基于关联规则算法和复杂系统熵聚类的中医药治疗特应性皮炎的证治规律研究
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摘要
目的分析探讨当代中医对特应性皮炎(AD)的辨证治疗的经验。方法基于关联规则算法和复杂系统熵聚类,通过检索2017年1月1日～2018年3月1日发表于中国知网、万方、维普、中国生物医学文献数据库中中医药治疗AD的文献,建立包含辨证分型、内服及外用中药的数据库,利用中医传承辅助平台V2.5进行数据分析。结果内服中药四气分布主要为温、寒、平、凉,药物的五味分布主要为甘、苦、辛、淡,药物归经多集中于脾肺。内服中药以茯苓、甘草、生地、白鲜皮、当归等15味药频次居多,外用中药以黄柏、苦参、白鲜皮、马齿苋、地肤子等10味中药频数最高。结论 AD辨证分型多集中于脾虚证,兼夹有湿邪、血燥。中药内服方以"健脾益气祛湿,祛风养血润燥"为主要治法,外用方以"清热燥湿,解毒止痒"为则;处方用药多从脾论治,可为中医临床辨证用药提供参考。
Objective To analyze and discuss the experience of symptom differentiation of atopic dermatitis(AD) and its treatment with modern Chinese medicine. Methods Based on the association rule algorithm and entropy clustering of complex system, Chinese medicine literature database on the treatment of atopic dermatitis in CNKI, Wanfang, VIP,China biomedical literature database from January 1 st 2017 to March 1 st 2018 was retrieved. And a database containing syndrome differentiation, Chinese medicine for internal and external use was established. TCMISS V2.5 was used to analyze the data. Results The distribution of four Qi of traditional Chinese medicine was mainly warm, cold, flat, cool,five flavor distribution was mainly sweet, bitter, Xin, light, the medicine mainly concentrated in the spleen and lung meridian. The most frequent oral traditional Chinese medicine were 15 herbs, such as Poria cocos, radix glycyrrhizae,dried radix rehmanniae, dictamni cortex, Angelica sinensis and so on. The most frequent Chinese medicine for external use were 10 herbs, including cortex phellodendri, radix sophorae flavescentis, dictamni cortex, purslane, fructus kochiae and so on. Conclusion AD dialectical typing is mainly spleen deficiency type, complicated with dampness and blood dryness. Chinese oral decoctions centre the treatment as invigorating spleen and Qi, clearing damp, dispelling wind, nourishing blood and moistening dryness. External formula conforms to the principle as clearing heat, drying wet, detoxifying and relieving itching. The formula is mostly treating from spleen, which can provide reference for TCM clinical dialectical medicine.
Objective To analyze and discuss the experience of symptom differentiation of atopic dermatitis(AD) and its treatment with modern Chinese medicine. Methods Based on the association rule algorithm and entropy clustering of complex system, Chinese medicine literature database on the treatment of atopic dermatitis in CNKI, Wanfang, VIP,China biomedical literature database from January 1 st 2017 to March 1 st 2018 was retrieved. And a database containing syndrome differentiation, Chinese medicine for internal and external use was established. TCMISS V2.5 was used to analyze the data. Results The distribution of four Qi of traditional Chinese medicine was mainly warm, cold, flat, cool,five flavor distribution was mainly sweet, bitter, Xin, light, the medicine mainly concentrated in the spleen and lung meridian. The most frequent oral traditional Chinese medicine were 15 herbs, such as Poria cocos, radix glycyrrhizae,dried radix rehmanniae, dictamni cortex, Angelica sinensis and so on. The most frequent Chinese medicine for external use were 10 herbs, including cortex phellodendri, radix sophorae flavescentis, dictamni cortex, purslane, fructus kochiae and so on. Conclusion AD dialectical typing is mainly spleen deficiency type, complicated with dampness and blood dryness. Chinese oral decoctions centre the treatment as invigorating spleen and Qi, clearing damp, dispelling wind, nourishing blood and moistening dryness. External formula conforms to the principle as clearing heat, drying wet, detoxifying and relieving itching. The formula is mostly treating from spleen, which can provide reference for TCM clinical dialectical medicine.
引文
[1]陶以成,郎娜,佘远遥,等.金黄膏治疗特应性皮炎45例[J]西部中医药,2015,28(6):100-101.
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[14]叶志健,季露露,刘伟娟.复方甘草酸苷对湿疹患者Th细胞免疫功能的影响[J].江西中医药,2009,40(12):45-46.
[15]张明,邓毅.甘草及其有效成分的药效学研究进展[J].西部中医药,2015,28(4):156-159.
[16]杨桂明,艾丹.白鲜皮抗炎有效部位的研究[J].时珍国医国药,2010,21(9):2209-2210.
[17]高向东,吴梧桐.当归及其成分阿魏酸对小鼠免疫功能的影响[J].中国生化药物杂志,1994,15(2):107-110.
[18]吕燕宁,邱全瑛.黄柏对小鼠DTH及其体内几种细胞因子的影响[J].北京中医药大学学报,1999,22(6):48-50.
[19]郑贤干,罗利飞.苦参素对慢性乙型肝炎患者外周血Th_1/Th_2平衡的调控作用[J].医药导报,2009,28(1):70-71.
[20]戴岳,夏玉凤,陈海标,等.地肤子70%醇提物抑制速发型及迟发型变态反应[J].中国现代应用药学,2001,18(1):8-10.
[2]Thomsen SF.Epidemiology and natural history of atopic diseases[J].Eur Clin Respir J,2015,2(4):475-514.
[3]钟卫红.中医辨证治疗特应性皮炎疗效观察[J].中医药学报,2002,30(1):26-27.
[4]周海啸.中医辨证治疗异位性皮炎临床观察[J].中国中医药信息杂志,2000,7(10):52-53.
[5]张芃,王萍.张志礼治疗异位性皮炎经验[J].中医杂志,1998,39(7):402-404.
[6]李正才.分型辨治特应性皮炎[J].辽宁中医杂志,2003,30(11):911-912.
[7]尤立平,刘永生,杨顶权,等.44例特应性皮炎中医临床证候分析与辨证治疗[J].中国中西医结合皮肤性病学杂志,2003,2(2):71-73.
[8]周爱妍,姬爱华,史传奎,等.健脾化湿法治疗儿童特应性皮炎30例[J].西部中医药,2014,27(8):73-74.
[9]吴志华.皮肤科治疗学[M].北京:科学出版社,2006:27-33.
[10]周芳,李萍.中医药治疗特应性皮炎研究进展[J].上海中医药杂志,2008,42(10):83-86.
[11]邢华.朱仁康治疗异位性皮炎的经验[J].中华中医药学刊,2007,25(2):229-230.
[12]孙晓冬.陈达灿教授从心脾论治特应性皮炎经验谈[J].中国中西医结合皮肤性病学杂志,2006,5(1):55-56.
[13]张灵鹏.复方甘草酸苷对慢性荨麻疹患者外周血T细胞亚群等的影响[J].中国药业,2010,19(3):15-16.
[14]叶志健,季露露,刘伟娟.复方甘草酸苷对湿疹患者Th细胞免疫功能的影响[J].江西中医药,2009,40(12):45-46.
[15]张明,邓毅.甘草及其有效成分的药效学研究进展[J].西部中医药,2015,28(4):156-159.
[16]杨桂明,艾丹.白鲜皮抗炎有效部位的研究[J].时珍国医国药,2010,21(9):2209-2210.
[17]高向东,吴梧桐.当归及其成分阿魏酸对小鼠免疫功能的影响[J].中国生化药物杂志,1994,15(2):107-110.
[18]吕燕宁,邱全瑛.黄柏对小鼠DTH及其体内几种细胞因子的影响[J].北京中医药大学学报,1999,22(6):48-50.
[19]郑贤干,罗利飞.苦参素对慢性乙型肝炎患者外周血Th_1/Th_2平衡的调控作用[J].医药导报,2009,28(1):70-71.
[20]戴岳,夏玉凤,陈海标,等.地肤子70%醇提物抑制速发型及迟发型变态反应[J].中国现代应用药学,2001,18(1):8-10.
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