4A沸石对海藻酸钠/壳聚糖微球性能的影响
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摘要
以壳聚糖和海藻酸钠为载体、4A沸石为性能改良剂,采用锐孔法制备了4A沸石/海藻酸钠/壳聚糖复合微球,利用显微镜、SEM、FTIR和XRD对复合微球进行了表征,考察了4A沸石对复合微球成球率和溶胀性能的影响。结果表明:随着4A沸石添加量的增加,复合微球的质量和粒径均增大,添加4A沸石有利于复合微球成球,成球率最高为98.5%(添加4A沸石1 g),且冷冻干燥后微球具有均匀的粒径和规则的球形形状。在不同pH(3、5、7)和温度下,4A沸石能有效抑制微球的过度溶胀,但仍然保持良好的pH和温度敏感性。
4 A zeolite/sodium alginate/chitosan composite microspheres were prepared by piercing method using chitosan and sodium alginate as carrier material and 4 A zeolite as performance modifier. The microspheres were characterized by microscope, SEM, FTIR and XRD. The effect of addition amount of4 A zeolite on the granulation rate and swelling properties of composite microspheres was investigated. The results showed that the mass and particle size of composite microspheres increased as the addition amount of 4 A zeolite increased. The addition of 4 A zeolite was beneficial to the formation of composite microspheres, and the highest percentage of granulation rate reached 98.5%(4 A zeolite usage amount was1 g). In addition, the freeze-dried composite microspheres had a uniform size distribution and regular spherical shape. Under different pH value and temperature conditions, 4 A zeolite could not only effectively inhibit the swelling of microspheres, but also make the composite microspheres remain good pH and temperature sensitivity.
4 A zeolite/sodium alginate/chitosan composite microspheres were prepared by piercing method using chitosan and sodium alginate as carrier material and 4 A zeolite as performance modifier. The microspheres were characterized by microscope, SEM, FTIR and XRD. The effect of addition amount of4 A zeolite on the granulation rate and swelling properties of composite microspheres was investigated. The results showed that the mass and particle size of composite microspheres increased as the addition amount of 4 A zeolite increased. The addition of 4 A zeolite was beneficial to the formation of composite microspheres, and the highest percentage of granulation rate reached 98.5%(4 A zeolite usage amount was1 g). In addition, the freeze-dried composite microspheres had a uniform size distribution and regular spherical shape. Under different pH value and temperature conditions, 4 A zeolite could not only effectively inhibit the swelling of microspheres, but also make the composite microspheres remain good pH and temperature sensitivity.
引文
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[28]Yan Jia(阎佳).Application of 4A-Zeolite in detergent and its prospect[J].Shan Dong Chemical Industry(山东化工),2010,39(1):24-26.
[29]Wen Yan(闻燕),Yang ZhiHui(杨智慧).Effect of pH value on swelling behavior of carboxymethyl chitosan and sodium alginate hydrogels[J].Journal of Tianjin University of Commerce(天津商业大学学报),2007,27(6):12-16.
[30]Huang Zhenghua(黄正华),Cao Yanping(曹雁平),Xu Duoxia(许朵霞),et al.The effects of gelling conditions on chitosan alginate gel rigidity[J].Journal of Chinese Institute of Food Science and Technology(中国食品学报),2015,15(2):163-167.
[31]Yu Yueqin(于跃芹),Xu Yang(许洋),Li Yanshun(李延顺).Synthesis and characterization of hydrogels cross-linked by N-Maleyl chitosan(N-MACH)[J].Polymer Materials Science&Engineering(高分子材料科学与工程),2010,25(7):133-135,139.
[2]Wang E L,Wang X L,Wang K Y,et al.Preparation,characterization and evaluation of the immune effect of alginate/chitosan composite microspheres encapsulating recombinant protein of Streptococcus iniae designed for fish oral vaccination[J].Fish and Shellfish Immunology,2018,73:262-271.
[3]Shi Zhanping(史占萍),Shi Mai(史迈),Zhang Wenhui(张文慧),et al.Preparation,characterization and toxicological analysis of alginatephospholipid vesicle composite hydrogels[J].Chemcial Journal of Chinese Uiversities(高等学校化学学报),2017,38(7):1270-1277.
[4]Zeinab A,Moosa S,Mohammad B,et al.Achillea millefolium essential oil and chitosan nanocapsules with enhanced activity against tetranychus urticae[J].Journal of Pest Science,2018,91:837-848.
[5]Xu Qunna(徐群娜),Fan Qianqian(范倩倩),Ma Jianzhong(马建中),et al.Recent advances in preparation and application of chitosan-based nanocapsules[J].Materials Review(材料导报),2015,29(1):81-85,91.
[6]Hu Yongli(胡永利),Zhang Shuping(张淑平).Progress in preparation and application of sodium alginate antibacterial materials[J].Chemical Industry and Engineering Progress(化工进展),2016,35(4):1126-1131.
[7]Wu Huiling(吴慧玲),Zhang Shuping(张淑平).Progress in the application of sodium alginate/nanomaterial composites[J].Chemical Industry and Engineering Progress(化工进展),2014,33(4):954-959.
[8]Xu Jun(徐军),Zhou HongJun(周红军),Zhou XinHua(周新华),et al.Preparation characterization and slow-release of chlorpyrifos/cationic modified chitosan/sodium alginate microspheres[J].Jiangsu Agricultural Sciences(江苏农业科学),2018,46(7):108-111.
[9]Wu Wenguo(吴文果),Liu Wei(刘伟),Wang Shibin(王士斌),et al.Drug loading and release of poly-L-arginine/calcium alginate microcapsules[J].Chemical Industry and Engineering Progress(化工进展),2014,33(5):1271-1275.
[10]Zhou Mingsong(周明松),Liu Qingfang(刘庆芳),Wang Suya(王素雅),et al.Preparation of avermectin microcapsules by electrostatic self-assembly method[J].Fine Chemicals(精细化工),2017,34(5):519-524.
[11]Menger F M,Migulin V A.Synthesis and properties of multiarmed Geminis[J].Journal of Organic Chemistry,1999,64(24):8916-8921.
[12]Max G,Ruth F,Heinz U.Dispersing and wetting agents for use in organic biocides:AU5112873[P].1974-07-18.
[13]Fernándezquiroz D,Gonzálezgómezá,Lizardimendoza J,et al.Effect of the molecular architecture on the thermosensitive properties of chitosan-g-poly(N-vinylcaprolactam)[J].Carbohydrate Polymers,2015,134(2):92-101.
[14]Zhang Yongli(张永利),Li Jiacheng(李嘉诚),Yan Huiqiong(颜慧琼),et al.Effect of modified montmorillonite on structure of drugloading sodium alginate gel microspheres and drug release properties[J].Journal of the Chinese Ceramic Society(硅酸盐学报),2015,(11):1663-1670.
[15]Yan Huiqiong(颜慧琼),Li Jiacheng(李嘉诚),Feng Yuhong(冯玉红),et al.Influence of bentonite on the performance of sodium alginate-chitosan hydrogel beads[J].Fine Chemicals(精细化工),2013,30(2):121-125.
[16]Xu Tingting(徐婷婷),Li Zhifang(李治方),Wu Jie(吴洁),et al.Investigation on the preparation and characterization of palygorskite/sodium alginate composite microspheres for the sustained releasing of Cu2+[J].Chemical Industry and Engineering Progress(化工进展),2013,32(2):410-413.
[17]Xin Lulu(辛露露),Li Fujun(李付军),Xue Fei(薛飞),et al.Preparation and properties of allicin/sodium alginate/gelatin/chitosan composite microspheres[J].Chemical Industry and Engineering Progress(化工进展),2017,(10):3826-3831.
[18]Nesam J M.The zeolite cage structure[J].Science,1986,231(4742):1093-1099.
[19]Jin Dong(金栋).Synthesis application and development prospect of zeolite 4A[J].Fine Chemical Industrial Raw Materials&Intermediates(精细化工原料及中间体),2011(1):23-27.
[20]Zhao Yongjie(赵永杰),Li Jun(李俊).Development in manufatcure and application of 4A zeolite[J].China Surfactant Detergent&Cosmetics(日用化学工业),2009,39(6):417-422.
[21]Li Jun(李军),Liu Yandong(刘延东).Properties and applications of4A zeolite molecular sieves[J].China Cleaning Industry(中国洗涤用品工业),2013,(6):21-23.
[22]Chen Liezhong(陈列忠),Chen Jianming(陈建明),Zhao Min(赵敏),et al.Microcapsulating and control efficacy of chlorpyrifos betacypermethrin on grubs(Anomala corpulenta)[J].Chinese Journal of Pesticide Science(农药学学报),2009,11(4):487-492.
[23]Xin Lulu(辛露露),Zhang Yu(张雨),Liu Baochuan(刘宝传),et al.Preparation and release behavior of avermectin microspheres[J].Fine Chemicals(精细化工),2018(4):653-656.
[24]Han Xiaona(韩晓娜),Huang Guoqing(黄国清),Xiao Junxia(肖军霞).Preparation of O-carboxymethyl chitosan/sodium alginate hydrogel beads and the effect of degree of substitution of O-carboxymethyl on the swelling properties of the beads[J].Journal of Chinese Institute of Food Science and Technology(中国食品学报),2014,14(10):67-74.
[25]Jin Lanshu(金兰淑),Gao Xiangqi(高湘骐),Liu Yang(刘洋),et al.Removal of Pb2+,Cu2+and Cd2+from composite pollution aqueous solution by zeolite 4A[J].Chinese Journal of Environmental Engineering(环境工程学报),2012,6(5):1599-1603.
[26]Ravikiran N,Swapna C,Navateja A,et al.Synthesis and characterization reduced-graphene oxide/TiO2/Zeolite-4A:Abifunctional nanocomposite for abatement of methylene blue[J].Materials Design,2015,86:621-626.
[27]Han Shuyun(韩淑芸),Gao Jinfeng(高金锋),Ji Lei(纪雷).Studies on the synthesis,structure and properties of 4A zeolite molecular sieve[J].Journal of QingDao University(青岛大学学报),1997,10(3):31-36.
[28]Yan Jia(阎佳).Application of 4A-Zeolite in detergent and its prospect[J].Shan Dong Chemical Industry(山东化工),2010,39(1):24-26.
[29]Wen Yan(闻燕),Yang ZhiHui(杨智慧).Effect of pH value on swelling behavior of carboxymethyl chitosan and sodium alginate hydrogels[J].Journal of Tianjin University of Commerce(天津商业大学学报),2007,27(6):12-16.
[30]Huang Zhenghua(黄正华),Cao Yanping(曹雁平),Xu Duoxia(许朵霞),et al.The effects of gelling conditions on chitosan alginate gel rigidity[J].Journal of Chinese Institute of Food Science and Technology(中国食品学报),2015,15(2):163-167.
[31]Yu Yueqin(于跃芹),Xu Yang(许洋),Li Yanshun(李延顺).Synthesis and characterization of hydrogels cross-linked by N-Maleyl chitosan(N-MACH)[J].Polymer Materials Science&Engineering(高分子材料科学与工程),2010,25(7):133-135,139.