中医药对Dll4-Notch信号通路及血管再生影响的研究
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摘要
从Dll4-Not ch信号通路、中医药对Dll 4-Not ch信号通路影响的研究、中医药对血管再生影响的研究3方面入手探讨中医药对Dll4-Not ch信号通路、血管再生的影响,指出Dll 4-Not ch信号通路是研究较多的、较为成熟的抗肿瘤血管再生的通路,其机理为阻断该通路而抑制血管再生,而通过介导Dll 4-Not ch信号通路来促进血管生成方面的研究未见报道,这将成为中医药在创伤、显微外科组织修复方面新的研究方向,能够进一步丰富中医药理论。
The effects of traditional Chinese medicine on D114-Notch signaling pathway and revascularization are discussed from the aspects of D114-Notch signaling pathway, study on the effects of TCM on D114-Notch signaling pathway and the study on the effects of TCM on revascularization, it is pointed out that D114-Notch signaling pathway is one of the more mature and effective approaches to fight against tumor revascularization, and its mechanism is to block the pathway and inhibit revascularization, while the study on mediating D114-Notch signaling pathway to promote revascularization has never been reported, and it would become the new research direction for TCM in trauma and microsurgical tissue repair, which could further enrich the theory of TCM.
The effects of traditional Chinese medicine on D114-Notch signaling pathway and revascularization are discussed from the aspects of D114-Notch signaling pathway, study on the effects of TCM on D114-Notch signaling pathway and the study on the effects of TCM on revascularization, it is pointed out that D114-Notch signaling pathway is one of the more mature and effective approaches to fight against tumor revascularization, and its mechanism is to block the pathway and inhibit revascularization, while the study on mediating D114-Notch signaling pathway to promote revascularization has never been reported, and it would become the new research direction for TCM in trauma and microsurgical tissue repair, which could further enrich the theory of TCM.
引文
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[12]杨丹丹.活血祛瘀法对缺血性心肌损伤作用的系统评价及实验研究[D].北京:北京中医药大学,2016.
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[15]马勇.丹红注射液防治小腿皮神经营养血管皮瓣术后血管危象的临床研究[D].福州:福建中医药大学,2014.
[16]周昭辉,刘甲,孙达武.桃红四物汤对大鼠随意皮瓣成活的影响[J].中医药导报,2011,17(7):75-76.
[17]李刚.基于“祛瘀生新”治则应用活血化瘀药物干预显微外科术后组织修复的实验及临床研究[D].长沙:湖南中医药大学,2015.
[18]李刚,程春生.“祛瘀生新”理论指导下胫腓骨骨皮瓣游离移植术后二次感染临床研究[J].新中医,2015,47(1):135-137.
[19]刘忠和,李盛华.陇中消肿止痛液对外伤后软组织损伤的实验研究[J].甘肃中医,2005,18(8):46-47.
[20]张绍文.消肿止痛合剂治疗创伤性炎症反应综合征的疗效观察[J].甘肃医药,2015,34(9):690-691.
[21]李盛华,潘文,闵云山,等.陇中消肿止痛液治疗创伤早期肿痛2638例的临床研究[J].甘肃中医,2001,14(4):33-34.
[22]赵萍.血管内皮细胞VEGF在鼠尾再植术后的表达及加味活血祛瘀糖浆干预的实验研究[J].甘肃中医,2010,23(2):38-40.
[23]赵萍.血管内皮细胞VEGF在鼠尾再植术后的表达及消肿止痛合剂干预的实验研究[D].兰州:兰州大学,2009.
[2]Blanco R,Gerhardt H.VEGF and Notch in tip and stalk cell selection[J].Cold Spring Harb Perspect Med,2013,3(1):1-19.
[3]Ishibashi S,Kondo H.Effect of intravitreal bevacizumab injection on iris and iridocorneal angle neovascularization in neovascular glaucoma[J].JUOEH,2015,37(4):299-304.
[4]Costache MI,Ioana M,Iordache S,et al.VEGF expression in pancreatic cancer and other malignancies:a review of the Literature[J].Rom J Intern Med,2015,53(3):199-208.
[5]Eilken HM,Admas RH.Dynamics of the endothelial cell behavior in sprouting angiogenesis[J].Current opinion in cell biology,2010,22(5):617-625.
[6]Jakobsson L,Franco CA,Bentley K,et al.Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting[J].Nature cell biology,2010,12(10):943-953.
[7]李文,李长生.VEGF-Notch信号通路与血管再生的关系[J].山东医药,2014,54(13):83-85.
[8]Noguera-Troise I,Daly C,Papadopoulos NJ,et al.Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis[J].Nature,2006,444(7122):1032-1037.
[9]苗学红.补肾疏肝方对肺腺癌A549细胞凋亡及Notch信号通路研究[J].郑州:郑州大学,2014.
[10]刘少琼,杨芳,禹正杨.姜黄素对大肠癌细胞抑制作用Notch信号通路的研究进展[J].湖南中医杂志,2013,29(12):163-168.
[11]苏垠旭.养肺活血方干预Notch信号通路影响肺纤维化免疫反应的实验研究[D].南京:南京中医药大学,2016.
[12]杨丹丹.活血祛瘀法对缺血性心肌损伤作用的系统评价及实验研究[D].北京:北京中医药大学,2016.
[13]陈可冀,李连达,翁维良.血瘀证与活血化瘀研究[J].中西医结合心脑血管病杂志,2005,3(1):1-2.
[14]陈可冀.现代活血化瘀学派的传承创新发展轨迹[J].中国中西医结合杂志,2015,35(12):1413-1414.
[15]马勇.丹红注射液防治小腿皮神经营养血管皮瓣术后血管危象的临床研究[D].福州:福建中医药大学,2014.
[16]周昭辉,刘甲,孙达武.桃红四物汤对大鼠随意皮瓣成活的影响[J].中医药导报,2011,17(7):75-76.
[17]李刚.基于“祛瘀生新”治则应用活血化瘀药物干预显微外科术后组织修复的实验及临床研究[D].长沙:湖南中医药大学,2015.
[18]李刚,程春生.“祛瘀生新”理论指导下胫腓骨骨皮瓣游离移植术后二次感染临床研究[J].新中医,2015,47(1):135-137.
[19]刘忠和,李盛华.陇中消肿止痛液对外伤后软组织损伤的实验研究[J].甘肃中医,2005,18(8):46-47.
[20]张绍文.消肿止痛合剂治疗创伤性炎症反应综合征的疗效观察[J].甘肃医药,2015,34(9):690-691.
[21]李盛华,潘文,闵云山,等.陇中消肿止痛液治疗创伤早期肿痛2638例的临床研究[J].甘肃中医,2001,14(4):33-34.
[22]赵萍.血管内皮细胞VEGF在鼠尾再植术后的表达及加味活血祛瘀糖浆干预的实验研究[J].甘肃中医,2010,23(2):38-40.
[23]赵萍.血管内皮细胞VEGF在鼠尾再植术后的表达及消肿止痛合剂干预的实验研究[D].兰州:兰州大学,2009.