血浆置换联合激素治疗血栓性血小板减少性紫癜疗效研究
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摘要
目的对血栓性血小板减少性紫癜(TTP)运用血浆置换联合激素治疗的疗效进行总结。方法对2006年3月~2010年3月由我科确诊的12例TTP患者给予血浆置换联合糖皮质激素治疗。结果本组经治疗后有11例患者症状明显改善,1例死于脑梗死并发急性肾功能衰竭,总有效率为91.7%;血浆置换治疗后5 d血小板恢复正常,住院9~14 d后均好转出院。结论血浆置换联合激素治疗TTP,安全性高,见效快,副作用少,治愈率高,能真正帮助患者减轻病痛,值得临床推广。
Objective To explore and summarize curative effect of plasma exchange combined with hormone therapy for idiopathic thrombocytopenic purpura(TTP) and thrombotic thrombocytopenic. Methods The 12 TTP patients diagnosed from March 2006 to March 2010 were treated with plasma exchange combined with glucocorticoid therapy. Results After treatment, 11 cases of patients with symptoms were significantly improved, 1 case died of cerebral infarction complicated with acute renal failure, the total effective rate was 91.7%. After 5 days plasma exchange treatment, platelet recovery normal. The patients were discharged with a better health condition after hospitalization for 9 to 14 d. Conclusion Plasma exchange combined with hormone in the treatment of TTP, with higher safety, quicker effect, less side effect, higher cure rate, really help patients to reduce pain, is worth the clinical promotion.
Objective To explore and summarize curative effect of plasma exchange combined with hormone therapy for idiopathic thrombocytopenic purpura(TTP) and thrombotic thrombocytopenic. Methods The 12 TTP patients diagnosed from March 2006 to March 2010 were treated with plasma exchange combined with glucocorticoid therapy. Results After treatment, 11 cases of patients with symptoms were significantly improved, 1 case died of cerebral infarction complicated with acute renal failure, the total effective rate was 91.7%. After 5 days plasma exchange treatment, platelet recovery normal. The patients were discharged with a better health condition after hospitalization for 9 to 14 d. Conclusion Plasma exchange combined with hormone in the treatment of TTP, with higher safety, quicker effect, less side effect, higher cure rate, really help patients to reduce pain, is worth the clinical promotion.
引文
[1]胡元,李旭东,黄仁魏,等.血浆置换联合激素治疗血栓性血小板减少性紫癜3例临床观察[J].国际内科学杂志,2009,36(5):305-307.
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[4]廖纯兴,张忠强,潘巧玲,等.血浆置换治疗血栓性血小板减少性紫癜的疗效观察[J].中南医学科学杂志,2012,40(1):70-72,82.
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[8]肖音,胡国瑜,袁朝晖,等.血浆置换联合激素治疗血栓性血小板减少性紫癜32例临床分析[J].中国医药指南,2013,(5):163.
[9]杨新平,彭宏,敖志文,等.血浆置换联合糖皮质激素治疗血栓性血小板减少性紫癜6例[J].实用临床医学,2010,11(9):28-30.
[10]韦夙,黄锦雄,叶红,等.血栓性血小板减少性紫癜6例临床分析[J].华夏医学,2011,24(3):309.
[11]李平.血栓性血小板减少性紫癜47例临床研究[D].北京协和医学院(中国医学科学院),2011.
[12]薛乾富,罗章琴,肖悦,等.血栓性血小板减少性紫癜11例及文献复习[J].检验医学与临床,2013,(19):2586-2587.
[2]Yun Yan,Zhang Dongxia,Han Xuanmao,et al.Diagnosis and treatment of thrombotic thrombocytopenic purpura clinical experience[J].Thrombosis and Hemostasis Science,2011,17(6):262-265.
[3]曲艺,高然,苏楠,等.血栓性血小板减少性紫癜的临床特征及治疗[J].中国全科医学,2012,15(27):3165-3167.
[4]廖纯兴,张忠强,潘巧玲,等.血浆置换治疗血栓性血小板减少性紫癜的疗效观察[J].中南医学科学杂志,2012,40(1):70-72,82.
[5]陈亨.血浆置换治疗血栓性血小板减少性紫癜疗效观察[J].临床医学,2011,31(9):53
[6]Fuge R,Bird JM,Fraser A,et al.Aclinicalfeatures,risk factor sand out come of thrombotic thrombocytopenic purpura occurring after bonemarrow transplantation[J].Br J Haematol,2001,113(1):58-64.
[7]孙玲.血栓性血小板减少性紫癜的临床研究及遗传性抗凝血酶缺乏症的分子机制研究[D].苏州大学,2013.
[8]肖音,胡国瑜,袁朝晖,等.血浆置换联合激素治疗血栓性血小板减少性紫癜32例临床分析[J].中国医药指南,2013,(5):163.
[9]杨新平,彭宏,敖志文,等.血浆置换联合糖皮质激素治疗血栓性血小板减少性紫癜6例[J].实用临床医学,2010,11(9):28-30.
[10]韦夙,黄锦雄,叶红,等.血栓性血小板减少性紫癜6例临床分析[J].华夏医学,2011,24(3):309.
[11]李平.血栓性血小板减少性紫癜47例临床研究[D].北京协和医学院(中国医学科学院),2011.
[12]薛乾富,罗章琴,肖悦,等.血栓性血小板减少性紫癜11例及文献复习[J].检验医学与临床,2013,(19):2586-2587.