TWEAK及其受体Fn14信号通路与肺部疾病的研究进展
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摘要
肿瘤坏死因子样凋亡微弱诱导剂(TWEAK)是肿瘤坏死因子超家族的新成员之一。TWEAK通过细胞间的相互作用或旁分泌方式与其受体成纤维细胞生长因子诱导早期反应蛋白14(Fn14)结合,调节细胞的增殖、分化、迁移、凋亡和炎症等多种活动。TWEAK/Fn14信号通路在肺损伤、哮喘以及肺癌等肺部疾病发生发展过程中的作用日益受到关注。
Tumor necrosis factor-like attenuated apoptosis inducer(TWEAK) is a new member of the tumor necrosis factor super family. TWEAK regulates cellular proliferation, differentiation, migration,apoptosis and inflammation by binding its receptor, fibroblast growth factor-inducible 14(Fn14), through the interaction between cells or in a paracrine fashion. The role of TWEAK/Fn14 signaling pathway in the development of lung diseases such as lung injury, asthma and lung cancer has drawn increasing attention.
Tumor necrosis factor-like attenuated apoptosis inducer(TWEAK) is a new member of the tumor necrosis factor super family. TWEAK regulates cellular proliferation, differentiation, migration,apoptosis and inflammation by binding its receptor, fibroblast growth factor-inducible 14(Fn14), through the interaction between cells or in a paracrine fashion. The role of TWEAK/Fn14 signaling pathway in the development of lung diseases such as lung injury, asthma and lung cancer has drawn increasing attention.
引文
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[2]Wang X,Xiao S,Xia Y.Tumor Necrosis Factor Receptor Mediates Fibroblast Growth Factor-Inducible 14 Signaling[J].Cell Physiol Biochem,2017,43(2):579-588.DOI:10.1159/000480530.
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[4]Wang A,Zhang F,Xu H,et al.TWEAK/Fn14 promotes pro-inflammatory cytokine secretion in hepatic stellate cells via NF-κB/STAT3 pathways[J].Mol Immunol,2017,87:67-75.DOI:10.1016/j.molimm.2017.04.003.
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[13]Liu Q,Xiao S,Xia Y.TWEAK/Fn14 Activation Participates in Skin Inflammation[J].Mediators Inflamm,2017,2017:6746870.DOI;10.1155/2017/6746870.
[14]Johnston AJ,Hoogenraad NJ.Fn14:a new player in cancer-induced cachexia[J].Curr Opin Clin Nutr Metab Care,2016,19(4):316-318.DOI:10.1097/MCO.0000000000000294.
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[19]Son A,Oshio T,Kawamura YI,et al.TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice[J].Mucosal Immunol,2013,6(6):1131-1142.DOI:10.1038/mi.2013.10.
[20]Novoyatleva T,Schymura Y,Janssen W,et al.Deletion of Fn14receptor protects from right heart fibrosis and dysfunction[J].Basic Res Cardiol,2013,108(2):325.DOI:10.1007/s00395-012-0325-x.
[21]Kuramitsu K,Sverdlov DY,Liu SB,et al.Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation[J].Am J Pathol,2013,183(1):182-194.DOI:10.1016/j.ajpath.2013.03.018.
[22]Zhou Y,Li P,Duan JX,et al.Aucubin Alleviates Bleomycin-Induced Pulmonary Fibrosis in a Mouse Model[J].Inflammation,2017,40(6):2062-2073.DOI:10.1007/s10753-017-0646-x.
[23]Papi A,Brightling C,Pedersen SE,et al.Asthma[J].Lancet,2018,391(10122):783-800.DOI:10.1016/S0140-6736(17)33311-1.
[24]李俊红,罗雅玲,赖文岩,等.地塞米松对哮喘小鼠肺组织中TWEAK及其受体Fn14表达的调节作用[J].细胞与分子免疫学杂志,2012,28(11):1138-1141.
[25]Itoigawa Y,Harada N,Harada S,et al.TWEAK enhances TGF-β-induced epithelial-mesenchymal transition in human bronchial epithelial cells[J].Respir Res,2015,16(1):1-15.DOI:10.1186/s12931-015-0207-5.
[26]Zhu C,Zhang L,Liu Z,et al.TWEAK/Fn14 interaction induces proliferation and migration in human airway smooth muscle cells via activating the NF-κB pathway[J].J Cell Biochem,2018,119(4):3528-3536.DOI:10.1002/jcb.26525.
[27]Hu G,Zeng W,Xia Y.TWEAK/Fn14 signaling in tumors[J].Tumour Biol,2017,39(6):1010428317714624.DOI:10.1177/1010428317714624.
[28]Whitsett TG,Fortin ESP,Dhruv HD,et al.FN14 expression correlates with MET in NSCLC and promotes MET-driven cell invasion[J].Clin Exp Metastasis,2014,31(6):613-623.DOI:10.1007/s10585-014-9653-6.
[29]Whitsett TG,Mathews IT,Cardone MH,et al.Mcl-1 mediates T W E AK/Fn14-induced non-small cell lung cancer survival and therapeutic response[J].Mol Cancer Res,2014,12(4):550-559.DOI:10.1158/1541-7786.MCR-13-0458.
[2]Wang X,Xiao S,Xia Y.Tumor Necrosis Factor Receptor Mediates Fibroblast Growth Factor-Inducible 14 Signaling[J].Cell Physiol Biochem,2017,43(2):579-588.DOI:10.1159/000480530.
[3]Sharif MN,Campanholle G,Nagiec EE,et al.Soluble Fn14 Is Detected and Elevated in Mouse and Human Kidney Disease[J].PLoS One,2016,11(5):e0155368.DOI:10.1371/journal.pone.0155368.
[4]Wang A,Zhang F,Xu H,et al.TWEAK/Fn14 promotes pro-inflammatory cytokine secretion in hepatic stellate cells via NF-κB/STAT3 pathways[J].Mol Immunol,2017,87:67-75.DOI:10.1016/j.molimm.2017.04.003.
[5]Xu WD,Zhao Y,Liu Y.Role of the TWEAK/Fnl4 pathway in autoimmune diseases[J].Immunol Res,2016,64(1):44-50.DOI:10.1007/s12026-015-8761-y.
[6]Perez JG,Tran NL,Rosenblum MG,et al.The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics[J].Oncogene,2016,35(17):2145-2155.DOI:10.1038/onc.2015.310.
[7]Meulendijks D,Lassen UN,Siu LL,et al.Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumor[J].Clin Cancer Res,2016,22(4):858-867.DOI:10.1158/1078-0432.CCR-15-1506.
[8]Nazeri A,Heydarpour P,Sadaghiani S,et al.A further TWEAK to multiple sclerosis pathophysiology[J].Mol Neurobiol,2014,49(1):78-87.DOI:10.1007/s12035-013-8490-y.
[9]Claus M,Herro R,Wolf D,et al.The TWEAK/Fn14 pathway is required for calcineurin inhibitor toxicity of the kidneys[J].Am J Transplant,2017.DOI:10.1111/ajt.14632.
[10]Burkly LC.TWEAK/Fn14 axis:the current paradigm of tissue injury-inducible function in the midst of complexities[J].Semin Immunol,2014,26(3):229-236.DOI:10.1016/j.smim.2014.02.006.
[11]Winkles JA.The TWEAK-Fn14 cytokine-receptor axis:discovery,biology and therapeutic targeting[J].Nat Rev Drug Discov,2008,7(5):411-425.DOI:10:1038/nrd2488.
[12]Qi X,Qin L,Du R,et al.Lipopolysaccharide Upregulated Intestinal Epithelial Cell Expression of Fn14 and Activation of Fn14Signaling Amplify Intestinal TLR4-Mediated Inflammation[J].Front Cell Infect Microbiol,2017,7:315.DOI:10.3389/fcimb.2017.00315.
[13]Liu Q,Xiao S,Xia Y.TWEAK/Fn14 Activation Participates in Skin Inflammation[J].Mediators Inflamm,2017,2017:6746870.DOI;10.1155/2017/6746870.
[14]Johnston AJ,Hoogenraad NJ.Fn14:a new player in cancer-induced cachexia[J].Curr Opin Clin Nutr Metab Care,2016,19(4):316-318.DOI:10.1097/MCO.0000000000000294.
[15]Francoso A,Simioni PU.Immunotherapy for the treatment of colorectal tumors:focus on approved and in-clinical-trial monoclonalantibodies[J].Drug Des Devel Ther,2017,11:177-184.DOI:10.2147/DDDT.S119036.
[16]Zou Y,Bao S,Wang F,et al.FN14 Blockade on Pulmonary Microvascular Endothelial Cells Improves the Outcome of Sepsis-Induced Acute Lung Injury[J].Shock,2018,49(2):213-220.DOI:10.1097/SHK.0000000000000915.
[17]丛鲁红,李晨,陈德生,等.可吸入颗粒物PM2.5对大鼠急性肺损伤及肺纤维化的影响[J].中国医师杂志,2016,18(6):857-860,864.DOI:10.3760/cma.j.issn.1008-1372.2016.06.015.
[18]Gomez IG,Roach AM,Nakagawa N,et al.TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease[J].J Am Soc Nephrol,2016,27(12):3639-3652.DOI:10.1681/ASN.2015111227.
[19]Son A,Oshio T,Kawamura YI,et al.TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice[J].Mucosal Immunol,2013,6(6):1131-1142.DOI:10.1038/mi.2013.10.
[20]Novoyatleva T,Schymura Y,Janssen W,et al.Deletion of Fn14receptor protects from right heart fibrosis and dysfunction[J].Basic Res Cardiol,2013,108(2):325.DOI:10.1007/s00395-012-0325-x.
[21]Kuramitsu K,Sverdlov DY,Liu SB,et al.Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation[J].Am J Pathol,2013,183(1):182-194.DOI:10.1016/j.ajpath.2013.03.018.
[22]Zhou Y,Li P,Duan JX,et al.Aucubin Alleviates Bleomycin-Induced Pulmonary Fibrosis in a Mouse Model[J].Inflammation,2017,40(6):2062-2073.DOI:10.1007/s10753-017-0646-x.
[23]Papi A,Brightling C,Pedersen SE,et al.Asthma[J].Lancet,2018,391(10122):783-800.DOI:10.1016/S0140-6736(17)33311-1.
[24]李俊红,罗雅玲,赖文岩,等.地塞米松对哮喘小鼠肺组织中TWEAK及其受体Fn14表达的调节作用[J].细胞与分子免疫学杂志,2012,28(11):1138-1141.
[25]Itoigawa Y,Harada N,Harada S,et al.TWEAK enhances TGF-β-induced epithelial-mesenchymal transition in human bronchial epithelial cells[J].Respir Res,2015,16(1):1-15.DOI:10.1186/s12931-015-0207-5.
[26]Zhu C,Zhang L,Liu Z,et al.TWEAK/Fn14 interaction induces proliferation and migration in human airway smooth muscle cells via activating the NF-κB pathway[J].J Cell Biochem,2018,119(4):3528-3536.DOI:10.1002/jcb.26525.
[27]Hu G,Zeng W,Xia Y.TWEAK/Fn14 signaling in tumors[J].Tumour Biol,2017,39(6):1010428317714624.DOI:10.1177/1010428317714624.
[28]Whitsett TG,Fortin ESP,Dhruv HD,et al.FN14 expression correlates with MET in NSCLC and promotes MET-driven cell invasion[J].Clin Exp Metastasis,2014,31(6):613-623.DOI:10.1007/s10585-014-9653-6.
[29]Whitsett TG,Mathews IT,Cardone MH,et al.Mcl-1 mediates T W E AK/Fn14-induced non-small cell lung cancer survival and therapeutic response[J].Mol Cancer Res,2014,12(4):550-559.DOI:10.1158/1541-7786.MCR-13-0458.