋病传播的主要方式,而家庭内配偶间经性传播已成为艾滋病进一步蔓延的重要因素之一。本文对配偶间HIV传播的研究方法、传播状况及相关影响因素进行综述,并提出降低配偶间HIV传播的干预策略。
Sexual transmission has become the main way of HIV transmission in China,and sexual transmission among spouses in family has become an important factor for the further spread of HIV. This article reviews the research methods,infection status and related factors of HIV transmission among spouses,and puts forward the intervention strategies to reduce the spread of HIV among spouses.
Sexual transmission has become the main way of HIV transmission in China,and sexual transmission among spouses in family has become an important factor for the further spread of HIV. This article reviews the research methods,infection status and related factors of HIV transmission among spouses,and puts forward the intervention strategies to reduce the spread of HIV among spouses.
引文
[1]中华人民共和国卫生部,联合国艾滋病规划署,世界卫生组织. 2011年中国艾滋病疫情估计[J].中国艾滋病性病,2012,18(1):1-5.Ministry of Health of the People′s Republic of China,UNAIDS,World Health Organization. 2011 AIDS epidemic estimates in China[J]. Chin J AIDS STD,2012,18(1):1-5.
[2] Donnell D,Baeten JM,Kiarie J,et al. Heterosexual HIV-1transmission after initiation of antiretroviral therapy:a prospective cohort analysis[J]. Lancet,2010,375(9731):2092-2098.
[3] Zhang YJ,Feng XX,Fan YG,et al.HIV transmission and related risk factors among serodiscordant couples in Liuzhou,China[J].J Med Virol,2015,87(4):553-556.
[4] Cohen MS,Chen YQ,McCauley M,et al. Prevention of HIV-1infection with early antiretroviral therapy[J]. N Engl J Med,2011,365(6):493-505.
[5] Jia Z,Mao Y,Zhang F,et al. Antiretroviral therapy to prevent HIV transmission in serodiscordant couples in China(2003-11):a national observational cohort study[J].Lancet,2013,382(9899):1195-1203.
[6] Tang Z,Lan G,Chen YQ,et al. HIV-1 treatment-as-prevention:a cohort study analysis of serodiscordant couples in rural southwest China[J]. Medicine:Baltimore,2015,94(24):e902.
[7]陈琳,潘晓红,杨介者,等.浙江省2009-2013年单阳家庭配偶HIV血清学阳转率分析[J].中华流行病学杂志,2015,36(8):857-861.Chen L,Pan XH,Yang JZ,et al.Incidence rate of HIV transmission in HIV discordant couples in Zhejiang province,2009-2013[J]. Chin J Epidemiol,2015,36(8):857-861.
[8] Yang RR,Gui X,Xiong Y,et al. Five-year follow-up observation of HIV prevalence in serodiscordant couples[J]. Int J Infect Dis,2015,33:179-184.
[9]蔡月仙,余大年,刘仲昌,等.配偶间HIV性传播危险因素研究[J].中国热带医学,2015,15(4):430-433.Cai YX,Yu DN,Liu ZC,et al. Risk factors associated with HIV transmission between spouses in Taishan city[J].China Tropical Medicine,2015,15(4):430-433.
[10]曾刚,陈虹,李崇行,等.四川省凉山州艾滋病病毒感染者配偶感染状况调查[J].疾病监测,2010,25(6):461-463.Zeng G,Chen H,Li CX,et al. Survey on HIV-Infection of spouses of HIV infected persons in Liangshan autonomous prefecture,Sichuan province[J]. Disease Surveillance,2010,25(6):461-463.
[11]杨蓉蓉,桂希恩,熊勇,等.艾滋病单阳家庭配偶抗-人类免疫缺陷病毒阳转状况的5年随访分析[J].中华传染病杂志,2014,32(6):334-337.Yang RR,Gui XE,Xiong Y,et al. Analysis on sero-conversion status of human immunodeficiency virus-discordant spouse during5-year follow-up period[J]. Chin J Infect Dis,2014,32(6):334-337.
[12]张振开,邓燕,文小青,等.桂林市HIV感染者/病人配偶间HIV传播状况及影响因素的调查研究[J].中华疾病控制杂志,2012,16(2):127-129.Zhang ZK,Deng Y,Wen XQ,et al. The survey on HIV infection situations and influencing factors between spouses in Guilin city[J].Chin J Dis Control Prev,2012,16(2):127-129.
[13]毛宇嵘,郑锡文,潘承东,等.新疆伊宁市婚前体检者艾滋病病毒感染情况调查[J].中国预防医学杂志,2001,2(1):12-13.Mao YR,Zheng XW,Pan CD,et al. HIV prevalence among premarital couples in Yining city,Xinjiang[J]. Chin Prev Med,2001,2(1):12-13.
[14]叶润华,项丽芬,杨跃诚,等.云南省德宏州新报告艾滋病病毒感染者溯源调查[J].中华流行病学杂志,2010,31(1):39-42.Ye RH,Xiang LF,Yang YC,et al.Tracing the sources of newly reported HIV infections in Dehong prefecture of Yunnan province[J]. Chin J Epidemiol,2010,31(1):39-42.
[15] Copen CE. Condom use during sexual intercourse among women and men aged 15-44 in the United States:2011-2015 National survey of family growth[J]. Natl Health Stat Report,2017,105:1-18.
[16]濮永成,韩文香,段启祥,等.陇川县14个艾滋病单阳家庭阴性配偶HIV阳转的原因分析[J].中国艾滋病性病,2012,18(6):382-384.Pu YC,Han WX,Duan QX, et al.Causal analysis of HIV seroconversion among the fourteen HIV discordant families in Longchuan county,Yunnan province[J]. Chin J AIDS STD,2012,18(6):382-384.
[17] Dunkle KL,Stephenson R,Karita E,et al. New heterosexually transmitted HIV infections in married or cohabiting couples in urban Zambia and Rwanda:an analysis of survey and clinical data[J]. Lancet,2008,371(9631):2183-2191.
[18] Kumarasamy N,Venkatesh KK,Srikrishnan AK,et al.Risk factors for HIV transmission among heterosexual discordant couples in South India[J]. HIV Med,2010,11(3):178-186.
[19] Wall KM,Kilembe W,Vwalika B,et al.Sustained effect of couples′HIV counselling and testing on risk reduction among Zambian HIV serodiscordant couples[J].Sex Transm Infect,2017,93(4):259-266.
[20]明帅,王璐,葛增,等.河南省某市HIV单阳家庭阴性配偶抗体阳转情况[J].中华预防医学杂志,2013,47(4):337-341.Ming S,Wang L,Ge Z,et al. Sero-conversion of HIV seronegative partners among discordant couples in a city of Henan province[J].Chin J Prev Med,2013,47(4):337-341.
[21] Dou Z,Chen RY,Xu J,et al. Changing baseline characteristics among patients in the China National Free Antiretroviral Treatment Program,2002-09[J].Int J Epidemiol,2010,39Suppl 2:ii56-64.
[22] Ma Y,Zhao DC,Yu L,et al. Predictors of virologic failure in HIV-1-infected adults on first line antiretroviral therapy in eight provinces in China[J].Clin Infect Dis,2010,50(2):264-271.
[23] Zhang F,Dou Z,Ma Y,et al. Five-year outcomes of the China National Free Antiretroviral Treatment Program[J]. Ann Intern Med,2009,151(4):241-251,W-52.
[24] Paterson DL,Swindells S,Mohr J,et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection[J].Ann Intern Med,2000,133(1):21-30.
[25]朱萍. HIV感染者配偶艾滋病队列研究[D].上海:复旦大学,2012.Zhu P.Cohort study of HIV/AIDS among seronegative couples of HIV infected individuals[D]. Shanghai:Fudan University,2012.
[26]Johnson LF,Lewis DA. The effect of genital tract infections on HIV-1 shedding in the genital tract:a systematic review and metaanalysis[J]. Sex Transm Dis,2008,35(11):946-959.
[27]李健,汤后林,韩晶,等.中国5省份2011-2014年新发现HIV感染者检测阳性前配偶感染情况及影响因素分析[J].中华流行病学杂志,2016,37(11):1497-1502.Li J,Tang HL,Han J,et al. HIV transmission in newly reported HIV infected couples before diagnoses in five provinces,China,2011-2014[J]. Chin J Epidemiol,2016,37(11):1497-1502.
[28] Roxby AC,Ben-Youssef L,Marx G,et al.Dual contraceptive method use in HIV-serodiscordant Kenyan couples[J]. J Fam Plann Reprod Health Care,2016,42(4):264-270.
[29] Rojanapithayakorn W.The 100%condom use programme in Asia[J]. Reprod Health Matters,2006,14(28):41-52.
[30]邹惠英,刘丽红,黎明,等.深圳市龙岗区妊娠妇女艾滋病知晓率及感染状况调查[J].热带医学杂志,2017,17(2):240-243.Zou HY,Liu LH,Li M,et al. Investigation on awareness rate and infection status of AIDS among pregnant women in Longgang district of Shenzhen[J]. J Trop Med,2017,17(2):240-243.
[31] Anglemyer A,Rutherford GW,Baggaley RC,et al. Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples[J]. Cochrane Database Syst Rev,2011,(8):CD009153.
[32]曹丕,吴建军,苏斌,等.艾滋病患者更换二线抗病毒药物的治疗效果[J].中国热带医学,2018,18(4):387-390.Cao P,Wu JJ,Su B,et al. Treatment outcomes of HIV-infected patients switched to second-line therapy[J]. China Tropical Medicine,2018,18(4):387-390.
[33]董玉连,农桂德,毛艳芳,等.广西钟山县艾滋病检测与治疗“一站式服务”模式效果[J].中国热带医学,2017,17(2):163-166.Dong YL,Nong GD,Mao YF,et al. Effectiveness of one-stop service model of HIV testing and treatment in Zhongshan,Guangxi Zhuang Autonomous Region[J]. China Tropical Medicine,2017,17(2):163-166.
[34] Celum C,Baeten JM.Tenofovir-based pre-exposure prophylaxis for HIV prevention:evolving evidence[J]. Curr Opin Infect Dis,2012,25(1):51-57.
[35] Sharma SC,Raison N,Khan S,et al. Male circumcision for the prevention of human immunodeficiency virus(HIV)acquisition:a meta-analysis[J]. BJU Int,2018,121(4):515-526.
[36] Manineng CM,MacLaren D,Baigry M,et al. Re-establishing safer medical-circumcision-integrated initiation ceremonies for HIV prevention in a rural setting in Papua New Guinea.A multimethod acceptability study[J]. PLoS One,2017,12(11):e0187577.
[37]罗皓,梁旭,陈坚,等.广西百色男性矿工包皮环切接受意愿的流行病学调查[J].中国医学科学院学报,2011,33(3):313-317.Luo H,Liang X,Chen J,et al. Acceptability of male circumcision among male miners in Baise of Guangxi[J]. Acta Academiae Medicinae Sinicae,2011,33(3):313-317.
[38]刘芳,郭美琼,张建霞,等.深圳市820例重点性病规范化治疗影响因素[J].中国热带医学,2017,17(2):156-159.Liu F,Guo MQ,Zhang JX,et al. Risk factors influencing standardized treatment of 820 patients with STD in Shenzhen[J].China Tropical Medicine,2017,17(2):156-159.
[2] Donnell D,Baeten JM,Kiarie J,et al. Heterosexual HIV-1transmission after initiation of antiretroviral therapy:a prospective cohort analysis[J]. Lancet,2010,375(9731):2092-2098.
[3] Zhang YJ,Feng XX,Fan YG,et al.HIV transmission and related risk factors among serodiscordant couples in Liuzhou,China[J].J Med Virol,2015,87(4):553-556.
[4] Cohen MS,Chen YQ,McCauley M,et al. Prevention of HIV-1infection with early antiretroviral therapy[J]. N Engl J Med,2011,365(6):493-505.
[5] Jia Z,Mao Y,Zhang F,et al. Antiretroviral therapy to prevent HIV transmission in serodiscordant couples in China(2003-11):a national observational cohort study[J].Lancet,2013,382(9899):1195-1203.
[6] Tang Z,Lan G,Chen YQ,et al. HIV-1 treatment-as-prevention:a cohort study analysis of serodiscordant couples in rural southwest China[J]. Medicine:Baltimore,2015,94(24):e902.
[7]陈琳,潘晓红,杨介者,等.浙江省2009-2013年单阳家庭配偶HIV血清学阳转率分析[J].中华流行病学杂志,2015,36(8):857-861.Chen L,Pan XH,Yang JZ,et al.Incidence rate of HIV transmission in HIV discordant couples in Zhejiang province,2009-2013[J]. Chin J Epidemiol,2015,36(8):857-861.
[8] Yang RR,Gui X,Xiong Y,et al. Five-year follow-up observation of HIV prevalence in serodiscordant couples[J]. Int J Infect Dis,2015,33:179-184.
[9]蔡月仙,余大年,刘仲昌,等.配偶间HIV性传播危险因素研究[J].中国热带医学,2015,15(4):430-433.Cai YX,Yu DN,Liu ZC,et al. Risk factors associated with HIV transmission between spouses in Taishan city[J].China Tropical Medicine,2015,15(4):430-433.
[10]曾刚,陈虹,李崇行,等.四川省凉山州艾滋病病毒感染者配偶感染状况调查[J].疾病监测,2010,25(6):461-463.Zeng G,Chen H,Li CX,et al. Survey on HIV-Infection of spouses of HIV infected persons in Liangshan autonomous prefecture,Sichuan province[J]. Disease Surveillance,2010,25(6):461-463.
[11]杨蓉蓉,桂希恩,熊勇,等.艾滋病单阳家庭配偶抗-人类免疫缺陷病毒阳转状况的5年随访分析[J].中华传染病杂志,2014,32(6):334-337.Yang RR,Gui XE,Xiong Y,et al. Analysis on sero-conversion status of human immunodeficiency virus-discordant spouse during5-year follow-up period[J]. Chin J Infect Dis,2014,32(6):334-337.
[12]张振开,邓燕,文小青,等.桂林市HIV感染者/病人配偶间HIV传播状况及影响因素的调查研究[J].中华疾病控制杂志,2012,16(2):127-129.Zhang ZK,Deng Y,Wen XQ,et al. The survey on HIV infection situations and influencing factors between spouses in Guilin city[J].Chin J Dis Control Prev,2012,16(2):127-129.
[13]毛宇嵘,郑锡文,潘承东,等.新疆伊宁市婚前体检者艾滋病病毒感染情况调查[J].中国预防医学杂志,2001,2(1):12-13.Mao YR,Zheng XW,Pan CD,et al. HIV prevalence among premarital couples in Yining city,Xinjiang[J]. Chin Prev Med,2001,2(1):12-13.
[14]叶润华,项丽芬,杨跃诚,等.云南省德宏州新报告艾滋病病毒感染者溯源调查[J].中华流行病学杂志,2010,31(1):39-42.Ye RH,Xiang LF,Yang YC,et al.Tracing the sources of newly reported HIV infections in Dehong prefecture of Yunnan province[J]. Chin J Epidemiol,2010,31(1):39-42.
[15] Copen CE. Condom use during sexual intercourse among women and men aged 15-44 in the United States:2011-2015 National survey of family growth[J]. Natl Health Stat Report,2017,105:1-18.
[16]濮永成,韩文香,段启祥,等.陇川县14个艾滋病单阳家庭阴性配偶HIV阳转的原因分析[J].中国艾滋病性病,2012,18(6):382-384.Pu YC,Han WX,Duan QX, et al.Causal analysis of HIV seroconversion among the fourteen HIV discordant families in Longchuan county,Yunnan province[J]. Chin J AIDS STD,2012,18(6):382-384.
[17] Dunkle KL,Stephenson R,Karita E,et al. New heterosexually transmitted HIV infections in married or cohabiting couples in urban Zambia and Rwanda:an analysis of survey and clinical data[J]. Lancet,2008,371(9631):2183-2191.
[18] Kumarasamy N,Venkatesh KK,Srikrishnan AK,et al.Risk factors for HIV transmission among heterosexual discordant couples in South India[J]. HIV Med,2010,11(3):178-186.
[19] Wall KM,Kilembe W,Vwalika B,et al.Sustained effect of couples′HIV counselling and testing on risk reduction among Zambian HIV serodiscordant couples[J].Sex Transm Infect,2017,93(4):259-266.
[20]明帅,王璐,葛增,等.河南省某市HIV单阳家庭阴性配偶抗体阳转情况[J].中华预防医学杂志,2013,47(4):337-341.Ming S,Wang L,Ge Z,et al. Sero-conversion of HIV seronegative partners among discordant couples in a city of Henan province[J].Chin J Prev Med,2013,47(4):337-341.
[21] Dou Z,Chen RY,Xu J,et al. Changing baseline characteristics among patients in the China National Free Antiretroviral Treatment Program,2002-09[J].Int J Epidemiol,2010,39Suppl 2:ii56-64.
[22] Ma Y,Zhao DC,Yu L,et al. Predictors of virologic failure in HIV-1-infected adults on first line antiretroviral therapy in eight provinces in China[J].Clin Infect Dis,2010,50(2):264-271.
[23] Zhang F,Dou Z,Ma Y,et al. Five-year outcomes of the China National Free Antiretroviral Treatment Program[J]. Ann Intern Med,2009,151(4):241-251,W-52.
[24] Paterson DL,Swindells S,Mohr J,et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection[J].Ann Intern Med,2000,133(1):21-30.
[25]朱萍. HIV感染者配偶艾滋病队列研究[D].上海:复旦大学,2012.Zhu P.Cohort study of HIV/AIDS among seronegative couples of HIV infected individuals[D]. Shanghai:Fudan University,2012.
[26]Johnson LF,Lewis DA. The effect of genital tract infections on HIV-1 shedding in the genital tract:a systematic review and metaanalysis[J]. Sex Transm Dis,2008,35(11):946-959.
[27]李健,汤后林,韩晶,等.中国5省份2011-2014年新发现HIV感染者检测阳性前配偶感染情况及影响因素分析[J].中华流行病学杂志,2016,37(11):1497-1502.Li J,Tang HL,Han J,et al. HIV transmission in newly reported HIV infected couples before diagnoses in five provinces,China,2011-2014[J]. Chin J Epidemiol,2016,37(11):1497-1502.
[28] Roxby AC,Ben-Youssef L,Marx G,et al.Dual contraceptive method use in HIV-serodiscordant Kenyan couples[J]. J Fam Plann Reprod Health Care,2016,42(4):264-270.
[29] Rojanapithayakorn W.The 100%condom use programme in Asia[J]. Reprod Health Matters,2006,14(28):41-52.
[30]邹惠英,刘丽红,黎明,等.深圳市龙岗区妊娠妇女艾滋病知晓率及感染状况调查[J].热带医学杂志,2017,17(2):240-243.Zou HY,Liu LH,Li M,et al. Investigation on awareness rate and infection status of AIDS among pregnant women in Longgang district of Shenzhen[J]. J Trop Med,2017,17(2):240-243.
[31] Anglemyer A,Rutherford GW,Baggaley RC,et al. Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples[J]. Cochrane Database Syst Rev,2011,(8):CD009153.
[32]曹丕,吴建军,苏斌,等.艾滋病患者更换二线抗病毒药物的治疗效果[J].中国热带医学,2018,18(4):387-390.Cao P,Wu JJ,Su B,et al. Treatment outcomes of HIV-infected patients switched to second-line therapy[J]. China Tropical Medicine,2018,18(4):387-390.
[33]董玉连,农桂德,毛艳芳,等.广西钟山县艾滋病检测与治疗“一站式服务”模式效果[J].中国热带医学,2017,17(2):163-166.Dong YL,Nong GD,Mao YF,et al. Effectiveness of one-stop service model of HIV testing and treatment in Zhongshan,Guangxi Zhuang Autonomous Region[J]. China Tropical Medicine,2017,17(2):163-166.
[34] Celum C,Baeten JM.Tenofovir-based pre-exposure prophylaxis for HIV prevention:evolving evidence[J]. Curr Opin Infect Dis,2012,25(1):51-57.
[35] Sharma SC,Raison N,Khan S,et al. Male circumcision for the prevention of human immunodeficiency virus(HIV)acquisition:a meta-analysis[J]. BJU Int,2018,121(4):515-526.
[36] Manineng CM,MacLaren D,Baigry M,et al. Re-establishing safer medical-circumcision-integrated initiation ceremonies for HIV prevention in a rural setting in Papua New Guinea.A multimethod acceptability study[J]. PLoS One,2017,12(11):e0187577.
[37]罗皓,梁旭,陈坚,等.广西百色男性矿工包皮环切接受意愿的流行病学调查[J].中国医学科学院学报,2011,33(3):313-317.Luo H,Liang X,Chen J,et al. Acceptability of male circumcision among male miners in Baise of Guangxi[J]. Acta Academiae Medicinae Sinicae,2011,33(3):313-317.
[38]刘芳,郭美琼,张建霞,等.深圳市820例重点性病规范化治疗影响因素[J].中国热带医学,2017,17(2):156-159.Liu F,Guo MQ,Zhang JX,et al. Risk factors influencing standardized treatment of 820 patients with STD in Shenzhen[J].China Tropical Medicine,2017,17(2):156-159.