二甲双胍联合克罗米芬治疗多囊卵巢综合征合并不孕症的疗效及其对内分泌的影响
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摘要
目的观察二甲双胍联合克罗米芬治疗多囊卵巢综合征(PCOS)合并不孕症的疗效及对内分泌的影响。方法90例PCOS合并不孕症患者随机应用克罗米芬(对照组)或二甲双胍联合克罗米芬(观察组)治疗,比较2组治疗后卵泡刺激素(FSH)、睾酮(T)、黄体生成素(LH)、空腹血糖(FPG)、子宫内膜厚度、妊娠率、排卵率、早孕流产率及生活质量。结果观察组FSH、T、LH、FPG水平及早孕流产率明显低于对照组,而子宫内膜厚度、妊娠率、排卵率及生活质量评分高于对照组(P<0.01或0.05)。结论二甲双胍联合克罗米芬治疗PCOS合并不孕症的疗效优于单用克罗米芬。
Objective To observe the clinical efficacy and endocrine effect of metformin and clomiphene for polycystic ovary syndrome(PCOS) with infertility. Methods Ninety patients with PCOS and infertility were randomly treated clomiphene(control group) or metformin and clomiphene(observation group). Levels of follicle stimulating hormone(FSH),testosterone, luteinizing hormone(LH), and fasting plasma glucose(FBG), endometrial thickness, pregnancy and ovulation rates, abortion rate of early pregnancy, and quality of life(QOL) were compared between 2 groups. Results Compared with control group, levels of FSH, testosterone, LH and FBG, and abortion rate of early pregnancy were lower, while endometrial thickness, pregnancy and ovulation rates, and QOL were higher in observation group(P<0.01 or 0.05). Conclusion Combined use of metformin and clomiphene is superior to single application of clomiphene in patients with PCOS and infertility.
Objective To observe the clinical efficacy and endocrine effect of metformin and clomiphene for polycystic ovary syndrome(PCOS) with infertility. Methods Ninety patients with PCOS and infertility were randomly treated clomiphene(control group) or metformin and clomiphene(observation group). Levels of follicle stimulating hormone(FSH),testosterone, luteinizing hormone(LH), and fasting plasma glucose(FBG), endometrial thickness, pregnancy and ovulation rates, abortion rate of early pregnancy, and quality of life(QOL) were compared between 2 groups. Results Compared with control group, levels of FSH, testosterone, LH and FBG, and abortion rate of early pregnancy were lower, while endometrial thickness, pregnancy and ovulation rates, and QOL were higher in observation group(P<0.01 or 0.05). Conclusion Combined use of metformin and clomiphene is superior to single application of clomiphene in patients with PCOS and infertility.
引文
[1]陈素平.达英-35联合二甲双胍治疗多囊卵巢综合征致不孕的临床疗效分析[J].深圳中西医结合杂志,2014,24(11):92-93.
[2]李蓉.疏肝补肾汤联合来曲唑治疗多囊卵巢综合征不孕不育症临床观察[J].深圳中西医结合杂志, 2017, 27(3):30-31.
[3]杨勇莉,王晓武,韦静.雌、孕激素联合克罗米芬、二甲双胍治疗多囊卵巢综合征合并不孕的临床疗效观察[J].中国妇幼保健, 2017, 32(16):3872-3875.
[4]覃庆媛,贺青蓉,叶焕巧,等.达英-35联合二甲双胍治疗多囊卵巢综合征不孕的疗效及其对患者内分泌性激素和代谢的影响[J].海南医学, 2017, 28(1):70-72.
[5]南燕,田燕妮.复方玄驹胶囊联合达英-35、克罗米芬治疗多囊卵巢综合征临床研究[J].陕西中医, 2017, 38(4):448-449.
[6]胡芸.二甲双胍联合炔雌醇环丙孕酮治疗多囊卵巢综合征不孕症临床观察[J].深圳中西医结合杂志, 2016, 26(19):81-82.
[7]张喜梅,马国芳.克罗米芬联合二甲双胍对多囊卵巢综合征患者外周血T细胞亚群及氧化应激水平的影响[J].山东医药, 2017, 57(12):88-90.
[8]王治鸿,刘翔华,张红梅,等.来曲唑联合炔雌醇环丙孕酮片二甲双胍治疗耐克罗米芬性多囊卵巢综合征的临床研究[J].中国药物与临床, 2016, 16(6):788-791.
[9]任红玲.二甲双胍联合克罗米芬治疗多囊卵巢综合征所致不孕的疗效分析[J].实用妇科内分泌杂志(电子版), 2016,3(1):162-163.
[10]黎艳,付丽,王慧英,等.克罗米酚联合二甲双胍对多囊卵巢综合征患者促进排卵疗效观察及对血清性激素结合球蛋白与硫酸脱氢表雄酮的影响[J].中国妇幼保健, 2016,31(2):418-420.
[11]徐岚,熊煜.炔雌醇环丙孕酮联合二甲双胍对多囊卵巢综合征患者排卵的影响[J].中国药房, 2016, 27(24):3368-3370.
[2]李蓉.疏肝补肾汤联合来曲唑治疗多囊卵巢综合征不孕不育症临床观察[J].深圳中西医结合杂志, 2017, 27(3):30-31.
[3]杨勇莉,王晓武,韦静.雌、孕激素联合克罗米芬、二甲双胍治疗多囊卵巢综合征合并不孕的临床疗效观察[J].中国妇幼保健, 2017, 32(16):3872-3875.
[4]覃庆媛,贺青蓉,叶焕巧,等.达英-35联合二甲双胍治疗多囊卵巢综合征不孕的疗效及其对患者内分泌性激素和代谢的影响[J].海南医学, 2017, 28(1):70-72.
[5]南燕,田燕妮.复方玄驹胶囊联合达英-35、克罗米芬治疗多囊卵巢综合征临床研究[J].陕西中医, 2017, 38(4):448-449.
[6]胡芸.二甲双胍联合炔雌醇环丙孕酮治疗多囊卵巢综合征不孕症临床观察[J].深圳中西医结合杂志, 2016, 26(19):81-82.
[7]张喜梅,马国芳.克罗米芬联合二甲双胍对多囊卵巢综合征患者外周血T细胞亚群及氧化应激水平的影响[J].山东医药, 2017, 57(12):88-90.
[8]王治鸿,刘翔华,张红梅,等.来曲唑联合炔雌醇环丙孕酮片二甲双胍治疗耐克罗米芬性多囊卵巢综合征的临床研究[J].中国药物与临床, 2016, 16(6):788-791.
[9]任红玲.二甲双胍联合克罗米芬治疗多囊卵巢综合征所致不孕的疗效分析[J].实用妇科内分泌杂志(电子版), 2016,3(1):162-163.
[10]黎艳,付丽,王慧英,等.克罗米酚联合二甲双胍对多囊卵巢综合征患者促进排卵疗效观察及对血清性激素结合球蛋白与硫酸脱氢表雄酮的影响[J].中国妇幼保健, 2016,31(2):418-420.
[11]徐岚,熊煜.炔雌醇环丙孕酮联合二甲双胍对多囊卵巢综合征患者排卵的影响[J].中国药房, 2016, 27(24):3368-3370.