灯盏乙素对瑞舒伐他汀在大鼠体内药代动力学特征的影响
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摘要
目的探讨在大鼠体内灯盏乙素对瑞舒伐他汀的药代动力学特征的影响效果。方法选择试验大鼠12只作为研究对象,随机分为观察组与对照组,每组6只,所有试验大鼠均予以瑞舒伐他汀灌胃处理,对照组无其他处理,观察组则加用灯盏乙素灌胃处理。在不同时点收集试验大鼠血样,测定瑞舒伐他汀血药浓度,并计算药代动力学情况。结果两组试验大鼠体内药代动力学参数在Cmax、AUC0-1、CL2/F上比较差异均有统计学意义(P<0.05),其中观察组大鼠Cmax、AUC0-1明显更高,而CL2/F明显更低,但两组在t1/2、tmax上差异不显著(P>0.05)。结论瑞舒伐他汀灌胃处理试验大鼠,加用灯盏乙素后会明显影响大鼠体内药代动力学指标,促进Cmax、AUC0-1升高,CL2/F下降,可见影响明显。
Objective To investigate the effect of scutellarin on the pharmacokinetics of rosuvastatin in rats. Methods Twelve rats were selected as the study subjects. They were randomly divided into observation group and control group. There were 6 rats in each group. All the rats were treated with rosuvastatin orally. There was no other treatment in the control group. Lamp sputum is administered by gavage. Blood samples of the test rats were collected at different time points, the blood concentration of rosuvastatin was measured, and the pharmacokinetics were calculated. Results There were significant differences in the pharmacokinetic parameters between Cmax, AUC0-1 and CL2/F between the two groups(P<0.05). The Cmax and AUC0-1 of the observation group were significantly higher. CL2/F was significantly lower, but the difference between t1/2 and tmax was not significant(P> 0.05). Conclusion Rats treated with rosuvastatin were treated with scutellarin, which significantly affected the pharmacokinetics of rats, promoted the increase of Cmax, AUC0-1, and decreased CL2/F.
Objective To investigate the effect of scutellarin on the pharmacokinetics of rosuvastatin in rats. Methods Twelve rats were selected as the study subjects. They were randomly divided into observation group and control group. There were 6 rats in each group. All the rats were treated with rosuvastatin orally. There was no other treatment in the control group. Lamp sputum is administered by gavage. Blood samples of the test rats were collected at different time points, the blood concentration of rosuvastatin was measured, and the pharmacokinetics were calculated. Results There were significant differences in the pharmacokinetic parameters between Cmax, AUC0-1 and CL2/F between the two groups(P<0.05). The Cmax and AUC0-1 of the observation group were significantly higher. CL2/F was significantly lower, but the difference between t1/2 and tmax was not significant(P> 0.05). Conclusion Rats treated with rosuvastatin were treated with scutellarin, which significantly affected the pharmacokinetics of rats, promoted the increase of Cmax, AUC0-1, and decreased CL2/F.
引文
[1]刘建明,叶锡勇,刘志军,等.灯盏乙素对瑞舒伐他汀在大鼠体内药代动力学的影响[J].中国临床药理学杂志,2017,33(11):1003-1006.
[2]朱丽伟,刘晓谦,冯京,等.灯盏乙素及其衍生物灯盏乙素乙酯在大鼠体内的药代动力学的比较[J].中国中药杂志,2013,38(19):3373-3377.
[3]王昆仑,莫为春,高明强,等.瑞舒伐他汀钙对老年脓毒症模型大鼠急性肺损伤的干预作用[J].中国老年学杂志,2017,37(11):2632-2633.
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[5]宋占春,白静慧,汪琦,等.瑞舒伐他汀对急性心肌梗死大鼠心肌细胞凋亡的拮抗作用及可能机制[J].中华医学杂志,2015,95(45):3695-3700.
[6]熊爱琴,马萍,刘俊梅,等.瑞舒伐他汀对慢性心力衰竭大鼠的心脏保护作用及其对非对称二甲基精氨酸代谢通路的影响[J].中国循环杂志,2014,17(9):743-747.
[7]姜金钟,苗维,田守森,等.瑞舒伐他汀对H型高血压大鼠血管内皮生长因子的影响[J].中华老年心脑血管病杂志,2017,19(12):1313-1315.
[8]王杰华,李国前,潘莹,等.瑞舒伐他汀对大鼠脑缺血再灌注后基质金属蛋白酶9和组织金属蛋白酶抑制物1表达的影响[J].中国临床药理学杂志,2017,33(8):706-709.
[9]夏明红,胡春光,吴陈欢,等.瑞舒伐他汀对急性心肌梗死大鼠心肌细胞凋亡及胱天蛋白酶-3基因表达的影响[J].中国临床药理学杂志,2018,34(2):134-136.
[2]朱丽伟,刘晓谦,冯京,等.灯盏乙素及其衍生物灯盏乙素乙酯在大鼠体内的药代动力学的比较[J].中国中药杂志,2013,38(19):3373-3377.
[3]王昆仑,莫为春,高明强,等.瑞舒伐他汀钙对老年脓毒症模型大鼠急性肺损伤的干预作用[J].中国老年学杂志,2017,37(11):2632-2633.
[4]冯涛.瑞舒伐他汀对急性脑缺血再灌注大鼠脑含水量及海马区MG的影响[J].中风与神经疾病杂志,2018,35(3):216-219.
[5]宋占春,白静慧,汪琦,等.瑞舒伐他汀对急性心肌梗死大鼠心肌细胞凋亡的拮抗作用及可能机制[J].中华医学杂志,2015,95(45):3695-3700.
[6]熊爱琴,马萍,刘俊梅,等.瑞舒伐他汀对慢性心力衰竭大鼠的心脏保护作用及其对非对称二甲基精氨酸代谢通路的影响[J].中国循环杂志,2014,17(9):743-747.
[7]姜金钟,苗维,田守森,等.瑞舒伐他汀对H型高血压大鼠血管内皮生长因子的影响[J].中华老年心脑血管病杂志,2017,19(12):1313-1315.
[8]王杰华,李国前,潘莹,等.瑞舒伐他汀对大鼠脑缺血再灌注后基质金属蛋白酶9和组织金属蛋白酶抑制物1表达的影响[J].中国临床药理学杂志,2017,33(8):706-709.
[9]夏明红,胡春光,吴陈欢,等.瑞舒伐他汀对急性心肌梗死大鼠心肌细胞凋亡及胱天蛋白酶-3基因表达的影响[J].中国临床药理学杂志,2018,34(2):134-136.
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