CHI3L1基因与支气管哮喘相关性的研究
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摘要
支气管哮喘是由环境因素和基因因素相互影响的一种多基因遗传病,其具有明显的家族遗传倾向,因此有关哮喘遗传基因的研究成为热点。CHI3L1基因为近年来新发现的与哮喘相关的一种基因,其编码蛋白为YKL-40,二者参与哮喘发病机制。该文将对CHI3L1基因的结构、多态性及其编码蛋白与哮喘的关系作一综述。
Bronchial asthma is a kind of polygenetic hereditary disease which is influenced by environmental factors and genetic factors.It has obvious familial genetic tendency,so the research on the genetic genes of asthma has become a hot spot.CHI3 L1 gene is a newly discovered gene related to asthma in recent years,and its encoding protein is YKL-40,both of them participate in the pathogenesis of asthma.This article reviews the structure,polymorphism of CHI3 L1 gene and the relationship between its coding protein and asthma.
Bronchial asthma is a kind of polygenetic hereditary disease which is influenced by environmental factors and genetic factors.It has obvious familial genetic tendency,so the research on the genetic genes of asthma has become a hot spot.CHI3 L1 gene is a newly discovered gene related to asthma in recent years,and its encoding protein is YKL-40,both of them participate in the pathogenesis of asthma.This article reviews the structure,polymorphism of CHI3 L1 gene and the relationship between its coding protein and asthma.
引文
[1] Zhu Y,Yan X,Zhai C,et al.Association between risk of asthma and gene polymorphisms in CHI3L1 and CHIA:a systematic meta-analysis[J].BMC Pulm Med,2017,17(1):193.
[2] 蔡旭龙,林娜.白介素-9基因多态性及其血清水平与黑衣壮儿童哮喘发病的关系[J].广西医学,2017,39(1):15-17.
[3] 李基明,张慧芬,沈晓丽,等.CHI3L1基因单核苷酸多态性与儿童哮喘易感性的相关性研究[J].中国当代儿科杂志,2015,17(2):144-148.
[4] Komi DE,Kazemi T,Bussink AP.New Insights Into the Relationship Between Chitinase-3-Like-1 and Asthma[J].Curr Allergy Asthma Rep,2016,16(8):57.
[5] 鲁衍强,李瑛,郭文竹,等.哮喘相关基因研究进展[J].新医学,2013,44(4):227-230.
[6] 王洪霞,刘春涛.支气管哮喘相关基因CHI3L1的研究进展[J].中华哮喘杂志,2012,6(3):183-186.
[7] Kang MJ,Yoon CM,Nam M,et al.Role of Chitinase 3-Like-1 in Interleukin-18-Induced Pulmonary Type 1,Type 2,and Type 17 Inflammation;Alveolar Destruction;and Airway Fibrosis in the Murine Lung[J].Am J Respir Cell Mol Biol,2015,53(6):863-871.
[8] Kim MJ,Shim DH,Cha HR,et al.Chitinase 3-like 1 protein plays a critical role in respiratory syncytial virus-induced airway inflammation[J].Allergy,2019,74(4):685-697.
[9] Ober C,Tan Z,Sun Y,et al.Effect of variation in CHI3L1 on serum YKL-40 level,risk of asthma,and lung function[J].N Engl J Med,2008,358(16):1682-1691.
[10] Lai T,Chen M,Deng Z,et al.YKL-40 is correlated with FEV1 and the asthma control test (ACT) in asthmatic patients:influence of treatment[J].BMC Pulm Med,2015,15:1.
[11] Naglot S,Aggarwal P,Dey S,et al.Estimation of Serum YKL-40 by Real-Time Surface Plasmon Resonance Technology in North-Indian Asthma Patients[J].J Clin Lab Anal,2017,31(2).[Epub 2016 Sep 12]
[12] Guerra S,Melen E,Sunyer J,et al.Genetic and epigenetic regulation of YKL-40 in childhood[J].J Allergy Clin Immunol,2018,141(3):1105-1114.
[13] Gavala ML,Kelly EA,Esnault S,et al.Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma[J].Clin Exp Allergy,2013,43(2):187-197.
[14] Bara I,Ozier A,Girodet PO,et al.Role of YKL-40 in bronchial smooth muscle remodeling in asthma[J].Am J Respir Crit Care Med,2012,185(7):715-722.
[15] Chupp GL,Lee CG,Jarjour N,et al.A chitinase-like protein in the lung and circulation of patients with severe asthma[J].N Engl J Med,2007,357(20):2016-2027.
[16] Kuepper M,Bratke K,Virchow JC.Chitinase-like protein and asthma[J].N Engl J Med,2008,358(10):1073-1075;author reply 1075.
[17] Lee CG,Hartl D,Lee GR,et al.Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis[J].J Exp Med,2009,206(5):1149-1166.
[18] 李琎,曲书强.CHI3 L1 基因与哮喘及其严重程度的关系[J].国际遗传学杂志,2016,39(5):282-284.
[19] 王盼,任立红.MiR-146a基因多态性与儿童哮喘的相关性研究进展[J].中国优生与遗传杂志,2018,26(3):4-5.
[20] 蔡旭龙,林玛丽,曹珊,等.IL1R1基因多态性与黑衣壮儿童哮喘的相关性研究[J].右江医学,2017,45(1):6-10.
[21] 鮑一笑,华丽.哮喘基因研究进展[J].中华实用儿科临床杂志,2013,28(16):1201-1203.
[22] 李基明.CHI3L1基因单核苷酸多态性与福建闽南地区汉族人群儿童哮喘易感性的相关性研究[D].福州:福建医科大学,2014.
[23] 邵亚望.支气管哮喘患儿CHI3L1基因多态性与气道重塑及炎症反应关联性的研究[D].兰州:兰州大学,2017.
[24] Tsai Y,Ko Y,Huang M,et al.CHI3L1 polymorphisms associate with asthma in a Taiwannese population[J].BMC Med Genet,2014,15:86.
[25] 陈敏,赖天文,招轩娜,等.CHI3L1基因多态性和血清YKL-40水平与支气管哮喘发病的关联性[J].吉林大学学报(医学版),2014,40(5):1058-1063.
[26] 钟雨,吴斌.CHI3LI基因多态性与支气管哮喘[J].大家健康(学术版),2013,7(10):6-7.
[27] Gomez JL,Crisafi GM,Holm CT,et al.Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40[J].Allergy Clin Immunol,2015,136(1):51-58.
[28] Wu AC,Lasky-su J,Rogers CA,et al.Polymorphisms of chitinases are not associated with asthma[J].J Allergy Clin Immunol,2010,125(3):754-757.
[2] 蔡旭龙,林娜.白介素-9基因多态性及其血清水平与黑衣壮儿童哮喘发病的关系[J].广西医学,2017,39(1):15-17.
[3] 李基明,张慧芬,沈晓丽,等.CHI3L1基因单核苷酸多态性与儿童哮喘易感性的相关性研究[J].中国当代儿科杂志,2015,17(2):144-148.
[4] Komi DE,Kazemi T,Bussink AP.New Insights Into the Relationship Between Chitinase-3-Like-1 and Asthma[J].Curr Allergy Asthma Rep,2016,16(8):57.
[5] 鲁衍强,李瑛,郭文竹,等.哮喘相关基因研究进展[J].新医学,2013,44(4):227-230.
[6] 王洪霞,刘春涛.支气管哮喘相关基因CHI3L1的研究进展[J].中华哮喘杂志,2012,6(3):183-186.
[7] Kang MJ,Yoon CM,Nam M,et al.Role of Chitinase 3-Like-1 in Interleukin-18-Induced Pulmonary Type 1,Type 2,and Type 17 Inflammation;Alveolar Destruction;and Airway Fibrosis in the Murine Lung[J].Am J Respir Cell Mol Biol,2015,53(6):863-871.
[8] Kim MJ,Shim DH,Cha HR,et al.Chitinase 3-like 1 protein plays a critical role in respiratory syncytial virus-induced airway inflammation[J].Allergy,2019,74(4):685-697.
[9] Ober C,Tan Z,Sun Y,et al.Effect of variation in CHI3L1 on serum YKL-40 level,risk of asthma,and lung function[J].N Engl J Med,2008,358(16):1682-1691.
[10] Lai T,Chen M,Deng Z,et al.YKL-40 is correlated with FEV1 and the asthma control test (ACT) in asthmatic patients:influence of treatment[J].BMC Pulm Med,2015,15:1.
[11] Naglot S,Aggarwal P,Dey S,et al.Estimation of Serum YKL-40 by Real-Time Surface Plasmon Resonance Technology in North-Indian Asthma Patients[J].J Clin Lab Anal,2017,31(2).[Epub 2016 Sep 12]
[12] Guerra S,Melen E,Sunyer J,et al.Genetic and epigenetic regulation of YKL-40 in childhood[J].J Allergy Clin Immunol,2018,141(3):1105-1114.
[13] Gavala ML,Kelly EA,Esnault S,et al.Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma[J].Clin Exp Allergy,2013,43(2):187-197.
[14] Bara I,Ozier A,Girodet PO,et al.Role of YKL-40 in bronchial smooth muscle remodeling in asthma[J].Am J Respir Crit Care Med,2012,185(7):715-722.
[15] Chupp GL,Lee CG,Jarjour N,et al.A chitinase-like protein in the lung and circulation of patients with severe asthma[J].N Engl J Med,2007,357(20):2016-2027.
[16] Kuepper M,Bratke K,Virchow JC.Chitinase-like protein and asthma[J].N Engl J Med,2008,358(10):1073-1075;author reply 1075.
[17] Lee CG,Hartl D,Lee GR,et al.Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis[J].J Exp Med,2009,206(5):1149-1166.
[18] 李琎,曲书强.CHI3 L1 基因与哮喘及其严重程度的关系[J].国际遗传学杂志,2016,39(5):282-284.
[19] 王盼,任立红.MiR-146a基因多态性与儿童哮喘的相关性研究进展[J].中国优生与遗传杂志,2018,26(3):4-5.
[20] 蔡旭龙,林玛丽,曹珊,等.IL1R1基因多态性与黑衣壮儿童哮喘的相关性研究[J].右江医学,2017,45(1):6-10.
[21] 鮑一笑,华丽.哮喘基因研究进展[J].中华实用儿科临床杂志,2013,28(16):1201-1203.
[22] 李基明.CHI3L1基因单核苷酸多态性与福建闽南地区汉族人群儿童哮喘易感性的相关性研究[D].福州:福建医科大学,2014.
[23] 邵亚望.支气管哮喘患儿CHI3L1基因多态性与气道重塑及炎症反应关联性的研究[D].兰州:兰州大学,2017.
[24] Tsai Y,Ko Y,Huang M,et al.CHI3L1 polymorphisms associate with asthma in a Taiwannese population[J].BMC Med Genet,2014,15:86.
[25] 陈敏,赖天文,招轩娜,等.CHI3L1基因多态性和血清YKL-40水平与支气管哮喘发病的关联性[J].吉林大学学报(医学版),2014,40(5):1058-1063.
[26] 钟雨,吴斌.CHI3LI基因多态性与支气管哮喘[J].大家健康(学术版),2013,7(10):6-7.
[27] Gomez JL,Crisafi GM,Holm CT,et al.Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40[J].Allergy Clin Immunol,2015,136(1):51-58.
[28] Wu AC,Lasky-su J,Rogers CA,et al.Polymorphisms of chitinases are not associated with asthma[J].J Allergy Clin Immunol,2010,125(3):754-757.