肠道菌群对药物代谢影响的研究进展
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摘要
肠道菌群是寄居在肠道的种类繁多、数量庞大的微生物群落,对药物等外来化合物的代谢至关重要,近年来肠道菌群作为机体"隐形器官"被广泛关注。通过查阅国内外相关文献,该文对机体中肠道菌群的分类、功能及其对中药化学成分和化学药物代谢的影响进行了分析、归纳和总结。了解肠道菌群对药物代谢的影响,明确药物转化过程,对于指导临床合理用药、个体化用药、毒理学评估及推动药物发现和研发具有重要意义,为后期研究高原环境下肠道菌群对药物代谢的影响提供理论指导。
A large number of gut flora communities have colonized in the intestine, which is crucial to the metabolism of foreign compounds such as drugs. In recent years, the gut flora has been widely regarded as the "invisible organ" of the body. By reviewing the pertinent literature at home and abroad, classifications and functions of intestinal flora and its influence on the chemical composition and chemical metabolism of Chinese medicine are analyzed in the article. Understanding the impact of intestinal flora on drug metabolism and the process of drug conversion has great significance in guiding clinical rational drug use and individual therapy, evaluating toxicity and promoting drug discovery and development, and providing theoretical guidance for the study of the effects of intestinal flora on drug metabolism in the plateau environment.
A large number of gut flora communities have colonized in the intestine, which is crucial to the metabolism of foreign compounds such as drugs. In recent years, the gut flora has been widely regarded as the "invisible organ" of the body. By reviewing the pertinent literature at home and abroad, classifications and functions of intestinal flora and its influence on the chemical composition and chemical metabolism of Chinese medicine are analyzed in the article. Understanding the impact of intestinal flora on drug metabolism and the process of drug conversion has great significance in guiding clinical rational drug use and individual therapy, evaluating toxicity and promoting drug discovery and development, and providing theoretical guidance for the study of the effects of intestinal flora on drug metabolism in the plateau environment.
引文
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[21] 张钰哲. 离体大鼠肠内菌群对知母甾体皂苷代谢研究[J]. 大理学院学报(综合版), 2012, 11(3):5-8. Zhang Y Z. In vitro study of rat Coliform bacteria metabolism of steroidal sponin extract from Anemarrhena asphodeloides[J]. J Dali Univ, 2012,11(3):5-8.
[22] Swanson H I. Drug metabolism by the host and gut microbiota: a partnership or rivalry[J]. Drug Metab Dispos, 2015, 43(10):1499-504.
[23] Yoo D H,Kim I S,Van Le T K,et al. Gut microbiota-mediated drug interactions between lovastatin and antibiotics[J]. Drug Metab Dispos, 2014, 42(9):1508-13.
[24] Kim I S,Yoo D H,Jung I H,et al. Reduced metabolic activity of gut microbiota by antibiotics can potentiate the antithrombotic effect of aspirin[J]. Biochem Pharmacol, 2016,122(15):72-9.
[25] 文仁国,孙国林,彭晓波,等.长期缺氧对婴幼儿肠道菌群代谢的影响[J]. 局解手术学杂志,2014,23(2):121-2. Wen R G,Sun G L,Peng X B,et al. Chronic hypoxia in altering metabolism of intestinal flora of infants[J]. J Reg Anat Oper Surg, 2014,23(2):121-2.
[2] Mai V, Draganov P V. Recent advances and remaining gaps in our knowledge of associations between gut microbiota and human health[J]. World J Gastroenterol, 2009, 15(1):81-5.
[3] Wang R, Sun Y,Yin Q, et al. The effects of metronidazole on cytochrome P450 activity and expression in rats after acute exposure to high altitude of 4300m[J]. Biomed Pharmacother, 2016,85:296-302.
[4] 张明霞,王荣,李文斌,等. 高原缺氧对药物转运体影响的研究进展[J]. 中国药理学通报,2018,34(3):316-21. Zhang M X,Wang R,Li W B,et al. Advances of studies on effect of drugtran sporter under hypoxia[J]. Chin Pharmacol Bull,2018,34(3):316-21.
[5] Pai R, Kang G. Microbes in the gut: a digestable account of host-symbiont interactions[J]. Indian J Med Res, 2008, 128(5):587-94.
[6] Eckburg P B, Bik E M, Bernstein C N, et al. Diversity of the human intestinal microbial flora[J]. Science, 2005, 308(5728):1635-8.
[7] 周正华. 肠道微环境与溃疡性结肠炎[J]. 世界华人消化杂志,2016,24(11):1695-700.
[7] Zhou Z H. Intestinal micro-ecology and ulcerative colitis[J]. World Chin J Digestol, 2016,24(11):evi'c M, Boji'c G, Salami H A, et al. The influence of intestinal tract and probiotics on the fate of orally administered drugs[J]. Curr Issues Mol Biol, 2014,16(2):55-68.
[9] Bagarolli R A,Tobar N,Oliveira A G, et al. Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice[J]. J Nutr Biochem, 2017,50:16-25.
[10] 杨文翠. 谷氨酰胺对急进高原缺氧大鼠肠道微生态影响的实验研究[D]. 兰州:兰州大学,2010. Yang W C. Effect of glutamine on change of intestinal microecology in rats exposed to acute plateau hypoxia[D]. Lanzhou: Lanzhou University,2010.
[11] Haiser H J, Turnbaugh P J. Developing a metagenomic view of xenobiotic metabolism[J]. Pharmacol Res, 2013, 69(1):21-31.
[12] Lee H J, Zhang H, Orlovich D A, et al. The influence of probiotic treatment on sulfasalazine metabolism in rat[J]. Xenobiotica, 2012, 42(8):791-7.
[13] Takeno S, Sakai T. Involvement of the intestinal microflora in nitrazepam-induced teratogenicity in rats and its relationship to nitroreduction[J]. Teratology, 1991,44(2):209-14.
[14] 祖先鹏, 林璋, 谢海胜. 等. 中药有效成分与肠道菌群相互作用的研究进展[J]. 中国中药杂志, 2016, 41(10):1766-72. Zu X P, Lin Z, Xie H S, et al. Interaction of effective ingredients from traditional Chinese medicines with intestinal microbiota[J]. Chin J Chin Mater Med, 2016,41(10):1766-72.
[15] 李芳,杨培民,曹广尚,等. 体外培养肠道菌群对白花蛇舌草黄酮提取物的代谢研究[J]. 医药导报,2016,35(8):809-13. Li F,Yang P M,Cao G S, et al. Study on the metabolism of Hedyotis Diffusa flavonoid extract by intestinal bacteria in vitro[J]. Her Med, 2016,35(8):809-13.
[16] 高霞,耿婷,马阳,等.离体大鼠肠道菌对6种皂苷类成分代谢研究[J]. 中国中药杂志,2016,41(12):2329-38. Gao X,Gen T,Ma Y, et al. Metabolism of six saponins by rat intestinal bacteria in vitro[J]. Chin J Chin Mater Med, 2016,41(12):2329-38
[17] Zhang M, Peng C S, Li X B. In vivo and in vitro metabolites from the main diester and monoester diterpenoid alkaloids in a traditional Chinese herb, the aconitum species[J]. Evid Based Complement Alternat Med, 2015, 2015(20):252434.
[18] 宋瑞,田媛,张尊建. 大黄4种饮片水提液体外肠道菌群转化比较研究[J]. 中国中药杂志,2012,37(12):1755-60. Song R,Tian Y,Zhang Z J. Comparison of transformation of four processed rhubarb aqueous extracts in intestinal bacteria in vitro[J].Chin J Chin Mater Med, 2012,37(12):1755-60.
[19] 杨肖锋,宋纯清.龙胆苦苷的肠内菌群代谢研究[J] .中国中药杂志,2000,25(11):673-6. Yang X F,Song C Q. Studies on the metabolism of gentiopcroside by rat intestinal flora[J]. Chin J Chin Mater Med, 2000,25(11):673-6.
[20] Quartieri A, García-Villalba R, Amaretti A, et al. Detection of novel metabolites of flaxseed lignans in vitro and in vivo[J]. Mol Nutr Food Res, 2016, 60(7):1590-601.
[21] 张钰哲. 离体大鼠肠内菌群对知母甾体皂苷代谢研究[J]. 大理学院学报(综合版), 2012, 11(3):5-8. Zhang Y Z. In vitro study of rat Coliform bacteria metabolism of steroidal sponin extract from Anemarrhena asphodeloides[J]. J Dali Univ, 2012,11(3):5-8.
[22] Swanson H I. Drug metabolism by the host and gut microbiota: a partnership or rivalry[J]. Drug Metab Dispos, 2015, 43(10):1499-504.
[23] Yoo D H,Kim I S,Van Le T K,et al. Gut microbiota-mediated drug interactions between lovastatin and antibiotics[J]. Drug Metab Dispos, 2014, 42(9):1508-13.
[24] Kim I S,Yoo D H,Jung I H,et al. Reduced metabolic activity of gut microbiota by antibiotics can potentiate the antithrombotic effect of aspirin[J]. Biochem Pharmacol, 2016,122(15):72-9.
[25] 文仁国,孙国林,彭晓波,等.长期缺氧对婴幼儿肠道菌群代谢的影响[J]. 局解手术学杂志,2014,23(2):121-2. Wen R G,Sun G L,Peng X B,et al. Chronic hypoxia in altering metabolism of intestinal flora of infants[J]. J Reg Anat Oper Surg, 2014,23(2):121-2.
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