一种可穿戴多生理信号采集系统
|
摘要
为了长期连续监测心血管慢性疾病患者的关键生理参数,设计了一种高性能小型化可穿戴多生理信号采集系统,从硬件、固件和软件3个方面实现了人体心冲击信号(ballistocardiogram,BCG)、心电信号(electrocardiogram,ECG)和脉搏血氧饱和度的长时间连续监测、联合采集和移动端APP上的实时显示。通过提取3种信号相应的特征参数并进行联合分析,可以反映重要心脏生理指标。对该系统的穿戴舒适性、功耗和信号强度进行实验测试,结果表明:该采集系统舒适性强,能精确采集人体心冲击信号、心电信号和脉搏血氧信号,最大工作电流仅为12.512 mA,可以应用于家庭中对于心血管慢性疾病患者的长期监护。
In order to monitor the physiological parameters of patients with chronic cardiovascular disease for a long time, a high performance miniaturized wearable multi-physiological-signal acquisition system is designed. The long-time continuous monitoring, joint acquisition and real-time display on mobile APP of ballistocardiogram(BCG)signal, electrocardiogram(ECG) signal and pulse blood oxygen saturation are realized from three aspects of hardware, firmware and software. By extracting the corresponding characteristic parameters of three signals and performing joint analysis, the important physiological indexes of the heart can be responded. The weaving comfort, power consumption and signal strength of the system are tested experimentally. The results show that the acquisition system is great comfortable, can accurately acquisit the BCG signal, ECG signal and pulse oximetry signals, its maximum working current is only 12.512 mA, and can be used in the family for long-term monitoring patients with chronic cardiovascular disease.
In order to monitor the physiological parameters of patients with chronic cardiovascular disease for a long time, a high performance miniaturized wearable multi-physiological-signal acquisition system is designed. The long-time continuous monitoring, joint acquisition and real-time display on mobile APP of ballistocardiogram(BCG)signal, electrocardiogram(ECG) signal and pulse blood oxygen saturation are realized from three aspects of hardware, firmware and software. By extracting the corresponding characteristic parameters of three signals and performing joint analysis, the important physiological indexes of the heart can be responded. The weaving comfort, power consumption and signal strength of the system are tested experimentally. The results show that the acquisition system is great comfortable, can accurately acquisit the BCG signal, ECG signal and pulse oximetry signals, its maximum working current is only 12.512 mA, and can be used in the family for long-term monitoring patients with chronic cardiovascular disease.
引文
[1] STARR I,SCHROEDER H A. Ballistocardiogram II:Normal standards,abnormalities commonly found in diseases of the heart and circulation,and their significance[J]. Journal of Clinical Investigation,1940,19(3):437-450.
[2] BAIG M M,GHOLAMHOSSEINI H,CONNOLLY M J. A comprehensive survey of wearable and wireless ECG monitoring systems for older adults[J]. Medical&Biological Engineering&Computing,2013,51(5):485-495.
[3] GORDON J W. Certain molar movements of the human body produced by the circulation of the blood[J]. Journal of Anatomy and Physiology,1877,11(3):533-536.
[4] STARR I,RAWSON A J,SCHROEDER H A,et al. Studies on the estimation of cardiac ouptut in man,and of abnormalities in cardiac function,from the heart′s recoil and the blood′s impacts:The ballistocardiogram[J]. American Journal of Physiology—Legacy Content,1939,127(1):1-28.
[5] ERICKSON J C,HAYES J A,BUSTAMANTE M,et al. Intsy:A low-cost,open-source,wireless multi-channel bioamplifier system[J]. Physiological Measurement,2018,39(3):035008.
[6] YOSHIDA T,KAWAKAMI T,KATO S,et al. Morphologymatching-based R-wave detection for noise-robust ECG gating[J]. Journal of Cardiovascular Magnetic Resonance,2016,18(S1):21.
[7] JENITTA J,RAJESWARI A. Denoising of ECG signal based on improved adaptive filter with EMD and EEMD[C]//2013IEEE Conference on Information&Communication Technologies. Thuckalay,India:IEEE,2013:957-962.
[8] JANSEN B H,LARSON B H,SHANKAR K. Monitoring of the ballistocardiogram with the static charge sensitive bed:Biomedical engineering[J]. IEEE Transactions on Biomedical Engineering,1991,38(8):748-751.
[9] PAALASMAA J,TOIVONEN H,PARTINEN M. Adaptive heartbeat modeling for beat-to-beat heart rate measurement in ballistocardiograms[J]. IEEE Journal of Biomedical and Health Informatics,2015,19(6):1945-1952.
[10] KORTELAINEN J M,VIRKKALA J. FFT averaging of multichannel BCG signals from bed mattress sensor to improve estimation of heart beat interval[C]//2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Lyon:IEEE,2007:6685-6688.
[11]侯立亚,李艳峥,吴水才,等.基于ARM的心电采集系统的设计[J].医疗卫生装备,2006,27(1):1-2.HOU L Y,LI Y Z,WU S C,et al. Design of ECG sampling system based on ARM[J]. Chinese Medical Equipment Journal,2006,27(1):1-2(in Chinese).
[12] NIKOLAEV N,GOTCHEV A. ECG signal denoising using wavelet domain wiener filtering[C]//2000 10 th European Signal Processing Conference. Tampere,Finland:IEEE,2015:1-4.
[13] HABERMAN Z C,JAHN R T,RUPAN B S,et al. Wireless sma-rtphone ECG enables large-scale screening in diverse populations[J]. Journal of Cardiovascular Electrophysiology,2015,26(5):520-526.
[14]唐宁.图像处理在Android手机血氧饱和度监测软件设计中的应用研究[D].上海:东华大学,2014.TANG N. Application research of image processing in the design of android blood oxygen saturation monitoring software[D].Shanghai:Donghua Uinversity,2014(in Chinese).
[15]杜欣,曾伟杰,李承炜,等.基于移动医疗的孕产妇健康监护系统[J].生物医学工程学杂志,2016,33(1):2-7.DU X,ZENG W J,LI C Y W,et al. Maternal health monitoring system based on mobile medical[J]. Journal of Biomedical Engineering,2016,33(1):2-7(in Chinese).
[16]提素芳,白广芹,李菲,等.电子血压计与汞柱血压计测量结果对比观察[J].心脑血管病防治,2015,15(2):145-146.TI S F,BAI G Q,LI F,et al. Contrast observe on the measurement results between electronic sphygmomanometer and mercury sphygmomanometer[J]. Prevention and Treatment of Cardio Cerebral Vascular Diseas,2015,15(2):145-146(in Chinese).
[17] KREHEL M,WOLF M,BOESEL L F,et al. Development of a luminous textile for reflective pulse oximetry measurements[J].Biomedical Optics Express,2014,5(8):2537-2547.
[18]李中健,井艳,李世锋,等.心电图波形特征分析[J].临床心血管病杂志,2008,24(3):195-197.LI Z J,JING Y,LI S F,et al. Analysis on characteristics of electrocardiograms[J]. Journal of Clinical Cardiology,2008,24(3):195-197(in Chinese).
[19]瞿年清,谢梦洲.脉搏波形释义[J].中国中医药信息杂志,2007,14(6):3-4.ZHAI N Q,XIE M Z. Interpretation of pulse wave[J]. Chinese Journal of Information on Traditional Chinese Medicine,2007,14(6):3-4(in Chinese).
[20] ZHANG X W,ZHANG L Y,WANG K,et al. A rapid approach to assess cardiac contractility by ballistocardiogram and electrocardiogram[J]. Biomedizinische Technik/Biomedical Engineering,2018,63(2):113-122.
[2] BAIG M M,GHOLAMHOSSEINI H,CONNOLLY M J. A comprehensive survey of wearable and wireless ECG monitoring systems for older adults[J]. Medical&Biological Engineering&Computing,2013,51(5):485-495.
[3] GORDON J W. Certain molar movements of the human body produced by the circulation of the blood[J]. Journal of Anatomy and Physiology,1877,11(3):533-536.
[4] STARR I,RAWSON A J,SCHROEDER H A,et al. Studies on the estimation of cardiac ouptut in man,and of abnormalities in cardiac function,from the heart′s recoil and the blood′s impacts:The ballistocardiogram[J]. American Journal of Physiology—Legacy Content,1939,127(1):1-28.
[5] ERICKSON J C,HAYES J A,BUSTAMANTE M,et al. Intsy:A low-cost,open-source,wireless multi-channel bioamplifier system[J]. Physiological Measurement,2018,39(3):035008.
[6] YOSHIDA T,KAWAKAMI T,KATO S,et al. Morphologymatching-based R-wave detection for noise-robust ECG gating[J]. Journal of Cardiovascular Magnetic Resonance,2016,18(S1):21.
[7] JENITTA J,RAJESWARI A. Denoising of ECG signal based on improved adaptive filter with EMD and EEMD[C]//2013IEEE Conference on Information&Communication Technologies. Thuckalay,India:IEEE,2013:957-962.
[8] JANSEN B H,LARSON B H,SHANKAR K. Monitoring of the ballistocardiogram with the static charge sensitive bed:Biomedical engineering[J]. IEEE Transactions on Biomedical Engineering,1991,38(8):748-751.
[9] PAALASMAA J,TOIVONEN H,PARTINEN M. Adaptive heartbeat modeling for beat-to-beat heart rate measurement in ballistocardiograms[J]. IEEE Journal of Biomedical and Health Informatics,2015,19(6):1945-1952.
[10] KORTELAINEN J M,VIRKKALA J. FFT averaging of multichannel BCG signals from bed mattress sensor to improve estimation of heart beat interval[C]//2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Lyon:IEEE,2007:6685-6688.
[11]侯立亚,李艳峥,吴水才,等.基于ARM的心电采集系统的设计[J].医疗卫生装备,2006,27(1):1-2.HOU L Y,LI Y Z,WU S C,et al. Design of ECG sampling system based on ARM[J]. Chinese Medical Equipment Journal,2006,27(1):1-2(in Chinese).
[12] NIKOLAEV N,GOTCHEV A. ECG signal denoising using wavelet domain wiener filtering[C]//2000 10 th European Signal Processing Conference. Tampere,Finland:IEEE,2015:1-4.
[13] HABERMAN Z C,JAHN R T,RUPAN B S,et al. Wireless sma-rtphone ECG enables large-scale screening in diverse populations[J]. Journal of Cardiovascular Electrophysiology,2015,26(5):520-526.
[14]唐宁.图像处理在Android手机血氧饱和度监测软件设计中的应用研究[D].上海:东华大学,2014.TANG N. Application research of image processing in the design of android blood oxygen saturation monitoring software[D].Shanghai:Donghua Uinversity,2014(in Chinese).
[15]杜欣,曾伟杰,李承炜,等.基于移动医疗的孕产妇健康监护系统[J].生物医学工程学杂志,2016,33(1):2-7.DU X,ZENG W J,LI C Y W,et al. Maternal health monitoring system based on mobile medical[J]. Journal of Biomedical Engineering,2016,33(1):2-7(in Chinese).
[16]提素芳,白广芹,李菲,等.电子血压计与汞柱血压计测量结果对比观察[J].心脑血管病防治,2015,15(2):145-146.TI S F,BAI G Q,LI F,et al. Contrast observe on the measurement results between electronic sphygmomanometer and mercury sphygmomanometer[J]. Prevention and Treatment of Cardio Cerebral Vascular Diseas,2015,15(2):145-146(in Chinese).
[17] KREHEL M,WOLF M,BOESEL L F,et al. Development of a luminous textile for reflective pulse oximetry measurements[J].Biomedical Optics Express,2014,5(8):2537-2547.
[18]李中健,井艳,李世锋,等.心电图波形特征分析[J].临床心血管病杂志,2008,24(3):195-197.LI Z J,JING Y,LI S F,et al. Analysis on characteristics of electrocardiograms[J]. Journal of Clinical Cardiology,2008,24(3):195-197(in Chinese).
[19]瞿年清,谢梦洲.脉搏波形释义[J].中国中医药信息杂志,2007,14(6):3-4.ZHAI N Q,XIE M Z. Interpretation of pulse wave[J]. Chinese Journal of Information on Traditional Chinese Medicine,2007,14(6):3-4(in Chinese).
[20] ZHANG X W,ZHANG L Y,WANG K,et al. A rapid approach to assess cardiac contractility by ballistocardiogram and electrocardiogram[J]. Biomedizinische Technik/Biomedical Engineering,2018,63(2):113-122.