NT-proBNP对判断急性心肌梗死患者疾病病情程度及预后的价值
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摘要
目的探讨NT-proBNP对判断急性心肌梗死患者疾病病情程度及预后的价值。方法方便收集2015年1月—2017年9月该院90例急性心肌梗死患者,根据患者预后情况分为:存活组和死亡组。对比存活组和死亡组入院时NT-proBNP及肌酸激酶同工酶水平;两组NT-proBNP与肌酸激酶同工酶水平的相关性;死亡组NT-proBNP水平与冠状动脉病变情况。结果存活组和死亡组入院时NT-proBNP水平分别为(863.42±158.27)ng/L、(72.52±16.28)U/L、(1 325.87±269.31)ng/L、(106.33±28.42)U/L,差异有统计学意义(t=25.43、16.34,P<0.05);存活组和死亡组NT-proBNP与肌酸激酶同工酶水平的相关性分别为0.685、0.724,提示两种指标有较好的相关性;死亡组中冠状动脉单支病变者与冠状动脉多支病变者NT-proBNP水平分别为(1 258.36±224.81)ng/L、(1528.34±362.28)ng/L,差异有统计学意义(P<0.05)。结论NT-proBNP可以评价急性心肌梗死患者冠状动脉梗死数量,预测患者临床预后,同时与肌酸激酶同工酶水平有较好的相关性。
Objective To investigate the value of NT-proBNP in judging the severity and prognosis of patients with acute myocardial infarction. Methods 90 patients with acute myocardial infarction from January 2015 to September 2017 were convenient enrolled. According to the prognosis of patients, they were divided into survival group and death group. The levels of NT-proBNP and creatine kinase isoenzyme were compared between the survival group and the death group. The correlation between NT-proBNP and creatine kinase isoenzyme levels in the two groups; the NT-proBNP level and coronary lesions in the death group were observed. Results The NT-proBNP levels in the survival and death groups were(863.42 ±158.27 ng/L,(72.52±16.28)U/L,(1 325.87±269.31)ng/L,(106.33±28.42)U/L, respectively. The significance of learning(t=25.43, 16.34, P<0.05); the correlation between NT-proBNP and creatine kinase isoenzyme levels in the survival group and the death group were 0.685 and 0.724, respectively, suggesting that the two indicators have a good correlation. The levels of NT-proBNP in patients with coronary artery single-vessel disease and coronary artery multi-vessel disease in the death group were(1 258.36±224.81)ng/L and(1 528.34±362.28)ng/L, respectively, and the difference was statistically significant(P<0.05). Conclusion NT-proBNP can evaluate the number of coronary infarction in patients with acute myocardial infarction, predict the clinical prognosis of patients, and have a good correlation with creatine kinase isoenzyme levels.
Objective To investigate the value of NT-proBNP in judging the severity and prognosis of patients with acute myocardial infarction. Methods 90 patients with acute myocardial infarction from January 2015 to September 2017 were convenient enrolled. According to the prognosis of patients, they were divided into survival group and death group. The levels of NT-proBNP and creatine kinase isoenzyme were compared between the survival group and the death group. The correlation between NT-proBNP and creatine kinase isoenzyme levels in the two groups; the NT-proBNP level and coronary lesions in the death group were observed. Results The NT-proBNP levels in the survival and death groups were(863.42 ±158.27 ng/L,(72.52±16.28)U/L,(1 325.87±269.31)ng/L,(106.33±28.42)U/L, respectively. The significance of learning(t=25.43, 16.34, P<0.05); the correlation between NT-proBNP and creatine kinase isoenzyme levels in the survival group and the death group were 0.685 and 0.724, respectively, suggesting that the two indicators have a good correlation. The levels of NT-proBNP in patients with coronary artery single-vessel disease and coronary artery multi-vessel disease in the death group were(1 258.36±224.81)ng/L and(1 528.34±362.28)ng/L, respectively, and the difference was statistically significant(P<0.05). Conclusion NT-proBNP can evaluate the number of coronary infarction in patients with acute myocardial infarction, predict the clinical prognosis of patients, and have a good correlation with creatine kinase isoenzyme levels.
引文
[1]冉兵,晁玥,王永刚,等.血清h-FABP、cTnⅠ、NT-proBNP联合超声心动图诊断急性心肌梗死的意义[J].临床医学研究与实践,2018(31):146-147.
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[9]马勇翔,李殿富.血浆NT-proBNP水平在急性心肌梗死病人造影剂肾病中的应用及相关性研究[J].中西医结合心脑血管病杂志,2018,16(12):1728-1731.
[10]N Ramakrishnan,M Kerisnan,S Hani,et al.Prognostic Value of NT-proBNP in Acute ST Elevation Myocardial Infarction Patients Who Underwent Primary Percutaneous Coronary Intervention[J]. Int J Car,2017,249.
[11]Pyung Oh,Jongwook Yu,Minsu Kim,et al. TCT-664Improved early risk stratification of patients with STsegment elevation myocardial infarction undergoing primary percutaneous coronary intervention using a combination of serum ST2 and NT-proBNP[J]. J Ame Col,2017,70(18).
[12]黄宏鑑,欧武英,许永莉.血清超敏C反应蛋白N末端B型利钠肽原检测对急性心肌梗死患者预后的影响[J].山西医药杂志,2017,46(14):1663-1665.
[13]许旭光,韩菡,顾燕,等.老年心肌梗死患者外周血内NTproBNP水平与梗死部位和预后质量的相关性分析[J].中国社区医师,2017,33(22):128-129.
[14]陈运起,李海丽,史丽.黄芪保心颗粒对急性心肌梗死伴心衰患者左心功能及血清H-FABP、cTnⅠ、Nt-proBNP的影响[J].中药药理与临床,2017,33(4):190-193.
[15]黄明剑,潘朝锌.NT-proBNP在急性心肌梗死心功能及预后评判价值研究进展[J].中西医结合心血管病电子杂志,2017,5(21):26.
[16]王薇.心肌肌钙蛋白I、肌钙蛋白T和NT-proBNP联合检测用于急性心肌梗死诊断中的效果[J].世界最新医学信息文摘,2017,17(61):115.
[2]蔡新宇,程绩,苏晴,等.急性心肌梗死患者血浆BNP、NTpro BNP、MYO及c TnI水平的表达及临床意义[J].现代生物医学进展,2018,18(20):3866-3869,3891.
[3]柳东红,农妍,彭影,等.血清NT-proBNP、hs-CRP和CysC检测在急性心肌梗死中的应用[J].检验医学与临床,2018,15(20):3063-3065.
[4]嵇朋,杨佳蕾,李小刚.血浆N末端B型钠尿肽前体和D-二聚体对急性脑梗死患者预后影响的研究[J].中华老年心脑血管病杂志,2018,20(10):1058-1061.
[5]王喆.肌钙蛋白T及肌红蛋白和氨基末端B型利钠肽前体联合检测在心肌梗死诊断中的临床价值[J].中国医学工程,2018,26(9):78-79.
[6]高渊,袁森,袁祖贻.双峰型NT-proBNP在急性ST抬高型心肌梗死病人近期预后评估中临床价值研究[J].内蒙古医科大学学报,2018,40(4):319-323,328.
[7]张凤珍.NT-proBNP、cTn I、cTn T联合检测在急性心肌梗死诊断中的应用价值[J].河南医学研究,2018,27(14):2598-2599.
[8]陈冠成,陈哲林,方填源,等.血浆NT-proBNP对心肌梗死发病部位及与预后的关系分析[J].河北医学,2018,24(7):1135-1139.
[9]马勇翔,李殿富.血浆NT-proBNP水平在急性心肌梗死病人造影剂肾病中的应用及相关性研究[J].中西医结合心脑血管病杂志,2018,16(12):1728-1731.
[10]N Ramakrishnan,M Kerisnan,S Hani,et al.Prognostic Value of NT-proBNP in Acute ST Elevation Myocardial Infarction Patients Who Underwent Primary Percutaneous Coronary Intervention[J]. Int J Car,2017,249.
[11]Pyung Oh,Jongwook Yu,Minsu Kim,et al. TCT-664Improved early risk stratification of patients with STsegment elevation myocardial infarction undergoing primary percutaneous coronary intervention using a combination of serum ST2 and NT-proBNP[J]. J Ame Col,2017,70(18).
[12]黄宏鑑,欧武英,许永莉.血清超敏C反应蛋白N末端B型利钠肽原检测对急性心肌梗死患者预后的影响[J].山西医药杂志,2017,46(14):1663-1665.
[13]许旭光,韩菡,顾燕,等.老年心肌梗死患者外周血内NTproBNP水平与梗死部位和预后质量的相关性分析[J].中国社区医师,2017,33(22):128-129.
[14]陈运起,李海丽,史丽.黄芪保心颗粒对急性心肌梗死伴心衰患者左心功能及血清H-FABP、cTnⅠ、Nt-proBNP的影响[J].中药药理与临床,2017,33(4):190-193.
[15]黄明剑,潘朝锌.NT-proBNP在急性心肌梗死心功能及预后评判价值研究进展[J].中西医结合心血管病电子杂志,2017,5(21):26.
[16]王薇.心肌肌钙蛋白I、肌钙蛋白T和NT-proBNP联合检测用于急性心肌梗死诊断中的效果[J].世界最新医学信息文摘,2017,17(61):115.