血管紧张素Ⅱ引起高血压的分子机制研究进展
摘要
高血压发生率高,我国高血压人口超过2.5亿,高血压及其并发症已占全球死亡原因的首位。高血压及相关机制的研究,对于其防治具有重要意义。最新研究表明血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)升高,血管紧张素1型(angiotensin receptor 1,AT1)受体上调,是造成高血压状态的关键因素。本文就这一领域分子机制研究的最新进展做一阐述,旨在梳理出高血压防治的新思路和药物新靶点。
引文
1 Lackland DT,Weber MA.Global burden of cardiovascular disease and stroke:hypertension at the core[J].Canadian J Cardiol,2015,31(5):569-571
2 Poulter NR,Prabhakaran D,Caulfield M.Hypertension[J].Lancet,2015,386(9995):801-812
3 Campbell NR,Lackland DT,Lisheng L,et al.Using the global burden of disease study to assist development of nation-specific fact sheets to promote prevention and control of hypertension and reduction in dietary salt:a resource from the World Hypertension League[J].JClini Hypert,2015,17(3):165-167
4 Norihiro K,Marie T,Fumihiko L,et al.Trans-ancestry genomewide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation[J].Natu Genet,2015,47(11):1282-1293
5唐家荣.难治性高血压集多重继发性病因和合并症于一体[J].中华高血压杂志,2014,22(11):1013-1014
6 Ruhs S,Strtz N,Quarch K,et al.Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2[J].Sci Rep,2017,7(1):15340
7 Sparks MA,Stegbauer J,Chen D,et al.Vascular type 1A angiotensin II receptors control BP by regulating renal blood flow and urinary sodium excretion[J].J Ame Soc Nephrol:2015,26(12):2953-2962
8 Poduri A,Rateri DL,Howatt DA,et al.Fibroblast angiotensin II type1a receptors contribute to angiotensin II-induced medial hyperplasia in the ascending aorta[J].Arteriosclerosis Thromb Vascul Biol,2015,35(9):1995-2002
9姜莹,王暘,张卉蕾,等.血管紧张素Ⅱ1型受体相关蛋白研究进展[J].现代生物医学进展,2017,17(11):2178-2180
10 Jung MH,Sung JY,Young WK,et al.Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1[J].Biochem Biophys Res Commun,2015,464(1):57-62
11 Montezano AC,Nguyen Dinh Cat A,Rios FJ,Touyz RM.Angiotensin II and vascular injury[J].Curr Hypert Rep,2014,16(6):431-436
12程茹,傅继华.外周5-羟色胺在动脉粥样硬化中的作用研究进展[J].药学研究,2017,36(5):283-286
13 Hu C,Rusin CG,Tan Z,et al.Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electricaloscillators[J].J Clin Invest,2012,122(6):2046-2053
14 Felizola SJ,Maekawa T,Nakamura Y,et al.Voltage-gated calcium channels in the human adrenal and primary aldosteronism[J].J Steroid Bioche Mol Biol,2014,144(part B):410-416
15 Matsuda K,Uruno A,Kogure N,et al.Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295Rcells[J].Mol Cell Endocrinol,2014,383(1-2):60-68
16 Maharjan S,Mopidevi B,Kaw MK.Human aldosterone synthase gene polymorphism promotes mi RNA binding and regulates gene expression[J].Physiol Genom,2014,46(24):860-865
17刘光霞,赵连春,卢亚敏.代谢综合征患者血清肾素-血管紧张素-醛固酮水平及临床意义[J].解放军医药杂志,2016,28(12):80-82
18 Carmichael CY,Wainford RD.Impact of global versus renal-specific sympathoinhibition in aldosterone-induced hypertension:implications for medical device-based treatment of resistant hypertension[J].Hypertension,2015,65(6):1160-1172
19 Pojoga LH,Yao TM,Opsasnick LA,et al.Cooperative role of mineralocorticoid receptor and caveolin-1 in regulating the vascular response to low nitric oxide-high angiotensin II-induced cardiovascular injury[J].J Pharmacol Exp Therapeut,2015,355(1):32-47
20 Mizuno M,Downey RM,Mitchell JH,et al.Aldosterone and salt loading independently exacerbate the exercise pressor reflex in rats[J].Hypertension,2015,66(3):627-633
21 Shen XZ,Li Y,Li L,et al.Microglia participate in neurogenic regulation of hypertension[J].Hypertension,2015,66(2):309-316
22 Bardgett ME,Holbein WW,Herrera-Rosales M,Toney GM.Ang II-salt hypertension depends on neuronal activity in the hypothalamic paraventricular nucleus but not on local actions of tumor necrosis factor-α[J].Hypertension,2014,63(3):527-534
23熊梅梅,吕柳青,肖红波,等.高糖和血管紧张素Ⅱ对人肾小管上皮细胞Toll样受体4信号表达及炎性和纤维化因子的影响[J].中华肾脏病杂志,2016,32(1):43-49
24陈剑伟,夏印,王烈.肾素-血管紧张素系统与静脉移植术后内膜增生的研究进展[J].血管与腔内血管外科杂志,2017,3(1):622-628
25王晶晶,梁广彬,邓凡,等.血管紧张素转化酶2-血管紧张素(1-7)-Mas轴在心血管和神经系统的作用[J].中国医学创新,2015,36:143-146
26熊力,王南丽.肾素-血管紧张素-醛固酮系统与心血管病的研究进展[J].中国循证心血管医学杂志,2013,5(2):203-205
27解家平,李惠勉.老年人血管紧张素Ⅱ受体高敏的潜在机制---附2例病例报道[J].中华高血压杂志,2017,7:695-697
2 Poulter NR,Prabhakaran D,Caulfield M.Hypertension[J].Lancet,2015,386(9995):801-812
3 Campbell NR,Lackland DT,Lisheng L,et al.Using the global burden of disease study to assist development of nation-specific fact sheets to promote prevention and control of hypertension and reduction in dietary salt:a resource from the World Hypertension League[J].JClini Hypert,2015,17(3):165-167
4 Norihiro K,Marie T,Fumihiko L,et al.Trans-ancestry genomewide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation[J].Natu Genet,2015,47(11):1282-1293
5唐家荣.难治性高血压集多重继发性病因和合并症于一体[J].中华高血压杂志,2014,22(11):1013-1014
6 Ruhs S,Strtz N,Quarch K,et al.Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2[J].Sci Rep,2017,7(1):15340
7 Sparks MA,Stegbauer J,Chen D,et al.Vascular type 1A angiotensin II receptors control BP by regulating renal blood flow and urinary sodium excretion[J].J Ame Soc Nephrol:2015,26(12):2953-2962
8 Poduri A,Rateri DL,Howatt DA,et al.Fibroblast angiotensin II type1a receptors contribute to angiotensin II-induced medial hyperplasia in the ascending aorta[J].Arteriosclerosis Thromb Vascul Biol,2015,35(9):1995-2002
9姜莹,王暘,张卉蕾,等.血管紧张素Ⅱ1型受体相关蛋白研究进展[J].现代生物医学进展,2017,17(11):2178-2180
10 Jung MH,Sung JY,Young WK,et al.Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1[J].Biochem Biophys Res Commun,2015,464(1):57-62
11 Montezano AC,Nguyen Dinh Cat A,Rios FJ,Touyz RM.Angiotensin II and vascular injury[J].Curr Hypert Rep,2014,16(6):431-436
12程茹,傅继华.外周5-羟色胺在动脉粥样硬化中的作用研究进展[J].药学研究,2017,36(5):283-286
13 Hu C,Rusin CG,Tan Z,et al.Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electricaloscillators[J].J Clin Invest,2012,122(6):2046-2053
14 Felizola SJ,Maekawa T,Nakamura Y,et al.Voltage-gated calcium channels in the human adrenal and primary aldosteronism[J].J Steroid Bioche Mol Biol,2014,144(part B):410-416
15 Matsuda K,Uruno A,Kogure N,et al.Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295Rcells[J].Mol Cell Endocrinol,2014,383(1-2):60-68
16 Maharjan S,Mopidevi B,Kaw MK.Human aldosterone synthase gene polymorphism promotes mi RNA binding and regulates gene expression[J].Physiol Genom,2014,46(24):860-865
17刘光霞,赵连春,卢亚敏.代谢综合征患者血清肾素-血管紧张素-醛固酮水平及临床意义[J].解放军医药杂志,2016,28(12):80-82
18 Carmichael CY,Wainford RD.Impact of global versus renal-specific sympathoinhibition in aldosterone-induced hypertension:implications for medical device-based treatment of resistant hypertension[J].Hypertension,2015,65(6):1160-1172
19 Pojoga LH,Yao TM,Opsasnick LA,et al.Cooperative role of mineralocorticoid receptor and caveolin-1 in regulating the vascular response to low nitric oxide-high angiotensin II-induced cardiovascular injury[J].J Pharmacol Exp Therapeut,2015,355(1):32-47
20 Mizuno M,Downey RM,Mitchell JH,et al.Aldosterone and salt loading independently exacerbate the exercise pressor reflex in rats[J].Hypertension,2015,66(3):627-633
21 Shen XZ,Li Y,Li L,et al.Microglia participate in neurogenic regulation of hypertension[J].Hypertension,2015,66(2):309-316
22 Bardgett ME,Holbein WW,Herrera-Rosales M,Toney GM.Ang II-salt hypertension depends on neuronal activity in the hypothalamic paraventricular nucleus but not on local actions of tumor necrosis factor-α[J].Hypertension,2014,63(3):527-534
23熊梅梅,吕柳青,肖红波,等.高糖和血管紧张素Ⅱ对人肾小管上皮细胞Toll样受体4信号表达及炎性和纤维化因子的影响[J].中华肾脏病杂志,2016,32(1):43-49
24陈剑伟,夏印,王烈.肾素-血管紧张素系统与静脉移植术后内膜增生的研究进展[J].血管与腔内血管外科杂志,2017,3(1):622-628
25王晶晶,梁广彬,邓凡,等.血管紧张素转化酶2-血管紧张素(1-7)-Mas轴在心血管和神经系统的作用[J].中国医学创新,2015,36:143-146
26熊力,王南丽.肾素-血管紧张素-醛固酮系统与心血管病的研究进展[J].中国循证心血管医学杂志,2013,5(2):203-205
27解家平,李惠勉.老年人血管紧张素Ⅱ受体高敏的潜在机制---附2例病例报道[J].中华高血压杂志,2017,7:695-697