微小RNA和长链非编码RNA介导的昼夜节律调控
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摘要
非编码RNA(ncRNA)是生物体细胞内一类重要的调控分子,其介导的昼夜节律调控日益受到研究者的重视。本文主要以黑腹果蝇Drosophila melanogaster和哺乳动物的相关研究为背景,阐述了微小RNA(miRNA)和长链非编码RNA(lncRNA)对昼夜节律的调控。miRNA介导的昼夜节律调控包括:生物体内(尤其是钟神经元中)具有节律性表达的miRNA;输入系统和miRNA存在相互调控,这主要是通过光照这个授时因子起作用;miRNA可直接调控核心振荡器,还可以调控其他基因而间接影响到核心振荡器;miRNA对输出系统的调控主要集中在代谢取食节律、运动节律、睡眠节律等。昼夜节律可调控lncRNA的表达,同时lncRNA也可调控昼夜节律,且lncRNA对基因调控范围广,作用机制复杂,这些都具有广阔的研究前景。本文将有助于进一步深入研究ncRNA对昼夜节律的调控。
Non-coding RNAs(ncRNAs) are a family of important regulatory molecules in organisms, and the regulation of circadian rhythms by ncRNAs has received increasing attention from researchers. In this article, we reviewed the regulation of circadian rhythms by microRNAs(miRNAs) and long-chain non-coding RNAs(lncRNAs) in the context of the related studies of Drosophila melanogaster and mammals. miRNA-mediated regulation of circadian rhythms includes: there are miRNAs with rhythmic expression in organisms, especially in clock neurons; the interaction between input systems and miRNAs mainly via the zeitgeber of light; miRNAs can directly regulate the core oscillator or indirectly affect the core oscillator by regulating other genes; and the regulation of miRNAs on the output system mainly focuses on metabolic feeding rhythms, locomotion rhythms, and sleep rhythms. The circadian rhythm and lncRNAs can regulate each other, and lncRNAs have a wide range of effects and complex mechanisms, which has broad research prospects. This article will be useful for further studies on the regulation of circadian rhythms by non-coding RNAs.
Non-coding RNAs(ncRNAs) are a family of important regulatory molecules in organisms, and the regulation of circadian rhythms by ncRNAs has received increasing attention from researchers. In this article, we reviewed the regulation of circadian rhythms by microRNAs(miRNAs) and long-chain non-coding RNAs(lncRNAs) in the context of the related studies of Drosophila melanogaster and mammals. miRNA-mediated regulation of circadian rhythms includes: there are miRNAs with rhythmic expression in organisms, especially in clock neurons; the interaction between input systems and miRNAs mainly via the zeitgeber of light; miRNAs can directly regulate the core oscillator or indirectly affect the core oscillator by regulating other genes; and the regulation of miRNAs on the output system mainly focuses on metabolic feeding rhythms, locomotion rhythms, and sleep rhythms. The circadian rhythm and lncRNAs can regulate each other, and lncRNAs have a wide range of effects and complex mechanisms, which has broad research prospects. This article will be useful for further studies on the regulation of circadian rhythms by non-coding RNAs.
引文
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Bu Y,Yoshida A,Chitnis N,Altman BJ,Tameire F,Oran A,Gennaro V,Armeson KE,McMahon SB,Wertheim GB,Dang CV,Ruggero D,Koumenis C,Fuchs SY,Diehl JA,2018.A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.Nat.Cell Biol.,20(1):104-115.
Chen W,Liu Z,Li T,Zhang R,Xue Y,Zhong Y,Bai W,Zhou D,Zhao Z,2014.Regulation of Drosophila circadian rhythms by miRNA let-7 is mediated by a regulatory cycle.Nat.Commun.,5:5549.
Chen X,Rosbash M,2016.mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression.Proc.Natl.Acad.Sci.USA,113(21):E2965-E2972.
Chen X,Rosbash M,2017.MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila.Nat.Commun.,8:14707.
Cheng HM,Papp JW,Varlamova O,Dziema H,Russell B,Curfman JP,Nakazawa T,Shimizu K,Okamura H,Impey S,Obrietan K,2007.microRNA modulation of circadian-clock period and entrainment.Neuron,54(5):813-829.
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Cui M,Zheng M,Sun B,Wang Y,Ye L,Zhang X,2015.A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis.Neoplasia,17(1):79-88.
Cusumano P,Biscontin A,Sandrelli F,Mazzotta GM,Tregnago C,De Pittà C,Costa R,2018.Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster.PLoS Genet.,14(7):e1007500.
Davis CJ,Bohnet SG,Meyerson JM,Krueger JM,2007.Sleep loss changes microRNA levels in the brain:a possible mechanism for state-dependent translational regulation.Neurosci.Lett.,422(1):68-73.
Davis CJ,Clinton JM,Krueger JM,2012.MicroRNA 138,let-7b,and 125a inhibitors differentially alter sleep and EEG delta-wave activity in rats.J.Appl.Physiol.,113(11):1756-1762.
Davis CJ,Clinton JM,Taishi P,Bohnet SG,Honn KA,Krueger JM,2011.MicroRNA 132 alters sleep and varies with time in brain.J.Appl.Physiol.,111(3):665-672.
Dubruille R,Murad A,Rosbash M,Emery P,2009.A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses.PLoS Genet.,5(12):e1000787.
Fan Z,Zhao M,Joshi PD,Li P,Zhang Y,Guo W,Xu Y,Wang H,Zhao Z,Yan J,2017.A class of circadian long non-coding RNAs mark enhancers modulating long-range circadian gene regulation.Nucleic Acids Res.,45(10):5720-5738.
Gao Q,Zhou L,Yang SY,Cao JM,2016.A novel role of microRNA 17-5p in the modulation of circadian rhythm.Sci.Rep.,6:30070.
Garaulet DL,Sun K,Li W,Wen J,Panzarino AM,O′Neil JL,Hiesinger PR,Young MW,Lai EC,2016.miR-124 regulates diverse aspects of rhythmic behavior in Drosophila.J.Neurosci.,36(12):3414-3421.
Gatfield D,Le Martelot G,Vejnar CE,Gerlach D,Schaad O,Fleury-Olela F,Ruskeep?? AL,Oresic M,Esau CC,Zdobnov EM,Schibler U,2009.Integration of microRNA miR-122 in hepatic circadian gene expression.Genes Dev.,23(11):1313-1326.
Goodwin PR,Meng A,Moore J,Hobin M,Fulga TA,Van Vactor D,Griffith LC,2018.MicroRNAs regulate sleep and sleep homeostasis in Drosophila.Cell Rep.,23(13):3776-3786.
Jonas S,Izaurralde E,2015.Towards a molecular understanding of microRNA-mediated gene silencing.Nat.Rev.Genet.,16(7):421-433.
Kadener S,Menet JS,Sugino K,Horwich MD,Weissbein U,Nawathean P,Vagin VV,Zamore PD,Nelson SB,Rosbash M,2009.A role for microRNAs in the Drosophila circadian clock.Genes Dev.,23(18):2179-2191.
Kojima S,Gatfield D,Esau CC,Green CB,2010.MicroRNA-122 modulates the rhythmic expression profile of the circadian deadenylase Nocturnin in mouse liver.PLoS ONE,5(6):e11264.
Ledford H,Callaway E,2017.Circadian clock scoop Nobel prize.Nature,550(7674):18.
Lee KH,Kim SH,Lee HR,Kim W,Kim DY,Shin JC,Yoo SH,Kim KT,2013.MicroRNA-185 oscillation controls circadian amplitude of mouse Cryptochrome 1 via translational regulation.Mol.Biol.Cell,24(14):2248-2255.
Luo W,Sehgal A,2012.Regulation of circadian behavioral output via a microRNA-JAK/STAT circuit.Cell,148(4):765-779.
Mendoza-Viveros L,Chiang CK,Ong JLK,Hegazi S,Cheng AH,Bouchard-Cannon P,Fana M,Lowden C,Zhang P,Bothorel B,Michniewicz MG,Magill ST,Holmes MM,Goodman RH,Simonneaux V,Figeys D,Cheng HM,2017.miR-132/212 modulates seasonal adaptation and dendritic morphology of the central circadian clock.Cell Rep.,19(3):505-520.
Na YJ,Sung JH,Lee SC,Lee YJ,Choi YJ,Park WY,Shin HS,Kim JH,2009.Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm.Exp.Mol.Med.,41(9):638-647.
Nagel R,Clijsters L,Agami R,2009.The miRNA-192/194 cluster regulates the Period gene family and the circadian clock.FEBS J.,276(19):5447-5455.
Nian X,Chen W,Bai W,Zhao Z,Zhang Y,2018.miR-263b controls circadian locomotor activity and the structural plasticity of small ventral lateral neurons by inhibition of Beadex.bioRxiv,doi:https://doi.org/10.1101/368043.
Oyama Y,Bartman CM,Gile J,Eckle T,2017.Circadian microRNAs in cardioprotection.Curr.Pharm.Des.,23(25):3723-3730.
Partch CL,Green CB,Takahashi JS,2014.Molecular architecture of the mammalian circadian clock.Trends Cell Biol.,24(2):90-99.
Pegoraro M,Tauber E,2018.Photoperiod-dependent expression of microRNA in Drosophila.bioRxiv,doi:https://doi.org/10.1101/464180.
Quinn JJ,Chang HY,2016.Unique features of long non-coding RNA biogenesis and function.Nat.Rev.Genet.,17(1):47-62.
Rinn JL,Kertesz M,Wang JK,Squazzo SL,Xu X,Brugmann SA,Goodnough LH,Helms JA,Farnham PJ,Segal E,Chang HY,2007.Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.Cell,129(7):1311-1323.
Sarachana T,Zhou R,Chen G,Manji HK,Hu VW,2010.Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines.Genome Med.,2(4):23.
Shende VR,Goldrick MM,Ramani S,Earnest DJ,2011.Expression and rhythmic modulation of circulating microRNAs targeting the clock gene Bmal1 in mice.PLoS ONE,6(7):e22586.
Shi L,Ko ML,Ko GY,2009.Rhythmic expression of microRNA-26a regulates the L-type voltage-gated calcium channel α1C subunit in chicken cone photoreceptors.J.Biol.Chem.,284(38):25791-25803.
Smith SS,Dole NS,Franceschetti T,Hrdlicka HC,Delany AM,2016.MicroRNA-433 Dampens glucocorticoid receptor signaling,impacting circadian rhythm and osteoblastic gene expression.J.Biol.Chem.,291(41):21717-21728.
Soshnev AA,Ishimoto H,McAllister BF,Li X,Wehling MD,Kitamoto T,Geyer PK,2011.A conserved long nocoding RNA affects sleep in Drosophila.Genetics,189(2):455-468.
Swingler TE,Horne R,Meng Q,Clark IM,2018.MicroRNA-455 is regulated in a circadian manner and targets a number of components of the circadian rhythm.Osteoarthr.Cartilage,26(Suppl.1):S164-S165.
Takahashi JS,2017.Transcriptional architecture of the mammalian circadian clock.Nat.Rev.Genet.,18(3):164-179.
The ENCODE Project Consortium,2012.An integrated encyclopedia of DNA elements in the human genome.Nature,489(7414):57-74.
Vodala S,Pescatore S,Rodriguez J,Buescher M,Chen YW,Weng R,Cohen SM,Rosbash M,2012.The oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs.Cell Metab.,16(5):601-612.
Wu S,Fesler A,Ju J,2016.Implications of circadian rhythm regulation by microRNAs in colorectal cancer.Cancer Transl.Med.,2(1):1-6.
Xu S,Witmer PD,Lumayag S,Kovacs B,Valle D,2007.MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster.J.Biol.Chem.,282(34):25053-25066.
Yang M,Lee JE,Padgett RW,Edery I,2008.Circadian regulation of a limited set of conserved microRNAs in Drosophila.BMC Genomics,9:83.
Yoo SH,Kojima S,Shimomura K,Koike N,Buhr ED,Furukawa T,Ko CH,Gloston G,Ayoub C,Nohara K,Reyes BA,Tsuchiya Y,Yoo OJ,Yagita K,Lee C,Chen Z,Yamazaki S,Green CB,Takahashi JS,2017.Period2 3′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.Proc.Natl.Acad.Sci.USA,114(42):E8855-E8864.
You S,Fulga TA,Van Vactor D,Jackson FR,2018.Regulation of circadian behavior by astroglial microRNAs in Drosophila.Genetics,208(3):1195-1207.
Zhang Y,Lamba P,Guo P,Emery P,2016.MiR-124 regulates the phase of Drosophila circadian locomotor behavior.J.Neurosci.,36(6):2007-2013.
Zhao X,Zhu X,Cheng S,Xie Y,Wang Z,Liu Y,Jiang Z,Xiao J,Guo H,Wang Y,2014.MiR-29a/b/c regulate human circadian gene hPER1 expression by targeting its 3′UTR.Acta Biochim.Biophys.Sin.,46(4):313-317.
Bartman CM,Oyama Y,Brodsky K,Khailova L,Walker L,Koeppen M,Eckle T,2017.Intense light-elicited upregulation of miR-21 facilitates glycolysis and cardioprotection through Per2-dependent mechanisms.PLoS ONE,12(4):e0176243.
Brown CJ,Ballabio A,Rupert JL,Lafreniere RG,Grompe M,Tonlorenzi R,Willard HF,1991.A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome.Nature,349(6304):38-44.
Bu Y,Yoshida A,Chitnis N,Altman BJ,Tameire F,Oran A,Gennaro V,Armeson KE,McMahon SB,Wertheim GB,Dang CV,Ruggero D,Koumenis C,Fuchs SY,Diehl JA,2018.A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.Nat.Cell Biol.,20(1):104-115.
Chen W,Liu Z,Li T,Zhang R,Xue Y,Zhong Y,Bai W,Zhou D,Zhao Z,2014.Regulation of Drosophila circadian rhythms by miRNA let-7 is mediated by a regulatory cycle.Nat.Commun.,5:5549.
Chen X,Rosbash M,2016.mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression.Proc.Natl.Acad.Sci.USA,113(21):E2965-E2972.
Chen X,Rosbash M,2017.MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila.Nat.Commun.,8:14707.
Cheng HM,Papp JW,Varlamova O,Dziema H,Russell B,Curfman JP,Nakazawa T,Shimizu K,Okamura H,Impey S,Obrietan K,2007.microRNA modulation of circadian-clock period and entrainment.Neuron,54(5):813-829.
Coon SL,Munson PJ,Cherukuri PF,Sugden D,Rath MF,M?ller M,Clokie SJ,Fu C,Olanich ME,Rangel Z,Werner T,NISC Coparative Sequencing Program,Mullikin JC,Klein DC,2012.Circadian changes in long noncoding RNAs in the pineal gland.Proc.Natl.Acad.Sci.USA,109(33):13319-13324.
Cui M,Zheng M,Sun B,Wang Y,Ye L,Zhang X,2015.A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis.Neoplasia,17(1):79-88.
Cusumano P,Biscontin A,Sandrelli F,Mazzotta GM,Tregnago C,De Pittà C,Costa R,2018.Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster.PLoS Genet.,14(7):e1007500.
Davis CJ,Bohnet SG,Meyerson JM,Krueger JM,2007.Sleep loss changes microRNA levels in the brain:a possible mechanism for state-dependent translational regulation.Neurosci.Lett.,422(1):68-73.
Davis CJ,Clinton JM,Krueger JM,2012.MicroRNA 138,let-7b,and 125a inhibitors differentially alter sleep and EEG delta-wave activity in rats.J.Appl.Physiol.,113(11):1756-1762.
Davis CJ,Clinton JM,Taishi P,Bohnet SG,Honn KA,Krueger JM,2011.MicroRNA 132 alters sleep and varies with time in brain.J.Appl.Physiol.,111(3):665-672.
Dubruille R,Murad A,Rosbash M,Emery P,2009.A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses.PLoS Genet.,5(12):e1000787.
Fan Z,Zhao M,Joshi PD,Li P,Zhang Y,Guo W,Xu Y,Wang H,Zhao Z,Yan J,2017.A class of circadian long non-coding RNAs mark enhancers modulating long-range circadian gene regulation.Nucleic Acids Res.,45(10):5720-5738.
Gao Q,Zhou L,Yang SY,Cao JM,2016.A novel role of microRNA 17-5p in the modulation of circadian rhythm.Sci.Rep.,6:30070.
Garaulet DL,Sun K,Li W,Wen J,Panzarino AM,O′Neil JL,Hiesinger PR,Young MW,Lai EC,2016.miR-124 regulates diverse aspects of rhythmic behavior in Drosophila.J.Neurosci.,36(12):3414-3421.
Gatfield D,Le Martelot G,Vejnar CE,Gerlach D,Schaad O,Fleury-Olela F,Ruskeep?? AL,Oresic M,Esau CC,Zdobnov EM,Schibler U,2009.Integration of microRNA miR-122 in hepatic circadian gene expression.Genes Dev.,23(11):1313-1326.
Goodwin PR,Meng A,Moore J,Hobin M,Fulga TA,Van Vactor D,Griffith LC,2018.MicroRNAs regulate sleep and sleep homeostasis in Drosophila.Cell Rep.,23(13):3776-3786.
Jonas S,Izaurralde E,2015.Towards a molecular understanding of microRNA-mediated gene silencing.Nat.Rev.Genet.,16(7):421-433.
Kadener S,Menet JS,Sugino K,Horwich MD,Weissbein U,Nawathean P,Vagin VV,Zamore PD,Nelson SB,Rosbash M,2009.A role for microRNAs in the Drosophila circadian clock.Genes Dev.,23(18):2179-2191.
Kojima S,Gatfield D,Esau CC,Green CB,2010.MicroRNA-122 modulates the rhythmic expression profile of the circadian deadenylase Nocturnin in mouse liver.PLoS ONE,5(6):e11264.
Ledford H,Callaway E,2017.Circadian clock scoop Nobel prize.Nature,550(7674):18.
Lee KH,Kim SH,Lee HR,Kim W,Kim DY,Shin JC,Yoo SH,Kim KT,2013.MicroRNA-185 oscillation controls circadian amplitude of mouse Cryptochrome 1 via translational regulation.Mol.Biol.Cell,24(14):2248-2255.
Luo W,Sehgal A,2012.Regulation of circadian behavioral output via a microRNA-JAK/STAT circuit.Cell,148(4):765-779.
Mendoza-Viveros L,Chiang CK,Ong JLK,Hegazi S,Cheng AH,Bouchard-Cannon P,Fana M,Lowden C,Zhang P,Bothorel B,Michniewicz MG,Magill ST,Holmes MM,Goodman RH,Simonneaux V,Figeys D,Cheng HM,2017.miR-132/212 modulates seasonal adaptation and dendritic morphology of the central circadian clock.Cell Rep.,19(3):505-520.
Na YJ,Sung JH,Lee SC,Lee YJ,Choi YJ,Park WY,Shin HS,Kim JH,2009.Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm.Exp.Mol.Med.,41(9):638-647.
Nagel R,Clijsters L,Agami R,2009.The miRNA-192/194 cluster regulates the Period gene family and the circadian clock.FEBS J.,276(19):5447-5455.
Nian X,Chen W,Bai W,Zhao Z,Zhang Y,2018.miR-263b controls circadian locomotor activity and the structural plasticity of small ventral lateral neurons by inhibition of Beadex.bioRxiv,doi:https://doi.org/10.1101/368043.
Oyama Y,Bartman CM,Gile J,Eckle T,2017.Circadian microRNAs in cardioprotection.Curr.Pharm.Des.,23(25):3723-3730.
Partch CL,Green CB,Takahashi JS,2014.Molecular architecture of the mammalian circadian clock.Trends Cell Biol.,24(2):90-99.
Pegoraro M,Tauber E,2018.Photoperiod-dependent expression of microRNA in Drosophila.bioRxiv,doi:https://doi.org/10.1101/464180.
Quinn JJ,Chang HY,2016.Unique features of long non-coding RNA biogenesis and function.Nat.Rev.Genet.,17(1):47-62.
Rinn JL,Kertesz M,Wang JK,Squazzo SL,Xu X,Brugmann SA,Goodnough LH,Helms JA,Farnham PJ,Segal E,Chang HY,2007.Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.Cell,129(7):1311-1323.
Sarachana T,Zhou R,Chen G,Manji HK,Hu VW,2010.Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines.Genome Med.,2(4):23.
Shende VR,Goldrick MM,Ramani S,Earnest DJ,2011.Expression and rhythmic modulation of circulating microRNAs targeting the clock gene Bmal1 in mice.PLoS ONE,6(7):e22586.
Shi L,Ko ML,Ko GY,2009.Rhythmic expression of microRNA-26a regulates the L-type voltage-gated calcium channel α1C subunit in chicken cone photoreceptors.J.Biol.Chem.,284(38):25791-25803.
Smith SS,Dole NS,Franceschetti T,Hrdlicka HC,Delany AM,2016.MicroRNA-433 Dampens glucocorticoid receptor signaling,impacting circadian rhythm and osteoblastic gene expression.J.Biol.Chem.,291(41):21717-21728.
Soshnev AA,Ishimoto H,McAllister BF,Li X,Wehling MD,Kitamoto T,Geyer PK,2011.A conserved long nocoding RNA affects sleep in Drosophila.Genetics,189(2):455-468.
Swingler TE,Horne R,Meng Q,Clark IM,2018.MicroRNA-455 is regulated in a circadian manner and targets a number of components of the circadian rhythm.Osteoarthr.Cartilage,26(Suppl.1):S164-S165.
Takahashi JS,2017.Transcriptional architecture of the mammalian circadian clock.Nat.Rev.Genet.,18(3):164-179.
The ENCODE Project Consortium,2012.An integrated encyclopedia of DNA elements in the human genome.Nature,489(7414):57-74.
Vodala S,Pescatore S,Rodriguez J,Buescher M,Chen YW,Weng R,Cohen SM,Rosbash M,2012.The oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs.Cell Metab.,16(5):601-612.
Wu S,Fesler A,Ju J,2016.Implications of circadian rhythm regulation by microRNAs in colorectal cancer.Cancer Transl.Med.,2(1):1-6.
Xu S,Witmer PD,Lumayag S,Kovacs B,Valle D,2007.MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster.J.Biol.Chem.,282(34):25053-25066.
Yang M,Lee JE,Padgett RW,Edery I,2008.Circadian regulation of a limited set of conserved microRNAs in Drosophila.BMC Genomics,9:83.
Yoo SH,Kojima S,Shimomura K,Koike N,Buhr ED,Furukawa T,Ko CH,Gloston G,Ayoub C,Nohara K,Reyes BA,Tsuchiya Y,Yoo OJ,Yagita K,Lee C,Chen Z,Yamazaki S,Green CB,Takahashi JS,2017.Period2 3′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.Proc.Natl.Acad.Sci.USA,114(42):E8855-E8864.
You S,Fulga TA,Van Vactor D,Jackson FR,2018.Regulation of circadian behavior by astroglial microRNAs in Drosophila.Genetics,208(3):1195-1207.
Zhang Y,Lamba P,Guo P,Emery P,2016.MiR-124 regulates the phase of Drosophila circadian locomotor behavior.J.Neurosci.,36(6):2007-2013.
Zhao X,Zhu X,Cheng S,Xie Y,Wang Z,Liu Y,Jiang Z,Xiao J,Guo H,Wang Y,2014.MiR-29a/b/c regulate human circadian gene hPER1 expression by targeting its 3′UTR.Acta Biochim.Biophys.Sin.,46(4):313-317.