基于DNA甲基化的中医药防治鼻咽癌研究进展
|
摘要
DNA甲基化是目前肿瘤发生发展机制研究中的热点。鼻咽癌是我国常见的头颈部恶性肿瘤,在我国主要集中于两广地区。近年来,越来越多研究报道发现鼻咽癌中的异常的DNA甲基化改变。中医药在临床上对鼻咽癌防治和预后有着良好疗效。中医药防治疾病的机制与表观遗传学调控相关,中医中药可能通过DNA甲基化这一表观遗传改变达到防治鼻咽癌的目的。文章主要综述DNA甲基化对中医药防治鼻咽癌方面的相关研究,为中医药治疗鼻咽癌的机制研究提供新的研究思路。
DNA methylation is a hot spot in the research of mechanism of tumorigenesis. Nasopharyngeal carcinoma is a common cancer in our country, mainly concentrated in Guangdong and Guangxi area. In recent years, more and more studies have reported abnormal DNA methylation changes in NPC. Traditional Chinese medicine has a good clinical effect on the prevention and treatment of nasopharyngeal carcinoma. Traditional Chinese medicine may be the purpose of preventing and treating nasopharyngeal cancer through epigenetic changes of DNA methylation. This article mainly reviews DNA methylation on the prevention and treatment of nasopharyngeal carcinoma with traditional Chinese medicine, and provides new research ideas for the mechanism of TCM treatment of nasopharyngeal carcinoma.
DNA methylation is a hot spot in the research of mechanism of tumorigenesis. Nasopharyngeal carcinoma is a common cancer in our country, mainly concentrated in Guangdong and Guangxi area. In recent years, more and more studies have reported abnormal DNA methylation changes in NPC. Traditional Chinese medicine has a good clinical effect on the prevention and treatment of nasopharyngeal carcinoma. Traditional Chinese medicine may be the purpose of preventing and treating nasopharyngeal cancer through epigenetic changes of DNA methylation. This article mainly reviews DNA methylation on the prevention and treatment of nasopharyngeal carcinoma with traditional Chinese medicine, and provides new research ideas for the mechanism of TCM treatment of nasopharyngeal carcinoma.
引文
[1] 梁锌, 杨剑, 高婷, 等. 中国鼻咽癌流行概况[J]. 中国肿瘤, 2016,25(11):835.
[2] 邓卓霞, 司勇锋, 陶仲强. 鼻咽癌病因研究及早期诊断与治疗[J]. 国际耳鼻咽喉头颈外科杂志, 2016,40(3):173.
[3] 黄露露, 姚庆华. 中医药联合同步放化疗对鼻咽癌疗效影响的Meta分析[J]. 陕西中医药大学学报, 2017,40(3):92.
[4] 柳吉玲, 劳国平, 王杰. 中医药治疗鼻咽癌放化疗后不良反应临床研究[J]. 中医药临床杂志, 2018,30(1):124.
[5] 李健, 张成, 赵志付. 表观遗传学中医研究现状及趋势[J]. 中华中医药杂志, 2016,31(3):954.
[6] 王一同, 李娟, 卢雯平. 基于表观遗传学调控的中医药防治乳腺癌研究进展[J]. 世界中西医结合杂志, 2017,3(4):15.
[7] Das P M, Singal R. DNA methylation and cancer[J]. J Clin Oncol, 2010,70(22):27.
[8] Baylin S B, Herman J G, Graff J R, et al. Alterations in DNA methylation: a fundamental aspect of neoplasia[J]. Adv Cancer Res,1998,72:141.
[9] Dai W, Zheng H, Cheung A K, et al. Genetic and epigenetic landscape of nasopharyngeal carcinoma[J]. Chin Clin Oncol,2016,5(2):16.
[10] 鄢冲. DNA启动子甲基化与鼻咽癌研究进展[J]. 徐州医学院学报, 2012,32(1):67.
[11] Lo K W, Teo P M L, Hui B Y, et al. High Resolution Allelotype of Microdissected Primary Nasopharyngeal Carcinoma[J]. Cancer Res, 2000,60(13):3348.
[12] Chow L S, Lo K W, Kwong J, et al. RASSF1A is a target tumor suppressor from 3p21.3 in nasopharyngeal carcinoma[J]. Int J Cancer, 2004,109(6):839.
[13] Fendri A, Masmoudi A A, Sellami-Boudawara T, et al. Inactivation of RASSF1A, RARbeta2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma[J]. Cancer Biol Ther,2009,8(5):444.
[14] Ni H, Zhou Z, Jiang B, et al. Inactivation of parkin by promoter methylation correlated with lymph node metastasis and genomic instability in nasopharyngeal carcinoma[J]. Tumour Biol,2017,39(3):1393394639.
[15] 倪海峰,江波,周玲,等.鼻咽癌中PMS3基因表达失活的甲基化调控机制[J].中华肿瘤杂志,2016,38(11),812.
[16] 牛维纳, 沈建军, 杨雯雯, 等. 抑癌基因甲基化与鼻咽癌易感性关系的Meta分析[J]. 山东医药, 2014,54(26):33.
[17] Fangyun T, Shea Ping Y, Kwong D L W, et al. Promoter hypermethylation of tumor suppressor genes in serum as potential biomarker for the diagnosis of nasopharyngeal carcinoma[J]. Cancer Epidemiol, 2013,37(5):708.
[18] Dote H, Cerna D, Burgan W E, et al. Enhancement of In vitro and In vivo Tumor Cell Radiosensitivity by the DNA Methylation Inhibitor Zebularine[J]. Clin Cancer Res,2005,11(12):4571.
[19] Hofstetter B, Niemierko A, Forrer C, et al. Impact of Genomic Methylation on Radiation Sensitivity of Colorectal Carcinoma[J]. Int J Radiat Oncol Biol Phys,2010,76(5):1512.
[20] Qiu H, Yashiro M, Shinto O, et al. DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells[J]. Cancer Sci,2009,100(1):181.
[21] Jiang W, Li Y Q, Liu N, et al. 5-Azacytidine enhances the radiosensitivity of CNE2 and SUNE1 cells in vitro and in vivo possibly by altering DNA methylation[J]. Plos One, 2014,9(4):e93273.
[22] Wang S, Zhang R, Claret F X, et al. Involvement of microRNA-24 and DNA methylation in resistance of nasopharyngeal carcinoma to ionizing radiation[J]. Mol Cancer Ther,2014,13(12):3163.
[23] Brennan K, Flanagan J M. Is there a link between genome-wide hypomethylation in blood and cancer risk[J]. Cancer Prevention Research, 2012,5(12):1345.
[24] Aoki Y, Nojima M, Suzuki H, et al. Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma[J]. Genome Med,2013,5(10):1.
[25] 魏绍峰, 张爱华. DNA低甲基化及其与肿瘤关系的研究进展[J]. 癌变·畸变·突变, 2016,28(3):243.
[26] Z L, L D, J J, et al. S100A4 hypomethylation affects epithelial-mesenchymal transition partially induced by LMP2A in nasopharyngeal carcinoma[J]. Mol Carcinoge,2016,55(10):1467.
[27] 张松, 李烁, 高春生. uPA基因启动子区低甲基化在鼻咽癌侵袭转移中的作用[J]. 肿瘤防治研究, 2012,39(6):691.
[28] 章明, 周莹, 吴超, 等. 女贞子对HepG2肝癌细胞相关基因去甲基化作用的研究[J]. 江西中医药, 2017,48(5):61.
[29] 俞春松. 姜黄素对皮肤鳞癌SCL-1细胞p16INK4a基因去甲基化作用研究[J]. 中国卫生检验杂志, 2017,27(6):857.
[30] 郭维. 消痰散结方对胃癌P16基因甲基化的影响[D]. 第二军医大学博士学位论文, 2010.
[31] 王柏琦, 陈艳华, 蒋丽琴, 等. 姜黄素对鼻咽癌细胞系CNE-1RECK基因表达及甲基化的影响[J]. 基础医学与临床, 2014,34(6):729.
[32] 周小军, 汪芸, 张丽娟, 等. FAM150B甲基化致低表达与鼻咽癌气虚癌变研究[J]. 中国中医基础医学杂志, 2016,22(1):96.
[2] 邓卓霞, 司勇锋, 陶仲强. 鼻咽癌病因研究及早期诊断与治疗[J]. 国际耳鼻咽喉头颈外科杂志, 2016,40(3):173.
[3] 黄露露, 姚庆华. 中医药联合同步放化疗对鼻咽癌疗效影响的Meta分析[J]. 陕西中医药大学学报, 2017,40(3):92.
[4] 柳吉玲, 劳国平, 王杰. 中医药治疗鼻咽癌放化疗后不良反应临床研究[J]. 中医药临床杂志, 2018,30(1):124.
[5] 李健, 张成, 赵志付. 表观遗传学中医研究现状及趋势[J]. 中华中医药杂志, 2016,31(3):954.
[6] 王一同, 李娟, 卢雯平. 基于表观遗传学调控的中医药防治乳腺癌研究进展[J]. 世界中西医结合杂志, 2017,3(4):15.
[7] Das P M, Singal R. DNA methylation and cancer[J]. J Clin Oncol, 2010,70(22):27.
[8] Baylin S B, Herman J G, Graff J R, et al. Alterations in DNA methylation: a fundamental aspect of neoplasia[J]. Adv Cancer Res,1998,72:141.
[9] Dai W, Zheng H, Cheung A K, et al. Genetic and epigenetic landscape of nasopharyngeal carcinoma[J]. Chin Clin Oncol,2016,5(2):16.
[10] 鄢冲. DNA启动子甲基化与鼻咽癌研究进展[J]. 徐州医学院学报, 2012,32(1):67.
[11] Lo K W, Teo P M L, Hui B Y, et al. High Resolution Allelotype of Microdissected Primary Nasopharyngeal Carcinoma[J]. Cancer Res, 2000,60(13):3348.
[12] Chow L S, Lo K W, Kwong J, et al. RASSF1A is a target tumor suppressor from 3p21.3 in nasopharyngeal carcinoma[J]. Int J Cancer, 2004,109(6):839.
[13] Fendri A, Masmoudi A A, Sellami-Boudawara T, et al. Inactivation of RASSF1A, RARbeta2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma[J]. Cancer Biol Ther,2009,8(5):444.
[14] Ni H, Zhou Z, Jiang B, et al. Inactivation of parkin by promoter methylation correlated with lymph node metastasis and genomic instability in nasopharyngeal carcinoma[J]. Tumour Biol,2017,39(3):1393394639.
[15] 倪海峰,江波,周玲,等.鼻咽癌中PMS3基因表达失活的甲基化调控机制[J].中华肿瘤杂志,2016,38(11),812.
[16] 牛维纳, 沈建军, 杨雯雯, 等. 抑癌基因甲基化与鼻咽癌易感性关系的Meta分析[J]. 山东医药, 2014,54(26):33.
[17] Fangyun T, Shea Ping Y, Kwong D L W, et al. Promoter hypermethylation of tumor suppressor genes in serum as potential biomarker for the diagnosis of nasopharyngeal carcinoma[J]. Cancer Epidemiol, 2013,37(5):708.
[18] Dote H, Cerna D, Burgan W E, et al. Enhancement of In vitro and In vivo Tumor Cell Radiosensitivity by the DNA Methylation Inhibitor Zebularine[J]. Clin Cancer Res,2005,11(12):4571.
[19] Hofstetter B, Niemierko A, Forrer C, et al. Impact of Genomic Methylation on Radiation Sensitivity of Colorectal Carcinoma[J]. Int J Radiat Oncol Biol Phys,2010,76(5):1512.
[20] Qiu H, Yashiro M, Shinto O, et al. DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells[J]. Cancer Sci,2009,100(1):181.
[21] Jiang W, Li Y Q, Liu N, et al. 5-Azacytidine enhances the radiosensitivity of CNE2 and SUNE1 cells in vitro and in vivo possibly by altering DNA methylation[J]. Plos One, 2014,9(4):e93273.
[22] Wang S, Zhang R, Claret F X, et al. Involvement of microRNA-24 and DNA methylation in resistance of nasopharyngeal carcinoma to ionizing radiation[J]. Mol Cancer Ther,2014,13(12):3163.
[23] Brennan K, Flanagan J M. Is there a link between genome-wide hypomethylation in blood and cancer risk[J]. Cancer Prevention Research, 2012,5(12):1345.
[24] Aoki Y, Nojima M, Suzuki H, et al. Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma[J]. Genome Med,2013,5(10):1.
[25] 魏绍峰, 张爱华. DNA低甲基化及其与肿瘤关系的研究进展[J]. 癌变·畸变·突变, 2016,28(3):243.
[26] Z L, L D, J J, et al. S100A4 hypomethylation affects epithelial-mesenchymal transition partially induced by LMP2A in nasopharyngeal carcinoma[J]. Mol Carcinoge,2016,55(10):1467.
[27] 张松, 李烁, 高春生. uPA基因启动子区低甲基化在鼻咽癌侵袭转移中的作用[J]. 肿瘤防治研究, 2012,39(6):691.
[28] 章明, 周莹, 吴超, 等. 女贞子对HepG2肝癌细胞相关基因去甲基化作用的研究[J]. 江西中医药, 2017,48(5):61.
[29] 俞春松. 姜黄素对皮肤鳞癌SCL-1细胞p16INK4a基因去甲基化作用研究[J]. 中国卫生检验杂志, 2017,27(6):857.
[30] 郭维. 消痰散结方对胃癌P16基因甲基化的影响[D]. 第二军医大学博士学位论文, 2010.
[31] 王柏琦, 陈艳华, 蒋丽琴, 等. 姜黄素对鼻咽癌细胞系CNE-1RECK基因表达及甲基化的影响[J]. 基础医学与临床, 2014,34(6):729.
[32] 周小军, 汪芸, 张丽娟, 等. FAM150B甲基化致低表达与鼻咽癌气虚癌变研究[J]. 中国中医基础医学杂志, 2016,22(1):96.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |