自噬在骨组织疾病中的调控作用研究进展
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摘要
骨是一种动态活性组织,通过持续的骨重塑维持矿化平衡和自身结构稳定。而自噬是细胞依赖溶酶体进行自体溶解的过程,对骨组织细胞功能具有重要作用,自噬平衡的打破与骨类疾病发生发展密不可分。因此,全面认识自噬对骨组织的调控作用具有重要理论意义和实际应用价值。本文就自噬的形成、自噬与骨组织细胞的作用机制及自噬在骨组织疾病发生发展中的调控机制做一综述,为进一步探讨通过调控自噬治疗骨类疾病提供指导。
Bone is a kind of dynamic active tissue,which could maintain mineralization balance and self-structure stability by sustaining bone remodeling.Autophagy is a process of self-lysis depending on the cells' lysosomal which plays an important role in the function of bone cells.The breaking of the autophagy balance is closely related to the development of bone diseases.Therefore,it is of great theoretical significance and practical value to fully understand the role of autophagy in the regulation of bone tissues.Thus,in this paper,the formation of the autophapy,the relationship between of the autophagy and the bone cells and the mechanism of autophagy in bone diseases are reviewed as well,in order to further explore the regulation of autophagy during the treatments about bone diseases.
Bone is a kind of dynamic active tissue,which could maintain mineralization balance and self-structure stability by sustaining bone remodeling.Autophagy is a process of self-lysis depending on the cells' lysosomal which plays an important role in the function of bone cells.The breaking of the autophagy balance is closely related to the development of bone diseases.Therefore,it is of great theoretical significance and practical value to fully understand the role of autophagy in the regulation of bone tissues.Thus,in this paper,the formation of the autophapy,the relationship between of the autophagy and the bone cells and the mechanism of autophagy in bone diseases are reviewed as well,in order to further explore the regulation of autophagy during the treatments about bone diseases.
引文
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[19]Motoi Y,Shimada K,Ishiguro K,et al.Lithium and autophagy[J].ACS chemical neuroscience,2014,5(6)∶434-442
[2]Shaid S,Brandts CH,Serve H,et al.Ubiquitination and selective autophagy[J].Cell Death&Differentiation,2013,20(1)∶21-30
[3]Song C,Song C,Tong F.Autophagy induction is a survival response against oxidative stress in bone marrow–derived mesenchymal stromal cells[J].Cytotherapy,2014,16(10)∶1361-1370
[4]Liu F,Fang F,Yuan H,et al.Suppression of autophagy by FIP200deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation[J].Journal of bone and mineral research:the official journal of the American Society for Bone and Mineral Research,2013,28(11)∶2414-2430
[5]Kirkin V,Lamark T,Sou YS,et al.A role for NBR1in autophagosomal degradation of ubiquitinated substrates[J].Molecular cell,2009,33(4)∶505-516
[6]Nollet M,Santucci-Darmanin S,Breuil V,et al.Autophagy in osteoblasts is involved in mineralization and bone homeostasis[J].Autophagy,2014,10(11)∶1965-1977
[7]Zahm AM,Bohensky J,Adams CS,et al.Bone cell autophagy is regulated by environmental factors[J].Cells Tissues Organs,2011,194(2-4)∶274-278
[8]Yang Y,Zheng X,Li B,et al.Increased activity of osteocyte autophagy in ovariectomized rats and its correlation with oxidative stress status and bone loss[J].Biochemical and biophysical research communications,2014,451(1)∶86-92
[9]King JS,Veltman DM,Insall RH.The induction of autophagy by mechanical stress[J].Autophagy,2011,7(12)∶1490-1499
[10]Chung Y H,Jang Y,Choi B,et al.Beclin-1Is Required for RANKL‐Induced Osteoclast Differentiation[J].Journal of cellular physiology,2014,229(12)∶1963-1971
[11]DeSelm C J,Miller B C,Zou W,et al.Autophagy proteins regulate the secretory component of osteoclastic bone resorption[J].Developmental cell,2011,21(5)∶966-974
[12]Chung YH,Yoon SY,Choi B,et al.Microtubule-associated protein light chain 3regulates Cdc42-dependent actin ring formation in osteoclast[J].The international journal of biochemistry&cell biology,2012,44(6)∶989-997
[13]Goode A,Layfield R.Recent advances in understanding the molecular basis of Paget disease of bone[J].Journal of clinical pathology,2010,63(3)∶199-203
[14]Albagha OME,Visconti MR,Alonso N,et al.Genomewide association study identifies variants at CSF1,OPTN and TNFRSF11Aas genetic risk factors for Paget's disease of bone[J].Nature genetics,2010,42(6)∶520-524
[15]Chen K,Yang YH,Jiang SD,et al.Decreased activity of osteocyte autophagy with aging may contribute to the bone loss in senile population[J].Histochemistry and cell biology,2014,142(3)∶285-295
[16]Li D,Wu Z,Duan Y,et al.TNFα-mediated apoptosis in human osteoarthritic chondrocytes sensitized by PI3K-NF-κB inhibitor,not mTOR inhibitor[J].Rheumatology international,2012,32(7)∶2017-2022
[17]Blanco FJ,Rego I,Ruiz-Romero C.The role of mitochondria in osteoarthritis[J].Nature Reviews Rheumatology,2011,7(3)∶161-169
[18]Rubinsztein DC,Codogno P,Levine B.Autophagy modulation as a potential therapeutic target for diverse diseases[J].Nature reviews Drug discovery,2012,11(9)∶709-730
[19]Motoi Y,Shimada K,Ishiguro K,et al.Lithium and autophagy[J].ACS chemical neuroscience,2014,5(6)∶434-442