鼻咽癌患者放射治疗期间两种鼻腔冲洗方法的效果对比

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英文篇名：Comparison of two methods of nasal irrigation during radiotherapy for patients with nasopharyngeal carcinoma 作者：陈瑶舟 ; 杨双利 英文作者：Chen Yaozhou;Yang Shuangli;The Fourth Affiliated Hospital of Guangxi Medical University; 关键词：鼻咽癌 ; 鼻腔冲洗 ; 生活质量 ; 鼻咽黏膜反应 英文关键词：nasopharyngeal carcinoma;;nasal irrigation;;quality of life;;nasopharyngeal mucosal reactions 中文刊名：GXYD 英文刊名：Journal of Guangxi Medical University 机构：广西医科大学第四附属医院; 出版日期：2019-03-30 出版单位：广西医科大学学报 年：2019 期：v.36 基金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题资助项目(No.Z2016191;No.Z20170895);; 柳州市科技攻关课题资助项目(No.2015J030512) 语种：中文; 页：GXYD201903034 页数：4 CN：03 ISSN：45-1211/R 分类号：139-142

摘要

目的:比较电动鼻腔冲洗仪与一次性鼻腔冲洗球两种鼻腔冲洗方法对鼻咽癌患者生活质量及鼻黏膜放射损伤的影响。方法:选取2015年9月至2016年6月在广西医科大学第四附属医院接受根治性放射治疗的60例鼻咽癌患者,随机分为研究组和对照组,每组30例。研究组在放射治疗期间采用气水式鼻腔洗器进行鼻咽冲洗护理,对照组使用一次性鼻腔冲洗球进行鼻咽冲洗护理,两组患者的冲洗液均为蒸馏水。采用鼻腔鼻窦结局测试-20量表(SNOT-20中文版)评估患者的生活质量,并通过鼻咽镜观察患者放射治疗后鼻黏膜放射损伤情况。结果:在放射治疗前及放射治疗早期,两组SNOT-20评分比较差异无统计学意义(P>0.05);与对照组比较,研究组放射治疗中期及放射治疗后期的SNOT-20评分明显降低,放疗后鼻咽黏膜损伤程度明显降低,差异均有统计学意义(均P<0.05)。结论:放射治疗期间使用气水式鼻腔冲洗器进行鼻咽冲洗护理,可减轻鼻咽癌患者鼻黏膜反应,改善患者放疗中期、后期的生活质量。
        Objective:To compare the influence of two methods of nasal irrigation on the quality of life and nasopharyngeal mucosal reactions of patients with nasopharyngeal carcinoma(NPC). Methods:From September 2015 to June 2016, 60 patients with NPC receiving radical radiotherapy in our hospital were selected, and randomly divided into a study group and a control group, with 30 cases in each group. The nasopharynx flushing nursing was carried out with air-water nasal lavage device during radiotherapy in the study group, and the nasopharyngeal irrigation was conducted by single-use nasal irrigator in the control group. The quality of life was evaluated by Sino-Nasal Outcome Test(SNOT-20 Chinese version). The nasal mucosa damage after radiotherapy was assessed. Results:There was no significant difference in SNOT-20 score between the two groups before and at the early stage of radiotherapy(P>0.05). Compared with the control group, the SNOT-20 score of the study group was significantly decreased in the middle and late stages of radiotherapy, and the degree of nasopharyngeal mucosal injury was markedly attenuated in the study group after radiotherapy(P<0.05). Conclusion:The application of air-water nasal irrigation device during radiotherapy could alleviate nasopharyngeal mucosal reactions of NPC patients, and improve the quality of life in middle-late stage of radiotherapy.

引文

[1] 周祥,张书旭,王锐濠,等.不同淋巴结转移状况的鼻咽癌调强放射治疗中腮腺和肿瘤靶区体积退缩与受照剂量的相关性[J].中华放射医学与防护杂志,2016,36(2):111-115.
    [2] 龚修云,金风,吴伟莉,等.局部晚期鼻咽癌诱导化疗后原发病灶靶区勾画的探讨[J].中华放射医学与防护杂志,2016,36(2):116-120.
    [3] 刘永玲,尚菲,金晓婷,等.吸入气体湿化对鼻内镜术后鼻导管双侧留置患者舒适度的影响[J].中华现代护理杂志,2017,23(12):1644-1647.
    [4] 陶源,陆兴,曾沛英.初次与再次手术鼻-鼻窦炎鼻息肉患者的生存质量调查[J].中国耳鼻咽喉颅底外科杂志,2017,23(3):251-255.
    [5] 谷铣之.肿瘤放射治疗学[M].北京:中国协和医科大学出版社,2008:1350-1351.
    [6] 左可军,方积乾,Piccirillo J F,等.鼻腔鼻窦结局测试-20(SNOT-20)量表中文版的研制[J].中华耳鼻咽喉头颈外科杂志,2008,43(10):751-756.
    [7] 孔琳,王磊,管西寅,等.碳离子调强放射治疗复发性局部晚期鼻咽癌的近期疗效及不良反应[J].中华放射医学与防护杂志,2016,36(8):601-606.
    [8] 陈利,黄晓延,曹午飞,等.鼻咽癌患者蒙特卡罗计算的介质与水吸收剂量差异分析[J].中华放射肿瘤学杂志,2015,24(2):136-137.
    [9] 王孝深.第8届全国鼻咽癌学术大会暨鼻咽癌规范化诊疗培训班结束[J].中华放射肿瘤学杂志,2017,26(5):494-494.
    [10] 满宪凤,范廷勇,邢军,等.鼻咽癌同步推量调强放射治疗与传统调强放射治疗的近远期疗效比较[J].中华肿瘤防治杂志,2016,23(4):244-247.
    [11] 李仕晟,杨曙.抑制PI3K-Akt通路逆转LMP1诱导的鼻咽癌细胞TRAIL抵抗[J].临床耳鼻咽喉头颈外科杂志,2016,30(9):744-747.
    [12] 朱红,李琳,罗巧兰,等.鼻内镜术后鼻腔冲洗病人行多模式健康教育效果观察[J],护理研究,2014,28(8):2873-2874.
    [13] 王慧敏,蔡纪堂,李静波,等.感染不同病原菌对慢性鼻-鼻窦炎伴鼻息肉患者内镜手术疗效及相关血清指标的影响研究[J].中华医院感染学杂志,2016,26(21):4935-4937.
    [14] 杜娟,彭云飞,孙东东.鼻腔冲洗在鼻内镜术后的应用观察[J].中国中西医结合耳鼻咽喉科杂志,2009,17(2):106,70.