种植体周围神经再生的研究进展
摘要
<正>牙种植体的骨感知现象成为口腔种植领域近年来的研究热点~([1～3])。大量关于骨感知的神经生理学和心理生理学的证据表明,种植体周围确实存在感觉神经反馈通路,证实种植体周围有感觉神经分布~([4])。但是,临床研究显示,种植义齿与天然牙的感觉有所不同,种植体对负荷的定位能力及触觉灵敏度比天然牙弱~([5,6])。因此,促进种植体周围神经再生,对于改进种植体的感觉功能是十分必要的。同时,大量
引文
1 Mishra SK,Chowdhary R,Chrcanovic BR,et al.Osseoperception in dental implants:a systematic review.Journal of Prosthodontics,2016,25(3):185-195.
2 Bhatnagar VM,Karani JT,Khanna A,et al.Osseoperception:an implant mediated sensory motor control-a review.Journal of Clinical and Diagnostic Research:JCDR,2015,9(9):ZE18-20.
3 Enkling N,Utz KH,Bayer S,et al.Osseoperception:active tactile sensibility of osseointegrated dental implants.The International Journal of Oral&Maxillofacial Implants,2010,25(6):1159-1167.
4 Kazemi M,Geramipanah F,Negahdari R,et al.Active tactile sensibility of single-tooth implants versus natural dentition:a split-mouth double-blind randomized clinical trial.Clinical Implant Dentistry and Related Research,2014,16(6):947-955.
5 Enkling N,Heussner S,Nicolay C,et al.Tactile sensibility of single tooth implants and natural teeth under local anaesthesia of the natural antagonistic teeth.Clinical Implant Dentistry and Related Research,2012,14(2):273-280.
6 Reveredo AM,Shetty S,Babu CLS,et al.Evaluation of active tactile perception of single tooth implant prosthesis.International Journal of Oral Implantology and Clinical Research,2013,4(1):1-6.
7 dos Santos Corpas L,Lambrichts I,Quirynen M,et al.Peri-implant bone innervation:histological findings in humans.European Journal of Oral Implantology,2014,7(3):283-292.
8 Bjurholm A,Kreicbergs A,Brodin E,et al.Substance P-and CGRP-immunoreactive nerves in bone.Peptides,1988,9(1):165-171.
9 Buma P,Elmans L,Oestreicher AB.Changes in innervation of long bones after insertion of an implant:immunocytochemical study in goats with antibodies to calcitonin gene-related peptide and B-50/GAP-43.Journal of Orthopaedic Research,1995,13(4):570-577.
10林野,陈琰.种植义齿的骨感知现象及研究.中华口腔医学研究杂志(电子版),2008,2(4):1-4.
11朱一博,林野,邱立新,等.牙种植体骨感知外周神经机制的动物实验.中华口腔医学杂志,2009,44(8):460-463.
12乔士冲,吕晓飞,庄龙飞,等.牙种植体周围骨内神经感受功能的初步研.上海口腔医学,2011,20(2):119-124.
13 Ysander M,Branemark R,Olmarker K,et al.Intramedullary osseointegration:development of a rodent model and study of histology and neuropeptide changes around titanium implants.Journal of Rehabilitation Research and Development,2001,38(2):183-190.
14 Wada S,Kojo T,Wang YH,et al.Effect of loading on the development of nerve fibers around oral implants in the dog mandible.Clinical Oral Implants Research,2001,12(3):219-224.
15 Huang Y,Van Dessel J,Martens W,et al.Sensory innervation around immediately vs.delayed loaded implants:a pilot study.International Journal of Oral Science,2015,7(1):49-55.
16 Grieznis L,Apse P,Blumfelds L.Passive tactile sensibility of teeth and osseointegrated dental implants in the maxilla.Stomatologija,2010,12(3):80-86.
17 Jacobs R,Vansteenberghe D.From osseoperception to implantmediated sensory-motor interactions and related clinical implications.Journal of Oral Rehabilitation,2006,33(4):282-292.
18 Duncan C,Shim SJ.Edouard Samson Address:the autonomic nerve supply of bone.An experimental study of the intraosseous adrenergic nervi vasorum in the rabbit.The Journal of Bone and Joint Surgery.British Volume,1977,59(3):323-330.
19 Herskovits M,Singh I.Effect of guanethidine-induced sympathectomy on osteoblastic activity in the rat femur evaluated by 3H·Proline autoradiography.Cells Tissues Organs,1984,120(3):151-155.
20 Yamashiro T,Fujiyama K,Fujiyoshi Y,et al.Inferior alveolar nerve transection inhibits increase in osteoclast appearance during experimental tooth movement.Bone,2000,26(6):663-669.
21 Yu X,Lv L,Zhang J,et al.Expression of neuropeptides and bone remodeling-related factors during periodontal tissue regeneration in denervated rats.Journal of Molecular Histology,2015,46(2):195-203.
22 He H,Chai J,Zhang S,et al.CGRP may regulate bone metabolism through stimulating osteoblast differentiation and inhibiting osteoclast formation.Molecular Medicine Reports,2016,13(5):3977-3984.
23 Yoo YM,Kwag JH,Kim KH,et al.Effects of neuropeptides and mechanical loading on bone cell resorption in vitro.?International Journal of Molecular Sciences,2014,15(4):5874-5883.
24 González-Hernández A,Marichal-Cancino BA,Lozano-Cuenca J,et al.Heteroreceptors modulating CGRP release at neurovascular junction:potential therapeutic implications on some vascular-related diseases.Bio Med Research International,2016,2016:2056786.
25向琳,陈晖璐,袁影,等.降钙素基因相关肽对种植体周围神经、血管再生及骨结合的作用.国际口腔医学杂志,2018,45(5):509-515.
26 Madduri S,Gander B.Schwann cell delivery of neurotrophic factors for peripheral nerve regeneration.Journal of the Peripheral Nervous System,2010,15(2):93-103.
27 Yuan Q,Gong P,Tan Z,et al.Schwann cell graft:a method to promote sensory responses of osseointegrated implants.Medical Hypotheses,2007,69(4):800-803.
28李保胜.不同种植体表面形貌对神经再生影响的初步研究.长春:吉林大学,2013.
29 Yuan Q,Liao D,Yang X,et al.Effect of implant surface microtopography on proliferation,neurotrophin secretion,and gene expression of Schwann cells.Journal of Biomedical Materials Research Part A,2010,93(1):381-388.
30 Yin C,Li B,Wang H,et al.Biological behaviors of RSC96cells and dorsal root ganglion neurons on different titanium surface topographies.Journal of Biomaterials and Tissue Engineering,2016,6(12):967-974.
31 Collazos-Castro JE,Cruz AM,Carballo-Vila M,et al.Neural cell growth on Ti O2anatase nanostructured surfaces.Thin Solid Films,2009,518(1):160-170.
32 Saghiri MA,Ghasemi M,Moayer AR,et al.A novel method to evaluate the neurocompatibility of dental implants.International Journal of Oral&Maxillofacial Implants,2014,29(1):41-50.
33 Li X,Liao D,Gong P,et al.Biological behavior of neurally differentiated periodontal ligament stem cells on different titanium implant surfaces.Journal of Biomedical Materials Research Part A,2014,102(8):2805-2812.
34 He H,Yao Y,Wang Y,et al.A novel bionic design of dental implant for promoting its long-term success using nerve growth factor(NGF):utilizing nano-springs to construct a stress-cushioning structure inside the implant.Medical Science Monitor,2012,18(8):HY42-HY46.
35姚洋,杜宇,古霞,等.局部注射外源性神经生长因子促进小鼠钛种植体周骨胶原早期成熟的研究.华西口腔医学杂志,2018,36(2):128-132.
36 Ma L,Xiang L,Yao Y,et al.CGRP?alpha application:Apotential treatment to improve osseoperception of endosseous dental implants.Medical Hypotheses,2013,81(2):297-299.
37孙琳琳.牙种植修复方式对种植体周神经纤维再生及骨组织改建的影响.大连:大连医科大学,2013.
38 Mai S,Motoyoshi M,Shinoda M,et al.Low-intensity pulsed ultrasound accelerates nerve regeneration following inferior alveolar nerve transection in rats.European Journal of Oral Sciences,2016,124(3):246-250.
39杨博,吴庆庆,张亮,等.低频脉冲超声对失下牙槽神经后下颌骨病理改变修复的影响.中国医学科学院学报,2017,39(2):215-224.
2 Bhatnagar VM,Karani JT,Khanna A,et al.Osseoperception:an implant mediated sensory motor control-a review.Journal of Clinical and Diagnostic Research:JCDR,2015,9(9):ZE18-20.
3 Enkling N,Utz KH,Bayer S,et al.Osseoperception:active tactile sensibility of osseointegrated dental implants.The International Journal of Oral&Maxillofacial Implants,2010,25(6):1159-1167.
4 Kazemi M,Geramipanah F,Negahdari R,et al.Active tactile sensibility of single-tooth implants versus natural dentition:a split-mouth double-blind randomized clinical trial.Clinical Implant Dentistry and Related Research,2014,16(6):947-955.
5 Enkling N,Heussner S,Nicolay C,et al.Tactile sensibility of single tooth implants and natural teeth under local anaesthesia of the natural antagonistic teeth.Clinical Implant Dentistry and Related Research,2012,14(2):273-280.
6 Reveredo AM,Shetty S,Babu CLS,et al.Evaluation of active tactile perception of single tooth implant prosthesis.International Journal of Oral Implantology and Clinical Research,2013,4(1):1-6.
7 dos Santos Corpas L,Lambrichts I,Quirynen M,et al.Peri-implant bone innervation:histological findings in humans.European Journal of Oral Implantology,2014,7(3):283-292.
8 Bjurholm A,Kreicbergs A,Brodin E,et al.Substance P-and CGRP-immunoreactive nerves in bone.Peptides,1988,9(1):165-171.
9 Buma P,Elmans L,Oestreicher AB.Changes in innervation of long bones after insertion of an implant:immunocytochemical study in goats with antibodies to calcitonin gene-related peptide and B-50/GAP-43.Journal of Orthopaedic Research,1995,13(4):570-577.
10林野,陈琰.种植义齿的骨感知现象及研究.中华口腔医学研究杂志(电子版),2008,2(4):1-4.
11朱一博,林野,邱立新,等.牙种植体骨感知外周神经机制的动物实验.中华口腔医学杂志,2009,44(8):460-463.
12乔士冲,吕晓飞,庄龙飞,等.牙种植体周围骨内神经感受功能的初步研.上海口腔医学,2011,20(2):119-124.
13 Ysander M,Branemark R,Olmarker K,et al.Intramedullary osseointegration:development of a rodent model and study of histology and neuropeptide changes around titanium implants.Journal of Rehabilitation Research and Development,2001,38(2):183-190.
14 Wada S,Kojo T,Wang YH,et al.Effect of loading on the development of nerve fibers around oral implants in the dog mandible.Clinical Oral Implants Research,2001,12(3):219-224.
15 Huang Y,Van Dessel J,Martens W,et al.Sensory innervation around immediately vs.delayed loaded implants:a pilot study.International Journal of Oral Science,2015,7(1):49-55.
16 Grieznis L,Apse P,Blumfelds L.Passive tactile sensibility of teeth and osseointegrated dental implants in the maxilla.Stomatologija,2010,12(3):80-86.
17 Jacobs R,Vansteenberghe D.From osseoperception to implantmediated sensory-motor interactions and related clinical implications.Journal of Oral Rehabilitation,2006,33(4):282-292.
18 Duncan C,Shim SJ.Edouard Samson Address:the autonomic nerve supply of bone.An experimental study of the intraosseous adrenergic nervi vasorum in the rabbit.The Journal of Bone and Joint Surgery.British Volume,1977,59(3):323-330.
19 Herskovits M,Singh I.Effect of guanethidine-induced sympathectomy on osteoblastic activity in the rat femur evaluated by 3H·Proline autoradiography.Cells Tissues Organs,1984,120(3):151-155.
20 Yamashiro T,Fujiyama K,Fujiyoshi Y,et al.Inferior alveolar nerve transection inhibits increase in osteoclast appearance during experimental tooth movement.Bone,2000,26(6):663-669.
21 Yu X,Lv L,Zhang J,et al.Expression of neuropeptides and bone remodeling-related factors during periodontal tissue regeneration in denervated rats.Journal of Molecular Histology,2015,46(2):195-203.
22 He H,Chai J,Zhang S,et al.CGRP may regulate bone metabolism through stimulating osteoblast differentiation and inhibiting osteoclast formation.Molecular Medicine Reports,2016,13(5):3977-3984.
23 Yoo YM,Kwag JH,Kim KH,et al.Effects of neuropeptides and mechanical loading on bone cell resorption in vitro.?International Journal of Molecular Sciences,2014,15(4):5874-5883.
24 González-Hernández A,Marichal-Cancino BA,Lozano-Cuenca J,et al.Heteroreceptors modulating CGRP release at neurovascular junction:potential therapeutic implications on some vascular-related diseases.Bio Med Research International,2016,2016:2056786.
25向琳,陈晖璐,袁影,等.降钙素基因相关肽对种植体周围神经、血管再生及骨结合的作用.国际口腔医学杂志,2018,45(5):509-515.
26 Madduri S,Gander B.Schwann cell delivery of neurotrophic factors for peripheral nerve regeneration.Journal of the Peripheral Nervous System,2010,15(2):93-103.
27 Yuan Q,Gong P,Tan Z,et al.Schwann cell graft:a method to promote sensory responses of osseointegrated implants.Medical Hypotheses,2007,69(4):800-803.
28李保胜.不同种植体表面形貌对神经再生影响的初步研究.长春:吉林大学,2013.
29 Yuan Q,Liao D,Yang X,et al.Effect of implant surface microtopography on proliferation,neurotrophin secretion,and gene expression of Schwann cells.Journal of Biomedical Materials Research Part A,2010,93(1):381-388.
30 Yin C,Li B,Wang H,et al.Biological behaviors of RSC96cells and dorsal root ganglion neurons on different titanium surface topographies.Journal of Biomaterials and Tissue Engineering,2016,6(12):967-974.
31 Collazos-Castro JE,Cruz AM,Carballo-Vila M,et al.Neural cell growth on Ti O2anatase nanostructured surfaces.Thin Solid Films,2009,518(1):160-170.
32 Saghiri MA,Ghasemi M,Moayer AR,et al.A novel method to evaluate the neurocompatibility of dental implants.International Journal of Oral&Maxillofacial Implants,2014,29(1):41-50.
33 Li X,Liao D,Gong P,et al.Biological behavior of neurally differentiated periodontal ligament stem cells on different titanium implant surfaces.Journal of Biomedical Materials Research Part A,2014,102(8):2805-2812.
34 He H,Yao Y,Wang Y,et al.A novel bionic design of dental implant for promoting its long-term success using nerve growth factor(NGF):utilizing nano-springs to construct a stress-cushioning structure inside the implant.Medical Science Monitor,2012,18(8):HY42-HY46.
35姚洋,杜宇,古霞,等.局部注射外源性神经生长因子促进小鼠钛种植体周骨胶原早期成熟的研究.华西口腔医学杂志,2018,36(2):128-132.
36 Ma L,Xiang L,Yao Y,et al.CGRP?alpha application:Apotential treatment to improve osseoperception of endosseous dental implants.Medical Hypotheses,2013,81(2):297-299.
37孙琳琳.牙种植修复方式对种植体周神经纤维再生及骨组织改建的影响.大连:大连医科大学,2013.
38 Mai S,Motoyoshi M,Shinoda M,et al.Low-intensity pulsed ultrasound accelerates nerve regeneration following inferior alveolar nerve transection in rats.European Journal of Oral Sciences,2016,124(3):246-250.
39杨博,吴庆庆,张亮,等.低频脉冲超声对失下牙槽神经后下颌骨病理改变修复的影响.中国医学科学院学报,2017,39(2):215-224.