乳腺癌功能磁共振成像与生物学预后因子的研究进展
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摘要
乳腺癌已成为女性最为常见的恶性肿瘤,如何对乳腺癌进行早期诊断、合理化治疗及判断预后意义重大。雌激素受体(ER)、孕激素受体(PR)、Ki-67、人表皮生长因子受体2(HER-2)等免疫组化指标在判断乳腺癌临床类型、转移情况及预后等方面具有重要作用。随着功能磁共振的发展,氢质子磁共振波谱(1H-MRS)、动态增强磁共振成像(DCE-MRI)、扩散加权成像(DWI)等被越来越广泛的用于乳腺组织的检查。研究功能磁共振与乳腺癌预后因子的相关性,对乳腺癌的临床分型、治疗及预后等方面有一定的指导作用。本文就相关进展进行综述。
Breast cancer has become the most common malignant tumor in women, it is of great significance to early diagnosis,rational treatment and prognosis of breast cancerprogesterone receptor(ER), progesterone receptor(PR), Ki-67, human epidermal growth factor receptor 2(HER-2) and other immunohistochemical markers in breast cancer to determine the clinical type, metastasis and prognosis plays an important role. With the development of functional magnetic resonance imaging, such as proton magnetic resonance spectroscopy(1 H-MRS) and dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) and diffusion weighted imaging(DWI) and so on are more and more used for the examination of the breast. To study the correlation of functional magnetic resonance imaging in breast cancer diagnosis and prognosis factors of breast cancer, and to guide the clinical treatment and prognosis of breast cancer. In this paper, the related progress were summarized.
Breast cancer has become the most common malignant tumor in women, it is of great significance to early diagnosis,rational treatment and prognosis of breast cancerprogesterone receptor(ER), progesterone receptor(PR), Ki-67, human epidermal growth factor receptor 2(HER-2) and other immunohistochemical markers in breast cancer to determine the clinical type, metastasis and prognosis plays an important role. With the development of functional magnetic resonance imaging, such as proton magnetic resonance spectroscopy(1 H-MRS) and dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) and diffusion weighted imaging(DWI) and so on are more and more used for the examination of the breast. To study the correlation of functional magnetic resonance imaging in breast cancer diagnosis and prognosis factors of breast cancer, and to guide the clinical treatment and prognosis of breast cancer. In this paper, the related progress were summarized.
引文
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[4]盛美红,汤卫霞,陆益花,等.MRI动态增强扫描早期强化比值联合周围血管管径鉴别诊断乳腺良恶性病变的价值[J].中华放射学杂志,2016,50(5):324-328Sheng Mei-hong,Tang Wei-xia,Lu Yi-hua,et al.The value of MRI enhanced contrast-enhanced ratio and peripheral vascular diameter in the differential diagnosis of breast benign and malignant lesions[J].Chinese Journal of Radiology,2016,50(5):324-328
[5]Takeda Y,Yoshikawa K.Contrast-enhanced dynamic MR imaging parameters and histological types of invasive ductal carcinoma of breas[J].Biomedicine&pharmacotherapy,2005,59(3):115-121
[6]Elsevier.Magnetic resonance imaging clinics of North America[M].W.B.Saunders Co,1993
[7]Zhao H L,Liu Y,Cheng L.Application of 3.0 Tesla system in breast magnetic resonance imaging[J].Chinese Journal of Ct and Mri,2009,24(7):18-22
[8]Medeiros L R,Duarte C S,Rosa D D,et al.Accuracy of magnetic resonance in suspicious breast lesions:a systematic quantita tive review and meta-analysis[J].Breast Cancer Research and Treatment,2011,126(2):273-285
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[10]关晏星,雷秋模,王莉,等.乳腺癌泌乳素受体与雌、孕激素受体的相关性[J].南昌大学学报(医学版),2001,41(1):40Guan Yan-xing,Lei Qiu-mo,Wang Li,et al.Relationship between prolactin receptor and estrogen receptor and progesterone receptor in breast cancer[J].Journal of nanchang university,2001,41(1):40
[11]代莹,傅静,魏兵,等.经他莫昔芬治疗的乳腺癌ER、PR阳性率和染色强度与预后的关系[J].临床与实验病理学杂志,2013,29(4):419-423Dai Ying,Fu Jing,Wei Bing,et al.The relationship between ER,PR positive rate and staining intensity and prognosis of breast cancer treated with tamoxifen[J].Journal of clinical and Experimental Pathology,2013,29(4):419-423
[12]Kim W H,Chang J M,Koo H R,et al.Impact of prior mammograms on combined reading of digital mammography and digital breast tomosynthesis[J].Acta Radiologica,2016[Epub ahead of print]
[13]Kurata T,Tsurutani J,Fujisaka Y,et al.Inhibition of EGFR,HER2and HER3 signaling with AZD8931 alone and in combination with paclitaxel:phase i study in Japanese patients with advanced solid malignancies and advanced breast cancer[J].Invest New Drugs,2014,32,946-954
[14]Tanner M,J覿rvinen P,Isola J.Amplification of HER-2/neu and topoisomerase IIalpha in primary and metastatic breast cancer[J].Cancer Research,2001,61(14):5345-5348
[15]赵莉芸,周纯武,张仁知,等.动态增强MRI定量参数与乳腺癌分子亚型的关系[J].中国医学影像技术,2013,(7):1126-1130Zhao Li-yun,Zhou Chun-wu,Zhang Ren-zhi,et al.The relationship between dynamic enhanced MRI quantitative parameters and molecular subtypes of breast cancer[J].Chinese medical imaging technology,2013,(7):1126-1130
[16]苏灵暄,曹艳君,姚伟,等.HER-2影响实体肿瘤血管生成的数值模拟研究[J].生物医学工程学进展,2013,34(4):203-207Su Ling-xuan,Cao Yan-jun,Yao Wei,et al.Numerical simulation study on the effect of HER-2 on the angiogenesis of solid tumor[J].Progress in Biomedical Engineering,2013,34(4):203-207
[17]韩慧.血管生成调节蛋白在乳腺癌中的表达及相关性研究[D].山东大学,2014Han Hui.Study on the expression and correlation of angiogenesis regulated protein in breast cancer[D].Shandong University,2014
[18]Kim J Y,Kim S H,Kim Y J,et al.Enhancement parameters on dynamic contrast enhanced breast MRI:do they correlate with prognostic factors and subtypes of breast cancers[J].Magnetic Resonance Imaging,2015,33(1):72-80
[19]费莹,许建铭,沈钧康,等.乳腺癌DCE-MRI定量参数与生物学预后因子的相关性研究[J].医学影像学杂志,2016,26(9):1625-1628Fei Ying,Xu Jian-mng,Shen Jun-kang,et al.Correlation between quantitative parameters of DCE-MRI and biological prognostic factors in breast cancer[J].Journal of medical imaging,2016,26(9):1625-1628
[20]Park S H,Hye-Young Choi M D,Hahn S Y.Correlations between apparent diffusion coefficient values of invasive ductal carcinoma and pathologic factors on diffusion-weighted MRI at 3.0 Tesla[J].Journal of Magnetic Resonance Imaging,2015,41(1):175-182
[21]Woodhams R,Matsunaga K,Kan S,et al.ADC mapping of benign and malignant breast tumors[J].Magnetic Resonance in Medical Sciences,2005,4(1):35-42
[22]Lo G G,Ai V,Chan J K,et al.Diffusion-weighted magnetic resonance imaging of breast lesions:first experiences at 3 T[J].Journal of Computer Assisted Tomography,2009,33(1):63-69
[23]Yoshito Tsushima M D,Ayako Takahashi-Taketomi M D,Keigo Endo M D.Magnetic resonance(MR)differential diagnosis of breast tumors using apparent diffusion coefficient(ADC)on 1.5-T[J].Journal of Magnetic Resonance Imaging,2009,30(2):249-255
[24]Hatakenaka M,Soeda H,Yabuuchi H,et al.Apparent diffusion coefficients of breast tumors:clinical application[J].Magnetic Resonance in Medical Sciences,2008,7(1):23-29
[25]Kuroki Y,Nasu K.Advances in breast MRI:diffusion-weighted imaging of the breast[J].Breast Cancer,2008,15(3):212-217
[26]姚尉,李成杰,杨静.MRI动态增强扫描及DWI在乳腺癌中的诊断价值[J].四川医学,2013,34(4):591-593Yao Wei,Li Cheng-jie,Yang Jing,et al.Diagnostic value of dynamic contrast-enhanced MRI and DWI in breast cancer[J].Journal of Sichuan Medical Sciences,2013,34(4):591-593
[27]Martincich L,Deantoni V,Bertotto I,et al.Correlations between diffusion-weighted imaging and breast cancer biomarkers[J].European Radiology,2012,22(7):1519-1528
[28]Stephen RM,Pagel MD,Brown K,et al.Monitoring the development of xenograft triple-negative breast cancer models using diffusion weighted magnetic resonance imaging[J].Exp Biol Med(Maywood),2012,237(11):1273-1280
[29]Jeh S K,Kim S H,Choi J J,et al.Comparison of automated breast ultrasonography to handheld ultrasonography in detecting and diagnosing breast lesions[J].Acta Radiologica,2016,(2)[Epub ahead of print]
[30]季冬,李铭,赵泽华,等.MR氢质子波谱成像在乳腺癌中的应用[J].中国医学计算机成像杂志,2010,16(2):111-114Ji Dong,Li Ming,Zhao Ze-hua,et al.Application of MR proton spectroscopy in breast cancer[J].Chinese Journal of Medical Imaging,2010,16(2):111-114
[31]Kim S H,Cha E S,Kim H S,et al.Diffusion-weighted imaging of breast cancer:Correlation of the apparent diffusion coefficient value with prognostic factors[J].Journal of Magnetic Resonance Imaging,2009,30(3):615-620
[32]Costantini M,Rinaldi P,Franceschini G,et al.Diffusion-weighted imaging in breast cancer:relationship between apparent diffusion coefficient and tumour aggressiveness[J].Clinical Radiology,2010,65(12):1005-1012
[33]李伟,龙晚生,陈曼琼,等.乳腺磁共振波谱分析特征与影响因素研究[J].中国医疗器械信息,2010,16(10):17-21Li Wei,Long Wan-sheng,Chen Manqiong,et al.Study on the Characteristics and Influencing Factors of Magnetic Resonance Spectroscopy of Breast[J].Chinese Journal of Medical Device,2010,16(10):17-21
[34]旷连勤,张玉龙,程海云,等.1H-MRS复合胆碱积分在乳腺良恶性病变鉴别诊断中的应用[J].中国医学影像技术,2014(10):1500-1504Kuang Lian-qin,Zhang Yu-long,Cheng Hai-yun,et al.Application of1H-MRS combined choline integral in the differential diagnosis of benign and malignant breast lesions[J].Chinese Journal of Medical Imaging Technology,2014(10):1500-1504
[35]汪晓红,彭卫军,谭红娜,等.氢质子磁共振波谱监测乳腺癌新辅助化疗疗效的应用研究[J].中国医学计算机成像杂志,2010,16(1):20-24Wang Xiao-hong,Peng Wei-jun,Tan Hong-na,et al.Application of proton magnetic resonance spectroscopy in neoadjuvant chemotherapy for breast cancer[J].Chinese Journal of Medical Imaging,2010,16(1):20-24
[36]Basara I,?rgü?,Coskun T.Single voxel in vivo proton magnetic resonance spectroscopy of breast lesions:experience in 77 cases[J].Diagnostic&Interventional Radiology,2012,19(3):221-226
[37]Patel K,Chowdhury N,Doddapaneni R,et al.Piperlongumine for Enhancing Oral Bioavailability and Cytotoxicity of Docetaxel in Triple-Negative Breast Cancer[J].Journal of Pharmaceutical Sciences,2015,104(12):4417-4426
[38]Tse G M,Cheung H S,Pang L M,et al.Characterization of lesions of the breast with proton MR spectroscopy:comparison of carcinomas,benign lesions,and phyllodes tumors[J].Revista De Neurologia,2003,44(8):81-92
[39]Titley J C,Leach M O.Phospholipid metabolites,prognosis and proliferation in human breast carcinoma[J].NMR in Biomedicine,2003,6(5):318-323
[2]Shao G,Fan L,Zhang J,et al.Association of DW/DCE-MRI features with prognostic factors in breast cancer[J].International Journal of Biological Markers,2016[Epub ahead of print]
[3]张辉,邹利光,逄鑫,等.大鼠乳腺癌CT灌注成像与肿瘤病理分级和微血管密度相关性研究[J].第三军医大学学报,2010,32(11):1131-1135Zhang Hui,Zou Li-guang,Pang Xin,et al.Correlation of CT perfusion imaging with pathological grading and microvessel density in rat breast cancer[J].Journal of Third Military Medical University,2010,32(11):1131-1135
[4]盛美红,汤卫霞,陆益花,等.MRI动态增强扫描早期强化比值联合周围血管管径鉴别诊断乳腺良恶性病变的价值[J].中华放射学杂志,2016,50(5):324-328Sheng Mei-hong,Tang Wei-xia,Lu Yi-hua,et al.The value of MRI enhanced contrast-enhanced ratio and peripheral vascular diameter in the differential diagnosis of breast benign and malignant lesions[J].Chinese Journal of Radiology,2016,50(5):324-328
[5]Takeda Y,Yoshikawa K.Contrast-enhanced dynamic MR imaging parameters and histological types of invasive ductal carcinoma of breas[J].Biomedicine&pharmacotherapy,2005,59(3):115-121
[6]Elsevier.Magnetic resonance imaging clinics of North America[M].W.B.Saunders Co,1993
[7]Zhao H L,Liu Y,Cheng L.Application of 3.0 Tesla system in breast magnetic resonance imaging[J].Chinese Journal of Ct and Mri,2009,24(7):18-22
[8]Medeiros L R,Duarte C S,Rosa D D,et al.Accuracy of magnetic resonance in suspicious breast lesions:a systematic quantita tive review and meta-analysis[J].Breast Cancer Research and Treatment,2011,126(2):273-285
[9]李瑞敏,顾雅佳,毛健,等.定量动态增强MRI鉴别乳腺良恶性病变的研究[J].中华放射学杂志,2011,45(2):164-169Li Rui-min,Gu Ya-jia,Mao Jing,et al.Quantitative dynamic enhanced MRI in differentiating benign and malignant breast lesions[J].Chinese Journal of Radiology,2011,45(2):164-169
[10]关晏星,雷秋模,王莉,等.乳腺癌泌乳素受体与雌、孕激素受体的相关性[J].南昌大学学报(医学版),2001,41(1):40Guan Yan-xing,Lei Qiu-mo,Wang Li,et al.Relationship between prolactin receptor and estrogen receptor and progesterone receptor in breast cancer[J].Journal of nanchang university,2001,41(1):40
[11]代莹,傅静,魏兵,等.经他莫昔芬治疗的乳腺癌ER、PR阳性率和染色强度与预后的关系[J].临床与实验病理学杂志,2013,29(4):419-423Dai Ying,Fu Jing,Wei Bing,et al.The relationship between ER,PR positive rate and staining intensity and prognosis of breast cancer treated with tamoxifen[J].Journal of clinical and Experimental Pathology,2013,29(4):419-423
[12]Kim W H,Chang J M,Koo H R,et al.Impact of prior mammograms on combined reading of digital mammography and digital breast tomosynthesis[J].Acta Radiologica,2016[Epub ahead of print]
[13]Kurata T,Tsurutani J,Fujisaka Y,et al.Inhibition of EGFR,HER2and HER3 signaling with AZD8931 alone and in combination with paclitaxel:phase i study in Japanese patients with advanced solid malignancies and advanced breast cancer[J].Invest New Drugs,2014,32,946-954
[14]Tanner M,J覿rvinen P,Isola J.Amplification of HER-2/neu and topoisomerase IIalpha in primary and metastatic breast cancer[J].Cancer Research,2001,61(14):5345-5348
[15]赵莉芸,周纯武,张仁知,等.动态增强MRI定量参数与乳腺癌分子亚型的关系[J].中国医学影像技术,2013,(7):1126-1130Zhao Li-yun,Zhou Chun-wu,Zhang Ren-zhi,et al.The relationship between dynamic enhanced MRI quantitative parameters and molecular subtypes of breast cancer[J].Chinese medical imaging technology,2013,(7):1126-1130
[16]苏灵暄,曹艳君,姚伟,等.HER-2影响实体肿瘤血管生成的数值模拟研究[J].生物医学工程学进展,2013,34(4):203-207Su Ling-xuan,Cao Yan-jun,Yao Wei,et al.Numerical simulation study on the effect of HER-2 on the angiogenesis of solid tumor[J].Progress in Biomedical Engineering,2013,34(4):203-207
[17]韩慧.血管生成调节蛋白在乳腺癌中的表达及相关性研究[D].山东大学,2014Han Hui.Study on the expression and correlation of angiogenesis regulated protein in breast cancer[D].Shandong University,2014
[18]Kim J Y,Kim S H,Kim Y J,et al.Enhancement parameters on dynamic contrast enhanced breast MRI:do they correlate with prognostic factors and subtypes of breast cancers[J].Magnetic Resonance Imaging,2015,33(1):72-80
[19]费莹,许建铭,沈钧康,等.乳腺癌DCE-MRI定量参数与生物学预后因子的相关性研究[J].医学影像学杂志,2016,26(9):1625-1628Fei Ying,Xu Jian-mng,Shen Jun-kang,et al.Correlation between quantitative parameters of DCE-MRI and biological prognostic factors in breast cancer[J].Journal of medical imaging,2016,26(9):1625-1628
[20]Park S H,Hye-Young Choi M D,Hahn S Y.Correlations between apparent diffusion coefficient values of invasive ductal carcinoma and pathologic factors on diffusion-weighted MRI at 3.0 Tesla[J].Journal of Magnetic Resonance Imaging,2015,41(1):175-182
[21]Woodhams R,Matsunaga K,Kan S,et al.ADC mapping of benign and malignant breast tumors[J].Magnetic Resonance in Medical Sciences,2005,4(1):35-42
[22]Lo G G,Ai V,Chan J K,et al.Diffusion-weighted magnetic resonance imaging of breast lesions:first experiences at 3 T[J].Journal of Computer Assisted Tomography,2009,33(1):63-69
[23]Yoshito Tsushima M D,Ayako Takahashi-Taketomi M D,Keigo Endo M D.Magnetic resonance(MR)differential diagnosis of breast tumors using apparent diffusion coefficient(ADC)on 1.5-T[J].Journal of Magnetic Resonance Imaging,2009,30(2):249-255
[24]Hatakenaka M,Soeda H,Yabuuchi H,et al.Apparent diffusion coefficients of breast tumors:clinical application[J].Magnetic Resonance in Medical Sciences,2008,7(1):23-29
[25]Kuroki Y,Nasu K.Advances in breast MRI:diffusion-weighted imaging of the breast[J].Breast Cancer,2008,15(3):212-217
[26]姚尉,李成杰,杨静.MRI动态增强扫描及DWI在乳腺癌中的诊断价值[J].四川医学,2013,34(4):591-593Yao Wei,Li Cheng-jie,Yang Jing,et al.Diagnostic value of dynamic contrast-enhanced MRI and DWI in breast cancer[J].Journal of Sichuan Medical Sciences,2013,34(4):591-593
[27]Martincich L,Deantoni V,Bertotto I,et al.Correlations between diffusion-weighted imaging and breast cancer biomarkers[J].European Radiology,2012,22(7):1519-1528
[28]Stephen RM,Pagel MD,Brown K,et al.Monitoring the development of xenograft triple-negative breast cancer models using diffusion weighted magnetic resonance imaging[J].Exp Biol Med(Maywood),2012,237(11):1273-1280
[29]Jeh S K,Kim S H,Choi J J,et al.Comparison of automated breast ultrasonography to handheld ultrasonography in detecting and diagnosing breast lesions[J].Acta Radiologica,2016,(2)[Epub ahead of print]
[30]季冬,李铭,赵泽华,等.MR氢质子波谱成像在乳腺癌中的应用[J].中国医学计算机成像杂志,2010,16(2):111-114Ji Dong,Li Ming,Zhao Ze-hua,et al.Application of MR proton spectroscopy in breast cancer[J].Chinese Journal of Medical Imaging,2010,16(2):111-114
[31]Kim S H,Cha E S,Kim H S,et al.Diffusion-weighted imaging of breast cancer:Correlation of the apparent diffusion coefficient value with prognostic factors[J].Journal of Magnetic Resonance Imaging,2009,30(3):615-620
[32]Costantini M,Rinaldi P,Franceschini G,et al.Diffusion-weighted imaging in breast cancer:relationship between apparent diffusion coefficient and tumour aggressiveness[J].Clinical Radiology,2010,65(12):1005-1012
[33]李伟,龙晚生,陈曼琼,等.乳腺磁共振波谱分析特征与影响因素研究[J].中国医疗器械信息,2010,16(10):17-21Li Wei,Long Wan-sheng,Chen Manqiong,et al.Study on the Characteristics and Influencing Factors of Magnetic Resonance Spectroscopy of Breast[J].Chinese Journal of Medical Device,2010,16(10):17-21
[34]旷连勤,张玉龙,程海云,等.1H-MRS复合胆碱积分在乳腺良恶性病变鉴别诊断中的应用[J].中国医学影像技术,2014(10):1500-1504Kuang Lian-qin,Zhang Yu-long,Cheng Hai-yun,et al.Application of1H-MRS combined choline integral in the differential diagnosis of benign and malignant breast lesions[J].Chinese Journal of Medical Imaging Technology,2014(10):1500-1504
[35]汪晓红,彭卫军,谭红娜,等.氢质子磁共振波谱监测乳腺癌新辅助化疗疗效的应用研究[J].中国医学计算机成像杂志,2010,16(1):20-24Wang Xiao-hong,Peng Wei-jun,Tan Hong-na,et al.Application of proton magnetic resonance spectroscopy in neoadjuvant chemotherapy for breast cancer[J].Chinese Journal of Medical Imaging,2010,16(1):20-24
[36]Basara I,?rgü?,Coskun T.Single voxel in vivo proton magnetic resonance spectroscopy of breast lesions:experience in 77 cases[J].Diagnostic&Interventional Radiology,2012,19(3):221-226
[37]Patel K,Chowdhury N,Doddapaneni R,et al.Piperlongumine for Enhancing Oral Bioavailability and Cytotoxicity of Docetaxel in Triple-Negative Breast Cancer[J].Journal of Pharmaceutical Sciences,2015,104(12):4417-4426
[38]Tse G M,Cheung H S,Pang L M,et al.Characterization of lesions of the breast with proton MR spectroscopy:comparison of carcinomas,benign lesions,and phyllodes tumors[J].Revista De Neurologia,2003,44(8):81-92
[39]Titley J C,Leach M O.Phospholipid metabolites,prognosis and proliferation in human breast carcinoma[J].NMR in Biomedicine,2003,6(5):318-323