香附候选标准饮片均匀化工艺研究
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摘要
目的:优选香附候选标准饮片的均匀化工艺。方法:采用L9(3)4正交试验设计,以出粉率、粉末均匀性、浸出物、HPLC特征峰积分总面积和α-香附酮含量为指标,优选最佳均匀化工艺。结果:香附候选标准饮片最佳均匀化工艺为:按粉碎设备1/2容积投入香附原形饮片,粉碎3次,每次55 s。结论:该均匀化工艺条件合理,稳定性好,为制定香附候选标准饮片均匀化技术规范提供了依据。
Objective:To select and optimize the homogenizing process of candidate standard pieces of Xiangfu(Cyperi Rhizoma). Methods:The optimal homogenization processing technology was investigated by orthogonal design,with the index of flour extraction rate,powder uniformity,the content of extract,integral total area of HPLC characteristic peak and content of α-cyperone. Results:The optimal processing technology was as follows:1/2 volume of the crushing equipment was filled with the original pieces of Xiangfu,which were smashed 3 times,55 seconds each time. Conclusion:The homogenization processing conditions are reasonably with good stability,which provide basis for technical specification of homogenizing candidate standard pieces of Xiangfu.
Objective:To select and optimize the homogenizing process of candidate standard pieces of Xiangfu(Cyperi Rhizoma). Methods:The optimal homogenization processing technology was investigated by orthogonal design,with the index of flour extraction rate,powder uniformity,the content of extract,integral total area of HPLC characteristic peak and content of α-cyperone. Results:The optimal processing technology was as follows:1/2 volume of the crushing equipment was filled with the original pieces of Xiangfu,which were smashed 3 times,55 seconds each time. Conclusion:The homogenization processing conditions are reasonably with good stability,which provide basis for technical specification of homogenizing candidate standard pieces of Xiangfu.
引文
[1]肖永庆,李丽,刘颖.加快中药标准饮片作为标准物质的基础研究步伐[J].中国中药杂志,2014,39(13):2428-2431.
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[3]任利,李伟,聂爱国,等.当归超微粉和普通粉的显微特征观察[J].河南中医学院学报,2005,20(6):27-28.
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[5]张琴,刘莉.川芎超微粉的粉体学性质研究[J].中草药,2010,41(11):1796-1799.
[6]乐大勇,王琼,安静,等.复方贝母散超微粉的制备及粉体表征和物理特性对比[J].中国实验方剂学杂志,2012,18(17):9-13.
[7]刘亮镜,祁俊,朱应成,等.柴葛退热散超微粉碎工艺优化[J].中国药房,2017,28(13):1837-1841.
[8]詹若挺,夏荃,成金乐,等.三七超微粉体与细粉、不同目数范围粉体的粒度分布和显微形貌特征的比较[J].中国粉体技术,2009,15(1):42-45.
[9]陈勇军,钱锦花,梁学良,等.中药超微粉均匀性评价研究[J].中国粉体技术,2014,20(3):52-55.
[10]项瑞,王玉蓉,杨连威,等.超微粉碎过程温度对羌活有效成分影响的考察[J].北京中医药大学学报,2010,33(2):123-126.
[2]李丽,刘颖,肖永庆.中药标准饮片作为标准物质应用若干问题探讨[J].北京中医药大学学报,2015,38(6):411-413.
[3]任利,李伟,聂爱国,等.当归超微粉和普通粉的显微特征观察[J].河南中医学院学报,2005,20(6):27-28.
[4]孙强,何应.当归超微粉的药剂学研究[J].中国药房,2007,18(15):1141-1143.
[5]张琴,刘莉.川芎超微粉的粉体学性质研究[J].中草药,2010,41(11):1796-1799.
[6]乐大勇,王琼,安静,等.复方贝母散超微粉的制备及粉体表征和物理特性对比[J].中国实验方剂学杂志,2012,18(17):9-13.
[7]刘亮镜,祁俊,朱应成,等.柴葛退热散超微粉碎工艺优化[J].中国药房,2017,28(13):1837-1841.
[8]詹若挺,夏荃,成金乐,等.三七超微粉体与细粉、不同目数范围粉体的粒度分布和显微形貌特征的比较[J].中国粉体技术,2009,15(1):42-45.
[9]陈勇军,钱锦花,梁学良,等.中药超微粉均匀性评价研究[J].中国粉体技术,2014,20(3):52-55.
[10]项瑞,王玉蓉,杨连威,等.超微粉碎过程温度对羌活有效成分影响的考察[J].北京中医药大学学报,2010,33(2):123-126.