银-铜/还原氧化石墨烯修饰的玻碳电极测定当归中的阿魏酸
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摘要
目的探讨阿魏酸在银-铜双金属/还原氧化石墨烯复合材料修饰的玻碳电极上的电化学行为。方法通过置换反应合成银-铜双金属纳米颗粒,以还原氧化石墨烯为载体负载银-铜双金属纳米颗粒并修饰在玻碳电极上,应用差分脉冲伏安法研究当归中阿魏酸的电化学行为。结果阿魏酸在pH 5.96的B-R缓冲溶液中,在银-铜双金属/还原氧化石墨烯修饰的玻碳电极上于0.30 V时产生1个稳定的还原峰,峰电流与阿魏酸浓度在0.103～8.24μmol/L范围内呈良好的线性关系,检测限为0.033μmol/L(S/N=3)。结论阿魏酸在银-铜双金属/还原氧化石墨烯复合材料修饰的玻碳电极上有较好的电化学行为,响应快,灵敏度高,峰形好,可用于测定当归中的阿魏酸。
Objective To investigate the electrochemical behavior of ferulic acid by a glassy carbon electrode modified with silver-copper bimetal/reduced graphene oxide composite(Ag-Cu/rGO). Methods Silver-copper bimetallic nanoparticles(Ag-Cu) were synthesized by the displacement reaction and Ag-Cu was loaded on the reduced graphene oxide(rGO), and then Ag-Cu/rGO was modified on the glassy carbon electrode(GCE) to study the electrochemical behavior of ferulic acid in Angelica sinensis by differential pulse voltammetry. Results Ferulic acid had a stable reduction peak at 0.30 V in pH 5.96 Britton-Robinson buffer solution at the Ag-Cu@rGO/GCE, and the reduction peak current was linear with the ferulic acid concentration in the range of 0.103-8.24 μmol/L, and the detection limit was 0.033 μmol/L(S/N=3). Conclusion Ferulic acid had good electrochemical behavior at the Ag-Cu@rGO/GCE with fast response, high sensitivity and well peak shape, and the modified electrode can be used to determine ferulic acid in Angelica sinensis.
Objective To investigate the electrochemical behavior of ferulic acid by a glassy carbon electrode modified with silver-copper bimetal/reduced graphene oxide composite(Ag-Cu/rGO). Methods Silver-copper bimetallic nanoparticles(Ag-Cu) were synthesized by the displacement reaction and Ag-Cu was loaded on the reduced graphene oxide(rGO), and then Ag-Cu/rGO was modified on the glassy carbon electrode(GCE) to study the electrochemical behavior of ferulic acid in Angelica sinensis by differential pulse voltammetry. Results Ferulic acid had a stable reduction peak at 0.30 V in pH 5.96 Britton-Robinson buffer solution at the Ag-Cu@rGO/GCE, and the reduction peak current was linear with the ferulic acid concentration in the range of 0.103-8.24 μmol/L, and the detection limit was 0.033 μmol/L(S/N=3). Conclusion Ferulic acid had good electrochemical behavior at the Ag-Cu@rGO/GCE with fast response, high sensitivity and well peak shape, and the modified electrode can be used to determine ferulic acid in Angelica sinensis.
引文
[1] 胡益勇,徐晓玉.阿魏酸的化学和药理研究进展[J].中成药,2006,28(2):253-255.
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[7] 刘娟秀,罗益远,刘训红,等.毛细管电泳同时测定苍耳类药材中7种酚酸类成分的含量[J].中国药学杂志,2015,50(4):366-370.
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[12] 翟秋阁,朱建君,杨婧婧,等.石墨烯/铜-银合金复合膜修饰玻碳电极同时测定鸟嘌呤和腺嘌呤[J].信阳师范学院学报(自然科学版),2014,27(4):542-546.
[13] 马瑜,丁古巧.石墨烯金属基复合材料研究进展[J].电子元件与材料,2017,36(9):75-78.
[14]李勇,赵亚茹,李焕,等.石墨烯增强金属基复合材料的研究进展[J].材料导报,2016,30(6):71-75.
[15]王小凤,黄自力,张海军.双金属纳米颗粒的制备方法[J].稀有金属材料与工程,2013,42(8):1751-1755.
[16] GUO Zhou,LI Dongdi,LUO Xianke,et al.Simultaneous determination of trace Cd ( II ),Pb ( II ) and Cu ( II ) by differential pulse anodic stripping voltammetry using a reduced graphene oxide chitosan/poly-L-lysine nanocomposite modified glassy carbon electrode[J].Colloid Interface Sci,2016,490:11-22.
[17] 林彤.HPLC法测定当归鸡精中阿魏酸的含量[J].中成药,2002,24(2):148-150.
[18] 赖木深,朱明芳,叶鸿清.ZnS量子点修饰的玻碳电极电化学法测定废水中的磺胺二甲嘧啶[J].广东药科大学学报,2018,34(4):425-429.
[2] 梁红冬.阿魏酸的合成及抗氧化性能的研究[J].化学与生物工程,2012,29(1):60-62.
[3] 叶喜德,李旭冉,念凤鸿,于欢,钟凌云,王军,占义泽,龚千锋.不同炮制方法对当归中阿魏酸含量的影响[J].今日药学,2018,28(1):28-30,38.
[4] 赵东平,杨文钰,陈兴福.阿魏酸的研究进展[J].时珍国医国药,2008,19(8):1839-1841.
[5] 顾志荣,陈晖,王亚丽,等.不同生长环境当归药材薄层色谱鉴别研究[J].时珍国医国药,2014,25(9):2164-2166.
[6] 刘敏,杨全伟,刘新国,等.高效液相色谱法测定舒肝颗粒中黄芩苷和阿魏酸的含量[J].中国医院药学杂志,2017,37(9):878-880.
[7] 刘娟秀,罗益远,刘训红,等.毛细管电泳同时测定苍耳类药材中7种酚酸类成分的含量[J].中国药学杂志,2015,50(4):366-370.
[8] 华永丽,郭延生,曲亚玲,等.荧光分光光度法测定当归中阿魏酸含量[J].中兽医医药杂志,2010,29(4):31-32.
[9] ABDEL-HAMID R,NEWAIR E.Voltammetric determination of ferulic acid using polypyrrole-multiwalled carbon nanotubes modified electrode with sample application[J].Nanomaterials,2015,5:1704-1715.
[10] 刘琳,陶凯丽,李雪,等.阿魏酸在纳米金/石墨烯修饰电极上的电化学行为及其测定[J].扬州大学学报(自然科学版),2017,20(2):31-36.
[11] 牛亚楠,龙宁,朱明芳,等.碳糊电极阴极溶出伏安法测定当归中阿魏酸[J].理化检验 (化学分册),2012,48(5):512-515.
[12] 翟秋阁,朱建君,杨婧婧,等.石墨烯/铜-银合金复合膜修饰玻碳电极同时测定鸟嘌呤和腺嘌呤[J].信阳师范学院学报(自然科学版),2014,27(4):542-546.
[13] 马瑜,丁古巧.石墨烯金属基复合材料研究进展[J].电子元件与材料,2017,36(9):75-78.
[14]李勇,赵亚茹,李焕,等.石墨烯增强金属基复合材料的研究进展[J].材料导报,2016,30(6):71-75.
[15]王小凤,黄自力,张海军.双金属纳米颗粒的制备方法[J].稀有金属材料与工程,2013,42(8):1751-1755.
[16] GUO Zhou,LI Dongdi,LUO Xianke,et al.Simultaneous determination of trace Cd ( II ),Pb ( II ) and Cu ( II ) by differential pulse anodic stripping voltammetry using a reduced graphene oxide chitosan/poly-L-lysine nanocomposite modified glassy carbon electrode[J].Colloid Interface Sci,2016,490:11-22.
[17] 林彤.HPLC法测定当归鸡精中阿魏酸的含量[J].中成药,2002,24(2):148-150.
[18] 赖木深,朱明芳,叶鸿清.ZnS量子点修饰的玻碳电极电化学法测定废水中的磺胺二甲嘧啶[J].广东药科大学学报,2018,34(4):425-429.
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