眼表过敏性疾病过敏原特点分析
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摘要
目的:研究Ig E相关眼表过敏性疾病过敏原特点及临床意义。方法:收集并分析本地区2011-2015年376例眼表过敏性疾病患者病历资料,分析过敏原及相关因素特点。结果:眼表过敏性疾病中,季节性过敏性结膜炎成年人占比64.8%,春季花粉过敏者高达65.4%,多伴发过敏性鼻炎和过敏性皮炎;常年性过敏性结膜炎青少年占比86.1%,尘螨过敏者高达65.9%,多伴发过敏性鼻炎;春季卡他性结膜炎过敏原不显著;特应性结膜炎尘螨过敏者高达90.5%,且混合过敏者多,容易合并多重过敏性疾病。结论:不同眼表过敏性疾病过敏原特点对临床诊断分型、后期治疗有指导性意义。
Objective:To investigate the characteristics and clinic significance of allergen test in ocular surface allergy.Method:376 ocular surface allergic diseases patient had been collected from 2011 to 2015,analyzing the clinic data,allergen test result,other related elements.Result:Ocular surface allergy had different types.About 64.8% patients were adult in seasonal allergic conjunctivitis,who allergic to spring pollens up to 65.4% and easier to complicate with allergic rhinitis and allergic dermatitis.About 86.1% patients were children and adolescents in perennial allergic conjunctivitis,who allergic to dust mite up to 65.9% and easier to complicate with allergic rhinitis.Vernal keratoconjunctivitis had no significant allergens.Atopic keratoconjunctivitis was always multi-sensitized,especially allergic to dust mite up to 90.5%,and was easier to comorbid with other allergic diseases.Conclusion:The patterns of allergen have great benefits for ocular surface allergy in clinic diagnosis and further management.
Objective:To investigate the characteristics and clinic significance of allergen test in ocular surface allergy.Method:376 ocular surface allergic diseases patient had been collected from 2011 to 2015,analyzing the clinic data,allergen test result,other related elements.Result:Ocular surface allergy had different types.About 64.8% patients were adult in seasonal allergic conjunctivitis,who allergic to spring pollens up to 65.4% and easier to complicate with allergic rhinitis and allergic dermatitis.About 86.1% patients were children and adolescents in perennial allergic conjunctivitis,who allergic to dust mite up to 65.9% and easier to complicate with allergic rhinitis.Vernal keratoconjunctivitis had no significant allergens.Atopic keratoconjunctivitis was always multi-sensitized,especially allergic to dust mite up to 90.5%,and was easier to comorbid with other allergic diseases.Conclusion:The patterns of allergen have great benefits for ocular surface allergy in clinic diagnosis and further management.
引文
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[11]穆剑,王梅,胡玉新,等.不同年龄过敏性结膜炎变应原分析[J].岭南急诊医学杂志,2013,18(5):359-361.
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[14]林燕梅.血清霉菌特异性Ig E阳性支气管哮喘患者的临床及过敏状态分析[J].中国医药指南,2014,12(20):32-33.
[15]吴延延,郑晓冬,蔡新颖.中国汉族特应性皮炎4757例患者过敏史相关性分析[J].中国皮肤性病学杂志,2016,30(5):464-467.
[2]Palmares J,Delgado L,Cidade M,et al.Allergic conjunctivitis:a national cross-sectional study of clinical characteristics and quality of life[J].Eur J Ophthalmol,2010,20(2):257-264.
[3]Leonardi A,Bogacka E,Fauquert J L,et al.Ocular allergy:recognizing and diagnosing hypersensitivity disorders of the ocular surface[J].Allergy,2012,67(11):1327-1337.
[4]Anderson D F,Zhang S,Bradding P,et al.The relative contribution of mast cell subsets to conjunctival TH2-like cytokines[J].Invest Ophthalmol Vis Sci,2001,42(5):995-1001.
[5]Leonardi A.Vernal keratoconjunctivitis:pathogenesis and treatment.[J].Prog Retin Eye Res,2002,21(2):319-339.
[6]Bonini S.Atopic keratoconjunctivitis[J].Allergy 2004,59(Suppl78):71-73.
[7]Baudouin C.Allergic reaction to topical eyedrops[J].Curr Opin Allergy Clin Immunol,2005,5(5):459-463.
[8]Thakur A,Willcox M D.Contact lens wearalters the production of certain inflammatory mediators in tears[J].Exp Eye Res,2000,70(3):255-259.
[9]Singh K,Axelrod S,Bielory L.The epidemiology of ocular and nasal allergy in the United States,1988-1994[J].J Allergy Clin Immunol,2010,126(4):778-783.
[10]田桂花.季节性过敏性和常年性过敏性结膜炎的变应原检测及治疗分析[J].临床眼科杂志,2008,16(4):345-346.
[11]穆剑,王梅,胡玉新,等.不同年龄过敏性结膜炎变应原分析[J].岭南急诊医学杂志,2013,18(5):359-361.
[12]赵德育.儿童变态反应性疾病[J].实用儿科临床杂志,2010,25(21):1609-1610.
[13]祝戎飞,黄南,张威,等.花粉浓度对过敏性鼻炎临床症状及抗过敏治疗效果的影响[J].华中科技大学学报(医学版),2010,39(5):708-711.
[14]林燕梅.血清霉菌特异性Ig E阳性支气管哮喘患者的临床及过敏状态分析[J].中国医药指南,2014,12(20):32-33.
[15]吴延延,郑晓冬,蔡新颖.中国汉族特应性皮炎4757例患者过敏史相关性分析[J].中国皮肤性病学杂志,2016,30(5):464-467.