摘要
目的探讨NT-proBNP对判断急性心肌梗死患者疾病病情程度及预后的价值。方法方便收集2015年1月—2017年9月该院90例急性心肌梗死患者,根据患者预后情况分为:存活组和死亡组。对比存活组和死亡组入院时NT-proBNP及肌酸激酶同工酶水平;两组NT-proBNP与肌酸激酶同工酶水平的相关性;死亡组NT-proBNP水平与冠状动脉病变情况。结果存活组和死亡组入院时NT-proBNP水平分别为(863.42±158.27)ng/L、(72.52±16.28)U/L、(1 325.87±269.31)ng/L、(106.33±28.42)U/L,差异有统计学意义(t=25.43、16.34,P<0.05);存活组和死亡组NT-proBNP与肌酸激酶同工酶水平的相关性分别为0.685、0.724,提示两种指标有较好的相关性;死亡组中冠状动脉单支病变者与冠状动脉多支病变者NT-proBNP水平分别为(1 258.36±224.81)ng/L、(1528.34±362.28)ng/L,差异有统计学意义(P<0.05)。结论NT-proBNP可以评价急性心肌梗死患者冠状动脉梗死数量,预测患者临床预后,同时与肌酸激酶同工酶水平有较好的相关性。
Objective To investigate the value of NT-proBNP in judging the severity and prognosis of patients with acute myocardial infarction. Methods 90 patients with acute myocardial infarction from January 2015 to September 2017 were convenient enrolled. According to the prognosis of patients, they were divided into survival group and death group. The levels of NT-proBNP and creatine kinase isoenzyme were compared between the survival group and the death group. The correlation between NT-proBNP and creatine kinase isoenzyme levels in the two groups; the NT-proBNP level and coronary lesions in the death group were observed. Results The NT-proBNP levels in the survival and death groups were(863.42 ±158.27 ng/L,(72.52±16.28)U/L,(1 325.87±269.31)ng/L,(106.33±28.42)U/L, respectively. The significance of learning(t=25.43, 16.34, P<0.05); the correlation between NT-proBNP and creatine kinase isoenzyme levels in the survival group and the death group were 0.685 and 0.724, respectively, suggesting that the two indicators have a good correlation. The levels of NT-proBNP in patients with coronary artery single-vessel disease and coronary artery multi-vessel disease in the death group were(1 258.36±224.81)ng/L and(1 528.34±362.28)ng/L, respectively, and the difference was statistically significant(P<0.05). Conclusion NT-proBNP can evaluate the number of coronary infarction in patients with acute myocardial infarction, predict the clinical prognosis of patients, and have a good correlation with creatine kinase isoenzyme levels.
引文
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